Search Results - "BLAESE, R. Michael"

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells by Ram, Zvi, Culver, Kenneth W, Oshiro, Eric M, Viola, John J, DeVroom, Hetty L, Otto, Edward, Long, Zhifeng, Chiang, Yawen, McGarrity, Gerard J, Muul, Linda M, Katz, David, Michael Blaese, R, Oldfield, Edward H

“…Intratumoral implantation of murine cells modified to produce retroviral vectors containing the herpes simplex virus-thymidine kinase (HSV-TK) gene induces…”
Get full text

Somatic mosaicism in the Wiskott–Aldrich syndrome: Molecular and functional characterization of genotypic revertants by Davis, Brian R, Yan, Qing, Bui, Jacquelin H, Felix, Kumar, Moratto, Daniele, Muul, Linda M, Prokopishyn, Nicole L, Blaese, R. Michael, Candotti, Fabio

“…Abstract The reasons underlying the occurrence of multiple revertant genotypes in Wiskott–Aldrich syndrome (WAS) patients remain unclear. We have identified…”
Get full text

Unprecedented diversity of genotypic revertants in lymphocytes of a patient with Wiskott-Aldrich syndrome by Davis, Brian R., DiCola, Michael J., Prokopishyn, Nicole L., Rosenberg, Jonathan B., Moratto, Daniele, Muul, Linda M., Candotti, Fabio, Michael Blaese, R.

“…Spontaneous somatic reversions of inherited mutations are poorly understood phenomena that are thought to occur uncommonly in a variety of genetic disorders…”
Get full text

Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts by Shearer, William T., MD, PhD, Fleisher, Thomas A., MD, Buckley, Rebecca H., MD, Ballas, Zuhair, MD, Ballow, Mark, MD, Blaese, R. Michael, MD, Bonilla, Francisco A., MD, PhD, Conley, Mary Ellen, MD, Cunningham-Rundles, Charlotte, MD, PhD, Filipovich, Alexandra H., MD, Fuleihan, Ramsay, MD, Gelfand, Erwin W., MD, Hernandez-Trujillo, Vivian, MD, Holland, Steven M., MD, Hong, Richard, MD, Lederman, Howard M., MD, PhD, Malech, Harry L., MD, Miles, Stephen, MD, Notarangelo, Luigi D., MD, Ochs, Hans D., MD, Orange, Jordan S., MD, PhD, Puck, Jennifer M., MD, Routes, John M., MD, Stiehm, E. Richard, MD, Sullivan, Kathleen, MD, PhD, Torgerson, Troy, MD, PhD, Winkelstein, Jerry, MD

“…The present uncertainty of which live viral or bacterial vaccines can be given to immunodeficient patients and the growing neglect of societal adherence to…”
Get full text

Seasonal viral influenza among persons with primary antibody immunodeficiency by Ballow, Mark, Henderson, Tiffany, Scalchunes, Christopher, Blaese, R. Michael

“…In approximately 26% of children, the diagnosis was confirmed by nasal or throat swab; only approximately 10% of adults had their flu symptoms confirmed by…”
Get full text

Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial by Muul, Linda Mesler, Tuschong, Laura M., Soenen, Sherry Lau, Jagadeesh, G. Jayashree, Ramsey, W. Jay, Long, Zhifeng, Carter, Charles S., Garabedian, Elizabeth K., Alleyne, Melinna, Brown, Margaret, Bernstein, Wendy, Schurman, Shepherd H., Fleisher, Thomas A., Leitman, Susan F., Dunbar, Cynthia E., Blaese, R. Michael, Candotti, Fabio

“…The first human gene therapy experiment begun in September 1990 used a retroviral vector containing the human adenosine deaminase (ADA) cDNA to transduce…”
Get full text

In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo by Okada, Takashi, Caplen, Natasha J., Ramsey, W. Jay, Onodera, Masafumi, Shimazaki, Kuniko, Nomoto, Tatsuya, Ajalli, Rahim, Wildner, Oliver, Morris, John, Kume, Akihiro, Hamada, Hirofumi, Blaese, R. Michael, Ozawa, Keiya

“…Background Hybrid adeno‐retroviral vector systems utilize the high efficiency of adenovirus transduction to direct the in situ production of retroviral…”
Get full text

Immune response to fetal calf serum by two adenosine deaminase-deficient patients after T cell gene therapy by Tuschong, Laura, Soenen, Sherry L, Blaese, R Michael, Candotti, Fabio, Muul, Linda Mesler

“…The first approved clinical gene therapy trial for adenosine deaminase (ADA) deficiency employed autologous T cells grown in fetal calf serum…”
Get more information

A multiinstitutional survey of the Wiskott-Aldrich syndrome by Sullivan, Kathleen E., Mullen, Craig A., Blaese, R.Michael, Winkelstein, Jerry A.

