Search Results - "BJÖRNHOLM, M"

Insulin signal transduction in human skeletal muscle: identifying the defects in Type II diabetes by Björnholm, M, Zierath, J R

“…Type II diabetes is characterized by defects in insulin action on peripheral tissues, such as skeletal muscle, adipose tissue and liver and pancreatic…”
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Leptin receptor action and mechanisms of leptin resistance by Münzberg, H, Björnholm, M, Bates, S H, Myers, Jr, M G

“…The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is…”
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Integrated Liver and Plasma Proteomics in Obese Mice Reveals Complex Metabolic Regulation by Stocks, Ben, Gonzalez-Franquesa, Alba, Borg, Melissa L., Björnholm, Marie, Niu, Lili, Zierath, Juleen R., Deshmukh, Atul S.

“…Obesity leads to the development of nonalcoholic fatty liver disease (NAFLD) and associated alterations to the plasma proteome. To elucidate the underlying…”
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Chronic glucocorticoid treatment increases de novo lipogenesis in visceral adipose tissue by Vienberg, S. G., Björnholm, M.

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Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation by Aoi, Wataru, Inoue, Ryo, Mizushima, Katsura, Honda, Akira, Björnholm, Marie, Takagi, Tomohisa, Naito, Yuji

“…Habitual exercise alters the intestinal microbiota composition, which may mediate its systemic benefits. We examined whether transplanting fecal microbiota…”
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Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation by Bjornholm, M., Kawano, Y., Lehtihet, M., Zierath, J. R.

“…Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin…”
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Adenosine A(3) receptors regulate heart rate, motor activity and body temperature by Yang, J N, Wang, Y, Garcia-Roves, P M, Björnholm, M, Fredholm, B B

“…To examine the phenotype of mice that lack the adenosine A(3) receptor (A(3)R). We examined the heart rate, body temperature and locomotion continuously by…”
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Adenosine A₃ receptors regulate heart rate, motor activity and body temperature by Yang, J.N, Wang, Y, Garcia-Roves, P.M, Björnholm, M, Fredholm, B.B

“…To examine the phenotype of mice that lack the adenosine A₃ receptor (A₃R). We examined the heart rate, body temperature and locomotion continuously by…”
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Adenosine A 3 receptors regulate heart rate, motor activity and body temperature by Yang, J. N., Wang, Y., Garcia‐Roves, P. M., Björnholm, M., Fredholm, B. B.

“…Aim:  To examine the phenotype of mice that lack the adenosine A 3 receptor (A 3 R). Methods:  We examined the heart rate, body temperature and locomotion…”
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Exercise‐induced overexpression of key regulatory proteins involved in glucose uptake and metabolism in tetraplegic persons: molecular mechanism for improved glucose homeostasis by Hjeltnes, Nils, Galuska, Dana, Björnholm, Marie, Aksnes, Anne-Kirsti, Lannem, Anne, Zierath, Juleen R., Wallberg-Henriksson, Harriet

“…ABSTRACT Complete spinal cord lesion leads to profound metabolic abnormalities and striking changes in muscle morphology. Here we assess the effects of…”
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Diacylglycerol kinase delta overexpression improves glucose clearance and protects against the development of obesity by Jollet, Maxence, Tramontana, Flavia, Jiang, Lake Q., Borg, Melissa L., Savikj, Mladen, Kuefner, Michael S., Massart, Julie, de Castro Barbosa, Thais, Mannerås-Holm, Louise, Checa, Antonio, Pillon, Nicolas J., Chibalin, Alexander V., Björnholm, Marie, Zierath, Juleen R.

“…Diacylglycerol kinase (DGK) isoforms catalyze an enzymatic reaction that removes diacylglycerol (DAG) and thereby terminates protein kinase C signaling by…”
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Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans by BJÖRNHOLM, M, HE, A. R, ATTERSAND, A, LAKE, S, LIU, S. C. H, LIENHARD, G. E, TAYLOR, S, ARNER, P, ZIERATH, J. R

“…Insulin receptor substrate (IRS) proteins play important roles in insulin action and pancreatic beta-cell function. At least four mammalian IRS molecules have…”
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Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients by A Krook, M Björnholm, D Galuska, X J Jiang, R Fahlman, M G Myers, Jr, H Wallberg-Henriksson, J R Zierath

“…Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients. A Krook , M Björnholm , D Galuska , X J Jiang ,…”
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Gene expression of the p85α regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects by Tsuchida, Hiroki, Björnholm, Marie, Fernström, Maria, Galuska, Dana, Johansson, Per, Wallberg-Henriksson, Harriet, Zierath, Juleen, Lake, Staffan, Krook, Anna

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Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients by Ryder, J W, Yang, J, Galuska, D, Rincón, J, Björnholm, M, Krook, A, Lund, S, Pedersen, O, Wallberg-Henriksson, H, Zierath, J R, Holman, G D

“…Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type…”
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Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected] by Storgaard, H, Song, X M, Jensen, C B, Madsbad, S, Björnholm, M, Vaag, A, Zierath, J R

“…To determine whether defects in the insulin signal transduction cascade are present in skeletal muscle from prediabetic individuals, we excised biopsies from…”
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Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation by BJÖRNHOLM, M, KAWANO, Y, LEHTIHET, M, ZIERATH, J. R

“…We examined the effect of physiological hyperinsulinemia on insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation and phosphatidylinositol (PI)…”
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Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes : A randomized controlled study by KARLSSON, Hakan K. R, HÄLLSTEN, Kirsti, BJÖRNHOLM, Marie, TSUCHIDA, Hiroki, CHIBALIN, Alexander V, VIRTANEN, Kirsi A, HEINONEN, Olli J, LÖNNQVIST, Fredrik, NUUTILA, Pirjo, ZIERATH, Juleen R

“…The effect of metformin or rosiglitazone monotherapy versus placebo on insulin signaling and gene expression in skeletal muscle of patients with newly…”
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Dissociation between Fat-Induced in Vivo Insulin Resistance and Proximal Insulin Signaling in Skeletal Muscle in Men at Risk for Type 2 Diabetes by Storgaard, Heidi, Jensen, Christine B., Björnholm, Marie, Song, Xiao Mei, Madsbad, Sten, Zierath, Juleen R., Vaag, Allan A.

“…The effect of short- (2 h) and long-term (24 h) low-grade Intralipid infusion on whole-body insulin action, cellular glucose metabolism, and proximal…”
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Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle by Widegren, Ulrika, Jiang, Xin Jian, Krook, Anna, Chibalin, Alexander V., Björnholm, Marie, Tally, Michael, Roth, Richard A., Henriksson, Jan, Wallberg‐Henriksson, Harriet, Zierath, Juleen R.

“…The molecular signaling mechanisms by which muscle contractions lead to changes in glucose metabolism and gene expression remain largely undefined. We assessed…”
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