Search Results - "BLUMENFELD, Hal"

Impaired consciousness in epilepsy by Blumenfeld, Hal, Prof

“…Summary Consciousness is essential to normal human life. In epileptic seizures consciousness is often transiently lost, which makes it impossible for the…”
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What is a seizure network? Long-range network consequences of focal seizures by Blumenfeld, Hal

“…What defines the spatial and temporal boundaries of seizure activity in brain networks? To fully answer this question a precise and quantitative definition of…”
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Cellular and Network Mechanisms of Spike‐Wave Seizures by Blumenfeld, Hal

“…Spike‐wave seizures are often considered a relatively “pure” form of epilepsy, with a uniform defect present in all patients and involvement of the whole brain…”
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Subcortical Cognition: The Fruit Below the Rind by Janacsek, Karolina, Evans, Tanya M, Kiss, Mariann, Shah, Leela, Blumenfeld, Hal, Ullman, Michael T

“…Cognitive neuroscience has highlighted the cerebral cortex while often overlooking subcortical structures. This cortical proclivity is found in basic and…”
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Epilepsy and the Consciousness System: Transient Vegetative State? by Blumenfeld, Hal, MD, PhD

“…Recent advances have shown much in common between epilepsy and other disorders of consciousness. Behavior in epileptic seizures often resembles a transient…”
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An adversarial collaboration protocol for testing contrasting predictions of global neuronal workspace and integrated information theory by Melloni, Lucia, Mudrik, Liad, Pitts, Michael, Bendtz, Katarina, Ferrante, Oscar, Gorska, Urszula, Hirschhorn, Rony, Khalaf, Aya, Kozma, Csaba, Lepauvre, Alex, Liu, Ling, Mazumder, David, Richter, David, Zhou, Hao, Blumenfeld, Hal, Boly, Melanie, Chalmers, David J, Devore, Sasha, Fallon, Francis, de Lange, Floris P, Jensen, Ole, Kreiman, Gabriel, Luo, Huan, Panagiotaropoulos, Theofanis I, Dehaene, Stanislas, Koch, Christof, Tononi, Giulio

“…The relationship between conscious experience and brain activity has intrigued scientists and philosophers for centuries. In the last decades, several theories…”
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Slowing less than 1 Hz is decreased near the seizure onset zone by Lundstrom, Brian Nils, Boly, Melanie, Duckrow, Robert, Zaveri, Hitten P., Blumenfeld, Hal

“…Focal slowing (<4 Hz) of brain waves is often associated with focal cerebral dysfunction and is assumed to be increased closest to the location of dysfunction…”
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From Molecules to Networks: Cortical/Subcortical Interactions in the Pathophysiology of Idiopathic Generalized Epilepsy by Blumenfeld, Hal

“…Generalized epilepsy involves abnormally synchronized activity in large‐scale neuronal networks. Burst firing of action potentials is a potent mechanism for…”
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Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging by Bai, Xiaoxiao, Vestal, Matthew, Berman, Rachel, Negishi, Michiro, Spann, Marisa, Vega, Clemente, Desalvo, Matthew, Novotny, Edward J, Constable, Robert T, Blumenfeld, Hal

“…Absence seizures are 5-10 s episodes of impaired consciousness accompanied by 3-4 Hz generalized spike-and-wave discharge on electroencephalography (EEG). The…”
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The spatial and signal characteristics of physiologic high frequency oscillations by Alkawadri, Rafeed, Gaspard, Nicolas, Goncharova, Irina I., Spencer, Dennis D., Gerrard, Jason L., Zaveri, Hitten, Duckrow, Robert B., Blumenfeld, Hal, Hirsch, Lawrence J.

“…Summary Objectives To study the incidence, spatial distribution, and signal characteristics of high frequency oscillations (HFOs) outside the epileptic…”
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Early cortical signals in visual stimulus detection by Kwon, Hunki, Kronemer, Sharif I., Christison-Lagay, Kate L., Khalaf, Aya, Li, Jiajia, Ding, Julia Z, Freedman, Noah C, Blumenfeld, Hal

“…During visual conscious perception, the earliest responses linked to signal detection are little known. The current study aims to reveal the cortical neural…”
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The pulse: transient fMRI signal increases in subcortical arousal systems during transitions in attention by Li, Rong, Ryu, Jun Hwan, Vincent, Peter, Springer, Max, Kluger, Dan, Levinsohn, Erik A., Chen, Yu, Chen, Huafu, Blumenfeld, Hal

