Search Results - "BLUE, Mary E"

Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome by Nance, Elizabeth, Kambhampati, Siva P, Smith, Elizabeth S, Zhang, Zhi, Zhang, Fan, Singh, Sarabdeep, Johnston, Michael V, Rangaramanujam, Kannan, Blue, Mary E, Kannan, Sujatha

“…Rett syndrome (RTT) is a pervasive developmental disorder that is progressive and has no effective cure. Immune dysregulation, oxidative stress, and excess…”
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Rett Syndrome and CDKL5 Deficiency Disorder: From Bench to Clinic by Kadam, Shilpa D, Sullivan, Brennan J, Goyal, Archita, Blue, Mary E, Smith-Hicks, Constance

“…Rett syndrome (RTT) and CDKL5 deficiency disorder (CDD) are two rare X-linked developmental brain disorders with overlapping but distinct phenotypic features…”
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Dendrimer Brain Uptake and Targeted Therapy for Brain Injury in a Large Animal Model of Hypothermic Circulatory Arrest by Mishra, Manoj K, Beaty, Claude A, Lesniak, Wojciech G, Kambhampati, Siva P, Zhang, Fan, Wilson, Mary A, Blue, Mary E, Troncoso, Juan C, Kannan, Sujatha, Johnston, Michael V, Baumgartner, William A, Kannan, Rangaramanujam M

“…Treatment of brain injury following circulatory arrest is a challenging health issue with no viable therapeutic options. Based on studies in a clinically…”
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Preclinical research in Rett syndrome: setting the foundation for translational success by Katz, David M, Berger-Sweeney, Joanne E, Eubanks, James H, Justice, Monica J, Neul, Jeffrey L, Pozzo-Miller, Lucas, Blue, Mary E, Christian, Diana, Crawley, Jacqueline N, Giustetto, Maurizio, Guy, Jacky, Howell, C James, Kron, Miriam, Nelson, Sacha B, Samaco, Rodney C, Schaevitz, Laura R, St Hillaire-Clarke, Coryse, Young, Juan L, Zoghbi, Huda Y, Mamounas, Laura A

“…In September of 2011, the National Institute of Neurological Disorders and Stroke (NINDS), the Eunice Kennedy Shriver National Institute of Child Health and…”
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Vitamin D Status in an Italian Pediatric Cohort: Is There a Role for Tobacco Smoking Exposure? by Clemente, Maria Grazia, Argiolas, Dario, Bassu, Stefania, Bitti, Angela, Locci, Cristian, Argiolas, Mauro, Argiolas, Lino, Saderi, Laura, Puci, Mariangela V, Sotgiu, Giovanni, Blue, Mary E, Antonucci, Roberto

“…Vitamin D deficiency is a common public health issue worldwide. The purpose of this study was to investigate the vitamin D status and its potential…”
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Are dopamine receptor and transporter changes in Rett syndrome reflected in Mecp2-deficient mice? by Wong, Dean F., Blue, Mary E., Brašić, James R., Nandi, Ayon, Valentine, Heather, Stansfield, Kirstie H., Rousset, Olivier, Bibat, Genila, Yablonski, Mary E., Johnston, Michael V., Gjedde, Albert, Naidu, SakkuBai

“…We tested the claim that the dopaminergic dysfunction of Rett Syndrome (RTT) also occurs in Mecp2-deficient mice that serve as a model of the syndrome. We used…”
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Nanotechnology Approaches to Targeting Inflammation and Excitotoxicity in a Canine Model of Hypothermic Circulatory Arrest–Induced Brain Injury by Grimm, Joshua C., MD, Magruder, J. Trent, MD, Wilson, Mary A., PhD, Blue, Mary E., PhD, Crawford, Todd C., MD, Troncoso, Juan C., MD, Zhang, Fan, PhD, Kannan, Sujatha, PhD, Sciortino, Christopher M., MD, PhD, Johnston, Michael V., MD, Kannan, Rangaramanujam M., PhD, Baumgartner, William A., MD

“…Background Neurocognitive dysfunction and injury remain problematic after cardiac procedures requiring hypothermic circulatory arrest (HCA). Due to poor…”
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MeCP2 expression and function during brain development: implications for Rett syndrome's pathogenesis and clinical evolution by Kaufmann, Walter E., Johnston, Michael V., Blue, Mary E.

“…Most cases of Rett syndrome (RTT) are associated with mutations of the transcriptional regulator MeCP2. On the basis of molecular structure, ontogeny, and…”
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Correction to: Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome by Nance, Elizabeth, Kambhampati, Siva P, Smith, Elizabeth S, Zhang, Zhi, Zhang, Fan, Singh, Sarabdeep, Johnston, Michael V, Kannan, Rangaramanujam M, Blue, Mary E, Kannan, Sujatha

“…After publication of the article [1], it has been brought to our attention that an author's name has been formatted incorrectly…”
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Temporal and Regional Alterations in NMDA Receptor Expression in Mecp2‐Null Mice by Blue, Mary E., Kaufmann, Walter E., Bressler, Joseph, Eyring, Charlotte, O'driscoll, Cliona, Naidu, Sakkubai, Johnston, Michael V.

