Search Results - "BOGANI, Costanza"

miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis by Norfo, Ruggiero, Zini, Roberta, Pennucci, Valentina, Bianchi, Elisa, Salati, Simona, Guglielmelli, Paola, Bogani, Costanza, Fanelli, Tiziana, Mannarelli, Carmela, Rosti, Vittorio, Pietra, Daniela, Salmoiraghi, Silvia, Bisognin, Andrea, Ruberti, Samantha, Rontauroli, Sebastiano, Sacchi, Giorgia, Prudente, Zelia, Barosi, Giovanni, Cazzola, Mario, Rambaldi, Alessandro, Bortoluzzi, Stefania, Ferrari, Sergio, Tagliafico, Enrico, Vannucchi, Alessandro M., Manfredini, Rossella

“…Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by megakaryocyte (MK) hyperplasia, bone marrow fibrosis, and abnormal stem cell…”
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mTOR inhibitors alone and in combination with JAK2 inhibitors effectively inhibit cells of myeloproliferative neoplasms by Bogani, Costanza, Bartalucci, Niccolò, Martinelli, Serena, Tozzi, Lorenzo, Guglielmelli, Paola, Bosi, Alberto, Vannucchi, Alessandro M

“…Dysregulated signaling of the JAK/STAT pathway is a common feature of chronic myeloproliferative neoplasms (MPN), usually associated with JAK2V617F mutation…”
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β3-Adrenoreceptor Blockade Reduces Hypoxic Myeloid Leukemic Cells Survival and Chemoresistance by Calvani, Maura, Dabraio, Annalisa, Bruno, Gennaro, De Gregorio, Veronica, Coronnello, Marcella, Bogani, Costanza, Ciullini, Sara, Marca, Giancarlo la, Vignoli, Marina, Chiarugi, Paola, Nardi, Margherita, Vannucchi, Alessandro Maria, Filippi, Luca, Favre, Claudio

“…β-adrenergic signaling is known to be involved in cancer progression; in particular, beta3-adrenoreceptor (β3-AR) is associated with different tumor…”
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Increased Risk of Lymphoid Neoplasms in Patients with Philadelphia Chromosome–Negative Myeloproliferative Neoplasms by VANNUCCHI, Alessandro M, MASALA, Giovanna, PONZIANI, Vanessa, PANCRAZZI, Alessandro, ANNUNZIATO, Francesco, BOSI, Alberto, ANTONIOLI, Elisabetta, CHIARA SUSINI, Maria, GUGLIELMELLI, Paola, PIERI, Lisa, MAGGI, Laura, CAINI, Saverio, PALLI, Domenico, BOGANI, Costanza

“…Association of myeloproliferative neoplasm (MPN) with lymphoproliferative neoplasm (LPN) has been occasionally reported. The aim of this study, which included…”
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Mitochondrial Expression and Functional Activity of Breast Cancer Resistance Protein in Different Multiple Drug-Resistant Cell Lines by SOLAZZO, Michela, FANTAPPIE, Ornella, D'AMICO, Massimo, SASSOLI, Chiara, TANI, Alessia, CIPRIANI, Greta, BOGANI, Costanza, FORMIGLI, Lucia, MAZZANTI, Roberto

“…The multidrug resistance (MDR) phenotype is characterized by the overexpression of a few transport proteins at the plasma membrane level, one of which is the…”
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Molecular Profiling of CD34+ Cells in Idiopathic Myelofibrosis Identifies a Set of Disease‐Associated Genes and Reveals the Clinical Significance of Wilms' Tumor Gene 1 (WT1) by Guglielmelli, Paola, Zini, Roberta, Bogani, Costanza, Salati, Simona, Pancrazzi, Alessandro, Bianchi, Elisa, Mannelli, Francesco, Ferrari, Sergio, Le Bousse‐Kerdilès, Marie‐Caroline, Bosi, Alberto, Barosi, Giovanni, Migliaccio, Anna Rita, Manfredini, Rossella, Vannucchi, Alessandro M.

