Search Results - "BLANCHARD, S. G"

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor by Parks, Derek J., Blanchard, Steven G., Bledsoe, Randy K., Chandra, Gyan, Consler, Thomas G., Kliewer, Steven A., Stimmel, Julie B., Willson, Timothy M., Zavacki, Ann Marie, Moore, David D., Lehmann, Jürgen M.

“…Bile acids regulate the transcription of genes that control cholesterol homeostasis through molecular mechanisms that are poorly understood. Physiological…”
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A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat by BROWN, K. K, HENKE, B. R, NOVAK, P. J, FAISON, W, BINZ, J. G, HASHIM, M. A, OLIVER, W. O, BROWN, H. R, PARKS, D. J, PLUNKET, K. D, TONG, W.-Q, MENIUS, J. A, BLANCHARD, S. G, ADKISON, K, NOBLE, S. A, WILLSON, T. M, COBB, J. E, MOOK, R, KALDOR, I, KLIEWER, S. A, LEHMANN, J. M, LENHARD, J. M, HARRINGTON, W. W

“…A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. K K…”
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Differential activity of rosiglitazone enantiomers at PPARγ by Parks, Derek J., Tomkinson, Nicholas C.O., Villeneuve, Manon S., Blanchard, Steven G., Willson, Timothy M.

“…Analysis of the enantiomers of rosiglitazone in a PPARγ binding assay suggests that the ( S)-(−)-isomer is responsible for the antidiabetic activity. Analysis…”
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Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands by Moore, Linda B., Parks, Derek J., Jones, Stacey A., Bledsoe, Randy K., Consler, Thomas G., Stimmel, Julie B., Goodwin, Bryan, Liddle, Christopher, Blanchard, Steven G., Willson, Timothy M., Collins, Jon L., Kliewer, Steven A.

“…Xenobiotics induce the transcription of cytochromes P450 (CYPs) 2B and 3A through the constitutive androstane receptor (CAR; NR1I3) and pregnane X receptor…”
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A Synthetic Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid (CDDO), Is a Ligand for the Peroxisome Proliferator-Activated Receptor γ by Wang, Yongping, Porter, Weston W, Suh, Nanjoo, Honda, Tadashi, Gribble, Gordon W, Leesnitzer, Lisa M, Plunket, Kelli D, Mangelsdorf, David J, Blanchard, Steven G, Willson, Timothy M, Sporn, Michael B

“…A novel synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), previously reported to have potent differentiating, antiproliferative,…”
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Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors by Xu, H.Eric, Lambert, Millard H, Montana, Valerie G, Parks, Derek J, Blanchard, Steven G, Brown, Peter J, Sternbach, Daniel D, Lehmann, Jürgen M, Wisely, G.Bruce, Willson, Timothy M, Kliewer, Steven A, Milburn, Michael V

“…The peroxisome proliferator–activated receptors (PPARs) are nuclear receptors for fatty acids (FAs) that regulate glucose and lipid homeostasis. We report the…”
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Effects of a potent melanocortin agonist on the diabetic/obese phenotype in yellow mice by ZEMEL, M. B, MOORE, J. W, JAMES, M, WILKISON, W. O, MOUSTAID, N, KIM, J. H, NICHOLS, J. S, BLANCHARD, S. G, PARKS, D. J, HARRIS, C, LEE, F. W, GRIZZLE, M

“…To test the hypothesis that a melanocortin agonist can reverse obesity and insulin resistance in mice overexpressing the agouti protein. EXPERIMENTAL MODEL:…”
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A Peroxisome Proliferator-Activated Receptor γ Ligand Inhibits Adipocyte Differentiation by Oberfield, Jennifer L., Collins, Jon L., Holmes, Christopher P., Goreham, Donna M., Cooper, Joel P., Cobb, Jeffery E., Lenhard, James M., Hull-Ryde, Emily A., Mohr, Christopher P., Blanchard, Steven G., Parks, Derek J., Moore, Linda B., Lehmann, Jürgen M., Plunket, Kelli, Miller, Ann B., Milburn, Michael V., Kliewer, Steven A., Willson, Timothy M.

