Search Results - "BOHGAKI, Toshiyuki"

First‐Line, Non‐Criterial Antiphospholipid Antibody Testing for the Diagnosis of Antiphospholipid Syndrome in Clinical Practice: A Combination of Anti–β2‐Glycoprotein I Domain I and Anti–Phosphatidylserine/Prothrombin Complex Antibodies Tests by Nakamura, Hiroyuki, Oku, Kenji, Amengual, Olga, Ohmura, Kazumasa, Fujieda, Yuichiro, Kato, Masaru, Bohgaki, Toshiyuki, Yasuda, Shinsuke, Atsumi, Tatsuya

“…Objective To assess the value of a combination of anti–β2‐glycoprotein I (anti‐β2GPI) domain I antibody and anti–phosphatidylserine/prothrombin complex…”
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RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks by Bohgaki, Miyuki, Bohgaki, Toshiyuki, El Ghamrasni, Samah, Srikumar, Tharan, Maire, Georges, Panier, Stephanie, Fradet-Turcotte, Amélie, Stewart, Grant S., Raught, Brian, Hakem, Anne, Hakem, Razqallah

“…Defective signaling or repair of DNA double-strand breaks has been associated with developmental defects and human diseases. The E3 ligase RING finger 168…”
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Ectopic RASGRP2 (CalDAG-GEFI) expression in rheumatoid synovium contributes to the development of destructive arthritis by Nakamura, Hiroyuki, Shimamura, Sanae, Yasuda, Shinsuke, Kono, Michihito, Kono, Michihiro, Fujieda, Yuichiro, Kato, Masaru, Oku, Kenji, Bohgaki, Toshiyuki, Shimizu, Tomohiro, Iwasaki, Norimasa, Atsumi, Tatsuya

“…Rheumatoid arthritis (RA) is an autoimmune polyarthritis, in which fibroblast-like synoviocytes (FLS) play a key role in cartilage and bone destruction through…”
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Complement and thrombosis in the antiphospholipid syndrome by Oku, Kenji, Nakamura, Hiroyuki, Kono, Michihiro, Ohmura, Kazumasa, Kato, Masaru, Bohgaki, Toshiyuki, Horita, Tetsuya, Yasuda, Shinsuke, and, Olga Amengual, Atsumi, Tatsuya

“…Abstract The involvement of complement activation in the pathophysiology of antiphospholipid syndrome (APS) was first reported in murine models of…”
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Pathogenic roles of anti-C1q antibodies in recurrent pregnancy loss by Ohmura, Kazumasa, Oku, Kenji, Kitaori, Tamao, Amengual, Olga, Hisada, Ryo, Kanda, Masatoshi, Shimizu, Yuka, Fujieda, Yuichiro, Kato, Masaru, Bohgaki, Toshiyuki, Horita, Tetsuya, Yasuda, Shinsuke, Sugiura-Ogasawara, Mayumi, Atsumi, Tatsuya

“…Recurrent pregnancy loss (RPL) is often considered idiopathic, however excessive complement activation has been observed in pregnancy related manifestations…”
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RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation by Guturi, Kiran Kumar Naidu, Bohgaki, Miyuki, Bohgaki, Toshiyuki, Srikumar, Tharan, Ng, Deborah, Kumareswaran, Ramya, El Ghamrasni, Samah, Jeon, Justin, Patel, Parasvi, Eldin, Mohamed Saad, Bristow, Rob, Cheung, Peter, Stewart, Grant S., Raught, Brian, Hakem, Anne, Hakem, Razqallah

“…Topoisomerase IIα (TOP2α) is essential for chromosomal condensation and segregation, as well as genomic integrity. Here we report that RNF168, an E3 ligase…”
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Autoantibodies against a complement component 1 q subcomponent contribute to complement activation and recurrent thrombosis/pregnancy morbidity in anti-phospholipid syndrome by Oku, Kenji, Amengual, Olga, Hisada, Ryo, Ohmura, Kazumasa, Nakagawa, Ikuma, Watanabe, Toshiyuki, Bohgaki, Toshiyuki, Horita, Tetsuya, Yasuda, Shinsuke, Atsumi, Tatsuya

