Search Results - "BLIKSLAGER, ANTHONY T"

The Integral Role of Tight Junction Proteins in the Repair of Injured Intestinal Epithelium by Slifer, Zachary M, Blikslager, Anthony T

“…The intestinal epithelial monolayer forms a transcellular and paracellular barrier that separates luminal contents from the interstitium. The paracellular…”
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The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase/Rho Kinases by Jin, Younggeon, Blikslager, Anthony T

“…The intestinal epithelial apical junctional complex, which includes tight and adherens junctions, contributes to the intestinal barrier function via their role…”
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Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research by Gonzalez, Liara M, Moeser, Adam J, Blikslager, Anthony T

“…Research in the field of ischemia-reperfusion injury continues to be plagued by the inability to translate research findings to clinically useful therapies…”
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Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function by Rose, Elizabeth C, Odle, Jack, Blikslager, Anthony T, Ziegler, Amanda L

“…Disruptions in the intestinal epithelial barrier can result in devastating consequences and a multitude of disease syndromes, particularly among preterm…”
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Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury by Jin, Younggeon, Blikslager, Anthony T

“…Intestinal anoxia/reoxygenation (A/R) injury induces loss of barrier function followed by epithelial repair. Myosin light chain kinase (MLCK) has been shown to…”
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Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration by Gonzalez, Liara M, Williamson, Ian, Piedrahita, Jorge A, Blikslager, Anthony T, Magness, Scott T

“…Significant advances in intestinal stem cell biology have been made in murine models; however, anatomical and physiological differences between mice and humans…”
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Restoration of Barrier Function in Injured Intestinal Mucosa by Blikslager, Anthony T, Moeser, Adam J, Gookin, Jody L, Jones, Samuel L, Odle, Jack

“…Departments of Clinical Sciences and Animal Science, North Carolina State University, Raleigh, North Carolina Mucosal repair is a complex event that…”
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In vivo assessment of a delayed release formulation of larazotide acetate indicated for celiac disease using a porcine model by Enomoto, Hiroko, Yeatts, James, Carbajal, Liliana, Krishnan, B Radha, Madan, Jay P, Laumas, Sandeep, Blikslager, Anthony T, Messenger, Kristen M

“…There is no FDA approved therapy for the treatment of celiac disease (CeD), aside from avoidance of dietary gluten. Larazotide acetate (LA) is a first in class…”
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Larazotide acetate induces recovery of ischemia-injured porcine jejunum via repair of tight junctions by Slifer, Zachary M, Hernandez, Liliana, Pridgen, Tiffany A, Carlson, Alexandra R, Messenger, Kristen M, Madan, Jay, Krishnan, B Radha, Laumas, Sandeep, Blikslager, Anthony T

“…Intestinal ischemia results in mucosal injury, including paracellular barrier loss due to disruption of tight junctions. Larazotide acetate (LA), a small…”
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The use of nonsteroidal anti-inflammatory drugs in critically ill horses by Cook, Vanessa L., Blikslager, Anthony T.

“…Objective To review the physiology of the cyclooxygenase (COX) enzymes with reference to the beneficial effects of nonsteroidal anti‐inflammatory drugs…”
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Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair by Ziegler, Amanda L, Pridgen, Tiffany A, Mills, Juliana K, Gonzalez, Liara M, Van Landeghem, Laurianne, Odle, Jack, Blikslager, Anthony T

“…Intestinal ischemic injury results sloughing of the mucosal epithelium leading to host sepsis and death unless the mucosal barrier is rapidly restored…”
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Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair by Krüger, Leandi, Gonzalez, Liara M, Pridgen, Tiffany A, McCall, Shannon J, von Furstenberg, Richard J, Harnden, Ivan, Carnighan, Gwendolyn E, Cox, Abigail M, Blikslager, Anthony T, Garman, Katherine S

“…Esophageal injury is a risk factor for diseases such as Barrett's esophagus (BE) and esophageal adenocarcinoma. To improve understanding of signaling pathways…”
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Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin by Nighot, Prashant K, Blikslager, Anthony T

“…Previously, we have demonstrated that the chloride channel ClC-2 modulates intestinal mucosal barrier function. In the present study, we investigated the role…”
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Porcine Models of the Intestinal Microbiota: The Translational Key to Understanding How Gut Commensals Contribute to Gastrointestinal Disease by Rose, Elizabeth C, Blikslager, Anthony T, Ziegler, Amanda L

“…In the United States, gastrointestinal disorders account for in excess of $130 billion in healthcare expenditures and 22 million hospitalizations annually…”
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Postoperative Ileus: Comparative Pathophysiology and Future Therapies by Hellstrom, Emily A, Ziegler, Amanda L, Blikslager, Anthony T

“…Postoperative ileus (POI), a decrease in gastrointestinal motility after surgery, is an important problem facing human and veterinary patients. 37.5% of horses…”
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Pharmaceutical Activation or Genetic Absence of ClC-2 Alters Tight Junctions During Experimental Colitis by Jin, Younggeon, Pridgen, Tiffany A, Blikslager, Anthony T

“…We have previously reported that the ClC-2 chloride channel has an important role in regulation of tight junction barrier function during experimental colitis,…”
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Age-Dependent Intestinal Repair: Implications for Foals with Severe Colic by Erwin, Sara J, Blikslager, Anthony T, Ziegler, Amanda L

“…Colic is a leading cause of death in horses, with the most fatal form being strangulating obstruction which directly damages the intestinal barrier. Following…”
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Prebiotic galactooligosaccharide improves piglet growth performance and intestinal health associated with alterations of the hindgut microbiota during the peri-weaning period by Boston, Timothy E, Wang, Feng, Lin, Xi, Kim, Sung Woo, Fellner, Vivek, Scott, Mark F, Ziegler, Amanda L, Van Landeghem, Laurianne, Blikslager, Anthony T, Odle, Jack

“…Weaning stress reduces growth performance and health of young pigs due in part to an abrupt change in diets from highly digestible milk to fibrous plant-based…”
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Effect of sucralfate on gastric permeability in an ex vivo model of stress‐related mucosal disease in dogs by Hill, Tracy L., Lascelles, B. Duncan X., Blikslager, Anthony T.

“…Background Sucralfate is a gastroprotectant with no known systemic effects. The efficacy of sucralfate for prevention and treatment of stress‐related mucosal…”
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Correction: Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair by Ziegler, Amanda L, Pridgen, Tiffany A, Mills, Juliana K, Gonzalez, Liara M, Van Landeghem, Laurianne, Odle, Jack, Blikslager, Anthony T

“…[This corrects the article DOI: 10.1371/journal.pone.0200674.]…”
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