Search Results - "BJÖRK, I"

Analgesia and sedation of mechanically ventilated patients - a national survey of clinical practice by WØIEN, H., STUBHAUG, A., BJØRK, I. T.

“…Background The importance of balanced sedation and pain treatment in intensive care units (ICUs) is evident, but regimes and use of medication differ widely…”
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Parent–child communication and timing of interventions are challenges in the Duchenne muscular dystrophy care by Sætrang, T, Bjørk, I T, Capjon, H, Rasmussen, M

“…Aim Duchenne muscular dystrophy (DMD) is an X‐linked myopathy affecting one in 3600–6000 live male births. The aim of this study was to gain further insight…”
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Mixed chimerism in the B cell lineage is a rapid and sensitive indicator of minimal residual disease in bone marrow transplant recipients with pre-B cell acute lymphoblastic leukemia by ZETTERQUIST, H, MATTSSON, J, UZUNEL, M, NÄSMAN-BJÖRK, I, SVENBERG, P, TAMMIK, L, BAYAT, G, WINIARSKI, J, RINGDEN, O

“…One of the major problems after allogeneic bone marrow transplantation (BMT) is a high frequency of leukemia relapse. We have prospectively studied the…”
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Targeting Risk Factors for Impaired Wound Healing and Wound Complications After Kidney Transplantation by Røine, E, Bjørk, I.T, Øyen, O

“…Abstract Background Because of potent immunosuppression, impaired wound healing and complications are frequent features after kidney transplantation (KTx)…”
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Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement by OLSON, S. T, BJÖRK, I, SHEFFER, R, CRAIG, P. A, SHORE, J. D, CHOAY, J

“…The synthetic antithrombin-binding heparin pentasaccharide and a full-length heparin of approximately 26 saccharides containing this specific sequence have…”
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Memory B lymphocytes determine repertoire oligoclonality early after haematopoietic stem cell transplantation by OMAZIC, B., LUNDKVIST, I., MATTSSON, J., PERMERT, J., NÄSMAN‐BJÖRK, I.

“…SUMMARY The objective of this study was to investigate if oligoclonality of the Ig repertoire post‐haematopoietic stem cell transplantation (HSCT) is…”
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Long‐term persistence of oligoclonal serum IgM repertoires in patients treated with allogeneic bone marrow transplantation (BMT) by Näsman Björk, I., Brissac, C., Remberger, M., Mattsson, J., Klaesson, S., Ringdén, O., Stewart, J., Lundkvist, I.

“…Immunoglobulin gene rearrangements in patients treated with BMT have restricted repertoire diversity. Clonal variability remains low for 3 months and…”
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A Novel Anti-angiogenic Form of Antithrombin with Retained Proteinase Binding Ability and Heparin Affinity by Larsson, Helena, Åkerud, Peter, Nordling, Kerstin, Raub-Segall, Elke, Claesson-Welsh, Lena, Björk, Ingemar

“…Latent antithrombin, an inactive antithrombin form with low heparin affinity, has previously been shown to efficiently inhibit angiogenesis and tumor growth…”
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Cystatin inhibition of cathepsin B requires dislocation of the proteinase occluding loop. Demonstration by release of loop anchoring through mutation of His110 by Pavlova, Alla, Krupa, Joanne C, Mort, John S, Abrahamson, Magnus, Björk, Ingemar

“…Cystatins A and C were both shown to inhibit cathepsin B by a two-step mechanism, involving an initial weak interaction followed by a conformational change…”
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T‐Cell Receptor Vβ Repertoire after Myeloablative and Reduced Intensity Conditioning Allogeneic Haematopoietic Stem Cell Transplantation by Hentschke, P., Omazic, B., Mattsson, J., Näsman‐Björk, I., Lundkvist, I., Gigliotti, D., Barkholt, L., Ringdén, O., Remberger, M.

“…T cells play an important role in the adaptive immune system. After haematopoietic stem cell transplantation (HSCT), T‐cell function is impaired. This is…”
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Role of ternary complexes, in which heparin binds both antithrombin and proteinase, in the acceleration of the reactions between antithrombin and thrombin or factor Xa by Danielsson, A, Raub, E, Lindahl, U, Björk, I

“…Oligosaccharides (10-20 monosaccharide units) with high affinity for antithrombin, as well as larger high-affinity heparin fractions (having relative molecular…”
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Oligoclonal dominance of immunglobulin VH3 rearrangements following allogeneic bone marrow transplantation by NÄSMAN-BJÖRK, I, LUNDKVIST, I

“…Normal numbers of circulating B lymphocytes are reached during the first 6 months following allogeneic BMT, but humoral immunity remains poor. The molecular…”
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Quantitative characterization of the thrombin-heparin interaction. Discrimination between specific and nonspecific binding models by Olson, S T, Halvorson, H R, Björk, I

“…Equilibrium binding of human alpha-thrombin to heparin was investigated at pH 7.4 as a function of thrombin and heparin concentrations, NaCl concentration,…”
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Differential changes in the association and dissociation rate constants for binding of cystatins to target proteinases occurring on N-terminal truncation of the inhibitors indicate that the interaction mechanism varies with different enzymes by Bjork, I, Pol, E, Raub-Segall, E, Abrahamson, M, Rowan, A.D, Mort, J.S

“…The importance of the N-terminal region of human cystatin C or chicken cystatin for the kinetics of interactions of the inhibitors with four cysteine…”
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Extension and structural variability of the antithrombin-binding sequence in heparin by Lindahl, U, Thunberg, L, Bäckström, G, Riesenfeld, J, Nordling, K, Björk, I

“…Oligosaccharides with different affinities for antithrombin were isolated following partial deaminative cleavage of pig mucosal heparin with nitrous acid. The…”
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A novel strategy to generate biologically active neo-glycosaminoglycan conjugates by Rong, Jianhui, Nordling, Kerstin, Björk, Ingemar, Lindahl, Ulf

“…Heparin and heparan sulfate are structurally related polysaccharides with a variety of biological effects/functions. Most of these effects are due to…”
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Extended criteria treatment for liver metastases with heavy tumour burden: excalibur by Longva, A.M.H., Smedman, T.M., Røsok, B., Yaqub, S., Brudvik, K.W., Björk, I., Connelly, J.P., Dorenberg, E., Fretland, Å.A., Glent, J.C.F., Dueland, S., Line, P.D., Lassen, K.

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Extended criteria treatment for liver metastases with heavy tumour burden: excalibur by Longva, A., Smedman, M., Røsok, B., Yaqub, S., Brudvik, K., Björk, I., Connelly, J., Dorenberg, E., Fretland, Å., Glent, J.C., Dueland, S., Line, P.-D., Lassen, K.

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The N-terminal region of cystatin A (stefin A) binds to papain subsequent to the two hairpin loops of the inhibitor. Demonstration of two-step binding by rapid-kinetic studies of cystatin A labeled at the N-terminus with a fluorescent reporter group by ESTRADA, SERGIO, OLSON, STEVEN T., RAUB-SEGALL, ELKE, BJÖRK, INGEMAR

“…The three-dimensional structures of cystatins, and other evidence, suggest that the flexible N-terminal region of these inhibitors may bind to target…”
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Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affinity and enhanced conformational stability by binding of a tetradecapeptide corresponding to the P1 to P14 region of the putative reactive bond loop of the inhibitor by Björk, I, Ylinenjärvi, K, Olson, S T, Bock, P E

“…A synthetic tetradecapeptide having the sequence of the region of the antithrombin chain amino-terminal to the reactive bond, i.e. comprising residues P1 to…”
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