Search Results - "BOERNER, Scott"

Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer by EDER, Joseph Paul, VANDE WOUDE, George F, BOERNER, Scott A, LO RUSSO, Patricia M

“…A wide variety of human malignancies exhibit sustained c-Met stimulation, overexpression, or mutation, including carcinomas of the breast, liver, lung, ovary,…”
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A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer by Yasufuku, Kazuhiro, MD, PhD, Pierre, Andrew, MD, MSc, Darling, Gail, MD, de Perrot, Marc, MD, MSc, Waddell, Thomas, MD, PhD, Johnston, Michael, MD, da Cunha Santos, Gilda, MD, PhD, Geddie, William, MD, Boerner, Scott, MD, Le, Lisa W., MSc, Keshavjee, Shaf, MD, MSc

“…Objective The study objective was to compare endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) with mediastinoscopy for mediastinal…”
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An overview of the optimal planning, design, and conduct of phase I studies of new therapeutics by LoRusso, Patricia M, Boerner, Scott A, Seymour, Lesley

“…Phase I clinical trials represent the first step in bringing promising new treatments from the laboratory to the clinic. Although the importance of phase I…”
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A Phase I Study of Foretinib, a Multi-Targeted Inhibitor of c-Met and Vascular Endothelial Growth Factor Receptor 2 by EDER, Joseph Paul, SHAPIRO, Geoffrey I, MCCALLUM, Stewart, HEATH, Elisabeth I, BOERNER, Scott A, LORUSSO, Patricia M, APPLEMAN, Leonard J, ZHU, Andrew X, MILES, Dale, KEER, Harold, CANCILLA, Belinda, CHU, Felix, HITCHCOCK-BRYAN, Suzanne, SHERMAN, Laurie

“…Foretinib is an oral multikinase inhibitor targeting Met, RON, Axl, and vascular endothelial growth factor receptor. We conducted a phase I,…”
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Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors by LoRusso, Patricia M, Li, Jing, Burger, Angelika, Heilbrun, Lance K, Sausville, Edward A, Boerner, Scott A, Smith, Daryn, Pilat, Mary Jo, Zhang, Jie, Tolaney, Sara M, Cleary, James M, Chen, Alice P, Rubinstein, Lawrence, Boerner, Julie L, Bowditch, Adam, Cai, Dongpo, Bell, Tracy, Wolanski, Andrew, Marrero, Allison M, Zhang, Yiping, Ji, Jiuping, Ferry-Galow, Katherine, Kinders, Robert J, Parchment, Ralph E, Shapiro, Geoffrey I

“…PARP is essential for recognition and repair of DNA damage. In preclinical models, PARP inhibitors modulate topoisomerase I inhibitor-mediated DNA damage. This…”
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Clinical experience of MEK inhibitors in cancer therapy by Wang, Ding, Boerner, Scott A., Winkler, James D., LoRusso, Patricia M.

“…Finding new therapies to assist in the treatment of cancer is a major challenge of clinical research. Small molecules that inhibit different molecular targets…”
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Protein expression of DNA damage repair proteins dictates response to topoisomerase and PARP inhibitors in triple-negative breast cancer by Boerner, Julie L, Nechiporchik, Nicole, Mueller, Kelly L, Polin, Lisa, Heilbrun, Lance, Boerner, Scott A, Zoratti, Gina L, Stark, Karri, LoRusso, Patricia M, Burger, Angelika

“…Patients with metastatic triple-negative breast cancer (TNBC) have a poor prognosis. New approaches for the treatment of TNBC are needed to improve patient…”
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Clinical development of vascular disrupting agents: what lessons can we learn from ASA404? by Lorusso, Patricia M, Boerner, Scott A, Hunsberger, Sally

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The value of second opinion in thyroid cytology: A review by Gerhard, Rene, Boerner, Scott L.

“…BACKGROUND Second‐opinion diagnosis (SOD) on pathological material is an accepted practice before definitive therapy is considered for referred patients. The…”
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Sample features associated with success rates in population-based EGFR mutation testing by Shiau, Carolyn J, Babwah, Jesse P, da Cunha Santos, Gilda, Sykes, Jenna R, Boerner, Scott L, Geddie, William R, Leighl, Natasha B, Wei, Cuihong, Kamel-Reid, Suzanne, Hwang, David M, Tsao, Ming-Sound

“…Epidermal growth factor receptor (EGFR) mutation testing has become critical in the treatment of patients with advanced non-small-cell lung cancer. This study…”
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A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma by Goncalves, Priscila H, Heilbrun, Lance K, Barrett, Michael T, Kummar, Shivaani, Hansen, Aaron R, Siu, Lillian L, Piekarz, Richard L, Sukari, Ammar W, Chao, Joseph, Pilat, Mary Jo, Smith, Daryn W, Casetta, Lindsay, Boerner, Scott A, Chen, Alice, Lenkiewicz, Elizabeth, Malasi, Smriti, LoRusso, Patricia M

“…Vorinostat is a histone deacetylase inhibitor (HDACi). Based on a confirmed partial response (PR) in an adenoid cystic carcinoma (ACC) patient treated with…”
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Anaplastic lymphoma kinase 5A4 immunohistochemistry as a diagnostic assay in lung cancer: A Canadian reference testing center's results in population‐based reflex testing by Fiset, Pierre O., Labbé, Catherine, Young, Kelvin, Craddock, Kenneth J., Smith, Adam C., Tanguay, Jeffrey, Pintilie, Melania, Wang, Ri, Torlakovic, Emina, Cheung, Carol, Santos, Gilda, Ko, Hyang‐Mi, Boerner, Scott L., Hwang, David M., Leighl, Natasha B., Tsao, Ming‐Sound