“…This study was aimed at the characterization of a gene expression signature of the pluripotent hematopoietic CD34+ stem cell in idiopathic myelofibrosis (IM),…”
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The JAK2V617 mutation induces constitutive activation and agonist hypersensitivity in basophils from patients with polycythemia vera by PIERI, Lisa, BOGANI, Costanza, GUGLIELMELL, Paola, ZINGARIELLO, Maria, ALBA RANA, Rosa, BARTALUCCI, Niccolò, BOSI, Alberto, VANNUCCHI, Alessandro M

“…The JAK2V617F mutation has been associated with constitutive and enhanced activation of neutrophils, while no information is available concerning other…”
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MicroRNA expression profile in granulocytes from primary myelofibrosis patients by Guglielmelli, Paola, Tozzi, Lorenzo, Pancrazzi, Alessandro, Bogani, Costanza, Antonioli, Elisabetta, Ponziani, Vanessa, Poli, Giada, Zini, Roberta, Ferrari, Sergio, Manfredini, Rossella, Bosi, Alberto, Vannucchi, Alessandro M

“…Objective Expression profiling of microRNA (miRNA) was performed in granulocytes isolated from patients with primary myelofibrosis (PMF), with the aim of…”
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Tetraspanin CD9 participates in dysmegakaryopoiesis and stromal interactions in primary myelofibrosis by Desterke, Christophe, Martinaud, Christophe, Guerton, Bernadette, Pieri, Lisa, Bogani, Costanza, Clay, Denis, Torossian, Frederic, Lataillade, Jean-Jacques, Hasselbach, Hans C, Gisslinger, Heinz, Demory, Jean-Loup, Dupriez, Brigitte, Boucheix, Claude, Rubinstein, Eric, Amsellem, Sophie, Vannucchi, Alessandro M, Le Bousse-Kerdilès, Marie-Caroline

“…Primary myelofibrosis is characterized by clonal myeloproliferation, dysmegakaryopoiesis, extramedullary hematopoiesis associated with myelofibrosis and…”
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B-, T-, and NK-cell lineage involvement in JAK2V617F-positive patients with idiopathic myelofibrosis by Bogani, Costanza, Guglielmelli, Paola, Antonioli, Elisabetta, Pancrazzi, Alessandro, Bosi, Alberto, Vannucchi, Alessandro Maria

“…Department of Hematology, University of Florence, Florence, Italy Correspondence: Alessandro Maria Vannucchi, Department of Hematology, University of Florence,…”
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Influence of JAK2V617F allele burden on phenotype in essential thrombocythemia by Antonioli, Elisabetta, Guglielmelli, Paola, Poli, Giada, Bogani, Costanza, Pancrazzi, Alessandro, Longo, Giovanni, Ponziani, Vanessa, Tozzi, Lorenzo, Pieri, Lisa, Santini, Valeria, Bosi, Alberto, Vannucchi, Alessandro M, Myeloproliferative Disorders Research Consortium (MPD-RC)

“…Department of Hematology, University of Florence, Florence, Italy; and the MPD-RC, Mount Sinai Hospital, New York, USA Correspondence: Alessandro M. Vannucchi,…”
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Variegation of the phenotype induced by the Gata1low mutation in mice of different genetic backgrounds by Martelli, Fabrizio, Ghinassi, Barbara, Panetta, Barbara, Alfani, Elena, Gatta, Valentina, Pancrazzi, Alessandro, Bogani, Costanza, Vannucchi, Alessandro Maria, Paoletti, Francesco, Migliaccio, Giovanni, Migliaccio, Anna Rita

“…All mice harboring the X-linked Gata1low mutation in a predominantly CD1 background are born anemic and thrombocytopenic. They recover from anemia at 1 month…”
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Ruxolitinib is an effective treatment for CALR‐positive patients with myelofibrosis by Guglielmelli, Paola, Rotunno, Giada, Bogani, Costanza, Mannarelli, Carmela, Giunti, Laura, Provenzano, Aldesia, Giglio, Sabrina, Squires, Matthew, Stalbovskaya, Viktoriya, Gopalakrishna, Prashanth, Vannucchi, Alessandro M.

