Search Results - "BLENIS, John"

TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease by Blenis, John

“…Michael N. Hall is this year’s recipient of the Lasker Basic Medical Research Award for the identification of the target of rapamycin, TOR. TOR is a master…”
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Molecular mechanisms of mTOR-mediated translational control by Ma, Xiaoju Max, Blenis, John

“…Key Points Mammalian cells have evolved elaborate mechanisms for translational control, most of which are sensitive to nutrient availability, cellular energy,…”
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The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation by Mendoza, Michelle C., Er, E. Emrah, Blenis, John

“…The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the…”
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Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization by Schild, Tanya, Low, Vivien, Blenis, John, Gomes, Ana P.

“…Metastases arising from tumors have the proclivity to colonize specific organs, suggesting that they must rewire their biology to meet the demands of the organ…”
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Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment by Low, Vivien, Li, Zhongchi, Blenis, John

“…The role of metabolites exchanged in the tumor microenvironment is largely thought of as fuels to drive the increased biosynthetic and bioenergetic demands of…”
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Nutrient signaling: Starvation flips a phosphoinositide switch on lysosomal catabolism by Nagiec, Michal J, Blenis, John

“…Lysosomes are highly dynamic organelles that rapidly respond to changes in cellular nutrient status. A new study identifies a phosphoinositide switch that…”
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Hippo–YAP and mTOR pathways collaborate to regulate organ size by Csibi, Alfred, Blenis, John

“…Regulation of organ size is achieved through the action of the mTOR and Hippo signalling pathways, which control cell proliferation and cell growth in response…”
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Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation by Zhang, Haiying, Freitas, Daniela, Kim, Han Sang, Fabijanic, Kristina, Li, Zhong, Chen, Haiyan, Mark, Milica Tesic, Molina, Henrik, Martin, Alberto Benito, Bojmar, Linda, Fang, Justin, Rampersaud, Sham, Hoshino, Ayuko, Matei, Irina, Kenific, Candia M., Nakajima, Miho, Mutvei, Anders Peter, Sansone, Pasquale, Buehring, Weston, Wang, Huajuan, Jimenez, Juan Pablo, Cohen-Gould, Leona, Paknejad, Navid, Brendel, Matthew, Manova-Todorova, Katia, Magalhães, Ana, Ferreira, José Alexandre, Osório, Hugo, Silva, André M., Massey, Ashish, Cubillos-Ruiz, Juan R., Galletti, Giuseppe, Giannakakou, Paraskevi, Cuervo, Ana Maria, Blenis, John, Schwartz, Robert, Brady, Mary Sue, Peinado, Héctor, Bromberg, Jacqueline, Matsui, Hiroshi, Reis, Celso A., Lyden, David

“…The heterogeneity of exosomal populations has hindered our understanding of their biogenesis, molecular composition, biodistribution and functions. By…”
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Nutrient regulation of the mTOR Complex 1 signaling pathway by Kim, Sang Gyun, Buel, Gwen R., Blenis, John

“…The mammalian target of rapamycin (mTOR) is an evolutionally conserved kinase which exists in two distinct structural and functional complexes, mTOR complex 1…”
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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex by Liu, Pengda, Gan, Wenjian, Chin, Y Rebecca, Ogura, Kohei, Guo, Jianping, Zhang, Jinfang, Wang, Bin, Blenis, John, Cantley, Lewis C, Toker, Alex, Su, Bing, Wei, Wenyi

“…mTOR serves as a central regulator of cell growth and metabolism by forming two distinct complexes, mTORC1 and mTORC2. Although mechanisms of mTORC1 activation…”
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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation by Choo, Andrew Y, Yoon, Sang-Oh, Kim, Sang Gyun, Roux, Philippe P, Blenis, John

“…The mammalian translational initiation machinery is a tightly controlled system that is composed of eukaryotic initiation factors, and which controls the…”
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The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation by Csibi, Alfredo, Lee, Gina, Yoon, Sang-Oh, Tong, Haoxuan, Ilter, Didem, Elia, Ilaria, Fendt, Sarah-Maria, Roberts, Thomas M., Blenis, John

“…Growth-promoting signaling molecules, including the mammalian target of rapamycin complex 1 (mTORC1), drive the metabolic reprogramming of cancer cells…”
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Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling by Lee, Gina, Zheng, Yuxiang, Cho, Sungyun, Jang, Cholsoon, England, Christina, Dempsey, Jamie M., Yu, Yonghao, Liu, Xiaolei, He, Long, Cavaliere, Paola M., Chavez, Andre, Zhang, Erik, Isik, Meltem, Couvillon, Anthony, Dephoure, Noah E., Blackwell, T. Keith, Yu, Jane J., Rabinowitz, Joshua D., Cantley, Lewis C., Blenis, John

“…mTORC1 is a signal integrator and master regulator of cellular anabolic processes linked to cell growth and survival. Here, we demonstrate that mTORC1 promotes…”
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Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1 by Zhu, Jidong, Blenis, John, Yuan, Junying

“…Mad1, a member of the Myc/Max/Mad family, suppresses Myc-mediated transcriptional activity by competing with Myc for heterodimerization with its obligatory…”
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Not all substrates are treated equally: Implications for mTOR, rapamycin-resistance, and cancer therapy by Choo, Andrew Y., Blenis, John

“…The mTORC1 signaling pathway is a critical regulator of cell growth and is hyper activated in many different cancers.  Rapamycin, an allosteric inhibitor of…”
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mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation by He, Long, Gomes, Ana P., Wang, Xin, Yoon, Sang Oh, Lee, Gina, Nagiec, Michal J., Cho, Sungyun, Chavez, Andre, Islam, Tasnia, Yu, Yonghao, Asara, John M., Kim, Bo Yeon, Blenis, John

“…The mammalian Target of Rapamycin Complex 1 (mTORC1)-signaling system plays a critical role in the maintenance of cellular homeostasis by sensing and…”
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ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions by ROUX, Philippe P, BLENIS, John

“…Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events by Holz, Marina K., Ballif, Bryan A., Gygi, Steven P., Blenis, John

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Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation by Shin, Sejeong, Wolgamott, Laura, Yu, Yonghao, Blenis, John, Yoon, Sang-Oh

“…The p70 ribosomal protein S6 kinase 1 (S6K1) plays a key role in cell growth and proliferation by regulating insulin sensitivity, metabolism, protein…”
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ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation by Shin, Sejeong, Buel, Gwen R., Nagiec, Michal J., Han, Min-Joon, Roux, Philippe P., Blenis, John, Yoon, Sang-Oh

“…ERK is a key coordinator of the epithelial-to-mesenchymal transition (EMT) in that a variety of EMT-inducing factors activate signaling pathways that converge…”
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