Search Results - "BLOUIN, Marie Jose"

Distinct perturbation of the translatome by the antidiabetic drug metformin by Larsson, Ola, Morita, Masahiro, Topisirovic, Ivan, Alain, Tommy, Blouin, Marie-Jose, Pollak, Michael, Sonenberg, Nahum

“…Metformin has been reported to lower cancer incidence among type Il diabetics. Metformin exhibits antiproliferative and antineoplastic effects associated with…”
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Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides by Hulea, Laura, Gravel, Simon-Pierre, Morita, Masahiro, Cargnello, Marie, Uchenunu, Oro, Im, Young Kyuen, Lehuédé, Camille, Ma, Eric H., Leibovitch, Matthew, McLaughlan, Shannon, Blouin, Marie-José, Parisotto, Maxime, Papavasiliou, Vasilios, Lavoie, Cynthia, Larsson, Ola, Ohh, Michael, Ferreira, Tiago, Greenwood, Celia, Bridon, Gaëlle, Avizonis, Daina, Ferbeyre, Gerardo, Siegel, Peter, Jones, Russell G., Muller, William, Ursini-Siegel, Josie, St-Pierre, Julie, Pollak, Michael, Topisirovic, Ivan

“…There is increasing interest in therapeutically exploiting metabolic differences between normal and cancer cells. We show that kinase inhibitors (KIs) and…”
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Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism by FENDT, Sarah-Maria, BELL, Eric L, PATNAIK, Akash, BLOUIN, Marie Jose, CANTLEY, Lewis C, GUARENTE, Leonard, BLENIS, John, POLLAK, Michael N, OLUMI, Aria F, VANDER HEIDEN, Matthew G, STEPHANOPOULOS, Gregory, KEIBLER, Mark A, DAVIDSON, Shawn M, WIRTH, Gregory J, FISKE, Brian, MAYERS, Jared R, SCHWAB, Matthias, BELLINGER, Gary, CSIBI, Alfredo

“…Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with increased survival in patients with cancer taking metformin;…”
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A phenotype of IGFBP-3 knockout mice revealed by dextran sulfate-induced colitis by Yancu, Debbie, Blouin, Marie-José, Birman, Elena, Florianova, Livia, Aleynikova, Olga, Zakikhani, Mahvash, VanderMeulen, Heather, Seidman, Ernest, Pollak, Michael

“…Insulin-like growth factor-1 (IGF-1) bioactivity has been shown to be attenuated by insulin-like growth factor binding protein-3 (IGFBP-3), one of six…”
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Metformin-induced reductions in tumor growth involves modulation of the gut microbiome by Broadfield, Lindsay A., Saigal, Amna, Szamosi, Jake C., Hammill, Joanne A., Bezverbnaya, Ksenia, Wang, Dongdong, Gautam, Jaya, Tsakiridis, Evangelia E., Di Pastena, Fiorella, McNicol, Jamie, Wu, Jianhan, Syed, Saad, Lally, James S.V., Raphenya, Amogelang R., Blouin, Marie-Jose, Pollak, Michael, Sacconi, Andrea, Blandino, Giovanni, McArthur, Andrew G., Schertzer, Jonathan D., Surette, Michael G., Collins, Stephen M., Bramson, Jonathan L., Muti, Paola, Tsakiridis, Theodoros, Steinberg, Gregory R.

“…Type 2 diabetes and obesity increase the risk of developing colorectal cancer. Metformin may reduce colorectal cancer but the mechanisms mediating this effect…”
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Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth by Algire, Carolyn, Zakikhani, Mahvash, Blouin, Marie-Jose, Shuai, Jian Hua, Pollak, Michael

“…We investigated the effects of metformin on the growth of lewis lung LLC1 carcinoma in C57BL/6J mice provided with either a control diet or a high-energy diet,…”
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Metformin improves healthspan and lifespan in mice by Martin-Montalvo, Alejandro, Mercken, Evi M., Mitchell, Sarah J., Palacios, Hector H., Mote, Patricia L., Scheibye-Knudsen, Morten, Gomes, Ana P., Ward, Theresa M., Minor, Robin K., Blouin, Marie-José, Schwab, Matthias, Pollak, Michael, Zhang, Yongqing, Yu, Yinbing, Becker, Kevin G., Bohr, Vilhelm A., Ingram, Donald K., Sinclair, David A., Wolf, Norman S., Spindler, Stephen R., Bernier, Michel, de Cabo, Rafael

“…Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin (0.1% w/w in diet)…”
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Serine deprivation enhances antineoplastic activity of biguanides by Gravel, Simon-Pierre, Hulea, Laura, Toban, Nader, Birman, Elena, Blouin, Marie-José, Zakikhani, Mahvash, Zhao, Yunhua, Topisirovic, Ivan, St-Pierre, Julie, Pollak, Michael

“…Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits antineoplastic activity in experimental models and has been reported…”
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Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells by Zakikhani, Mahvash, Blouin, Marie-José, Piura, Esther, Pollak, Michael N