“…Our previous postmortem study of girls with Rett Syndrome (RTT), a development disorder caused by MECP2 mutations, found increases in the density of…”
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Apoptosis Has a Prolonged Role in the Neurodegeneration after Hypoxic Ischemia in the Newborn Rat by Nakajima, Wako, Ishida, Akira, Lange, Mary S, Gabrielson, Kathleen L, Wilson, Mary Ann, Martin, Lee J, Blue, Mary E, Johnston, Michael V

“…Birth asphyxia can cause moderate to severe brain injury. It is unclear to what degree apoptotic or necrotic mechanisms of cell death account for damage after…”
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Recent advances in understanding synaptic abnormalities in Rett syndrome [version 1; peer review: 2 approved] by Johnston, Michael V, Blue, Mary E, Naidu, Sakkubai

“…Rett syndrome is an extremely disabling X-linked nervous system disorder that mainly affects girls in early childhood and causes autism-like behavior, severe…”
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Neonatal serotonin depletion alters behavioral responses to spatial change and novelty by Hohmann, Christine F, Walker, Ellen M, Boylan, Carolyn B, Blue, Mary E

“…Abstract Multiple brain disorders that show serotonergic imbalances have a developmental onset. Experimental models indicate a role for serotonin as a…”
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Glutamate Excitotoxicity Mediates Neuronal Apoptosis After Hypothermic Circulatory Arrest by Tseng, Elaine E., MD, Brock, Malcolm V., MD, Lange, Mary S., MA, Troncoso, Juan C., MD, Blue, Mary E., PhD, Lowenstein, Charles J., MD, Johnston, Michael V., MD, Baumgartner, William A., MD

“…Background Prolonged hypothermic circulatory arrest results in neuronal cell death and neurologic injury. We have previously shown that hypothermic circulatory…”
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Alpha II-Spectrin Breakdown Products Serve as Novel Markers of Brain Injury Severity in a Canine Model of Hypothermic Circulatory Arrest by Weiss, Eric S., MD, MPH, Wang, Kevin K.W., PhD, Allen, Jeremiah G., MD, Blue, Mary E., PhD, Nwakanma, Lois U., MD, Liu, Ming Cheng, MD, Lange, Mary S., MA, Berrong, Jennifer, Wilson, Mary Ann, PhD, Gott, Vincent L., MD, Troncoso, Juan C., MD, Hayes, Ronald L., PhD, Johnston, Michael V., MD, Baumgartner, William A., MD

“…Background The development of specific biomarkers to aid in the diagnosis and prognosis of neuronal injury is of paramount importance in cardiac surgery. Alpha…”
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Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest by Arnaoutakis, George J., MD, George, Timothy J., MD, Wang, Kevin K., PhD, Wilson, Mary Ann, PhD, Allen, Jeremiah G., MD, Robinson, Chase W., MHS, Haggerty, Kara A., BS, Weiss, Eric S., MD, MPH, Blue, Mary E., PhD, Talbot, Charles C., BA, Troncoso, Juan C., MD, Johnston, Michael V., MD, Baumgartner, William A., MD

“…Objectives Ubiquitin carboxyl-terminal esterase-L1 (UCHL1) is a protein highly selectively expressed in neurons and has been linked to neurodegenerative…”
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Transcriptional Profile of Brain Injury in Hypothermic Circulatory Arrest and Cardiopulmonary Bypass by Allen, Jeremiah G., MD, Weiss, Eric S., MD, Wilson, Mary Ann, PhD, Arnaoutakis, George J., MD, Blue, Mary E., PhD, Talbot, C. Conover, BA, Jie, Chunfa, PhD, Lange, Mary S., MA, Troncoso, Juan C., MD, Johnston, Michael V., MD, Baumgartner, William A., MD

“…Background Little is known about the molecular mechanisms of neurologic complications after hypothermic circulatory arrest (HCA) with cardiopulmonary bypass…”
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Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model by Zhang, Fan, Trent Magruder, J., Lin, Yi-An, Crawford, Todd C., Grimm, Joshua C., Sciortino, Christopher M., Wilson, Mary Ann, Blue, Mary E., Kannan, Sujatha, Johnston, Michael V., Baumgartner, William A., Kannan, Rangaramanujam M.

“…Hypothermic circulatory arrest (HCA) provides neuroprotection during cardiac surgery but entails an ischemic period that can lead to excitotoxicity,…”
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Dendrimer nanotherapy targeting of glial dysfunction improves inflammation and neurobehavioral phenotype in adult female Mecp2‐heterozygous mouse model of Rett syndrome by Khoury, Elizabeth Smith, Patel, Ruchit V., O'Ferrall, Caroline, Fowler, Amanda, Sah, Nirnath, Sharma, Anjali, Gupta, Siddharth, Scafidi, Susanna, Kurtz, Joshua S., Olmstead, Sarah J., Kudchadkar, Sapna R., Kannan, Rangaramanujam M., Blue, Mary E., Kannan, Sujatha

“…Rett syndrome is an X‐linked neurodevelopmental disorder caused by mutation of Mecp2 gene and primarily affects females. Glial cell dysfunction has been…”
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Neurobiology of Rett syndrome: a genetic disorder of synapse development by Johnston, Michael V., Jeon, Ok-Hee, Pevsner, Jonathan, Blue, Mary E., Naidu, SakkuBai

“…Rett syndrome is a developmental disorder that restricts brain growth beginning in the first year of life and evidence from neuropathology and neuroimaging…”
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