“…Background The presence of anaplastic lymphoma kinase (ALK) rearrangement predicts response to ALK tyrosine kinase inhibitor (TKI) therapy. Fluorescence in…”
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Validation of BRCA testing on cytologic samples of high‐grade serous carcinoma by Lou, Si Kei, Grenier, Sylvie, Care, Melanie, McCuaig, Jeanna, Stockley, Tracy L., Clarke, Blaise, Ruff, Heather M., Boerner, Scott L.

“…Background Testing for BRCA1/2 gene alterations in patients with high‐grade serous carcinoma (HGSC) is a critical determinant of treatment eligibility for…”
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Evaluation of Indeterminate Thyroid Cytology by Second-Opinion Diagnosis or Repeat Fine-Needle Aspiration: Which Is the Best Approach? by Gerhard, Rene, Boerner, Scott L.

“…Objective: This study investigated a published series evaluating the role of second-opinion diagnosis (SOD) or repeat fine-needle aspiration cytology (RFNA)…”
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Histologic Artifacts in Abdominal, Vaginal, Laparoscopic, and Robotic Hysterectomy Specimens: A Blinded, Retrospective Review by KRIZOVA, Adriana, CLARKE, Blaise A, BERNARDINI, Marcus Q, JAMES, Sarah, KALLOGER, Steve E, BOERNER, Scott L, MULLIGAN, Anna Marie

“…Total laparoscopic hysterectomy (LH) is a minimally invasive technique, which results in comparable morbidity and better cosmesis compared with total abdominal…”
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Accelerating Cancer Therapy Development: The Importance of Combination Strategies and Collaboration. Summary of an Institute of Medicine Workshop by LORUSSO, Patricia M, CANETTA, Renzo, WAGNER, John A, BALOGH, Erin P, NASS, Sharyl J, BOERNER, Scott A, HOHNEKER, John

“…Cancer cells contain multiple genetic changes in cell signaling pathways that drive abnormal cell survival, proliferation, invasion, and metastasis…”
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Identifying treatment options for BRAFV600 wild-type metastatic melanoma: A SU2C/MRA genomics-enabled clinical trial by LoRusso, Patricia M, Sekulic, Aleksandar, Sosman, Jeffrey A, Liang, Winnie S, Carpten, John, Craig, David W, Solit, David B, Bryce, Alan H, Kiefer, Jeffrey A, Aldrich, Jessica, Nasser, Sara, Halperin, Rebecca, Byron, Sara A, Pilat, Mary Jo, Boerner, Scott A, Durecki, Diane, Hendricks, William P D, Enriquez, Daniel, Izatt, Tyler, Keats, Jonathan, Legendre, Christophe, Markovic, Svetomir N, Weise, Amy, Naveed, Fatima, Schmidt, Jessica, Basu, Gargi D, Sekar, Shobana, Adkins, Jonathan, Tassone, Erica, Sivaprakasam, Karthigayini, Zismann, Victoria, Calvert, Valerie S, Petricoin, Emanuel F, Fecher, Leslie Anne, Lao, Christopher, Eder, J Paul, Vogelzang, Nicholas J, Perlmutter, Jane, Gorman, Mark, Manica, Barbara, Fox, Lisa, Schork, Nicholas, Zelterman, Daniel, DeVeaux, Michelle, Joseph, Richard W, Cowey, C Lance, Trent, Jeffrey M

“…Although combination BRAF and MEK inhibitors are highly effective for the 40-50% of cutaneous metastatic melanomas harboring BRAFV600 mutations, targeted…”
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Diagnosis and subclassification of lymphomas and non-neoplastic lesions involving mediastinal lymph nodes using endobronchial ultrasound-guided transbronchial needle aspiration by Ko, Hyang Mi, da Cunha Santos, Gilda, Darling, Gail, Pierre, Andrew, Yasufuku, Kazuhiro, Boerner, Scott L., Geddie, William R.

“…Introduction: The value of endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) has been established for staging mediastinal lymph…”
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Molecular yield and cytomorphologic assessment of fine needle aspiration specimen supernatants by Ruff, Heather M., Lou, Si Kei, Hahn, Elan, Grenier, Sylvie, Stockley, Tracy L., Boerner, Scott L.

“…Cytology samples are frequently relied upon for the diagnosis of advanced cancer such as lung cancer. As the recommendations for solid malignancies biomarker…”
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Implementation of PD-L1 22C3 IHC pharmDxTM in Cell Block Preparations of Lung Cancer: Concordance with Surgical Resections and Technical Validation of CytoLyt® Prefixation by Lou, Si Kei, Ko, Hyang Mi, Kinoshita, Tomonari, MacDonald, Scott, Weiss, Jessica, Czarnecka-Kujawa, Katarzyna, Boerner, Scott L., Yasufuku, Kazuhiro, Tsao, Ming-Sound, Schwock, Joerg

“…Background: Programmed death ligand-1 (PD-L1) assessed by immunohistochemistry (IHC) is used as biomarker for pembrolizumab therapy in advanced stage lung…”
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