Search Results - "BLAZKA, MARK E."

Role of inflammation in chemical-induced hepatotoxicity by Luster, Michael I., Simeonova, Petia P., Gallucci, Randle M., Bruccoleri, Alex, Blazka, Mark E., Yucesoy, Berran

“…The liver, which is the major organ responsible for the metabolism of drugs and toxic chemicals, is also the primary target organ for many toxic chemicals…”
Get full text

Comparative assessment of the acute skin irritation potential of detergent formulations using a novel human 4-h patch test method by Robinson, Michael K., Kruszewski, Francis H., Al-Atrash, Jenan, Blazka, Mark E., Gingell, Ralph, Heitfeld, Fred A., Mallon, David, Snyder, Neil K., Swanson, Judith E., Casterton, Phillip L.

“…Predictive skin irritation test methods, which do not require use of animals, are needed for the pre-market assessment of detergent formulations. The utility…”
Get full text

Developmental and sex differences in cadmium distribution and metallothionein induction and localization by Blazka, M E, Nolan, C V, Shaikh, Z A

“…Age- and sex-related differences in hepatic and renal distribution of cadmium (Cd) and the effect of Cd injection (10 mumol/kg) on tissue zinc (Zn), copper…”
Get more information

Role of Proinflammatory Cytokines in Acetaminophen Hepatotoxicity by Blazka, M.E., Wilmer, J.L., Holladay, S.D., Wilson, R.E., Luster, M.I.

“…Acetaminophen (APAP) intoxication has been shown to activate Kupffer cells. Kupffer cell activation is also associated with the release of proinflammatory…”
Get full text

Histopathology of acetaminophen-induced liver changes: role of interleukin 1 alpha and tumor necrosis factor alpha by Blazka, M E, Elwell, M R, Holladay, S D, Wilson, R E, Luster, M I

“…Administration of 500 mg/kg acetaminophen (APAP) to female B6C3F1 mice resulted in well-documented pathophysiological changes in the liver manifested as…”
Get more information

Asbestos stimulates IL-8 production from human lung epithelial cells by Rosenthal, GJ, Germolec, DR, Blazka, ME, Corsini, E, Simeonova, P, Pollock, P, Kong, LY, Kwon, J, Luster, MI

“…Studies have indicated that soluble products, including chemotactic factors, released by activated lung macrophages and fibroblasts are critical mediators in…”
Get full text

The Role of Tumor Necrosis Factor α in Chemical-Induced Hepatotoxicity by LUSTER, MICHAEL I., SIMEONOVA, PETIA P., GALLUCCI, RANDLE M., BRUCCOLERI, ALEX, BLAZKA, MARK E., YUCESOY, BERRAN, MATHESON, JOANNA M.

“…: Only recently have toxicologists come to understand the role of inflammation, and TNFα specifically, in classical toxicological processes. This relationship…”
Get full text

Metal Transport in Cells: Cadmium Uptake by Rat Hepatocytes and Renal Cortical Epithelial Cells by Shaikh, Zahir A., Blazka, Mark E., Endo, Tetsuya

Get full text

Metal Transport in Cells: Cadmium Uptake by Rat Hepatocytes and Renal Cortical Epithelial Cells by Shaikh, Zahir A., Blazka, Mark E., Endo, Tetsuya

“…The toxic metals appear to use the transport pathways that exist for biologically essential metals. In this regard interactions between the toxic and essential…”
Get full text

Tumor necrosis factor-alpha and nitric oxide production in endotoxin-primed rats administered carbon tetrachloride by Chamulitrat, W, Blazka, M E, Jordan, S J, Luster, M I, Mason, R P

“…Tumor necrosis factor-alpha (TNF alpha) is elevated in the sera of rats administered non-lethal doses of carbon tetrachloride (CCl4) followed by endotoxin…”
Get more information

Comparative Pulmonary Absorption, Distribution, and Toxicity of Copper Gallium Diselenide, Copper Indium Diselenide, and Cadmium Telluride in Sprague–Dawley Rats by Morgan, Daniel L., Shines, Cassandra J., Jeter, Shawn P., Blazka, Mark E., Elwell, Michael R., Wilson, Ralph E., Ward, Sandra M., Price, Herman C., Moskowitz, Paul D.

“…Copper gallium diselenide (CGS), copper indium diselenide (CIS), and cadmium telluride (CdTe) are novel compounds used in the photovoltaic and semiconductor…”
Get full text

Sex differences in hepatic and renal cadmium accumulation and metallothionein induction. Role of estradiol by Blazka, M E, Shaikh, Z A

“…The role of estradiol in sex differences in hepatic and renal cadmium accumulation and metallothionein (MT) induction was investigated. Male and female rats…”
Get more information

Effect of lead acetate on nitrite production by murine brain endothelial cell cultures by Blazka, M E, Harry, G J, Luster, M I

“…One of the mechanisms by which lead may cause a perturbation in the nervous system is the alteration of endothelial cell function. This study investigated the…”
Get more information

Hypersensitivity of cultured ataxia-telangiectasia cells to etoposide by Henner, W D, Blazka, M E

“…Fibroblasts from patients with ataxia-telangiectasia (A-T) were found to be hypersensitive to killing by the antineoplastic agent etoposide. The A-T fibroblast…”
Get more information

Pulmonary response of Fischer 344 rats to acute nose-only inhalation of indium trichloride by Blazka, M E, Tepper, J S, Dixon, D, Winsett, D W, O'Connor, R W, Luster, M I

“…We have previously shown that rats dosed intratracheally with indium trichloride (InCl3) develop severe lung damage and fibrosis. However, it is not clear what…”
Get more information

Acetaminophen-induced hepatotoxicity is associated with early changes in AP-1 DNA binding activity by Blazka, M E, Bruccoleri, A, Simeonova, P P, Germolec, D R, Pennypacker, K R, Luster, M I

“…The AP-1 transcription factor family, which is involved in early response genes, consists of two groups of proteins, Fos-related antigens (fra) and Jun…”
Get more information

Pulmonary toxicity to intratracheally administered indium trichloride in Fischer 344 rats by Blazka, M E, Dixon, D, Haskins, E, Rosenthal, G J

“…The use of indium by the semiconductor industry has risen sharply in recent years with the discovery that the electrical properties of compounds such as indium…”
Get more information