Search Results - "BLESA, Rafael"

Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome by Lleó, Alberto, Zetterberg, Henrik, Pegueroles, Jordi, Karikari, Thomas K., Carmona-Iragui, María, Ashton, Nicholas J., Montal, Victor, Barroeta, Isabel, Lantero-Rodríguez, Juan, Videla, Laura, Altuna, Miren, Benejam, Bessy, Fernandez, Susana, Valldeneu, Silvia, Garzón, Diana, Bejanin, Alexandre, Iulita, Maria Florencia, Camacho, Valle, Medrano-Martorell, Santiago, Belbin, Olivia, Clarimon, Jordi, Lehmann, Sylvain, Alcolea, Daniel, Blesa, Rafael, Blennow, Kaj, Fortea, Juan

“…Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology with high accuracy in the general population. In this study,…”
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Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors by Powers, Rani K., Culp-Hill, Rachel, Ludwig, Michael P., Smith, Keith P., Waugh, Katherine A., Minter, Ross, Tuttle, Kathryn D., Lewis, Hannah C., Rachubinski, Angela L., Granrath, Ross E., Carmona-Iragui, María, Wilkerson, Rebecca B., Kahn, Darcy E., Joshi, Molishree, Lleó, Alberto, Blesa, Rafael, Fortea, Juan, D’Alessandro, Angelo, Costello, James C., Sullivan, Kelly D., Espinosa, Joaquin M.

“…Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by ill-defined mechanisms. Here we report a large metabolomics study of…”
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Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse by Alcolea, Daniel, Pegueroles, Jordi, Muñoz, Laia, Camacho, Valle, López‐Mora, Diego, Fernández‐León, Alejandro, Le Bastard, Nathalie, Huyck, Els, Nadal, Alicia, Olmedo, Verónica, Sampedro, Frederic, Montal, Victor, Vilaplana, Eduard, Clarimón, Jordi, Blesa, Rafael, Fortea, Juan, Lleó, Alberto

“…Objective To determine the cutoffs that optimized the agreement between 18F‐Florbetapir positron emission tomography (PET) and Aβ1‐42, Aβ1‐40, tTau, pTau and…”
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Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia by Zhu, Nuole, Santos-Santos, Miguel, Illán-Gala, Ignacio, Montal, Victor, Estellés, Teresa, Barroeta, Isabel, Altuna, Miren, Arranz, Javier, Muñoz, Laia, Belbin, Olivia, Sala, Isabel, Sánchez-Saudinós, Maria Belén, Subirana, Andrea, Videla, Laura, Pegueroles, Jordi, Blesa, Rafael, Clarimón, Jordi, Carmona-Iragui, Maria, Fortea, Juan, Lleó, Alberto, Alcolea, Daniel

“…Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative diseases. Studies of glial fibrillary acidic…”
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Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer’s disease by Morenas-Rodríguez, Estrella, Alcolea, Daniel, Suárez-Calvet, Marc, Muñoz-Llahuna, Laia, Vilaplana, Eduard, Sala, Isabel, Subirana, Andrea, Querol-Vilaseca, Marta, Carmona-Iragui, María, Illán-Gala, Ignacio, Ribosa-Nogué, Roser, Blesa, Rafael, Haass, Christian, Fortea, Juan, Lleó, Alberto

“…The role of innate immunity in dementia with Lewy bodies (DLB) has been little studied. We investigated the levels in cerebrospinal fluid (CSF) of glial…”
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Cortical microstructure in the amyotrophic lateral sclerosis–frontotemporal dementia continuum by Illán-Gala, Ignacio, Montal, Victor, Pegueroles, Jordi, Vilaplana, Eduard, Alcolea, Daniel, Dols-Icardo, Oriol, de Luna, Noemi, Turón-Sans, Janina, Cortés-Vicente, Elena, Martinez-Roman, Luis, Sánchez-Saudinós, Maria Belén, Subirana, Andrea, Videla, Laura, Sala, Isabel, Barroeta, Isabel, Valldeneu, Sílvia, Blesa, Rafael, Clarimón, Jordi, Lleó, Alberto, Fortea, Juan, Rojas-García, Ricard

“…OBJECTIVETo characterize the cortical macrostructure and microstructure of behavioral and cognitive changes along the amyotrophic lateral sclerosis…”
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The Aβ1-42/Aβ1-40 ratio in CSF is more strongly associated to tau markers and clinical progression than Aβ1-42 alone by Delaby, Constance, Estellés, Teresa, Zhu, Nuole, Arranz, Javier, Barroeta, Isabel, Carmona-Iragui, María, Illán-Gala, Ignacio, Santos-Santos, Miguel Ángel, Altuna, Miren, Sala, Isabel, Sánchez-Saudinós, M Belén, Videla, Laura, Valldeneu, Sílvia, Subirana, Andrea, Tondo, Mireia, Blanco-Vaca, Francisco, Lehmann, Sylvain, Belbin, Olivia, Blesa, Rafael, Fortea, Juan, Lleó, Alberto, Alcolea, Daniel

