Search Results - "BLADIN, Christopher"
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A Randomized Trial of Tenecteplase versus Alteplase for Acute Ischemic Stroke
Published in The New England journal of medicine (22-03-2012)“…In this phase 2B trial involving 75 patients with acute ischemic stroke, tenecteplase was more effective than alteplase in achieving reperfusion and clinical…”
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Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke
Published in The New England journal of medicine (09-05-2019)“…In a randomized trial involving patients with stroke and salvageable regions of brain detected on imaging, 39.4% of those who received alteplase had no or…”
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Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection
Published in The New England journal of medicine (12-03-2015)“…In patients with ischemic stroke and a proximal cerebral arterial occlusion and salvageable tissue on imaging, alteplase followed by thrombectomy with a stent…”
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Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke: The EXTEND-IA TNK Part 2 Randomized Clinical Trial
Published in JAMA : the journal of the American Medical Association (07-04-2020)“…IMPORTANCE: Intravenous thrombolysis with tenecteplase improves reperfusion prior to endovascular thrombectomy for ischemic stroke compared with alteplase…”
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Symptomatic Intracranial Hemorrhage With Tenecteplase vs Alteplase in Patients With Acute Ischemic Stroke: The Comparative Effectiveness of Routine Tenecteplase vs Alteplase in Acute Ischemic Stroke (CERTAIN) Collaboration
Published in JAMA neurology (01-07-2023)“…Symptomatic intracranial hemorrhage (sICH) is a serious complication of stroke thrombolytic therapy. Many stroke centers have adopted 0.25-mg/kg tenecteplase…”
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Effect of Telestroke on Emergent Stroke Care and Stroke Outcomes
Published in Stroke (1970) (01-06-2014)Get full text
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Melbourne Mobile Stroke Unit and Reperfusion Therapy: Greater Clinical Impact of Thrombectomy Than Thrombolysis
Published in Stroke (1970) (01-03-2020)“…Background and Purpose- Mobile stroke units (MSUs) are increasingly used worldwide to provide prehospital triage and treatment. The benefits of MSUs in giving…”
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Nurses’ Role in Implementing and Sustaining Acute Telemedicine: A Mixed‐Methods, Pre‐Post Design Using an Extended Technology Acceptance Model
Published in Journal of nursing scholarship (01-01-2020)“…Purpose Technology‐based systems like telemedicine are frequently being implemented into healthcare settings, impacting clinician practices. Little is known…”
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Quality of Acute Care and Long-Term Quality of Life and Survival: The Australian Stroke Clinical Registry
Published in Stroke (1970) (01-04-2017)“…BACKGROUND AND PURPOSE—Uncertainty exists over whether quality improvement strategies translate into better health-related quality of life (HRQoL) and survival…”
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Clopidogrel Plus Aspirin Versus Warfarin in Patients With Stroke and Aortic Arch Plaques
Published in Stroke (1970) (01-05-2014)“…BACKGROUND AND PURPOSE—Severe atherosclerosis in the aortic arch is associated with a high risk of recurrent vascular events, but the optimal antithrombotic…”
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The acute telestroke model of care in Australia: a potential roadmap for other emergency medical services?
Published in Medical journal of Australia (06-06-2022)Get full text
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Long-term unmet needs and associated factors in stroke or TIA survivors: An observational study
Published in Neurology (04-07-2017)“…OBJECTIVE:To extensively investigate long-term unmet needs in survivors of stroke or TIA and to identify factors associated with these unmet needs…”
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Tenecteplase in ischemic stroke offers improved recanalization: Analysis of 2 trials
Published in Neurology (04-07-2017)“…OBJECTIVE:To test whether patients with complete vessel occlusion show greater recanalization at 24 hours and have improved clinical outcomes at 24 hours and…”
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Management of Poststroke Hyperglycemia: Results of the TEXAIS Randomized Clinical Trial
Published in Stroke (1970) (01-12-2023)“…Hyperglycemia in acute ischemic stroke reduces the efficacy of stroke thrombolysis and thrombectomy, with worse clinical outcomes. Insulin-based therapies are…”
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Quality of life after stroke: a longitudinal analysis of a cluster randomized trial
Published in Quality of life research (01-08-2022)“…Purpose Health-related quality of life (QoL) is poor after stroke, but may be improved with comprehensive care plans. We aimed to determine the effects of an…”
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Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial
Published in Lancet neurology (01-04-2008)“…Summary Background Whether intravenous tissue plasminogen activator (alteplase) is effective beyond 3 h after onset of acute ischaemic stroke is unclear. We…”
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Editorial: Emerging Areas in Extracranial Carotid Stenosis Evaluation and Management
Published in Frontiers in neurology (06-04-2022)Get full text
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Cost-effectiveness of the Victorian Stroke Telemedicine program
Published in Australian health review (20-05-2022)“…Objective Stroke telemedicine improves the provision of reperfusion therapies in regional hospitals, yet evidence of its cost-effectiveness using patient-level…”
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Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke: Analysis of 2 Randomized Controlled Trials
Published in Circulation (New York, N.Y.) (31-01-2017)“…We pooled 2 clinical trials of tenecteplase compared with alteplase for the treatment of acute ischemic stroke, 1 that demonstrated superiority of tenecteplase…”
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The efficacy and safety of enoxaparin versus unfractionated heparin for the prevention of venous thromboembolism after acute ischaemic stroke (PREVAIL Study): an open-label randomised comparison
Published in The Lancet (British edition) (21-04-2007)“…Summary Background Venous thromboembolism prophylaxis with low molecular weight heparin or unfractionated heparin is recommended in acute ischaemic stroke, but…”
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