Search Results - "BLEYZAC, N"

A Generic Model for Quantitative Prediction of Interactions Mediated by Efflux Transporters and Cytochromes: Application to P-Glycoprotein and Cytochrome 3A4 by Tod, Michel, Goutelle, S., Bleyzac, N., Bourguignon, L.

“…Background and Objective The In Vivo Mechanistic Static Model (IMSM) is a powerful method used to predict the magnitude of drug–drug interactions (DDIs)…”
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Impact of a Bayesian Individualization of Cyclosporine Dosage Regimen for Children Undergoing Allogeneic Hematopoietic Cell Transplantation: A Cost-Effectiveness Analysis by Beyron, C., Ceraulo, A., Bertrand, Y., Bleyzac, N., Philippe, M.

“…Cyclosporine A (CsA) is the main drug used to prevent graft-versus-host disease in patients undergoing allogeneic hematopoietic stem cell transplantation…”
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A Model for Predicting the Interindividual Variability of Drug-Drug Interactions by Tod, M., Bourguignon, L., Bleyzac, N., Goutelle, S.

“…Pharmacokinetic drug-drug interactions are frequently characterized and quantified by an AUC ratio (Rauc). The typical value of the AUC ratio in case of…”
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Should busulfan therapeutic range be narrowed in pediatrics? Experience from a large cohort of hematopoietic stem cell transplant children by Philippe, M, Goutelle, S, Guitton, J, Fonrose, X, Bergeron, C, Girard, P, Bertrand, Y, Bleyzac, N

“…Busulfan, the corner stone of hematopoietic stem cell transplantation regimens, has a narrow therapeutic window. Therapeutic drug monitoring (TDM)-guided…”
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The use of pharmacokinetic models in paediatric onco-haematology: effects on clinical outcome through the examples of busulfan and cyclosporine by Bleyzac, N.

“…Overall survival after allogeneic haematopoietic stem cell transplantation (HSCT) is reduced by the high rate of transplantation‐related mortality (TRM),…”
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High methotrexate exposure and toxicity in children with t(9;22) positive acute lymphoblastic leukaemia treated with imatinib by Loue, C., Garnier, N., Bertrand, Y., Bleyzac, N.

“…Summary What is known and objective Although there is one report on the possible reduced clearance of methotrexate in an adult patient when given concomitantly…”
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Estimating renal function when adjusting the dosage of antibiotics: Facts and fables by Goutelle, S., Bleyzac, N., Mioux, L., de la Gastine, B., Bourguignon, L.

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Pediatric-Adult Care Transition: Perceptions of Adolescent and Young Adult Patients with Sickle Cell Disease and Their Healthcare Providers by Hoegy, Delphine, Guilloux, Ronald, Bleyzac, Nathalie, Gauthier-Vasserot, Alexandra, Cannas, Giovanna, Bertrand, Yves, Dussart, Claude, Janoly-Dumenil, Audrey

“…Introduction: The pediatric-adult care transition, which takes place during adolescence, is a high-risk period for medical care adherence in chronic diseases,…”
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Quantitative Prediction of Drug–Drug Interactions Involving Inhibitory Metabolites by Physiologically Based Pharmacokinetic Models: Is it Worth It? by Tod, M, Goutelle, S, Bourguignon, L, Bleyzac, N

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Improved outcome of children transplanted for high-risk leukemia by using a new strategy of cyclosporine-based GVHD prophylaxis by Bleyzac, N, Cuzzubbo, D, Rénard, C, Garnier, N, Dubois, V, Domenech, C, Goutagny, M-P, Plesa, A, Grardel, N, Goutelle, S, Janoly-Duménil, A, Bertrand, Y

“…There is currently a major concern regarding the optimal immunosuppression therapy to be administered after hematopoietic stem cell transplantation (HSCT) to…”
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Outcome of 27 patients with Hurler's syndrome transplanted from either related or unrelated haematopoietic stem cell sources by SOUILLET, G, GUFFON, N, GALAMBRUN, C, BERTRAND, Y, FROISSART, R, DORCHE, C, GEBUHRER, L, GARIN, C, BERARD, J, GUIBAUD, P, MAIRE, I, PUJOL, M, TAYLOR, P, SEVIN, F, BLEYZAC, N, MULIER, C, DURIN, A, KEBAILI, K

