Search Results - "BOCZKOWSKI, JORGE"

Biomedical applications and potential health risks of nanomaterials: molecular mechanisms by Lanone, Sophie, Boczkowski, Jorge

“…Nanotechnologies, defined as techniques aimed to conceive, characterize and produce material at the nanometer scale, represent a fully expanding domain, and…”
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Comparative toxicity of 24 manufactured nanoparticles in human alveolar epithelial and macrophage cell lines by Lanone, Sophie, Rogerieux, Françoise, Geys, Jorina, Dupont, Aurélie, Maillot-Marechal, Emmanuelle, Boczkowski, Jorge, Lacroix, Ghislaine, Hoet, Peter

“…A critical issue with nanomaterials is the clear understanding of their potential toxicity. We evaluated the toxic effect of 24 nanoparticles of similar…”
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Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD by Baarsma, Hoeke A, Skronska-Wasek, Wioletta, Mutze, Kathrin, Ciolek, Florian, Wagner, Darcy E, John-Schuster, Gerrit, Heinzelmann, Katharina, Günther, Andreas, Bracke, Ken R, Dagouassat, Maylis, Boczkowski, Jorge, Brusselle, Guy G, Smits, Ron, Eickelberg, Oliver, Yildirim, Ali Ö, Königshoff, Melanie

“…Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. One main pathological feature of COPD is the loss of functional alveolar…”
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Heme oxygenase‐1 induction attenuates senescence in chronic obstructive pulmonary disease lung fibroblasts by protecting against mitochondria dysfunction by Even, Benjamin, Fayad‐Kobeissi, Sarah, Gagliolo, Jean‐Marie, Motterlini, Roberto, Boczkowski, Jorge, Foresti, Roberta, Dagouassat, Maylis

“…Chronic obstructive pulmonary disease (COPD) is associated with lung fibroblast senescence, a process characterized by an irreversible proliferation arrest…”
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Microglia Determine Brain Region-Specific Neurotoxic Responses to Chemically Functionalized Carbon Nanotubes by Bussy, Cyrill, Al-Jamal, Khuloud T, Boczkowski, Jorge, Lanone, Sophie, Prato, Maurizio, Bianco, Alberto, Kostarelos, Kostas

“…Surface tunability and their ability to translocate plasma membranes make chemically functionalized carbon nanotubes (f-CNTs) promising intracellular delivery…”
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CO–metal interaction: vital signaling from a lethal gas by Boczkowski, Jorge, Poderoso, Juan J., Motterlini, Roberto

“…The past few years have witnessed intense research into the biological significance of carbon monoxide (CO) as an essential signaling mediator in cells and…”
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Activation of Lung p53 by Nutlin-3a Prevents and Reverses Experimental Pulmonary Hypertension by MOURARET, Nathalie, MARCOS, Elisabeth, AMSELLEM, Valérie, ADNOT, Serge, ABID, Shariq, GARY-BOBO, Guillaume, SAKER, Mirna, HOUSSAINI, Amal, DUBOIS-RANDE, Jean-Luc, BOYER, Laurent, BOCZKOWSKI, Jorge, DERUMEAUX, Genevieve

“…Induction of cellular senescence through activation of the p53 tumor suppressor protein is a new option for treating proliferative disorders. Nutlins prevent…”
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Anti-inflammatory effect of gold nanoparticles supported on metal oxides by Fujita, Takashi, Zysman, Maeva, Elgrabli, Dan, Murayama, Toru, Haruta, Masatake, Lanone, Sophie, Ishida, Tamao, Boczkowski, Jorge

“…Gold (Au) can be deposited as nanoparticles (NPs) smaller than 10 nm in diameter on a variety of metal oxide (MOx) NPs. Au/MOx have high catalytic performance…”
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Critical role of surface chemical modifications induced by length shortening on multi-walled carbon nanotubes-induced toxicity by Bussy, Cyrill, Pinault, Mathieu, Cambedouzou, Julien, Landry, Marion Julie, Jegou, Pascale, Mayne-L'hermite, Martine, Launois, Pascale, Boczkowski, Jorge, Lanone, Sophie

“…Given the increasing use of carbon nanotubes (CNT) in composite materials and their possible expansion to new areas such as nanomedicine which will both lead…”
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Macrophage autophagy protects mice from cerium oxide nanoparticle-induced lung fibrosis by Annangi, Balasubramanyam, Lu, Zhuyi, Bruniaux, Jonathan, Ridoux, Audrey, da Silva, Vanessa Marques, Vantelon, Delphine, Boczkowski, Jorge, Lanone, Sophie

“…Cerium (Ce) is a rare earth element, rapidly oxidizing to form CeO , and currently used in numerous commercial applications, especially as nanoparticles (NP)…”
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mTOR pathway activation drives lung cell senescence and emphysema by Houssaini, Amal, Breau, Marielle, Kebe, Kanny, Abid, Shariq, Marcos, Elisabeth, Lipskaia, Larissa, Rideau, Dominique, Parpaleix, Aurelien, Huang, Jin, Amsellem, Valerie, Vienney, Nora, Validire, Pierre, Maitre, Bernard, Attwe, Aya, Lukas, Christina, Vindrieux, David, Boczkowski, Jorge, Derumeaux, Genevieve, Pende, Mario, Bernard, David, Meiners, Silke, Adnot, Serge

