Search Results - "BLACKBURN, H"

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection by Blackburn, Elizabeth H., Epel, Elissa S., Lin, Jue

“…Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes. Telomere attrition can lead to potentially maladaptive cellular changes,…”
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Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System by Chen, Baohui, Gilbert, Luke A., Cimini, Beth A., Schnitzbauer, Joerg, Zhang, Wei, Li, Gene-Wei, Park, Jason, Blackburn, Elizabeth H., Weissman, Jonathan S., Qi, Lei S., Huang, Bo

“…The spatiotemporal organization and dynamics of chromatin play critical roles in regulating genome function. However, visualizing specific, endogenous genomic…”
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Telomerase: an RNP enzyme synthesizes DNA by Blackburn, Elizabeth H, Collins, Kathleen

“…Telomerase is a eukaryotic ribonucleoprotein (RNP) whose specialized reverse transcriptase action performs de novo synthesis of one strand of telomeric DNA…”
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Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults by Rehkopf, David H, Needham, Belinda L, Lin, Jue, Blackburn, Elizabeth H, Zota, Ami R, Wojcicki, Janet M, Epel, Elissa S

“…Leukocyte telomere length (LTL) is a putative biological marker of immune system age, and there are demonstrated associations between LTL and cardiovascular…”
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Telomere states and cell fates by Blackburn, Elizabeth H

“…Telomere length has frequently been used as a means to predict the future life of cells. Here recent findings are integrated into a new, probabilistic view of…”
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Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging by Blackburn, Elizabeth H, Greider, Carol W, Szostak, Jack W

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A gene bank's collection of genetic diversity among minor chicken breeds by Blackburn, H D, Krehbiel, B C

“…Genetic differences among heritage or fancier breeds of chickens have not been quantified in the United States. Gene banks collecting germplasm for conserving…”
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Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999–2002 by Needham, Belinda L., Adler, Nancy, Gregorich, Steven, Rehkopf, David, Lin, Jue, Blackburn, Elizabeth H., Epel, Elissa S.

“…The purpose of this study was to examine the association between socioeconomic status (SES) and leukocyte telomere length (LTL) – a marker of cell aging that…”
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A fine structure genetic analysis evaluating ecoregional adaptability of a Bos taurus breed (Hereford) by Blackburn, H D, Krehbiel, B, Ericsson, S A, Wilson, C, Caetano, A R, Paiva, S R

“…Ecoregional differences contribute to genetic environmental interactions and impact animal performance. These differences may become more important under…”
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Telomeres and telomerase: their mechanisms of action and the effects of altering their functions by Blackburn, Elizabeth H.

“…The molecular features of telomeres and telomerase are conserved among most eukaryotes. How telomerase and telomeres function and how they interact to promote…”
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The Major Reverse Transcriptase―Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis by LISTERMAN, Imke, JIE SUN, GAZZANIGA, Francesca S, LUKAS, Jason L, BLACKBURN, Elizabeth H

“…Human telomerase reverse transcriptase (hTERT; the catalytic protein subunit of telomerase) is subjected to numerous alternative splicing events, but the…”
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Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood by Entringer, Sonja, Epel, Elissa S, Kumsta, Robert, Lin, Jue, Hellhammer, Dirk H, Blackburn, Elizabeth H, Wüst, Stefan, Wadhwa, Pathik D

“…Leukocyte telomere length (LTL) is a predictor of age-related disease onset and mortality. The association in adults of psychosocial stress or stress…”
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Direct optimal growth analysis for timesteppers by Barkley, D., Blackburn, H. M., Sherwin, S. J.

“…Methods are described for transient growth analysis of flows with arbitrary geometric complexity, where in particular the flow is not required to vary slowly…”
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Visualization of actin filaments and monomers in somatic cell nuclei by Belin, Brittany J, Cimini, Beth A, Blackburn, Elizabeth H, Mullins, R Dyche

“…In addition to its long-studied presence in the cytoplasm, actin is also found in the nuclei of eukaryotic cells. The function and form (monomer, filament, or…”
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Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources by Zalli, Argita, Carvalho, Livia A., Lin, Jue, Hamer, Mark, Erusalimsky, Jorge D., Blackburn, Elizabeth H., Steptoe, Andrew

“…Recent work has linked psychological stress with premature cellular aging as indexed by reduced leukocyte telomere lenght. The combination of shorter telomeres…”
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Depression, anxiety and telomere length in young adults: evidence from the National Health and Nutrition Examination Survey by Needham, B L, Mezuk, B, Bareis, N, Lin, J, Blackburn, E H, Epel, E S

“…Telomere length has been hypothesized to be a marker of cumulative exposure to stress, and stress is an established cause of depression and anxiety disorders…”
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Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length by Xie, Zhengwei, Jay, Kyle A., Smith, Dana L., Zhang, Yi, Liu, Zairan, Zheng, Jiashun, Tian, Ruilin, Li, Hao, Blackburn, Elizabeth H.

“…Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after…”
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Switching and Signaling at the Telomere by Blackburn, Elizabeth H.

“…This review describes the structure of telomeres, the protective DNA-protein complexes at eukaryotic chromosomal ends, and several molecular mechanisms…”
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Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study by Ornish, Dean, Prof, Lin, Jue, PhD, Chan, June M, Prof, Epel, Elissa, PhD, Kemp, Colleen, RN, Weidner, Gerdi, Prof, Marlin, Ruth, MD, Frenda, Steven J, MA, Magbanua, Mark Jesus M, PhD, Daubenmier, Jennifer, PhD, Estay, Ivette, PhD, Hills, Nancy K, PhD, Chainani-Wu, Nita, DMD, Carroll, Peter R, Prof, Blackburn, Elizabeth H, Prof

“…Summary Background Telomere shortness in human beings is a prognostic marker of ageing, disease, and premature morbidity. We previously found an association…”
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Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings by Wolkowitz, Owen M, Mellon, Synthia H, Epel, Elissa S, Lin, Jue, Dhabhar, Firdaus S, Su, Yali, Reus, Victor I, Rosser, Rebecca, Burke, Heather M, Kupferman, Eve, Compagnone, Mariana, Nelson, J Craig, Blackburn, Elizabeth H

“…Depression is associated with an unusually high rate of aging-related illnesses and early mortality. One aspect of "accelerated aging" in depression may be…”
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