“…Over the last 15 years, we have performed a total of 30 haematopoietic stem cell transplants on 27 children suffering from Hurler's syndrome. These children…”
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Cytomegalovirus Infection in Pediatric Allogenic Hematopoietic Stem Cell Transplantation. A Single Center Experience by Sedky, M., Mekki, Y., Mialou, V., Bleyzac, N., Girard, S., Salama, E., Abdel Rahman, H., Bertrand, Y.

“…We report a retrospective analysis of Cytomegalovirus (CMV) infection: incidence, recurrence, resistance, and subsequent disease of 81 children who underwent…”
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Lacidipine efficacy and safety for high blood pressure treatment in pediatric oncohematology by Bernard, E, Mialou, V, Dony, A, Garnier, N, Renard, C, Bleyzac, N

“…In adults, lacidipine seems to have no CYP3A4-inhibiting action. This particular characteristic makes it advantageous when combined with drugs metabolized by…”
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Vancomycin: what dosages are needed to achieve efficacy in paediatric hematology/oncology? by Zegbeh, H, Bleyzac, N, Berhoune, C, Bertrand, Y

“…In children and infants, the determination of optimal dosages is essential from the beginning of treatments with vancomycin because of the high risk of…”
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Influence of underlying disease on busulfan disposition in pediatric bone marrow transplant recipients : A nonparametric population pharmacokinetic study by BERTHOLLE-BONNET, V, BLEYZAC, N, GALAMBRUN, C, MIALOU, V, BERTRAND, Y, SOUILLET, G, AULAGNER, G

“…Busulfan is an alkylating agent used in a conditioning regimen prior to bone marrow transplantation. Busulfan has a narrow therapeutic index, giving rise to…”
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Cyclosporin A inhibits dendritic cell maturation promoted by TNF-α or LPS but not by double-stranded RNA or CD40L by Duperrier, K., Farre, A., Bienvenu, J., Bleyzac, N., Bernaud, J., Gebuhrer, L., Rigal, D., Eljaafari, A.

“…Here, we investigated the influence of cyclosporin A (CsA) on dendritic cell (DC) generation. With this aim, human DC were propagated from monocytes in…”
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Efficacy and plasma levels of ropivacaine for children: controlled regional analgesia following lower limb surgery by Duflo, F, Sautou-Miranda, V, Pouyau, A, Taylor, P, Combet, S, Chotel, F, Bleyzac, N, Chassard, D

“…Continuous regional analgesia (CRA) is considered a safe and efficacious technique for postoperative pain relief in children after lower limb surgery. We…”
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Clinical and pharmacological risk factors for acute graft-versus-host disease after paediatric bone marrow transplantation from matched-sibling or unrelated donors by MARTIN, P, BLEYZAC, N, SOUILLET, G, GALAMBRUN, C, BERTRAND, Y, MAIRE, P. H, JELLIFFE, R. W, AULAGNER, G

“…The aim of this study was to identify the risk factors for acute graft-versus-host disease (aGVHD) in children transplanted from a matched-sibling donor (MSD)…”
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HSV excretion after bone marrow transplantation: a 4-year survey by Morfin, Florence, Bilger, Karin, Boucher, Anne, Thiebaut, Anne, Najioullah, Fatiha, Bleyzac, Nathalie, Raus, Nicole, Bosshard, Sylvie, Aymard, Michèle, Michallet, Mauricette, Thouvenot, Danielle

“…Background: Herpes simplex virus (HSV) oral excretions are common after bone marrow transplantation (BMT). Objective: We report a 4-year systematic survey of…”
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Human herpes virus-6 encephalitis in a paediatric bone marrow recipient: successful treatment with pharmacokinetic monitoring and high doses of ganciclovir by Janoly-Duménil, A, Galambrun, C, Basset, T, Mialou, V, Bertrand, Y, Bleyzac, N

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