Search Results - "BLUME, Beatrix"

A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies by Zimmermann, Astrid, Zenke, Frank T, Chiu, Li-Ya, Dahmen, Heike, Pehl, Ulrich, Fuchss, Thomas, Grombacher, Thomas, Blume, Beatrix, Vassilev, Lyubomir T, Blaukat, Andree

“…Radiotherapy and chemical DNA-damaging agents are among the most widely used classes of cancer therapeutics today. Double-strand breaks (DSB) induced by many…”
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Receptor-Mediated Increase in Cytoplasmic Free Calcium Required for Activation of Pathogen Defense in Parsley by Blume, Beatrix, Nürnberger, Thorsten, Nass, Norbert, Scheel, Dierk

“…Transient influx of Ca2+ constitutes an early element of signaling cascades triggering pathogen defense responses in plant cells. Treatment with the…”
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NPP1, a Phytophthora‐associated trigger of plant defense in parsley and Arabidopsis by Fellbrich, Guido, Romanski, Annette, Varet, Anne, Blume, Beatrix, Brunner, Frédéric, Engelhardt, Stefan, Felix, Georg, Kemmerling, Birgit, Krzymowska, Magdalena, Nürnberger, Thorsten

“…Summary Activation of non‐cultivar‐specific plant defense against attempted microbial infection is mediated through the recognition of pathogen‐derived…”
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Expression of ACC oxidase promoter—GUS fusions in tomato and Nicotiana plumbaginifolia regulated by developmental and environmental stimuli by Blume, Beatrix, Grierson, Donald

“…Summary The enzyme ACC oxidase, catalysing the last step in the biosynthesis of the plant hormone ethylene, is encoded by a small multigene family in tomato,…”
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Differential expression of the 1‐aminocyclopropane‐1‐carboxylate oxidase gene family of tomato by Barry, Cornelius S., Blume, Beatrix, Bouzayen, Mondher, Cooper, Wendy, Hamilton, Andrew J., Grierson, Donald

“…The tomato ACC oxidase gene family is comprised of three members designated ACO1, ACO2 and ACO3. These are highly homologous throughout the protein coding…”
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No evidence for binding between resistance gene product Cf-9 of tomato and avirulence gene product AVR9 of cladosporium fulvum by LUDERER, Rianne, RIVAS, Susana, ZUIDEMA, Douwe, VERVOORT, Jacques, DE LORENZO, Giulia, JONES, Jonathan D. G, DE WIT, Pierre J. G. M, JOOSTEN, Matthieu H. A. J, NÜRNBERGER, Thorsten, MATTEI, Benedetta, VAN DEN HOOVEN, Henno W, VAN DER HOORN, Renier A. L, ROMEIS, Tina, WEHRFRITZ, Josa-M, BLUME, Beatrix, NENNSTIEL, Dirk

“…The gene-for-gene model postulates that for every gene determining resistance in the host plant, there is a corresponding gene conditioning avirulence in the…”
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A Novel Principle for Partial Agonism of Liver X Receptor Ligands by Albers, Michael, Blume, Beatrix, Schlueter, Thomas, Wright, Matthew B., Kober, Ingo, Kremoser, Claus, Deuschle, Ulrich, Koegl, Manfred

“…Partial, selective activation of nuclear receptors is a central issue in molecular endocrinology but only partly understood. Using LXRs as an example, we show…”
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Phytophthora parasitica elicitor-induced reactions in cells of Petroselinum crispum by Fellbrich, G. (Institute of Plant Biochemistry (Germany)), Blume, B, Brunner, F, Hirt, H, Kroj, T, Ligterink, W, Romanski, A, Nuernberger, T

“…Cultured parsley (Petroselinum crispum) cells respond to treatment with elicitors derived from different species of the genus Phytophthora with transcript…”
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Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase‑2 (MetAP-2) Inhibitors by Heinrich, Timo, Seenisamy, Jeyaprakashnarayanan, Blume, Beatrix, Bomke, Jörg, Calderini, Michel, Eckert, Uwe, Friese-Hamim, Manja, Kohl, Rainer, Lehmann, Martin, Leuthner, Birgitta, Musil, Djordje, Rohdich, Felix, Zenke, Frank T

“…Co- and post-translational processing are crucial maturation steps to generate functional proteins. MetAP-2 plays an important role in this process, and…”
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Identification of Methionine Aminopeptidase‑2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer by Heinrich, Timo, Seenisamy, Jeyaprakashnarayanan, Becker, Frank, Blume, Beatrix, Bomke, Jörg, Dietz, Melanie, Eckert, Uwe, Friese-Hamim, Manja, Gunera, Jakub, Hansen, Kerrin, Leuthner, Birgitta, Musil, Djordje, Pfalzgraf, Jens, Rohdich, Felix, Siegl, Christian, Spuck, Dieter, Wegener, Ansgar, Zenke, Frank T

“…The recently disclosed next generation of reversible, selective, and potent MetAP-2 inhibitors introduced a cyclic tartronic diamide scaffold. However, the…”
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Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models by Friese-Hamim, Manja, Ortiz Ruiz, Maria J, Bogatyrova, Olga, Keil, Marina, Rohdich, Felix, Blume, Beatrix, Leuthner, Birgitta, Czauderna, Frank, Hahn, Diane, Jabs, Julia, Jaehrling, Frank, Heinrich, Timo, Kellner, Roland, Chan, Katherine, Tong, Amy H Y, Wienke, Dirk, Moffat, Jason, Blaukat, Andree, Zenke, Frank T

“…N-terminal processing by methionine aminopeptidases (MetAP) is a crucial step in the maturation of proteins during protein biosynthesis. Small-molecule…”
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A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors by Albers, Michael, Blume, Beatrix, Schlueter, Thomas, Wright, Matthew B, Kober, Ingo, Kremoser, Claus, Deuschle, Ulrich, Koegl, Manfred

“…Partial, selective activation of nuclear receptors is a central issue in molecular endocrinology but only partly understood. Using LXRs as an example, we show…”
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Estrogen-Related Receptor α Expression and Function Is Associated with the Transcriptional Coregulator AIB1 in Breast Carcinoma by HECK, Stefanie, ROM, Joachim, THEWES, Verena, BECKER, Natalia, BLUME, Beatrix, SINN, Hans Peter, DEUSCHLE, Ulrich, SOHN, Christof, SCHNEEWEISS, Andreas, LICHTER, Peter

“…The significance of the estrogen-related receptor alpha (ERRalpha) as prognostic marker for poor clinical outcome in breast carcinoma has recently been…”
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Receptor-Mediated Increase in Cytoplasmic Free Calcium Required for Activation of Pathogen Defense in Parsley by Blume, Beatrix, Nurnberger, Thorsten, Nass, Norbert, Scheel, Dierk

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Evidence for RNA-Oligonucleotides in Plant Vacuoles Isolated from Cultured Tomato Cells by Abel, Steffen, Blume, Beatrix, Konrad Glund

“…We have shown that highly purified vacuoles of suspension-cultured tomato (Lycopersicon esculentum) cells contain RNA-oligonucleotides, using two different…”
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