Search Results - "BODIN, Karl"

Pathogenetic mechanisms of amyloid A amyloidosis by Simons, J. Paul, Al-Shawib, Raya, Ellmerich, Stephan, Speck, Ivana, Aslam, Samrina, Hutchinson, Winston L., Mangione, Palma P., Disterer, Petra, Gilbertson, Janet A., Hunt, Toby, Millar, David J., Minogue, Shane, Bodin, Karl, Pepys, Mark B., Hawkins, Philip N.

“…Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited…”
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4β-Hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians by Diczfalusy, Ulf, Miura, Jun, Roh, Hyung-Keun, Mirghani, Rajaa A, Sayi, Jane, Larsson, Hanna, Bodin, Karl G, Allqvist, Annika, Jande, Mary, Kim, Jong-Wook, Aklillu, Eleni, Gustafsson, Lars L, Bertilsson, Leif

“…OBJECTIVESTo study the potential endogenous marker of CYP3A activity, 4β-hydroxycholesterol, and its relation to sex and the CYP3A5 geno/haplotypes and compare…”
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Novel pathways of bile acid metabolism involving CYP3A4 by Bodin, Karl, Lindbom, Ulla, Diczfalusy, Ulf

“…The hepatic predominating cytochrome P450, CYP3A4, plays an essential role in the detoxification of bile acids and is important in pathological conditions such…”
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Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols by Karu, Kersti, Hornshaw, Martin, Woffendin, Gary, Bodin, Karl, Hamberg, Mats, Alvelius, Gunvor, Sjövall, Jan, Turton, John, Wang, Yuqin, Griffiths, William J

“…In humans, the brain accounts for about 20% of the body's free cholesterol, most of which is synthesized de novo in brain. To maintain cholesterol balance…”
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Fxr[superscript -/-] mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids by Marschall, Hanns-Ulrich, Wagner, Martin, Bodin, Karl, Zollner, Gernot, Fickert, Peter, Gumhold, Judith, Silbert, Dagmar, Fuchsbichler, Andrea, Sjovall, Jan, Trauner, Michael

“…Farnesoid X receptor knockout (Fxr[superscript -/-]) mice cannot upregulate the bile salt export pump in bile acid loading or cholestatic conditions. To…”
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Analysis of Oxysterols by Electrospray Tandem Mass Spectrometry by Griffiths, William J., Wang, Yuqin, Alvelius, Gunvor, Liu, Suya, Bodin, Karl, Sjövall, Jan

“…Oxysterols are oxygenated derivatives of cholesterol. They are intermediates in cholesterol excretion pathways and may also be regarded as transport forms of…”
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Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: cholesterol autoxidation is the key by Liere, Philippe, Pianos, Antoine, Eychenne, Bernard, Cambourg, Annie, Bodin, Karl, Griffiths, William, Schumacher, Michael, Baulieu, Etienne-Emile, Sjövall, Jan

“…Pregnenolone (PREG) and dehydroepiandrosterone (DHEA), and their respective sulfated forms PREGS and DHEAS, were among the first steroids to be identified in…”
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Matrix-Assisted Laser Desorption/Ionization High-Energy Collision-Induced Dissociation of Steroids:  Analysis of Oxysterols in Rat Brain by Wang, Yuqin, Hornshaw, Martin, Alvelius, Gunvor, Bodin, Karl, Liu, Suya, Sjövall, Jan, Griffiths, William J

“…Neutral steroids have traditionally been analyzed by gas chromatography/mass spectrometry (GC/MS) after necessary derivatization reactions. However, GC/MS is…”
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Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin by Niemi, Mikko, Kivistö, Kari T, Diczfalusy, Ulf, Bodin, Karl, Bertilsson, Leif, Fromm, Martin F, Eichelbaum, Michel

“…Rifampicin (rifampin) is a potent inducer of cytochrome P450 (CYP) 3A4. It was recently identified as a substrate of the polymorphic organic anion transporting…”
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Targeted lipidomic analysis of oxysterols in the embryonic central nervous system by Wang, Yuqin, Sousa, Kyle M, Bodin, Karl, Theofilopoulos, Spyridon, Sacchetti, Paola, Hornshaw, Martin, Woffendin, Gary, Karu, Kersti, Sjövall, Jan, Arenas, Ernest, Griffiths, William J

“…In this study two regions of embryonic (E11) mouse central nervous system (CNS) have been profiled for their unesterified sterol content. Using…”
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Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1 by Araya, Zufan, Hosseinpour, Fardin, Bodin, Karl, Wikvall, Kjell

“…The metabolism of 25-hydroxyvitamin D(3) was studied with a crude mitochondrial cytochrome P450 extract from pig kidney and with recombinant human CYP27A1…”
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Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterolss by Karu, Kersti, Hornshaw, Martin, Woffendin, Gary, Bodin, Karl, Hamberg, Mats, Alvelius, Gunvor, Sjövall, Jan, Turton, John, Wang, Yuqin, Griffiths, William J.

