Search Results - "BLASCHUK, Orest"

N-cadherin antagonists as oncology therapeutics by Blaschuk, Orest W.

“…The cell adhesion molecule (CAM), N-cadherin, has emerged as an important oncology therapeutic target. N-cadherin is a transmembrane glycoprotein mediating the…”
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Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia by Parker, Jessica, Hockney, Sean, Blaschuk, Orest W, Pal, Deepali

“…This review discusses current research on acute paediatric leukaemia, the leukaemic bone marrow (BM) microenvironment and recently discovered therapeutic…”
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Potential Therapeutic Applications of N-Cadherin Antagonists and Agonists by Blaschuk, Orest W

“…This review focuses on the cell adhesion molecule (CAM), known as neural (N)-cadherin (CDH2). The molecular basis of N-cadherin-mediated intercellular adhesion…”
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Novel N-cadherin antagonist causes glioblastoma cell death in a 3D bioprinted co-culture model by Smits, Imke P.M., Blaschuk, Orest W., Willerth, Stephanie M.

“…Glioblastoma multiforme (GBM) is a deadly type of brain cancer. There is a need to identify novel therapies for GBM as current treatments only marginally…”
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Cadherins as novel targets for anti-cancer therapy by Blaschuk, Orest W., Devemy, Emmanuelle

“…The cell adhesion molecules N-, VE- and OB-cadherin have been implicated as regulators of tumor growth and metastasis. We discuss evidence that N- and…”
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Discovery and development of N-cadherin antagonists by Blaschuk, Orest W

“…This article describes over 20 years of research on antagonists of the cell adhesion molecule, N-cadherin. Four types of antagonists are discussed: synthetic…”
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N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer by Mrozik, Krzysztof Marek, Blaschuk, Orest William, Cheong, Chee Man, Zannettino, Andrew Christopher William, Vandyke, Kate

“…In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-cadherin is a hallmark of epithelial-to-mesenchymal transition,…”
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Therapeutic targeting of N‐cadherin is an effective treatment for multiple myeloma by Mrozik, Krzysztof M., Cheong, Chee Man, Hewett, Duncan, Chow, Annie W.S., Blaschuk, Orest W., Zannettino, Andrew C.W., Vandyke, Kate

“…Summary Elevated expression of the cell adhesion molecule N‐cadherin (cadherin 2, type 1, N‐cadherin (neuronal); CDH2) is associated with poor prognosis in…”
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Identification of a novel dual E- and N-cadherin antagonist by Devemy, Emmanuelle, Blaschuk, Orest W.

“…E- and N-cadherin are related calcium-dependent cell adhesion molecules that exert an influence over multiple biological and disease processes. Antagonists of…”
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Inhibition of N-cadherin retards smooth muscle cell migration and intimal thickening via induction of apoptosis by Lyon, Cressida A., PhD, Koutsouki, Evgenia, PhD, Aguilera, Concepcion M., PhD, Blaschuk, Orest W., PhD, George, Sarah Jane, PhD

“…Objectives Inhibition of vascular smooth muscle cell (VSMC) migration is a potential strategy for reducing intimal thickening during in-stent restenosis and…”
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Identification of a novel N-cadherin antagonist by Devemy, Emmanuelle, Blaschuk, Orest W.

“…The cell adhesion molecule, N-cadherin plays a pivotal role in many biological and disease processes. Drugs that modulate N-cadherin function should therefore…”
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A simple method for inducing estrous cycle stage-specific morphological changes in the vaginal epithelium of immature female mice by Merkwitz, Claudia, Blaschuk, Orest, Eplinius, Franziska, Winkler, Jana, Prömel, Simone, Schulz, Angela, Ricken, Albert

“…The vaginal epithelium of the adult female laboratory rodent changes from mucous secretion to cornification over the course of the estrous cycle. The…”
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LCRF‐0006, a small molecule mimetic of the N‐cadherin antagonist peptide ADH‐1, synergistically increases multiple myeloma response to bortezomib by Mrozik, Krzysztof M., Cheong, Chee M., Hewett, Duncan R., Noll, Jacqueline E., Opperman, Khatora S., Adwal, Alaknanda, Russell, Darryl L., Blaschuk, Orest W., Vandyke, Kate, Zannettino, Andrew C. W.

“…N‐cadherin is a homophilic cell‐cell adhesion molecule that plays a critical role in maintaining vascular stability and modulating endothelial barrier…”
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The ductal origin of structural and functional heterogeneity between pancreatic islets by Merkwitz, Claudia, Blaschuk, Orest W., Schulz, Angela, Lochhead, Paul, Meister, Jaroslawna, Ehrlich, Angela, Ricken, Albert M.

“…Islets form in the pancreas after the first endocrine cells have arisen as either single cells or small cell clusters in the epithelial cords. These cords…”
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Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: involvement of fibroblast growth factor receptor-mediated signalling by Erez, Noam, Zamir, Eli, Gour, Barbara J, Blaschuk, Orest W, Geiger, Benjamin

“…Cadherins are a family of transmembrane glycoproteins mediating calcium-dependent, homophilic cell–cell adhesion. In addition, these molecules are involved in…”
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N-Cadherin–Dependent Cell–Cell Contacts Promote Human Saphenous Vein Smooth Muscle Cell Survival by Koutsouki, Evgenia, Beeching, Cressida A, Slater, Sadie C, Blaschuk, Orest W, Sala-Newby, Graciela B, George, Sarah J

“…OBJECTIVE—Vascular smooth muscle cell (VSMC) apoptosis is thought to contribute to atherosclerotic plaque instability. Cadherin mediates calcium-dependent…”
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Plasma membrane components of adherens junctions (Review) by Blaschuk, Orest W, Rowlands, Tracey M

“…This review focuses on the three known plasma membrane components of adherens junctions: E-cadherin, nectin-2 and vezatin. The structures of these three…”
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Estrogens Potentiate the Stimulatory Effects of Follicle-Stimulating Hormone on N-Cadherin Messenger Ribonucleic Acid Levels in Cultured Mouse Sertoli Cells by MacCalman, Colin D, Getsios, Spiro, Farookhi, Riaz, Blaschuk, Orest W

“…Gonadal steroids and FSH are key regulators of Sertoli cell function. N-Cadherin (N-cad) is a calcium-dependent cell adhesion molecule that mediates Sertoli…”
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N-cadherin antagonists as oncology therapeutics by Blaschuk, Orest W.

“…The cell adhesion molecule (CAM), N-cadherin, has emerged as an important oncology therapeutic target. N-cadherin is a transmembrane glycoprotein mediating the…”
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A Novel Family of Cyclic Peptide Antagonists Suggests That N-cadherin Specificity Is Determined by Amino Acids That Flank the HAV Motif by Williams, Emma, Williams, Gareth, Gour, Barbara J., Blaschuk, Orest W., Doherty, Patrick

“…The classical cadherins (e.g. N-, E-, and P- cadherin) are well established homophilic adhesion molecules; however, the mechanism that governs cadherin…”
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