Search Results - "BLOXHAM, D. P"

The pharmacology and pharmacokinetics of the retinoids by Allen, J G, Bloxham, D P

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Hypolipidemic effect of polymethylenemethane thiosulfonates: inhibitors of acetoacetyl coenzyme A thiolase by Salam, W H, Bloxham, D P

“…A new series of bifunctional thiosulfonates of the general formula CH3SO2S-(CH2)n-SSO2CH3(SS1 polymethylene bis methane thiosulfonate) with variable…”
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Biologic properties of romazarit (Ro 31-3948), a potential disease-modifying antirheumatic drug by Bloxham, D P, Bradshaw, D, Cashin, C H, Dodge, B B, Lewis, E J, Westmacott, D, Self, C R

“…The biologic effects of a new potential disease-modifying antirheumatic drug, romazarit (Ro 31-3948,…”
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The use of tritiated water to measure absolute rates of hepatic glycogen synthesis by Postle, A D, Bloxham, D P

“…Glucogen synthesis in rat liver in vivo was measured by the incorporation of 3H from 3H2O into glycogen. In meal-fed rats incorporation and the incorporation…”
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Developmental changes in the fatty (fafa) rat: evidence for defective thermogenesis preceding the hyperlipogenesis and hyperinsulinaemia by Godbole, V, York, D A, Bloxham, D P

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Primary Structure of Porcine Heart Citrate Synthase by Bloxham, David P., Parmelee, David C., Kumar, Santosh, Wade, Roger D., Ericsson, Lowell H., Neurath, Hans, Walsh, Kenneth A., Titani, Koiti

“…The sequence of 437 amino acid residues of porcine heart citrate synthase [citrate oxaloacetate-lyase (pro-3S-CH2COO→ acetyl-CoA), EC 4. 1. 3. 7] has been…”
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The chemical reactivity of the histidine-195 residue in lactate dehydrogenase thiomethylated at the cysteine-165 residue by Bloxham, D P

“…The specific thiomethylation of cysteine-165 (insertion of a methylthio group, CH3-S-) in pig heart lactate dehydrogenase results in a decreased affinity for…”
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Complete sequence of the glt A gene encoding citrate synthase in Escherichia coli by NER, S. S, BHAYANA, V, BELL, A. W, GILES, I. G, DUCKWORTH, H. W, BLOXHAM, D. P

“…The sequence of a 3265 base pair HindIII-EcoRI restriction fragment spanning the glt A gene from Escherichia coli was determined. The sequences for initiation…”
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Romazarit. A potential disease-modifying antirheumatic drug by Self, Christopher R, Barber, William E, Machin, Peter J, Osbond, John M, Smithen, Carey E, Tong, Brian P, Wickens, James C, Bloxham, David P, Bradshaw, David

“…The synthesis of a series of substituted heterocyclic alkoxypropionic acids is described. They were evaluated for antiinflammatory effects in two animal models…”
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Specific inhibition of L-type pyruvate kinase by the triazine dye Procion Blue MX-R by Byford, M F, Bloxham, D P

“…Incubation of the triazine dye Procion Blue MX-R with L- and M-type pyruvate kinase resulted in rapid time- and dye-concentration-dependent loss of activity…”
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Studies on the biosynthesis of hepatic pyruvate kinase and its correlation with enhanced hepatic lipogenesis in meal-trained rats by Hopkirk, T J, Bloxham, D P

“…Metabolic and enzymic changes were measured in meal-trained rats fed on high-carbohydrate diet. Rates of hepatic fatty acid synthesis are probably greater than…”
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Chemotactic activity of recombinant human interleukin-1 by Westmacott, D, Wadsworth, J, Bloxham, D P

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Selective inhibition of cholesterol synthesis by cell-free preparations of rat liver by using inhibitors of cytoplasmic acetoacetyl-coenzyme A thiolase by Bloxham, D P

“…Cytoplasmic acetoacetyl-CoA thiolase (acetyl-CoA C-acetyltransferase, EC 2.3.1.9) was partially purified from rat liver. The enzyme was irreversibly…”
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Biosynthesis of rat liver pyruvate kinase. Measurement of enzyme lifetime and the rate of synthesis at weaning by Hopkirk, T J, Bloxham, D P

“…Sodium dodecyl sulphate/polyacrylamide-gel electrophoresis of immunoprecipitates of liver cytosol with anti-(L-type pyruvate kinase) serum revealed proteins of…”
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The induction of synthesis of L-type pyruvate kinase in cultured rat hepatocytes by Poole, G P, Postle, A D, Bloxham, D P

“…Hepatocytes were isolated from preweaned neonatal and adult rats and maintained in primary monolayer culture. Cells from preweaned newborns possessed no L-type…”
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The turnover of L-type pyruvate kinase in cultured rat hepatocytes by Poole, G P, Bloxham, D P

“…Hepatocytes were isolated by collagenase perfusion of livers from rats that had been allowed access to a carbohydrate-rich diet or laboratory chow or had been…”
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The development of SS'-polymethylenebis(methanethiosulphonates) as reversible cross-linking reagents for thiol groups and their use to form stable catalytically active cross-linked dimers within glyceraldehyde 3-phosphate dehydrogenase by Bloxham, D P, Sharma, R P

“…The synthesis of a series of SS'-polymethylenebis(methanethiosulphonates) including the pentane, hexane, octane, decane and dodecane derivatives is described…”
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Synthesis and use of bifunctional chloromethylalkanedione derivatives of variable chain length for cross-linking thiol groups in oligomeric proteins. Specific cross-linking in glyceraldehyde 3-phosphate dehydrogenase by Bloxham, D P

“…Bischloromethylpentanedione, bischloromethylhexanedione, bischloromethyloctanedione and bischloromethyldecanedione were synthesized from their corresponding…”
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Enhancement of the anti-anabolic response to adenosine 3':5'-cyclic monophosphate during development. The inhibition of hepatic protein synthesis by Klaipongpan, A, Bloxham, D P, Akhtar, M

“…Cyclic AMP causes an age-dependent inhibition of protein synthesis in rat liver. The onset of inhibition is about 10--12 days after birth. The developmental…”
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Selective modification of rabbit muscle pyruvate kinase by 5-chloro-4-oxopentanoic acid by Bloxham, D P, Chalkley, R A

“…Rabbit muscle pyruvate kinase was irreverisbly inactivated by 5-chloro-4-oxopentanoic acid with a pKa of 9.2. The inhibition was time-dependent and was related…”
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