Search Results - "BLASIAK, Janusz"

Senescence in the pathogenesis of age-related macular degeneration by Blasiak, Janusz

“…Age-related macular degeneration (AMD) is a complex eye disease underlined by the death of photoreceptors and degeneration of retinal pigment epithelium (RPE)…”
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Single-Strand Annealing in Cancer by Blasiak, Janusz

“…DNA double-strand breaks (DSBs) are among the most serious forms of DNA damage. In humans, DSBs are repaired mainly by non-homologous end joining (NHEJ) and…”
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DNA-Damaging Anticancer Drugs - A Perspective for DNA Repair- Oriented Therapy by Blasiak, Janusz

“…DNA-damaging drugs in cancer present two main problems: therapeutic resistance and side effects and both can associate with DNA repair, which can be targeted…”
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Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration by Blasiak, Janusz, Pawlowska, Elzbieta, Szczepanska, Joanna, Kaarniranta, Kai

“…Age-related macular degeneration (AMD) is a complex eye disease with many pathogenesis factors, including defective cellular waste management in retinal…”
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Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD) by Kaarniranta, Kai, Pawlowska, Elzbieta, Szczepanska, Joanna, Jablkowska, Aleksandra, Blasiak, Janusz

“…Age-related macular degeneration (AMD) is a complex eye disease that affects millions of people worldwide and is the main reason for legal blindness and vision…”
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Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations by Pawlowska, Elzbieta, Blasiak, Janusz, Szczepanska, Joanna

“…Vitamin C is an antioxidant that may scavenge reactive oxygen species preventing DNA damage and other effects important in cancer transformation. Dietary…”
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Nutrients to Improve Mitochondrial Function to Reduce Brain Energy Deficit and Oxidative Stress in Migraine by Fila, Michal, Chojnacki, Cezary, Chojnacki, Jan, Blasiak, Janusz

“…The mechanisms of migraine pathogenesis are not completely clear, but P-nuclear magnetic resonance studies revealed brain energy deficit in migraineurs. As…”
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PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis by Kaarniranta, Kai, Kajdanek, Jakub, Morawiec, Jan, Pawlowska, Elzbieta, Blasiak, Janusz

“…PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is a transcriptional coactivator of many genes involved in energy management and…”
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An Interplay between Senescence, Apoptosis and Autophagy in Glioblastoma Multiforme-Role in Pathogenesis and Therapeutic Perspective by Pawlowska, Elzbieta, Szczepanska, Joanna, Szatkowska, Magdalena, Blasiak, Janusz

“…Autophagy, cellular senescence, programmed cell death and necrosis are key responses of a cell facing a stress. These effects are partly interconnected, but…”
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Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration by Kaarniranta, Kai, Tokarz, Paulina, Koskela, Ali, Paterno, Jussi, Blasiak, Janusz

“…Age-related macular degeneration (AMD) is an eye disease underlined by the degradation of retinal pigment epithelium (RPE) cells, photoreceptors, and…”
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Potential of Schisandra chinensis (Turcz.) Baill. in Human Health and Nutrition: A Review of Current Knowledge and Therapeutic Perspectives by Nowak, Adriana, Zakłos-Szyda, Małgorzata, Błasiak, Janusz, Nowak, Agnieszka, Zhang, Zhuo, Zhang, Bolin

“…(Turcz.) Baill. (SCE) is a plant with high potential for beneficial health effects, confirmed by molecular studies. Its constituents exert anti-cancer effects…”
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Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond by Kaarniranta, Kai, Koskela, Ali, Szczepanska, Joanna, Pawlowska, Elzbieta, Blasiak, Janusz

“…Age-related macular degeneration (AMD) is a multifactorial disease of the retina featured by degeneration and loss of photoreceptors and retinal pigment…”
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The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment by Tokarz, Paulina, Blasiak, Janusz

“…microRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression by targeting specific mRNAs. microRNAs play a role in several…”
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Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD) by Tokarz, Paulina, Kaarniranta, Kai, Blasiak, Janusz

“…Cells in aerobic condition are constantly exposed to reactive oxygen species (ROS), which may induce damage to biomolecules, including proteins, nucleic acids…”
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The Long Noncoding RNA HOTAIR in Breast Cancer: Does Autophagy Play a Role? by Pawłowska, Elżbieta, Szczepanska, Joanna, Blasiak, Janusz

“…HOTAIR (HOX transcript antisense RNA) plays a critical role in chromatin dynamics through the interaction with histone modifiers resulting in transcriptional…”
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Oxidative Stress, Hypoxia, and Autophagy in the Neovascular Processes of Age-Related Macular Degeneration by Blasiak, Janusz, Petrovski, Goran, Veréb, Zoltán, Facskó, Andrea, Kaarniranta, Kai

“…Age-related macular degeneration (AMD) is the leading cause of severe and irreversible loss of vision in the elderly in developed countries. AMD is a complex…”
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The Aging Stress Response and Its Implication for AMD Pathogenesis by Blasiak, Janusz, Pawlowska, Elzbieta, Sobczuk, Anna, Szczepanska, Joanna, Kaarniranta, Kai

“…Aging induces several stress response pathways to counterbalance detrimental changes associated with this process. These pathways include nutrient signaling,…”
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Autophagy in DNA damage response by Czarny, Piotr, Pawlowska, Elzbieta, Bialkowska-Warzecha, Jolanta, Kaarniranta, Kai, Blasiak, Janusz

“…DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be…”
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Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders by Fila, Michal, Chojnacki, Jan, Pawlowska, Elzbieta, Szczepanska, Joanna, Chojnacki, Cezary, Blasiak, Janusz

“…Migraine, the leading cause of disability in the population aged below 50, is associated with functional gastrointestinal (GI) disorders (FGIDs) such as…”
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Vitamin D May Protect against Breast Cancer through the Regulation of Long Noncoding RNAs by VDR Signaling by Blasiak, Janusz, Chojnacki, Jan, Pawlowska, Elzbieta, Jablkowska, Aleksandra, Chojnacki, Cezary

“…Dietary vitamin D3 has attracted wide interest as a natural compound for breast cancer prevention and therapy, supported by in vitro and animal studies. The…”
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