Search Results - "BLUMER, Jeffrey"

A Multicenter, Randomized, Observer-blinded, Active-controlled Study Evaluating the Safety and Effectiveness of Ceftaroline Compared With Ceftriaxone Plus Vancomycin in Pediatric Patients With Complicated Community-acquired Bacterial Pneumonia by Blumer, Jeffrey L, Ghonghadze, Tina, Cannavino, Christopher, O’Neal, Tanya, Jandourek, Alena, Friedland, Hillel David, Bradley, John S

“…BACKGROUND:The broad-spectrum cephalosporin ceftaroline, a metabolite of the prodrug ceftaroline fosamil, has shown in vitro activity against clinical isolates…”
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Pharmacokinetics, Safety and Tolerability of Single Dose Dalbavancin in Children 12–17 Years of Age by Bradley, John S, Puttagunta, Sailaja, Rubino, Christopher M, Blumer, Jeffrey L, Dunne, Michael, Sullivan, Janice E

“…BACKGROUND:Dalbavancin is a lipoglycopeptide antibiotic with Gram-positive activity and novel pharmacokinetic (PK) properties that result in a prolonged…”
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Mycobactericidal activity of bedaquiline plus rifabutin or rifampin in ex vivo whole blood cultures of healthy volunteers: A randomized controlled trial by Wallis, Robert S, Good, Caryn E, O'Riordan, Mary A, Blumer, Jeffrey L, Jacobs, Michael R, Griffiss, J McLeod, Healan, Amanda, Salata, Robert A

“…Bedaquiline, an antimycobacterial agent approved for drug-resistant tuberculosis, is metabolized by CYP3A4, an hepatic enzyme strongly induced by rifampin, an…”
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Development and validation of an LC-MS/MS method for the simultaneous determination of bedaquiline and rifabutin in human plasma by Gray, Wesley A., Waldorf, Byron, Rao, Manasa Geeta, Stiles, Brenda L., Griffiss, J. McLeod, Salata, Robert A., Blumer, Jeffrey L.

“…•An LC–MS/MS method for the simultaneous determination of bedaquiline and rifabutin in human plasma for therapeutic drug monitoring is described.•This isotope…”
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Eszopiclone for insomnia associated with attention-deficit/hyperactivity disorder by Sangal, R Bart, Blumer, Jeffrey L, Lankford, D Alan, Grinnell, Todd A, Huang, Holly

“…To evaluate efficacy and safety of eszopiclone compared with placebo in children and adolescents with insomnia associated with attention-deficit/hyperactivity…”
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Impact of Rifabutin or Rifampin on Bedaquiline Safety, Tolerability, and Pharmacokinetics Assessed in a Randomized Clinical Trial with Healthy Adult Volunteers by Healan, Amanda M, Griffiss, J McLeod, Proskin, Howard M, O'Riordan, Mary Ann, Gray, Wesley A, Salata, Robert A, Blumer, Jeffrey L

“…Bedaquiline is a diarylquinoline that specifically inhibits mycobacterial ATP synthase. Bedaquiline has been used to effectively treat tuberculosis (TB) caused…”
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Assessing time to pulmonary function benefit following antibiotic treatment of acute cystic fibrosis exacerbations by VanDevanter, Donald R, O'Riordan, Mary A, Blumer, Jeffrey L, Konstan, Michael W

“…Cystic Fibrosis (CF) is a life-shortening genetic disease in which ~80% of deaths result from loss of lung function linked to inflammation due to chronic…”
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Intravenous Zanamivir in Hospitalized Patients With Influenza by Bradley, John S, Blumer, Jeffrey L, Romero, José R, Michaels, Marian G, Munoz, Flor M, Kimberlin, David W, Pahud, Barbara, DeBiasi, Roberta L, Yamamoto, Go, Roberts, Grace, Hossain, Mohammad, Shortino, Denise, Yates, Phillip J, Adams, Bryan, Peppercorn, Amanda

“…Children with severe influenza infection may require parenteral therapy if oral or inhaled therapies are ineffective or cannot be administered. Results from a…”
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Determination of appropriate weight-based cutoffs for empiric cefazolin dosing using data from a phase 1 pharmacokinetics and safety study of cefazolin administered for surgical prophylaxis in pediatric patients aged 10 to 12 years by Schmitz, Michael L, Blumer, Jeffrey L, Cetnarowski, Wes, Rubino, Christopher M

“…Despite over 40 years of worldwide usage, relatively few data have been published on the pharmacokinetics of cefazolin in pediatric surgical patients. The…”
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A Phase 1 Pharmacokinetic and Safety Study of Extended-Duration, High-dose Cefixime for Cephalosporin-resistant Neisseria gonorrhoeae in the Pharynx by Barbee, Lindley A, Nayak, Seema U, Blumer, Jeffrey L, OʼRiordan, Mary Ann, Gray, Wesley, Zenilman, Jonathan M, Golden, Matthew R, Griffiss, J McLeod