“…Studies of attention emphasize cortical circuits for salience monitoring and top-down control. However, subcortical arousal systems have a major influence on…”
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Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study by Guo, Jennifer N, MD, Kim, Robert, BS, Chen, Yu, MS, Negishi, Michiro, PhD, Jhun, Stephen, MEng, Weiss, Sarah, BS, Ryu, Jun Hwan, BA, Bai, Xiaoxiao, PhD, Xiao, Wendy, MA, Feeney, Erin, BS, Rodriguez-Fernandez, Jorge, MD, Mistry, Hetal, BS, Crunelli, Vincenzo, Prof, Crowley, Michael J, PhD, Mayes, Linda C, Prof, Constable, R Todd, Prof, Blumenfeld, Hal, Prof

“…Summary Background The neural underpinnings of impaired consciousness and of the variable severity of behavioural deficits from one absence seizure to the next…”
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Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy by Dezsi, Gabi, Ozturk, Ezgi, Stanic, Davor, Powell, Kim L., Blumenfeld, Hal, O'Brien, Terence J., Jones, Nigel C.

“…Summary Purpose Ethosuximide (ESX) is a drug of choice for the symptomatic treatment of absence seizures. Chronic treatment with ESX has been reported to have…”
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Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures by McCafferty, Cian, Gruenbaum, Benjamin F., Tung, Renee, Li, Jing-Jing, Zheng, Xinyuan, Salvino, Peter, Vincent, Peter, Kratochvil, Zachary, Ryu, Jun Hwan, Khalaf, Aya, Swift, Kohl, Akbari, Rashid, Islam, Wasif, Antwi, Prince, Johnson, Emily A., Vitkovskiy, Petr, Sampognaro, James, Freedman, Isaac G., Kundishora, Adam, Depaulis, Antoine, David, François, Crunelli, Vincenzo, Sanganahalli, Basavaraju G., Herman, Peter, Hyder, Fahmeed, Blumenfeld, Hal

“…Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and unresponsiveness, with yet-unknown neuronal mechanisms. Here we report…”
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Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations by Sanganahalli, Basavaraju G, Thompson, Garth J, Parent, Maxime, Verhagen, Justus V, Blumenfeld, Hal, Herman, Peter, Hyder, Fahmeed

“…The thalamus is a crucial subcortical hub that impacts cortical activity. Tracing experiments in animals and post-mortem humans suggest rich morphological…”
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Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity by Kronemer, Sharif I., Aksen, Mark, Ding, Julia Z., Ryu, Jun Hwan, Xin, Qilong, Ding, Zhaoxiong, Prince, Jacob S., Kwon, Hunki, Khalaf, Aya, Forman, Sarit, Jin, David S., Wang, Kevin, Chen, Kaylie, Hu, Claire, Agarwal, Akshar, Saberski, Erik, Wafa, Syed Mohammad Adil, Morgan, Owen P., Wu, Jia, Christison-Lagay, Kate L., Hasulak, Nicholas, Morrell, Martha, Urban, Alexandra, Todd Constable, R., Pitts, Michael, Mark Richardson, R., Crowley, Michael J., Blumenfeld, Hal

“…The full neural circuits of conscious perception remain unknown. Using a visual perception task, we directly recorded a subcortical thalamic awareness…”
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Decreased Subcortical Cholinergic Arousal in Focal Seizures by Motelow, Joshua E., Li, Wei, Zhan, Qiong, Mishra, Asht M., Sachdev, Robert N.S., Liu, Geoffrey, Gummadavelli, Abhijeet, Zayyad, Zaina, Lee, Hyun Seung, Chu, Victoria, Andrews, John P., Englot, Dario J., Herman, Peter, Sanganahalli, Basavaraju G., Hyder, Fahmeed, Blumenfeld, Hal

“…Impaired consciousness in temporal lobe seizures has a major negative impact on quality of life. The prevailing view holds that this disorder impairs…”
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Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI by HERMAN, Peter, SANGANAHALLI, Basavaraju G, BLUMENFELD, Hal, ROTHMAN, Douglas L, HYDER, Fahmeed

“…Layer-specific neurophysiologic, hemodynamic, and metabolic measurements are needed to interpret high-resolution functional magnetic resonance imaging (fMRI)…”
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Decreased resting functional connectivity after traumatic brain injury in the rat by Mishra, Asht Mangal, Bai, Xiaoxiao, Sanganahalli, Basavaraju G, Waxman, Stephen G, Shatillo, Olena, Grohn, Olli, Hyder, Fahmeed, Pitkänen, Asla, Blumenfeld, Hal

“…Traumatic brain injury (TBI) contributes to about 10% of acquired epilepsy. Even though the mechanisms of post-traumatic epileptogenesis are poorly known, a…”
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