Search Results - "BODNAR, Andrew J"

Single-cell RNA sequencing reveals differential cell cycle activity in key cell populations during nephrogenesis by Bais, Abha S., Cerqueira, Débora M., Clugston, Andrew, Bodnar, Andrew J., Ho, Jacqueline, Kostka, Dennis

“…The kidney is a complex organ composed of more than 30 terminally differentiated cell types that all are required to perform its numerous homeostatic…”
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Dicer function is required in the metanephric mesenchyme for early kidney development by Chu, Jessica Y S, Sims-Lucas, Sunder, Bushnell, Daniel S, Bodnar, Andrew J, Kreidberg, Jordan A, Ho, Jacqueline

“…MicroRNAs (miRNAs) are small, noncoding regulatory RNAs that act as posttranscriptional repressors by binding to the 3'-untranslated region (3'-UTR) of target…”
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Sexual Dimorphic Regulation of MicroRNAs Alters Sodium Transport in the Kidney Distal Nephron by Farrell, Corinne E., Liu, Xiaoning, Ozbaki Yagan, Nejla, Mutchler, Stephanie, Bodnar, Andrew J., Ho, Jacqueline, Butterworth, Michael

“…Background Hypertension affects more than one billion people worldwide. A key regulator of blood pressure homeostasis is aldosterone, the final signaling…”
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Endothelial-Derived miR-17∼92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury by Chiba, Takuto, Cerqueira, Débora M, Li, Yao, Bodnar, Andrew J, Mukherjee, Elina, Pfister, Katherine, Phua, Yu Leng, Shaikh, Kai, Sanders, Brandon T, Hemker, Shelby L, Pagano, Patrick J, Wu, Yijen L, Ho, Jacqueline, Sims-Lucas, Sunder

“…Damage to the renal microvasculature is a hallmark of renal ischemia-reperfusion injury (IRI)-mediated AKI. The miRNA cluster (encoding , , , , , and )…”
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MicroRNA-17~92 Is Required for Nephrogenesis and Renal Function by MARRONE, April K, STOLZ, Donna B, BASTACKY, Sheldon I, KOSTKA, Dennis, BODNAR, Andrew J, HO, Jacqueline

“…Deletion of all microRNAs (miRNAs) in nephron progenitors leads to premature loss of these cells, but the roles of specific miRNAs in progenitors have not been…”
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Aldosterone‐induced microRNAs act as feedback regulators of mineralocorticoid receptor signaling in kidney epithelia by Ozbaki‐Yagan, Nejla, Liu, Xiaoning, Bodnar, Andrew J., Ho, Jacqueline, Butterworth, Michael Bruce

“…The final steps in the Renin‐Angiotensin‐Aldosterone signaling System (RAAS) involve binding of the corticosteroid hormone, aldosterone to its…”
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MicroRNA-19 is regulated by aldosterone in a sex-specific manner to alter kidney sodium transport by Farrell, Corinne E, Liu, Xiaoning, Yagan, Nejla Ozbaki, Suda, Amanda C, Cerqueira, Debora M, Bodnar, Andrew J, Kashlan, Ossama B, Subramanya, Arohan R, Ho, Jacqueline, Butterworth, Michael B

“…A key regulator of blood pressure homeostasis is the steroid hormone aldosterone, which is released as the final signaling hormone of the…”
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Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors by Phua, Yu Leng, Chen, Kevin Hong, Hemker, Shelby L, Marrone, April K, Bodnar, Andrew J, Liu, Xiaoning, Clugston, Andrew, Kostka, Dennis, Butterworth, Michael B, Ho, Jacqueline

“…We have previously demonstrated that loss of in nephron progenitors in a mouse model results in renal hypodysplasia and chronic kidney disease. Clinically,…”
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Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation by Cargill, Kasey, Hemker, Shelby L, Clugston, Andrew, Murali, Anjana, Mukherjee, Elina, Liu, Jiao, Bushnell, Daniel, Bodnar, Andrew J, Saifudeen, Zubaida, Ho, Jacqueline, Bates, Carlton M, Kostka, Dennis, Goetzman, Eric S, Sims-Lucas, Sunder

“…Nephron progenitors, the cell population that give rise to the functional unit of the kidney, are metabolically active and self-renew under glycolytic…”
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Increased rates of vesicoureteral reflux in mice from deletion of Dicer in the peri-Wolffian duct stroma by Anslow, Melissa J., Bodnar, Andrew J., Cerqueira, Débora M., Bushnell, Daniel, Shrom, Brynn E., Sims-Lucas, Sunder, Bates, Carlton M., Ho, Jacqueline

“…Background Vesicoureteral reflux (VUR), backflow of urine into the kidney, is associated with urinary tract infections and chronic kidney disease. Integrity of…”
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A MicroRNA Cluster miR‐23–24–27 Is Upregulated by Aldosterone in the Distal Kidney Nephron Where it Alters Sodium Transport by Liu, Xiaoning, Edinger, Robert S., Klemens, Christine A., Phua, Yu L., Bodnar, Andrew J., LaFramboise, William A., Ho, Jacqueline, Butterworth, Michael B.