“…To investigate the prevalence and significance of the autoantibodies against complement component 1 q subcomponent (C1q) in patients with APS. In all, 40…”
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Anti-cyclic citrullinated peptide antibody titers decrease in rheumatoid arthritis patients treated with tocilizumab: A pilot study by Noguchi, Atsushi, Yasuda, Shinsuke, Hisada, Ryo, Kato, Masaru, Oku, Kenji, Bohgaki, Toshiyuki, Suzuki, Miho, Matsumoto, Yoshihiro, Atsumi, Tatsuya

“…Objectives: To analyze the effects of tocilizumab on peripheral B-cell subpopulation and its ability to produce anti-cyclic citrullinated peptide (CCP)…”
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Potential therapeutics for antiphospholipid antibody associated thrombocytopenia: A systematic review and meta-analysis by Abe, Nobuya, Oku, Kenji, Amengual, Olga, Fujieda, Yuichiro, Kato, Masaru, Bohgaki, Toshiyuki, Yasuda, Shinsuke, Mori, Rintaro, Morishita, Eriko, Suzuki-Inoue, Katsue, Atsumi, Tatsuya

“…Objectives: Thrombocytopenia is frequently observed in antiphospholipid antibody (aPL) carriers. Due to the paradoxical risks of thrombosis and hemorrhage, the…”
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Effect of combined treatment with bisphosphonate and vitamin D on atherosclerosis in patients with systemic lupus erythematosus: a propensity score-based analysis by Ohmura, Kazumasa, Kato, Masaru, Watanabe, Toshiyuki, Oku, Kenji, Bohgaki, Toshiyuki, Horita, Tetsuya, Yasuda, Shinsuke, Ito, Yoichi M, Sato, Norihiro, Atsumi, Tatsuya

“…Premature atherosclerosis is one of the major complications of systemic lupus erythematosus (SLE). Recently, the biological linkage between atherosclerosis and…”
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Significance of fully automated tests for the diagnosis of antiphospholipid syndrome by Oku, Kenji, Amengual, Olga, Kato, Masaru, Bohgaki, Toshiyuki, Horita, Tetsuya, Yasuda, Shinsuke, Sakamoto, Naoya, Ieko, Masahiro, Norman, Gary L, Atsumi, Tatsuya

“…Abstract Antiphospholipid antibodies (aPLs) can vary both immunologically and functionally, thus it is important to effectively and correctly identify their…”
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Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome by Bohgaki, Toshiyuki, Bohgaki, Miyuki, Cardoso, Renato, Panier, Stephanie, Zeegers, Dimphy, Li, Li, Stewart, Grant S, Sanchez, Otto, Hande, M Prakash, Durocher, Daniel, Hakem, Anne, Hakem, Razqallah

“…Eukaryotic cells have evolved to use complex pathways for DNA damage signaling and repair to maintain genomic integrity. RNF168 is a novel E3 ligase that…”
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Treatment of Vasodilator-resistant Mixed Connective Tissue Disease-associated Pulmonary Arterial Hypertension with Glucocorticoid and Cyclophosphamide by Sugawara, Eri, Kato, Masaru, Hisada, Ryo, Oku, Kenji, Bohgaki, Toshiyuki, Horita, Tetsuya, Yasuda, Shinsuke, Atsumi, Tatsuya

“…Pulmonary arterial hypertension (PAH) associated with systemic lupus erythematosus (SLE) or mixed connective tissue disease (MTCD), in contrast to other types…”
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Alternative pathway activation due to low level of complement factor H in primary antiphospholipid syndrome by Nakamura, Hiroyuki, Oku, Kenji, Ogata, Yusuke, Ohmura, Kazumasa, Yoshida, Yoko, Kitano, Etsuko, Fujieda, Yuichiro, Kato, Masaru, Bohgaki, Toshiyuki, Amengual, Olga, Yasuda, Shinsuke, Fujimura, Yoshihiro, Seya, Tsukasa, Atsumi, Tatsuya