“…Chronic obstructive pulmonary disease (COPD) is a highly prevalent and devastating condition for which no curative treatment is available. Exaggerated lung…”
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The telomerase activator TA-65 protects from cigarette smoke-induced small airway remodeling in mice through extra-telomeric effects by Tiendrébéogo, Arnaud Jean Florent, Soumagne, Thibaud, Pellegrin, François, Dagouassat, Maylis, Tran Van Nhieu, Jeanne, Caramelle, Philippe, Paul, Emmanuel N., Even, Benjamin, Zysman, Maeva, Julé, Yvon, Samb, Abdoulaye, Boczkowski, Jorge, Lanone, Sophie, Schlemmer, Frédéric

“…Small airway remodeling (SAR) is a key phenomenon of airflow obstruction in smokers, leading to chronic obstructive pulmonary disease (COPD). SAR results in an…”
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Mitochondrial Respiratory Chain and NAD(P)H Oxidase Are Targets for the Antiproliferative Effect of Carbon Monoxide in Human Airway Smooth Muscle by Camille TaillÃ, Jamel El-Benna, Sophie Lanone, Jorge Boczkowski, Roberto Motterlini

“…Carbon monoxide (CO), one of the end products of heme oxygenase activity, inhibits smooth muscle proliferation by decreasing ERK1/2 phosphorylation and cyclin…”
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Role of metal oxide nanoparticles in histopathological changes observed in the lung of welders by Andujar, Pascal, Simon-Deckers, Angélique, Galateau-Sallé, Françoise, Fayard, Barbara, Beaune, Gregory, Clin, Bénédicte, Billon-Galland, Marie-Annick, Durupthy, Olivier, Pairon, Jean-Claude, Doucet, Jean, Boczkowski, Jorge, Lanone, Sophie

“…Although major concerns exist regarding the potential consequences of human exposure to nanoparticles (NP), no human toxicological data is currently available…”
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Biodistribution and clearance of instilled carbon nanotubes in rat lung by Elgrabli, Dan, Floriani, Magali, Abella-Gallart, Steve, Meunier, Laurent, Gamez, Christelle, Delalain, Patrice, Rogerieux, Françoise, Boczkowski, Jorge, Lacroix, Ghislaine

“…Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies…”
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HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism by Converso, Daniela P, Taillé, Camille, Carreras, Maria Cecilia, Jaitovich, Ariel, Poderoso, Juan José, Boczkowski, Jorge

“…This study investigated whether inducible HO-1 is targeted to mitochondria and its putative effects on oxidative metabolism in rat liver. Western blot and…”
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Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin by Val, Stéphanie, Belade, Esther, George, Isabelle, Boczkowski, Jorge, Baeza-Squiban, Armelle

“…Particulate pollution is suspected to contribute to obstructive lung diseases characterized by chronic inflammation, mucus hypersecretion and bronchial…”
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Pulmonary exposure to metallic nanomaterials during pregnancy irreversibly impairs lung development of the offspring by Paul, Emmanuel, Franco-Montoya, Marie-Laure, Paineau, Erwan, Angeletti, Bernard, Vibhushan, Shamila, Ridoux, Audrey, Tiendrebeogo, Arnaud, Salome, Murielle, Hesse, Bernhard, Vantelon, Delphine, Rose, Jérôme, Canouï-Poitrine, Florence, Boczkowski, Jorge, Lanone, Sophie, Delacourt, Christophe, Pairon, Jean-Claude

“…Due to the growing commercial applications of manufactured nanoparticles (NPs), toxicological studies on NPs, especially during the critical window of…”
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p21-Dependent Protective Effects of a Carbon Monoxide–Releasing Molecule-3 in Pulmonary Hypertension by Abid, Shariq, Houssaïni, Amal, Mouraret, Nathalie, Marcos, Elisabeth, Amsellem, Valerie, Wan, Feng, Dubois-Randé, Jean Luc, Derumeaux, Geneviève, Boczkowski, Jorge, Motterlini, Roberto, Adnot, Serge

“…OBJECTIVE—Carbon monoxide–releasing molecules (CORMs) represent a pharmacological alternative to CO gas inhalation. Here, we questioned whether CORM-3, a…”
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Role for telomerase in pulmonary hypertension by Mouraret, Nathalie, Houssaïni, Amal, Abid, Shariq, Quarck, Rozenn, Marcos, Elisabeth, Parpaleix, Aurelien, Gary-Bobo, Guillaume, Dubois-Randé, Jean-Luc, Derumeaux, Geneviève, Boczkowski, Jorge, Delcroix, Marion, Blasco, Maria A, Lipskaia, Larissa, Amsellem, Valérie, Adnot, Serge

“…Cells exhibiting dysregulated growth may express telomerase reverse transcriptase (TERT), the dual function of which consists of maintaining telomere length,…”
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