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Co‐targeting the PI3K/mTOR and JAK2 signalling pathways produces synergistic activity against myeloproliferative neoplasms by Bartalucci, Niccolò, Tozzi, Lorenzo, Bogani, Costanza, Martinelli, Serena, Rotunno, Giada, Villeval, Jean‐Luc, Vannucchi, Alessandro M.

“…Aberrant JAK2 signalling plays a central role in myeloproliferative neoplasms (MPN). JAK2 inhibitors have proven to be clinically efficacious, however, they…”
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Hypermethylation of CXCR4 Promoter in CD34+ Cells from Patients with Primary Myelofibrosis by Bogani, Costanza, Ponziani, Vanessa, Guglielmelli, Paola, Desterke, Cristophe, Rosti, Vittorio, Bosi, Alberto, Le Bousse‐Kerdilès, Marie‐Caroline, Barosi, Giovanni, Vannucchi, Alessandro M.

“…Constitutive mobilization of CD34+ cells in patients with primary myelofibrosis (PMF) has been attributed to proteolytic disruption of the CXCR4/SDF‐1 axis and…”
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A Retrospective Analysis of Safety and Efficacy of Ruxolitinib in CALR-Positive Patients with Myelofibrosis by Guglielmelli, Paola, Rotunno, Giada, Bogani, Costanza, Mannarelli, Carmela, Squires, Matthew, Stalbovskaya, Viktoriya, Gopalakrishna, Prashanth, Vannucchi, Alessandro M.

“…BACKGROUND In the phase 3 COMFORT-II study, ruxolitinib, a potent JAK1/JAK2 inhibitor, demonstrated durable reductions in splenomegaly and symptoms, as well as…”
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The PI3K Specific Inhibitor BKM120 Results Effective and Synergizes With Ruxolitinib In Preclinical Models Of Myeloproliferative Neoplasms by Bartalucci, Niccolò, Bogani, Costanza, Martinelli, Serena, Mannarelli, Carmela, Villeval, Jean-Luc, Vannucchi, Alessandro M.

“…A gain-of-function mutation in Janus kinase 2 (JAK2V617F) is at the basis of the majority of chronic myeloproliferative neoplasms (MPN). The dual JAK1/JAK2…”
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Overexpression of microRNA-16-2 contributes to the abnormal erythropoiesis in polycythemia vera by Guglielmelli, Paola, Tozzi, Lorenzo, Bogani, Costanza, Iacobucci, Ilaria, Ponziani, Vanessa, Martinelli, Giovanni, Bosi, Alberto, Vannucchi, Alessandro M.

“…Deregulated expression of microRNAs is associated with neoplasia. Here, we show that mature miR-16 levels are abnormally increased in CD34+ cells of patients…”
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Integrative analysis of copy number and gene expression data suggests novel pathogenetic mechanisms in primary myelofibrosis by Salati, Simona, Zini, Roberta, Nuzzo, Simona, Guglielmelli, Paola, Pennucci, Valentina, Prudente, Zelia, Ruberti, Samantha, Rontauroli, Sebastiano, Norfo, Ruggiero, Bianchi, Elisa, Bogani, Costanza, Rotunno, Giada, Fanelli, Tiziana, Mannarelli, Carmela, Rosti, Vittorio, Salmoiraghi, Silvia, Pietra, Daniela, Ferrari, Sergio, Barosi, Giovanni, Rambaldi, Alessandro, Cazzola, Mario, Bicciato, Silvio, Tagliafico, Enrico, Vannucchi, Alessandro M., Manfredini, Rossella

“…Primary myelofibrosis (PMF) is a Myeloproliferative Neoplasm (MPN) characterized by megakaryocyte hyperplasia, progressive bone marrow fibrosis, extramedullary…”
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Epigenetic therapy in myeloproliferative neoplasms: evidence and perspectives by Vannucchi, Alessandro M., Guglielmelli, Paola, Rambaldi, Alessandro, Bogani, Costanza, Barbui, Tiziano

“…•  The myeloproliferative neoplasms •  The molecular pathogenesls of MPN •  Epigenetic events In cancer •  Epigenetic events In MPN •  Drugs for epigenetic…”
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