“…Although complement activation has been proposed as a possible thrombophilic mechanism in antiphospholipid syndrome (APS), the origin of complement activation…”
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Interferon-inducible Mx1 protein is highly expressed in renal tissues from treatment-naïve lupus nephritis, but not in those under immunosuppressive treatment by Shimizu, Yuka, Yasuda, Shinsuke, Kimura, Taichi, Nishio, Saori, Kono, Michihiro, Ohmura, Kazumasa, Shimamura, Sanae, Kono, Michihito, Fujieda, Yuichiro, Kato, Masaru, Oku, Kenji, Bohgaki, Toshiyuki, Fukasawa, Yuichiro, Tanaka, Shinya, Atsumi, Tatsuya

“…Objectives: The aim of this study was to clarify the consequences of Mx1, one of the IFN-inducible proteins, in the peripheral blood as well as in renal…”
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DNA double-strand break signaling and human disorders by Bohgaki, Toshiyuki, Bohgaki, Miyuki, Hakem, Razqallah

“…DNA double-strand breaks are among the most serious types of DNA damage and their signaling and repair is critical for all cells and organisms. The repair of…”
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Clinical significance of plasma presepsin levels in patients with systemic lupus erythematosus by Tanimura, Shun, Fujieda, Yuichiro, Kono, Michihiro, Shibata, Yuhei, Hisada, Ryo, Sugawara, Eri, Nakamura, Hiroyuki, Ohmura, Kazumasa, Shimamura, Sanae, Mitani, Asako, Shida, Haruki, Watanabe, Toshiyuki, Kato, Masaru, Oku, Kenji, Bohgaki, Toshiyuki, Amengual, Olga, Yasuda, Shinsuke, Shimizu, Chikara, Atsumi, Tatsuya

“…Objectives: Presepsin (PSEP: soluble CD14 subtype) is produced from bacteria-stimulated monocytes or neutrophils, thus recognized as a biomarker of sepsis…”
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Autologous haematopoietic stem cell transplantation for Japanese patients with systemic sclerosis: Long-term follow-up on a phase II trial and treatment-related fatal cardiomyopathy by Nakamura, Hiroyuki, Odani, Toshio, Yasuda, Shinsuke, Noguchi, Atsushi, Fujieda, Yuichiro, Kato, Masaru, Oku, Kenji, Bohgaki, Toshiyuki, Sugita, Junichi, Endo, Tomoyuki, Teshima, Takanori, Atsumi, Tatsuya

“…Objectives: The objective of this study is to elucidate the efficacy and safety of autologous haematopoietic stem cell transplantation (HSCT) for Japanese…”
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Successful treatment with clarithromycin for patients with polymyalgia rheumatica by Ohe, Masashi, Bohgaki, Toshiyuki

“…KCI Citation Count: 2…”
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Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC) by Oku, Kenji, Atsumi, Tatsuya, Akiyama, Yuji, Amano, Hirofumi, Azuma, Naoto, Bohgaki, Toshiyuki, Asanuma, Yu Funakubo, Horita, Tetsuya, Hosoya, Tadashi, Ichinose, Kunihiro, Kato, Masaru, Katsumata, Yasuhiro, Kawaguchi, Yasushi, Kawakami, Atsushi, Koga, Tomohiro, Kohsaka, Hitoshi, Kondo, Yuya, Kubo, Kanae, Kuwana, Masataka, Mimori, Akio, Mimori, Tsuneyo, Mimura, Toshihide, Murakami, Kosaku, Nakano, Kazuhisa, Nakayamada, Shingo, Ogishima, Hiroshi, Ohmura, Kazumasa, Saito, Kazuyoshi, Sano, Hajime, Shibuya, Mihoko, Takahashi, Yuko, Takasaki, Yoshinari, Takeuchi, Tsutomu, Tamura, Naoto, Tanaka, Yoshiya, Tsuboi, Hiroto, Tsunoda, Shinichiro, Yukawa, Naoichiro, Yamakawa, Noriyuki, Yamamoto, Kazuhiko, Sumida, Takayuki

“…Objective: To evaluate the performance of the 2012 Systemic Lupus International Collaborating Clinics criteria (SLICC-12) on classifying systemic lupus…”
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