“…The epithelial sodium channel (ENaC) is expressed in the epithelial cells of the distal convoluted tubules, connecting tubules, and cortical collecting duct…”
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Deletion of hypoxia‐responsive microRNA‐210 results in a sex‐specific decrease in nephron number by Hemker, Shelby L., Cerqueira, Débora M., Bodnar, Andrew J., Cargill, Kasey R., Clugston, Andrew, Anslow, Melissa J., Sims‐Lucas, Sunder, Kostka, Dennis, Ho, Jacqueline

“…Low nephron number results in an increased risk of developing hypertension and chronic kidney disease. Intrauterine growth restriction is associated with a…”
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In utero exposure to maternal diabetes impairs nephron progenitor differentiation by Cerqueira, Débora M, Hemker, Shelby L, Bodnar, Andrew J, Ortiz, Daniella M, Oladipupo, Favour O, Mukherjee, Elina, Gong, Zhenwei, Appolonia, Corynn, Muzumdar, Radhika, Sims-Lucas, Sunder, Ho, Jacqueline

“…The incidence of diabetes mellitus has significantly increased among women of childbearing age, and it has been shown that prenatal exposure to maternal…”
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Aldosterone regulates microRNAs in the cortical collecting duct to alter sodium transport by Edinger, Robert S, Coronnello, Claudia, Bodnar, Andrew J, Labarca, Mariana, Bhalla, Vivek, LaFramboise, William A, Benos, Panayiotis V, Ho, Jacqueline, Johnson, John P, Butterworth, Michael B

“…A role for microRNAs (miRs) in the physiologic regulation of sodium transport in the kidney has not been established. In this study, we investigated the…”
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Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development by Cerqueira, Débora M., Bodnar, Andrew J., Leng Phua, Yu, Freer, Rachel, Hemker, Shelby L., Walensky, Loren D., Hukriede, Neil A., Ho, Jacqueline

“…ABSTRACT Low nephron endowment at birth has been associated with an increased risk for developing hypertension and chronic kidney disease. We demonstrated in…”
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Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival by Phua, Yu Leng, Chu, Jessica Y. S., Marrone, April K., Bodnar, Andrew J., Sims‐Lucas, Sunder, Ho, Jacqueline

“…MicroRNAs are small noncoding RNAs that post‐transcriptionally regulate mRNA levels. While previous studies have demonstrated that miRNAs are indispensable in…”
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miR-17/-20a Alleviates Renal Interstitial Fibrosis by Repressing Frmd6 Expression in Renal Epithelia: SA-PO340 by Santos, Debora Malta C.S, Tayeb, Maliha, Bodnar, Andrew J., Appolonia, Corynn, Tan, Roderick J., Subramanya, Arohan R., Bitzer, Markus, Ho, Jacqueline

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Aldosterone‐Induced MicroRNAs Act as Negative Feedback Regulators for the Mineralocorticoid Receptor in Kidney Distal Nephron Epithelia by Ozbaki‐Yagan, Nejla, Liu, Xiaoning, Bodnar, Andrew J, Ho, Jaqueline, Butterworth, Michael Bruce

“…Regulated sodium (Na+) homeostasis in the kidney is achieved by the action of the renin‐angiotensin‐aldosterone signaling cascade. The terminal signaling…”
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In Utero Exposure to Maternal Diabetes Reprograms Nephron Formation and Predisposes to Hypertension and CKD: FR-PO402 by Santos, Debora Malta C.S, Chiba, Takuto, do Nascimento, Ariane Bruder, Clugston, Andrew S., Tayeb, Maliha, Bodnar, Andrew J., Kostka, Dennis, do Nascimento, Thiago Bruder, Sims-Lucas, Sunder, Ho, Jacqueline

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Renal stromal mi RNA s are required for normal nephrogenesis and glomerular mesangial survival by Phua, Yu Leng, Chu, Jessica Y S, Marrone, April K, Bodnar, Andrew J, Sunder Sims‐Lucas, Ho, Jacqueline

“…MicroRNAs are small noncoding RNAs that post‐transcriptionally regulate mRNA levels. While previous studies have demonstrated that miRNAs are indispensable in…”
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