“…Cerebrospinal fluid (CSF) Aβ1-42 levels and the Aβ1-42/Aβ1-40 ratio are markers of amyloid pathology, but previous studies suggest that their levels might be…”
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Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease by Pera, Marta, Alcolea, Daniel, Sánchez-Valle, Raquel, Guardia-Laguarta, Cristina, Colom-Cadena, Martí, Badiola, Nahuai, Suárez-Calvet, Marc, Lladó, Albert, Barrera-Ocampo, Alvaro A., Sepulveda-Falla, Diego, Blesa, Rafael, Molinuevo, José L., Clarimón, Jordi, Ferrer, Isidre, Gelpi, Ellen, Lleó, Alberto

“…Autosomal-dominant Alzheimer disease (ADAD) is a genetic disorder caused by mutations in Amyloid Precursor Protein ( APP ) or Presenilin ( PSEN ) genes…”
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Glucocerebrosidase mutations confer a greater risk of dementia during Parkinson's disease course by Setó-Salvia, Núria, Pagonabarraga, Javier, Houlden, Henry, Pascual-Sedano, Berta, Dols-Icardo, Oriol, Tucci, Arianna, Paisán-Ruiz, Coro, Campolongo, Antonia, Antón-Aguirre, Sofía, Martín, Inés, Muñoz, Laia, Bufill, Enric, Vilageliu, Lluïsa, Grinberg, Daniel, Cozar, Mónica, Blesa, Rafael, Lleó, Alberto, Hardy, John, Kulisevsky, Jaime, Clarimón, Jordi

“…Mutations in the glucocerebrosidase gene are associated with Parkinson's disease and Lewy body dementia. However, whether these alterations have any effect on…”
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MOTS-c promotes muscle differentiation in vitro by García-Benlloch, Sandra, Revert-Ros, Francisco, Blesa, Jose Rafael, Alis, Rafael

“…MOTS-c (mitochondrial open reading frame of the 12 S rRNA-c) is a newly discovered peptide that has been shown to have a protective role in whole-body…”
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Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction in adults with Down syndrome by Belbin, Olivia, Xiao, Mei-Fang, Xu, Desheng, Carmona-Iragui, Maria, Pegueroles, Jordi, Benejam, Bessy, Videla, Laura, Fernández, Susana, Barroeta, Isabel, Nuéez-Llaves, Raúl, Montal, Victor, Vilaplana, Eduard, Altuna, Miren, Clarimón, Jordi, Alcolea, Daniel, Blesa, Rafael, Lleó, Alberto, Worley, Paul F, Fortea, Juan

“…Abstract Background Alzheimer’s disease (AD) is the major cause of death in adults with Down syndrome (DS). There is an urgent need for objective markers of AD…”
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Pathophysiological Underpinnings of Extra-Motor Neurodegeneration in Amyotrophic Lateral Sclerosis: New Insights From Biomarker Studies by Reyes-Leiva, David, Dols-Icardo, Oriol, Sirisi, Sonia, Cortés-Vicente, Elena, Turon-Sans, Janina, de Luna, Noemi, Blesa, Rafael, Belbin, Olivia, Montal, Victor, Alcolea, Daniel, Fortea, Juan, Lleó, Alberto, Rojas-García, Ricard, Illán-Gala, Ignacio

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) lie at opposing ends of a clinical, genetic, and neuropathological continuum…”
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Progranulin Protein Levels in Cerebrospinal Fluid in Primary Neurodegenerative Dementias by Morenas-Rodríguez, Estrella, Cervera-Carles, Laura, Vilaplana, Eduard, Alcolea, Daniel, Carmona-Iragui, María, Dols-Icardo, Oriol, Ribosa-Nogué, Roser, Muñoz-Llahuna, Laia, Sala, Isabel, Belén Sánchez-Saudinós, M, Blesa, Rafael, Clarimón, Jordi, Fortea, Juan, Lleó, Alberto