“…BACKGROUNDThere are no fully oral recommended treatment regimens for gonorrhea. Inadequately treated pharyngeal gonococcal infections are a likely reservoir…”
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Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients: A multicenter, randomized trial by WINSTON, Drew J, MAZIARZ, Richard T, CHANDRASEKAR, Pranatharthi H, LAZARUS, Hillard M, GOLDMAN, Mitchell, BLUMER, Jeffrey L, LEITZ, Gerhard J, TERRITO, Mary C

“…Allogeneic hematopoietic stem-cell transplant recipients often receive fluconazole or an amphotericin B preparation for antifungal prophylaxis. Because of…”
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Pharmacologic Management of Insomnia in Children and Adolescents: Consensus Statement by Mindell, Jodi A, Emslie, Graham, Blumer, Jeffrey, Genel, Myron, Glaze, Daniel, Ivanenko, Anna, Johnson, Kyle, Rosen, Carol, Steinberg, Frank, Roth, Thomas, Banas, Bridget

“…The purpose of this work was to develop a consensus statement on the current status and future role for pharmacologic management of insomnia in children and…”
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A population pharmacokinetic modeling approach shows that serum penicillin G concentrations are below inhibitory concentrations by two weeks after benzathine penicillin G injection in the majority of young adults by Neely, Michael, Kaplan, Edward L, Blumer, Jeffrey L, Faix, Dennis J, Broderick, Michael P

“…Serum penicillin G falls to low levels 2 weeks after injection as benzathine penicillin G (BPG) in young adults. Using Pmetrics and previously reported…”
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Serum penicillin G levels are lower than expected in adults within two weeks of administration of 1.2 million units by Broderick, Michael P, Hansen, Christian J, Russell, Kevin L, Kaplan, Edward L, Blumer, Jeffrey L, Faix, Dennis J

“…When introduced in the 1950s, benzathine penicillin G (BPG) was shown to be effective in eradicating group A beta-hemolytic streptococcus (GAS) for at least 3…”
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Comparison of Pharmacokinetics and Safety of Voriconazole Intravenous-to-Oral Switch in Immunocompromised Children and Healthy Adults by DRISCOLL, Timothy A, YU, Lolie C, PING LIU, FRANGOUL, Haydar, KRANCE, Robert A, NEMECEK, Eneida, BLUMER, Jeffrey, ARRIETA, Antonio, GRAHAM, Michael L, BRADFIELD, Scott M, BARUCH, Alice

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Controlled Clinical Trial of Zolpidem for the Treatment of Insomnia Associated With Attention-Deficit/ Hyperactivity Disorder in Children 6 to 17 Years of Age by Blumer, Jeffrey L, Findling, Robert L, Shih, Weichung Joe, Soubrane, Christina, Reed, Michael D

“…The goal was to evaluate the hypnotic efficacy of zolpidem at 0.25 mg/kg per day (maximum of 10 mg/day), compared with placebo, in children 6 through 17 years…”
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Comparison of Pharmacokinetics and Safety of Voriconazole Intravenous-to-Oral Switch in Immunocompromised Adolescents and Healthy Adults by DRISCOLL, Timothy A, FRANGOUL, Haydar, NEMECEK, Eneida R, MURPHEY, Donald K, YU, Lolie C, BLUMER, Jeffrey, KRANCE, Robert A, BARUCH, Alice, PING LIU

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The Pharmacokinetics and Safety of Micafungin, a Novel Echinocandin, in Premature Infants by Heresi, Gloria P, Gerstmann, Dale R, Reed, Michael D, van den Anker, John N, Blumer, Jeffrey L, Kovanda, Laura, Keirns, James J, Buell, Donald N, Kearns, Gregory L

“…BACKGROUND:Candidal fungal infection rates in neonates are increasing and are a significant cause of mortality, especially in low birth weight infants…”
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Dosing Colistimethate Every 8 h Results in Higher Plasma Concentrations of Active Colistin Than Every 12-Hourly Dosing without Increase in Nephrotoxicity: A Phase 1 Pharmacokinetics Trial in Healthy Adult Volunteers by Yendewa, George A, Griffiss, John McLeod, Gray, Wesley A, Healen, Amanda, Proskin, Howard M, Fulton, Scott A, O'Riordan, Mary Ann, Hoppel, Charles, Blumer, Jeffrey L, Salata, Robert A

“…Despite its use for decades, pharmacokinetic (PK) and safety studies on colistin are limited. We conducted a phase l, open-label trial to evaluate the safety…”
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The efficacy and safety of meropenem and tobramycin vs ceftazidime and tobramycin in the treatment of acute pulmonary exacerbations in patients with cystic fibrosis by Blumer, Jeffrey L, Saiman, Lisa, Konstan, Michael W, Melnick, David

“…Cystic fibrosis (CF) is characterized by chronic pulmonary infection with acute pulmonary exacerbations (APEs) requiring IV antibiotic treatment. We report on…”
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