“…The Wiskott-Aldrich syndrome is an X-linked primary immunodeficiency originally characterized by the clinical triad of thrombocytopenia, eczema, and…”
Get full text

Wiskott-Aldrich syndrome/X-linked thrombocytopenia : WASP gene mutations, protein expression, and phenotype by ZHU, Q, WATANABE, C, LIU, T, HOLLENBAUGH, D, BLAESE, R. M, KANNER, S. B, ARUFFO, A, OCHS, H. D

“…Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT), caused by mutations of the WAS protein (WASP) gene, represent different phenotypes of the…”
Get full text

What is the status of gene therapy for primary immunodeficiency? by Blaese, R Michael

“…The efforts to find satisfactory treatments for seriously ill patients with primary immunodeficiency have resulted in the development of important new…”
Get full text

The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid by Higginbotham, James N, Seth, Prem, Blaese, R Michael, Ramsey, W Jay

“…Preclinical and clinical studies with adenoviral vectors have clearly illustrated the potential advantages of this gene transfer system. However, many studies…”
Get more information

Wiskott-Aldrich Syndrome/X-Linked Thrombocytopenia: WASP Gene Mutations, Protein Expression, and Phenotype by Zhu, Qili, Watanabe, Chiaki, Liu, Ting, Hollenbaugh, Diane, Blaese, R. Michael, Kanner, Steven B., Aruffo, Alejandro, Ochs, Hans D.

“…Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT), caused by mutations of the WAS protein (WASP) gene, represent different phenotypes of the…”
Get full text

Preferential survival of CD4+ T lymphocytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infected individuals by Morgan, Richard A, Walker, Robert, Carter, Charles S, Natarajan, Ven, Tavel, Jorge A, Bechtel, Chris, Herpin, Betsy, Muul, Linda, Zheng, Zhili, Jagannatha, Shyla, Bunnell, Bruce A, Fellowes, Vicki, Metcalf, Julia A, Stevens, Randy, Baseler, Michael, Leitman, Susan F, Read, Elizabeth J, Blaese, R Michael, Lane, H Clifford

“…The present study examined the safety and relative in vivo survival of genetically engineered CD4+ T lymphocytes in human immunodeficiency virus (HIV)-infected…”
Get more information

Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene transfer by Candotti, F, Agbaria, R, Mullen, C A, Touraine, R, Balzarini, J, Johns, D G, Blaese, R M

“…Metabolic suicide gene transfer is widely applied for gene therapy of cancer, and retroviral vectors expressing the herpes simplex virus thymidine kinase…”
Get full text

Development of Gene Therapy for Immunodeficiency: Adenosine Deaminase Deficiency by Blaese, Michael R

Get full text

Transfer of the Bacterial Gene for Cytosine Deaminase to Mammalian Cells Confers Lethal Sensitivity to 5-Fluorocytosine: A Negative Selection System by Mullen, Craig A., Kilstrup, Mogens, Blaese, R. Michael

“…Expression of the bacterial gene for cytosine deaminase (CD; EC 3.5.4.1) in mammalian cells was evaluated as a negative selection system or suicide vector for…”
Get full text

In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats by RAM, Z, CULVER, K. W, WALBRIDGE, S, BLAESE, R. M, OLDFIELD, E. H

“…Gene transfer with vectors derived from murine retroviruses is restricted to cells which are proliferating and synthesizing DNA at the time of infection. This…”
Get full text

Successful Peripheral T-Lymphocyte–Directed Gene Transfer for a Patient With Severe Combined Immune Deficiency Caused by Adenosine Deaminase Deficiency by Onodera, Masafumi, Ariga, Tadashi, Kawamura, Nobuaki, Kobayashi, Ichiro, Ohtsu, Makoto, Yamada, Masafumi, Tame, Atsushi, Furuta, Hirofumi, Okano, Motohiko, Matsumoto, Shuzo, Kotani, Hitoshi, McGarrity, Gerard J., Michael Blaese, R., Sakiyama, Yukio

“…Ten patients with adenosine deaminase deficiency (ADA−) have been enrolled in gene therapy clinical trials since the first patient was treated in September…”
Get full text

Induction of an antitumor immunological response by an intratumoral injection of dendritic cells pulsed with genetically engineered Semliki Forest virus to produce interleukin-18 combined with the systemic administration of interleukin-12 by YAMANAKA, Ryuya, TSUCHIYA, Naoto, YAJIMA, Naoki, HONMA, Junpei, HASEGAWA, Hitoshi, TANAKA, Ryuichi, RAMSEY, Jay, BLAESE, R. Michael, XANTHOPOULOS, Kleanthis G

“…The aim of this study was to investigate further immunogene treatment of malignant brain tumor to improve its therapeutic efficacy. Intratumoral dendritic…”
Get full text