“…Progranulin is implicated in frontotemporal dementia (FTD), but its role in other neurodegenerative disorders is unknown. To investigate the levels of…”
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Cerebral Amyloid Angiopathy-Related Atraumatic Convexal Subarachnoid Hemorrhage: An ARIA before the Tsunami by Martínez-Lizana, Eva, Carmona-Iragui, María, Alcolea, Daniel, Gómez-Choco, Manuel, Vilaplana, Eduard, Sánchez-Saudinós, María B, Clarimón, Jordi, Hernández-Guillamon, Mar, Munuera, Josep, Gelpi, Ellen, Gómez-Anson, Beatriz, de Juan-Delago, Manel, Delgado-Mederos, Raquel, Montaner, Joan, Ois, Angel, Amaro, Sergi, Blesa, Rafael, Martí-Fàbregas, Joan, Lleó, Alberto, Fortea, Juan

“…Atraumatic convexal subarachnoid hemorrhage (cSAH) in elderly patients is a rare entity that has been associated with cerebral amyloid angiopathy (CAA) and…”
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Diagnosis of prodromal and Alzheimer's disease dementia in adults with Down syndrome using neuropsychological tests by Benejam, Bessy, Videla, Laura, Vilaplana, Eduard, Barroeta, Isabel, Carmona‐Iragui, Maria, Altuna, Miren, Valldeneu, Silvia, Fernandez, Susana, Giménez, Sandra, Iulita, Florencia, Garzón, Diana, Bejanin, Alexandre, Bartrés‐Faz, David, Videla, Sebastià, Alcolea, Daniel, Blesa, Rafael, Lleó, Alberto, Fortea, Juan

“…Introduction We aimed to define prodromal Alzheimer's disease (AD) and AD dementia using normative neuropsychological data in a large population‐based cohort…”
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Evaluation of biochemical and hematological parameters in adults with Down syndrome by de Gonzalo-Calvo, David, Barroeta, Isabel, Nan, Madalina Nicoleta, Rives, José, Garzón, Diana, Carmona-Iragui, María, Benejam, Bessy, Videla, Laura, Fernández, Susana, Altuna, Miren, Valldeneu, Sílvia, Blesa, Rafael, Lleó, Alberto, Blanco-Vaca, Francisco, Fortea, Juan, Tondo, Mireia

“…Down syndrome (DS) is the most common worldwide cause of intellectual disability of genetic origin and the most common chromosomal disorder affecting live-born…”
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Sustained response to Rituximab in anti-AChR and anti-MuSK positive Myasthenia Gravis patients by Illa, Isabel, Diaz-Manera, Jordi, Rojas-Garcia, Ricard, Pradas, Jesus, Rey, Antonio, Blesa, Rafael, Juarez, Candido, Gallardo, Eduard

“…Abstract We report the results of treatment with Rituximab in six severe, non-responder MG patients. We treated three AChR + MG and three MuSK + MG patients,…”
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Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease by Benejam, Bessy, Aranha, Mateus Rozalem, Videla, Laura, Padilla, Concepción, Valldeneu, Silvia, Fernández, Susana, Altuna, Miren, Carmona-Iragui, Maria, Barroeta, Isabel, Iulita, Maria Florencia, Montal, Víctor, Pegueroles, Jordi, Bejanin, Alexandre, Giménez, Sandra, González-Ortiz, Sofía, Videla, Sebastián, Bartrés-Faz, David, Alcolea, Daniel, Blesa, Rafael, Lleó, Alberto, Fortea, Juan

“…Adults with Down syndrome are at an ultra-high risk of developing early-onset Alzheimer's disease. Episodic memory deficits are one of the earliest signs of…”
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Longitudinal Clinical and Cognitive Changes Along the Alzheimer Disease Continuum in Down Syndrome by Videla, Laura, Benejam, Bessy, Pegueroles, Jordi, Carmona-Iragui, María, Padilla, Concepción, Fernández, Susana, Barroeta, Isabel, Altuna, Miren, Valldeneu, Silvia, Garzón, Diana, Ribas, Laia, Montal, Víctor, Arranz Martínez, Javier, Rozalem Aranha, Mateus, Alcolea, Daniel, Bejanin, Alexandre, Iulita, Maria Florencia, Videla Cés, Sebastià, Blesa, Rafael, Lleó, Alberto, Fortea, Juan

“…Importance Alzheimer disease (AD) is the main medical problem in adults with Down syndrome (DS). However, the associations of age, intellectual disability…”
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Reelin Expression and Glycosylation Patterns Are Altered in Alzheimer's Disease by Botella-López, Arancha, Burgaya, Ferran, Gavín, Rosalina, García-Ayllón, M. Salud, Gómez-Tortosa, Estrella, Peña-Casanova, Jordi, Ureña, Jesús M., Río, José A. Del, Blesa, Rafael, Soriano, Eduardo, Sáez-Valero, Javier

“…Reelin is a glycoprotein that is essential for the correct cytoarchitectonic organization of the developing CNS. Its function in the adult brain is less…”
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