“…Rapamycin and its analogues inhibit mTOR, which leads to decreased protein synthesis and decreased cancer cell proliferation in many experimental systems…”
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Carbon Source and Myc Expression Influence the Antiproliferative Actions of Metformin by JAVESHGHANI, Shiva, ZAKIKHANI, Mahvash, AUSTIN, Shane, BAZILE, Miguel, BLOUIN, Marie-José, TOPISIROVIC, Ivan, ST-PIERRE, Julie, POLLAK, Michael N

“…Epidemiologic and experimental data have led to increased interest in possible roles of biguanides in cancer prevention and/or treatment. Prior studies suggest…”
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Treatment with insulin analog X10 and IGF-1 increases growth of colon cancer allografts by Hvid, Henning, Blouin, Marie-José, Birman, Elena, Damgaard, Jesper, Poulsen, Fritz, Fels, Johannes Josef, Fledelius, Christian, Hansen, Bo Falck, Pollak, Michael

“…Obesity and type 2 diabetes are associated with an increased risk for development of certain forms of cancer, including colon cancer. The publication of highly…”
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Metformin improves healthspan and lifespan in mice by Martin-Montalvo, Alejandro, Mercken, Evi M., Mitchell, Sarah J., Palacios, Hector H., Mote, Patricia L., Scheibye-Knudsen, Morten, Gomes, Ana P., Ward, Theresa M., Minor, Robin K., Blouin, Marie-José, Schwab, Matthias, Pollak, Michael, Zhang, Yongqing, Yu, Yinbing, Becker, Kevin G., Bohr, Vilhelm A., Ingram, Donald K., Sinclair, David A., Wolf, Norman S., Spindler, Stephen R., Bernier, Michel, de Cabo, Rafael

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Germ line knockout of IGFBP-3 reveals influences of the gene on mammary gland neoplasia by Blouin, Marie-José, Bazile, Miguel, Birman, Elena, Zakikhani, Mahvash, Florianova, Livia, Aleynikova, Olga, Powell, David R., Pollak, Michael

“…Insulin-like growth factor binding protein-3 (IGFBP-3) is an important carrier protein for insulin-like growth factors (IGFs) in the circulation. IGFBP-3…”
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Dietary Feeding of Silibinin Inhibits Prostate Tumor Growth and Progression in Transgenic Adenocarcinoma of the Mouse Prostate Model by RAINA, Komal, BLOUIN, Marie-Jose, POLLAK, Michael N, AGARWA, Rajesh, SINGH, Rana P, MAJEED, Noreen, DEEP, Gagan, VARGHESE, Leyon, GLODE, L. Michael, GREENBERG, Norman M, HWANG, David, COHEN, Pinchas

“…Herein, for the first time, we evaluated the chemopreventive efficacy of dietary silibinin against prostate cancer (PCa) growth and progression in transgenic…”
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Effects of castration on insulin levels and glucose tolerance in the mouse differ from those in man by Inoue, Takamitsu, Zakikhani, Mahvash, David, Stéphanie, Algire, Carolyn, Blouin, Marie-José, Pollak, Michael

“…BACKGROUND Plasma insulin concentration is increased in prostate cancer patients during androgen deprivation therapy (ADT) and hyperinsulinemia has been…”
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Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose by Blouin, Marie-José, Zhao, Yunhua, Zakikhani, Mahvash, Algire, Carolyn, Piura, Esther, Pollak, Michael

“…Abstract PTEN loss of function enhances proliferation, but effects on cellular energy metabolism are less well characterized. We used an inducible PTEN…”
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Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft by Singh, Rana P., Deep, Gagan, Blouin, Marie-José, Pollak, Michael N., Agarwal, Rajesh

“…Chemoprevention is an upcoming approach to control cancer including prostate cancer (PCa). Here, we studied the efficacy and associated mechanisms of a…”
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IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer by Dool, Carly Jade, Mashhedi, Haider, Zakikhani, Mahvash, David, Stéphanie, Zhao, Yunhua, Birman, Elena, Carboni, Joan M, Gottardis, Marco, Blouin, Marie-José, Pollak, Michael

“…Epidemiologic and experimental evidence suggest that a subset of breast cancer is insulin responsive, but it is unclear whether safe and effective therapies…”
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The hedgehog pathway inhibitor cyclopamine increases levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells by Levitt, Randy J, Zhao, Yunhua, Blouin, Marie-José, Pollak, Michael

“…Abstract The hedgehog signalling inhibitor cyclopamine has been shown to induce growth inhibition and cell cycle arrest in prostate cancer cell lines, but the…”
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Stimulation of MC38 tumor growth by insulin analog X10 involves the serine synthesis pathway by Hvid, Henning, Fendt, Sarah-Maria, Blouin, Marie-José, Birman, Elena, Voisin, Gregory, Svendsen, Angela Manegold, Frank, Russell, Vander Heiden, Matthew G, Stephanopoulos, Gregory, Hansen, Bo Falck, Pollak, Michael

“…Recent evidence suggests that type II diabetes is associated with increased risk and/or aggressive behavior of several cancers, including those arising from…”
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