Search Results - "BODE, M"

AKT as a Therapeutic Target for Cancer by Song, Mengqiu, Bode, Ann M, Dong, Zigang, Lee, Mee-Hyun

“…Many cellular processes in cancer are attributed to kinase signaling networks. V-akt murine thymoma viral oncogene homolog (AKT) plays a major role in the…”
Get full text

ACSL family: The regulatory mechanisms and therapeutic implications in cancer by Quan, Jing, Bode, Ann M., Luo, Xiangjian

“…Accumulating evidence shows that deregulation of fatty acid (FA) metabolism is associated with the development of cancer. Long-chain acyl-coenzyme A synthases…”
Get full text

The Two Faces of Capsaicin by BODE, Ann M, ZIGANG DONG

“…Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the principal pungent component in hot peppers, including red chili peppers, jalapeños, and habaneros…”
Get full text

Molecular targets of phytochemicals for cancer prevention by Lee, Ki Won, Dong, Zigang, Bode, Ann M

“…Dietary phytochemicals, which are thought to be safe for use as cancer prevention agents, have emerged as modulators of key cellular signalling pathways. The…”
Get full text

Mitochondrial network structure homeostasis and cell death by Xie, Long‐long, Shi, Feng, Tan, Zheqiong, Li, Yueshuo, Bode, Ann M., Cao, Ya

“…Mitochondria are the major cellular energy‐producing organelles and intracellular source of reactive oxygen species. These organelles are responsible for…”
Get full text

Identification of preexisting adaptive immunity to Cas9 proteins in humans by Charlesworth, Carsten T., Deshpande, Priyanka S., Dever, Daniel P., Camarena, Joab, Lemgart, Viktor T., Cromer, M. Kyle, Vakulskas, Christopher A., Collingwood, Michael A., Zhang, Liyang, Bode, Nicole M., Behlke, Mark A., Dejene, Beruh, Cieniewicz, Brandon, Romano, Rosa, Lesch, Benjamin J., Gomez-Ospina, Natalia, Mantri, Sruthi, Pavel-Dinu, Mara, Weinberg, Kenneth I., Porteus, Matthew H.

“…The CRISPR–Cas9 system is a powerful tool for genome editing, which allows the precise modification of specific DNA sequences. Many efforts are underway to use…”
Get full text

A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells by Vakulskas, Christopher A., Dever, Daniel P., Rettig, Garrett R., Turk, Rolf, Jacobi, Ashley M., Collingwood, Michael A., Bode, Nicole M., McNeill, Matthew S., Yan, Shuqi, Camarena, Joab, Lee, Ciaran M., Park, So Hyun, Wiebking, Volker, Bak, Rasmus O., Gomez-Ospina, Natalia, Pavel-Dinu, Mara, Sun, Wenchao, Bao, Gang, Porteus, Matthew H., Behlke, Mark A.

“…Translation of the CRISPR–Cas9 system to human therapeutics holds high promise. However, specificity remains a concern especially when modifying stem cell…”
Get full text

Post-translational modification of p53 in tumorigenesis by Dong, Zigang, Bode, Ann M

“…Interest in the tumour suppressor p53 has generated much information regarding the complexity of its function and regulation in carcinogenesis. However, gaps…”
Get full text

Implications of Genetic and Epigenetic Alterations of CDKN2A (p16INK4a) in Cancer by Zhao, Ran, Choi, Bu Young, Lee, Mee-Hyun, Bode, Ann M., Dong, Zigang

“…Aberrant gene silencing is highly associated with altered cell cycle regulation during carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor…”
Get full text

In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota by BODE, Lisa M, BUNZEL, Diana, HUCH, Melanie, CHO, Cyu-Sung, RUHLAND, Denise, BUNZEL, Mirko, BUB, Achim, FRANZ, Charles Map, KULLING, Sabine E

“…Strong interindividual differences in the microbial conversion of some dietary polyphenols have been reported. In-depth studies of trans-resveratrol metabolism…”
Get full text

Proper-motion age dating of the progeny of Nova Scorpii AD 1437 by Shara, M. M., Iłkiewicz, K., Mikołajewska, J., Pagnotta, A., Bode, M. F., Crause, L. A., Drozd, K., Faherty, J., Fuentes-Morales, I., Grindlay, J. E., Moffat, A. F. J., Pretorius, M. L., Schmidtobreick, L., Stephenson, F. R., Tappert, C., Zurek, D.

“…The re-discovery of the binary star system that created the Nova Scorpii AD 1437 stellar outburst shows that it is now a dwarf nova, suggesting that nova…”
Get full text

Chiral magnetic order at surfaces driven by inversion asymmetry by Heinze, S, Ferriani, P, Bode, M, Bihlmayer, G, Heide, M, Kubetzka, A, Wiesendanger, R, Pietzsch, O, Blügel, S, von Bergmann, K

“…Chirality is a fascinating phenomenon that can manifest itself in subtle ways, for example in biochemistry (in the observed single-handedness of biomolecules)…”
Get full text

Targeting CDK1 in cancer: mechanisms and implications by Wang, Qiushi, Bode, Ann M., Zhang, Tianshun

“…Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as promising candidate targets for cancer treatment. These proteins complexed…”
Get full text

Phenotype-environment mismatches reduce connectivity in the sea by Marshall, D.J, Monro, K, Bode, M, Keough, M.J, Swearer, S

“…The connectivity of marine populations is often surprisingly lower than predicted by the dispersal capabilities of propagules alone. Estimates of connectivity,…”
Get full text

Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells by Ma, Chaobing, Zu, Xueyin, Liu, Kangdong, Bode, Ann M, Dong, Zigang, Liu, Zhenzhen, Kim, Dong Joon

“…Altered genetic features in cancer cells lead to a high rate of aerobic glycolysis and metabolic reprogramming that is essential for increased cancer cell…”
Get full text

Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity by LUQING ZHAO, BODE, Ann M, YA CAO, ZIGANG DONG

“…MicroRNA (miRNA) influences carcinogenesis at multiple stages and it can effectively control tumor radiosensitivity by affecting DNA damage repair, cell cycle…”
Get full text

The functional contrariety of JNK by Bode, Ann M., Dong, Zigang

“…The JNK proteins are activated by multiple and diverse stimuli, leading to varied and seemingly contradictory cellular responses. In particular, JNKs have been…”
Get full text

The Second Life of Methylarginines as Cardiovascular Targets by Jarzebska, Natalia, Mangoni, Arduino A, Martens-Lobenhoffer, Jens, Bode-Böger, Stefanie M, Rodionov, Roman N

“…Endogenous methylarginines were proposed as cardiovascular risk factors more than two decades ago, however, so far, this knowledge has not led to the…”
Get full text

Erg251 has complex and pleiotropic effects on sterol composition, azole susceptibility, filamentation, and stress response phenotypes by Zhou, Xin, Hilk, Audrey, Solis, Norma V, Pereira De Sa, Nivea, Hogan, Bode M, Bierbaum, Tessa A, Del Poeta, Maurizio, Filler, Scott G, Burrack, Laura S, Selmecki, Anna

“…Ergosterol is essential for fungal cell membrane integrity and growth, and numerous antifungal drugs target ergosterol. Inactivation or modification of…”
Get full text

The enigmatic effects of caffeine in cell cycle and cancer by Bode, Ann M, Dong, Zigang

“…Abstract Caffeine may very well be the most frequently ingested neuroactive drug in the world. Mechanistically, caffeine has been reported to affect cell cycle…”
Get full text