“…In humans, the brain accounts for about 20% of the body's free cholesterol, most of which is synthesized de novo in brain. To maintain cholesterol balance…”
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On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation by Meaney, Steve, Bodin, Karl, Diczfalusy, Ulf, Björkhem, Ingemar

“…Oxysterols possess powerful biological activities. Some of their effects on the regulation of key enzymes are similar to those of cholesterol, but are much…”
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Antibodies to human serum amyloid P component eliminate visceral amyloid deposits by Pepys, Mark B, Bodin, Karl, Ellmerich, Stephan, Kahan, Melvyn C, Tennent, Glenys A, Loesch, Andrzej, Gilbertson, Janet A, Hutchinson, Winston L, Mangione, Palma P, Gallimore, J. Ruth, Millar, David J, Minogue, Shane, Dhillon, Amar P, Taylor, Graham W, Bradwell, Arthur R, Petrie, Aviva, Gillmore, Julian D, Bellotti, Vittorio, Botto, Marina, Hawkins, Philip N

“…Accumulation of amyloid fibrils in the viscera and connective tissues causes systemic amyloidosis, which is responsible for about one in a thousand deaths in…”
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4β-Hydroxycholesterol is a new endogenous CYP3A marker : relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians by DICZFALUSY, Ulf, MIURA, Jun, AKLILLU, Eleni, GUSTAFSSON, Lars L, BERTILSSON, Leif, ROH, Hyung-Keun, MIRGHANI, Rajaa A, SAYI, Jane, LARSSON, Hanna, BODIN, Karl G, ALLQVIST, Annika, JANDE, Mary, KIMD, Jong-Wook

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Determination of exogenous Melatonin and its 6-hydroxy metabolite in human plasma by liquid chromatography-mass spectrometry by HÄRTTER, Sebastian, MORITA, Sachiyo, BODIN, Karl, URSING, Carina, TYBRING, Gunnel, BERTILSSON, Leif

“…Melatonin has recently garnered interest as a possible treatment for sleep disorders, and this has created a desire for appropriate pharmacokinetic studies. No…”
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Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis by Theofilopoulos, Spyridon, Wang, Yuqin, Kitambi, Satish Srinivas, Sacchetti, Paola, Sousa, Kyle M, Bodin, Karl, Kirk, Jayne, Saltó, Carmen, Gustafsson, Magnus, Toledo, Enrique M, Karu, Kersti, Gustafsson, Jan-Åke, Steffensen, Knut R, Ernfors, Patrik, Sjövall, Jan, Griffiths, William J, Arenas, Ernest

“…Cholic acid and 24( S ),25-epoxycholesterol are endogenous midbrain LXR ligands that are neurogenic for red nucleus or dopaminergic neurons, respectively…”
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Antiepileptic drugs increase plasma levels of 4β-hydroxycholesterol in humans -: Evidence for involvement of cytochrome P450 3A4 by Bodin, K, Bretillon, L, Aden, Y, Bertilsson, L, Broomé, U, Einarsson, C, Diczfalusy, U

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On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function by Meaney, Steve, Bodin, Karl, Diczfalusy, Ulf, Björkhem, Ingemar

“…Oxysterols possess powerful biological activities. Some of their effects on the regulation of key enzymes are similar to those of cholesterol, but are much…”
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Pregnenolone sulfate in the brain: A controversial neurosteroid by Schumacher, Michael, Liere, Philippe, Akwa, Yvette, Rajkowski, Krzysztof, Griffiths, William, Bodin, Karl, Sjövall, Jan, Baulieu, Etienne-Emile

“…Pregnenolone sulfate (PREGS) has been shown, either at high nanomolar or at micromolar concentrations, to increase neuronal activity by inhibiting GABAergic…”
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