Radiographic features of the spine in fluoride therapy for osteoporosis

In the search for a simple method of assessing the therapeutic efficacy of sodium fluoride, a prospective study of vertebral radiography during such treatment was carried out. Treatment of osteoporosis with sodium fluoride, calcium and vitamin D was found to enhance the vertical markings of the vert...

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Bibliographic Details
Published in:	Journal of bone and joint surgery. British volume Vol. 69; no. 2; pp. 190 - 194
Main Authors:	SCHNITZLER, C. M, SWEET, M. B. E, BLUMENFELD, T. S, ISAACSON, D. C
Format:	Journal Article
Language:	English
Published:	London British Editorial Society of Bone and Joint Surgery 01-03-1987
Subjects:	Adult Aged Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Calcium - therapeutic use Drug Evaluation Drug Therapy, Combination Female Fractures, Spontaneous - diagnostic imaging Fractures, Spontaneous - epidemiology Humans Male Medical sciences Middle Aged Osteoporosis - complications Osteoporosis - diagnostic imaging Osteoporosis - drug therapy Pharmacology. Drug treatments Prospective Studies Radiography Sodium Fluoride - therapeutic use Spinal Diseases - complications Spinal Diseases - diagnostic imaging Spinal Diseases - drug therapy Spinal Injuries - diagnostic imaging Spinal Injuries - epidemiology Spine - diagnostic imaging Time Factors Vitamin D - therapeutic use Therapeutic efficiency Human Osteoporosis Chemotherapy Calcium X ray radiography Diseases of the osteoarticular system Oral administration Vertebral column Sodium Fluorides
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Summary:	In the search for a simple method of assessing the therapeutic efficacy of sodium fluoride, a prospective study of vertebral radiography during such treatment was carried out. Treatment of osteoporosis with sodium fluoride, calcium and vitamin D was found to enhance the vertical markings of the vertebral trabecular pattern in 69% of patients. This response was graded 1 (failure), 2 (good) and 3 (excellent); Grade 2 or 3 was attained after a mean treatment period of 31.7 months. Subsequent analysis of the vertebral fracture rate revealed that new vertebral fractures had occurred only in patients with Grade 1 and not in those with Grade 2 or 3. We recommend that treatment should aim at increasing the vertebral trabecular pattern to Grade 2 or 3 and that the duration of therapy should be approximately 30 months.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0301-620X 2044-5377
DOI:	10.1302/0301-620X.69B2.3818747