“…The peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that regulate glucose and lipid homeostasis. The PPARγ subtype plays a…”
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N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents by Henke, Brad R, Blanchard, Steven G, Brackeen, Marcus F, Brown, Kathleen K, Cobb, Jeff E, Collins, Jon L, Harrington, W. Wallace, Hashim, Mir A, Hull-Ryde, Emily A, Kaldor, Istvan, Kliewer, Steven A, Lake, Debra H, Leesnitzer, Lisa M, Lehmann, Jürgen M, Lenhard, James M, Orband-Miller, Lisa A, Miller, John F, Mook, Robert A, Noble, Stewart A, Oliver, William, Parks, Derek J, Plunket, Kelli D, Szewczyk, Jerzy R, Willson, Timothy M

“…We have identified a novel series of antidiabetic N-(2-benzoylphenyl)-l-tyrosine derivatives which are potent, selective PPARγ agonists. Through the use of in…”
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Amiloride intercalates into DNA and inhibits DNA topoisomerase II by Besterman, J M, Elwell, L P, Blanchard, S G, Cory, M

“…Amiloride is capable of inhibiting DNA synthesis in mammalian cells in culture. Recent evidence indicates that the enzyme, DNA topoisomerase II, is probably…”
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Antibody Specific to the α Subunit of the Guanine Nucleotide-Binding Regulatory Protein Go: Developmental Appearance and Immunocytochemical Localization in Brain by Chang, Kwen-Jen, Pugh, William, Blanchard, Steven G., McDermed, John, Tam, James P.

“…A polyclonal rabbit antibody (9120) against the α subunit of the ``other'' guanine nucleotide-binding protein Go (α o) was raised against a synthetic α o…”
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Benzomorphan sites are ligand recognition sites of putative epsilon-receptors by Chang, K J, Blanchard, S G, Cuatrecasas, P

“…The binding characteristics of benzomorphan sites of rat brain membranes are compared with those of kappa-sites of human placenta and guinea pig brain…”
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HIV protease inhibitors block adipogenesis and increase lipolysis in vitro by Lenhard, James M, Furfine, Eric S, Jain, Renu G, Ittoop, Olivia, Orband-Miller, Lisa A, Blanchard, Steven G, Paulik, Mark A, Weiel, James E

“…AIDS therapies employing HIV protease inhibitors (PIs) are associated with changes in fat metabolism. However, the cellular mechanisms affected by PIs are not…”
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Characterization of the binding of a morphine (mu) receptor-specific ligand: Tyr-Pro-NMePhe-D-Pro-NH2, [3H]-PL17 by Blanchard, S G, Lee, P H, Pugh, W W, Hong, J S, Chang, K J

“…The highly mu-receptor-selective ligand Tyr-Pro-NMePhe-D-Pro-NH2 (PL17) was custom tritiated and its binding to rat brain membranes was directly measured. The…”
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Development of a Scintillation Proximity Assay for Peroxisome Proliferator-Activated Receptor γ Ligand Binding Domain by Nichols, James S., Parks, Derek J., Consler, Thomas G., Blanchard, Steven G.

“…A scintillation proximity assay for peroxisome proliferator-activated receptor γ ligand binding domain is described. Scintillation proximity offers an…”
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125I aqueous waste volume reduction at a pharmaceutical research laboratory by Edwards, B E, Couch, N W, Myers, K D, Blanchard, S G, Chandra, G, Parr, A F

“…A wide variety of radioactive waste is generated by pharmaceutical research. One particularly high volume low specific activity waste stream produced by a…”
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Unmasking of Magnesium-Dependent High-Affinity Binding Sites for [DAla2, DLeu5] Enkephalin after Pretreatment of Brain Membranes with Guanine Nucleotides by Chang, Kwen-Jen, Blanchard, Steven G., Cuatrecasas, Pedro

“…The regulation of μ - and δ -opiate receptors by guanine nucleotides and cations was studied by examining the binding of [3H][DAla2,DLeu$^{5}$]enkephalin to…”
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Characterization of the association of tritiated enkephalin with neuroblastoma cells under conditions optimal for receptor down regulation by Blanchard, S G, Chang, K J, Cuatrecasas, P

“…The uptake of tritium-labeled [D-Ala2,D-Leu5]enkephalin ([3H]DADLE) by mouse neuroblastoma cells (N4TG1) was investigated under conditions which are optimal…”
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Purification of Torpedo californica post-synaptic membranes and fractionation of their constituent proteins by Elliott, J, Blanchard, S G, Wu, W, Miller, J, Strader, C D, Hartig, P, Moore, H P, Racs, J, Raftery, M A

“…A rapid methof for preparation of membrane fractions highly enriched in nicotinic acetylcholine receptor from Torpedo californica electroplax is described. The…”
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Phorbol Ester Receptors and Protein Kinase C in Primary Neuronal Cultures: Development and Stimulation of Endogenous Phosphorylation by Burgess, Susan K., Sahyoun, Naji, Blanchard, Steven G., LeVine, Harry, Chang, Kwen-Jen, Cuatrecasas, Pedro

“…Embryonic rat neurons cultured in defined medium, essentially in the absence of glia, were highly enriched in phorbol ester receptors. The neurons displayed a…”
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