Search Results - "BJUGSTAD, K"

The boundlessness of behavioral neuroscience: A look across 30 years by Bjugstad, K.B., Sanberg, P.R.

“…It has been more than thirty years since the two inaugural IBNS presidents sat down at a larger neuroscience conference and decided that there should be more…”
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Biocompatibility of poly(ethylene glycol)-based hydrogels in the brain: An analysis of the glial response across space and time by Bjugstad, K. B., Lampe, K., Kern, D. S., Mahoney, M.

“…Poly(ethylene glycol) or PEG‐based hydrogels provide a useful methodology for tissue engineering and the controlled‐release of drugs within the central nervous…”
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Semen quality and infertility status can be identified through measures of oxidation–reduction potential by Arafa, M., Agarwal, A., Al Said, S., Majzoub, A., Sharma, R., Bjugstad, K. B., AlRumaihi, K., Elbardisi, H.

“…Summary Standard analyses for evaluating semen quality require technical expertise and are interpretive in nature. Oxidative stress (OS) alters many of the…”
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Development of porous PEG hydrogels that enable efficient, uniform cell-seeding and permit early neural process extension by Namba, R.M., Cole, A.A., Bjugstad, K.B., Mahoney, M.J.

“…Three-dimensional polymer scaffolds are useful culture systems for neural cell growth and can provide permissive substrates that support neural processes as…”
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Evaluation of intra- and inter-observer reliability of the ORP (oxidation-reduction potential) test for OS (oxidative stress) in male factor infertility by Agarwal, A, Roychoudhury, S, Sharma, R, Gupta, S, Majzoub, A, Bjugstad, K, Sabanegh, E.S

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Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice by Kern, D S, Maclean, K N, Jiang, H, Synder, E Y, Sladek, Jr, J R, Bjugstad, K B

“…Tau accumulation, in the form of neurofibrillary tangles (NFT), is an early neuropathological characteristic of Alzheimer's disease (AD) and early onset AD…”
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Biocompatibility of PEG-based hydrogels in primate brain by Bjugstad, K B, Redmond, Jr, D E, Lampe, K J, Kern, D S, Sladek, Jr, J R, Mahoney, M J

“…Degradable polymers have been used successfully in a wide variety of peripheral applications from tissue regeneration to drug delivery. These polymers induce…”
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Evidence That Oxidative Stress Is Associated with the Pathophysiology of Inherited Hydrocephalus in the H-Tx Rat Model by Socci, D.J., Bjugstad, K.B., Jones, H.C., Pattisapu, J.V., Arendash, G.W.

“…Oxidative stress can contribute to many neurological disease processes. Because many events known to involve oxidative stress (infection, hemorrhage, brain…”
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AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons by Elsworth, J.D., Redmond, D.E., Leranth, C., Bjugstad, K.B., Sladek, J.R., Collier, T.J., Foti, S.B., Samulski, R.J., Vives, K.P., Roth, R.H.

“…Neural transplantation offers the potential of treating Parkinson's disease by grafting fetal dopamine neurons to depleted regions of the brain. However,…”
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Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF by Redmond Jr, D.E., Elsworth, J.D., Roth, R.H., Leranth, C., Collier, T.J., Blanchard, B., Bjugstad, K.B., Samulski, R.J., Aebischer, P., Sladek Jr, J.R.

“…In spite of partial success in treating Parkinson's disease by using ectopically placed grafts of dopamine‐producing cells, restoration of the original…”
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Age at symptom onset predicts severity of motor impairment and clinical outcome of glutaric acidemia type 1 by Bjugstad, Kimberly B., Goodman, Stephen I., Freed, Curt R.

“…Objectives: In patients with glutaric acidemia type 1 (GAI), biochemical and molecular markers fail to predict the course of individual patients; therefore we…”
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AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL by SONDHI, D, PETERSON, D. A, REDMOND, D. E, LEOPOLD, P. L, KAMINSKY, S. M, HACKETT, N. R, CRYSTAL, R. G, GIANNARISI, E. L, SANDERS, C. T, MENDEZ, B. S, DE, B, ROSTKOWSKI, A. B, BLANCHARD, B, BJUGSTAD, K, SLADEK, J. R

“…Late infantile neuronal ceroid lipofuscinosis (LINCL) is a fatal, autosomal recessive disease resulting from mutations in the CLN2 gene with consequent…”
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Embryonic substantia nigra grafts show directional outgrowth to cografted striatal grafts and potential for pathway reconstruction in nonhuman primate by Sladek, Jr, J R, Bjugstad, K B, Collier, T J, Bundock, E A, Blanchard, B C, Elsworth, J D, Roth, R H, Redmond, Jr, D E

“…Transplantation of embryonic dopamine (DA) neurons has been tested as a therapy for Parkinson's disease. Most studies placed DA neurons into the striatum…”
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In vitro and in vivo studies investigating possible antioxidant actions of nicotine: relevance to Parkinson’s and Alzheimer’s diseases by Linert, W., Bridge, M.H., Huber, M., Bjugstad, K.B., Grossman, S., Arendash, G.W.

“…An inverse relationship appears to exist between cigarette smoking and the risk of Parkinson’s and Alzheimer’s diseases. Since both diseases are characterized…”
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IGF‐1 and bFGF reduce glutaric acid and 3‐hydroxyglutaric acid toxicity in striatal cultures by Bjugstad, K. B., Zawada, W. M., Goodman, S. I., Freed, C. R.

“…Glutaric acid (GA) and 3‐hydroxyglutaric acid (3GA) are thought to contribute to the degeneration of the caudate and putamen that is seen in some children with…”
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Infant mice with glutaric acidaemia type I have increased vulnerability to 3‐nitropropionic acid toxicity by Bjugstad, K. B., Crnic, L. S., Goodman, S. I., Freed, C. R.

“…Summary Glutaric acidaemia type I (GA I) is an inborn error of metabolism caused by a deficiency of glutaryl‐CoA dehydrogenase (GCDH) and is characterized…”
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Intravascular infusions of soluble β-amyloid compromise the blood–brain barrier, activate CNS glial cells and induce peripheral hemorrhage by Su, George C, Arendash, Gary W, Kalaria, Rajesh N, Bjugstad, Kimberly B, Mullan, Michael

“…Vascular wall levels of soluble β-amyloid 1–40 (Aβ 1–40) are elevated in Alzheimer's disease (AD). Moreover, plasma Aβ levels are increased in familial AD, as…”
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Preventive actions of a synthetic antioxidant in a novel animal model of AIDS dementia by Bjugstad, Kimberly B., Flitter, William D., Garland, William A., Su, George C., Arendash, Gary W.

“…Accumulating evidence indicates that the mechanism for causing AIDS dementia complex (ADC) involves the release of damaging inflammatory-related agents by…”
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Intravascular β-amyloid infusion increases blood pressure : implications for a vasoactive role of β-amyloid in the pathogenesis of Alzheimer's disease by ARENDASH, G. W, SU, G. C, CRAWFORD, F. C, BJUGSTAD, K. B, MULLAN, M

“…Hypertension has been recognized as a risk factor for Alzheimer's disease (AD). Moreover, serum beta-amyloid (A beta) levels are elevated in several mutations…”
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CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-alpha infusion model for AIDS dementia complex by Bjugstad, K B, Flitter, W D, Garland, W A, Philpot, R M, Kirstein, C L, Arendash, G W

“…AIDS dementia complex (ADC) is characterized by increased apoptosis, gliosis, and oxidative stress in the CNS, as well as a compromised blood-brain barrier…”
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