Search Results - "BIX, Gregory J"

Roles of blood-brain barrier integrins and extracellular matrix in stroke by Edwards, Danielle N, Bix, Gregory J

“…Ischemicstroke is a leading cause of death and disability in the United States, but recent advances in treatments [i.e., endovascular thrombectomy and tissue…”
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Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates by Rutkai, Ibolya, Mayer, Meredith G., Hellmers, Linh M., Ning, Bo, Huang, Zhen, Monjure, Christopher J., Coyne, Carol, Silvestri, Rachel, Golden, Nadia, Hensley, Krystle, Chandler, Kristin, Lehmicke, Gabrielle, Bix, Gregory J., Maness, Nicholas J., Russell-Lodrigue, Kasi, Hu, Tony Y., Roy, Chad J., Blair, Robert V., Bohm, Rudolf, Doyle-Meyers, Lara A., Rappaport, Jay, Fischer, Tracy

“…Neurological manifestations are a significant complication of coronavirus disease (COVID-19), but underlying mechanisms aren’t well understood. The development…”
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Mice deficient in endothelial α5 integrin are profoundly resistant to experimental ischemic stroke by Roberts, Jill, de Hoog, Leon, Bix, Gregory J

“…Stroke is a disease in dire need of better therapies. We have previously shown that a fragment of the extracellular matrix proteoglycan, perlecan, has…”
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The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins by Edwards, Danielle N., Bix, Gregory J.

“…Ischemic stroke is a leading cause of death and disability with limited therapeutic options. Resulting inflammatory mechanisms after reperfusion (removal of…”
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Integrin α5β1 inhibition by ATN-161 reduces neuroinflammation and is neuroprotective in ischemic stroke by Edwards, Danielle N, Salmeron, Kathleen, Lukins, Douglas E, Trout, Amanda L, Fraser, Justin F, Bix, Gregory J

“…Stroke remains a leading cause of death and disability with limited therapeutic options. Endothelial cell β1 integrin receptors play a direct role in…”
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Bilateral carotid artery stenosis causes unexpected early changes in brain extracellular matrix and blood-brain barrier integrity in mice by Roberts, Jill M, Maniskas, Michael E, Bix, Gregory J

“…Bilateral carotid artery stenosis (BCAS) is one experimental model of vascular dementia thought to preferentially impact brain white matter. Indeed, few…”
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Perlecan: a review of its role in neurologic and musculoskeletal disease by Lavorgna, Tessa R, Gressett, Timothy E, Chastain, Wesley H, Bix, Gregory J

“…Perlecan is a 500 kDa proteoglycan residing in the extracellular matrix of endothelial basement membranes with five distinct protein domains and three heparan…”
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Intra-arterial verapamil post-thrombectomy is feasible, safe, and neuroprotective in stroke by Fraser, Justin F, Maniskas, Michael, Trout, Amanda, Lukins, Doug, Parker, Lindsey, Stafford, W Lane, Alhajeri, Abdulnasser, Roberts, Jill, Bix, Gregory J

“…Large vessel ischemic stroke represents the most disabling subtype. While t-PA and endovascular thrombectomy can recanalize the occluded vessel, good clinical…”
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Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing Proteoglycan With Roles in Tissue Development Has Relevance to Connective Tissue Repair and Regeneration by Hayes, Anthony J, Farrugia, Brooke L, Biose, Ifechukwude J, Bix, Gregory J, Melrose, James

“…This review highlights the multifunctional properties of perlecan (HSPG2) and its potential roles in repair biology. Perlecan is ubiquitous, occurring in…”
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Brain endothelial cell specific integrins and ischemic stroke by Guell, Kathleen, Bix, Gregory J

“…Ischemic stroke, a devastating event caused by the blockage of a blood vessel(s) supplying the brain, continues to affect thousands of people in the USA every…”
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Interleukin 1 alpha administration is neuroprotective and neuro-restorative following experimental ischemic stroke by Salmeron, Kathleen E, Maniskas, Michael E, Edwards, Danielle N, Wong, Raymond, Rajkovic, Ivana, Trout, Amanda, Rahman, Abir A, Hamilton, Samantha, Fraser, Justin F, Pinteaux, Emmanuel, Bix, Gregory J

“…Stroke remains a leading cause of death and disability worldwide despite recent treatment breakthroughs. A primary event in stroke pathogenesis is the…”
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Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents by Lee, Boyeon, Clarke, Douglas, Al Ahmad, Abraham, Kahle, Michael, Parham, Christi, Auckland, Lisa, Shaw, Courtney, Fidanboylu, Mehmet, Orr, Anthony Wayne, Ogunshola, Omolara, Fertala, Andrzej, Thomas, Sarah A, Bix, Gregory J

“…Stroke is the leading cause of long-term disability and the third leading cause of death in the United States. While most research thus far has focused on…”
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Co-administration of extracellular matrix-based biomaterials with neural stem cell transplantation for treatment of central nervous system injury by Damle, Eshan B, Morrison, Vivianne E, Cioma, Jozef, Volic, Milla, Bix, Gregory J

“…Injuries and disorders of the central nervous system (CNS) present a particularly difficult challenge for modern medicine to address, given the complex nature…”
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Review of Alterations in Perlecan-Associated Vascular Risk Factors in Dementia by Trout, Amanda L, Rutkai, Ibolya, Biose, Ifechukwude J, Bix, Gregory J

“…Perlecan is a heparan sulfate proteoglycan protein in the extracellular matrix that structurally and biochemically supports the cerebrovasculature by…”
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Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin α5β1 and ERK-dependent signaling pathways by Clarke, Douglas N, Al Ahmad, Abraham, Lee, Boyeon, Parham, Christi, Auckland, Lisa, Fertala, Andrezj, Kahle, Michael, Shaw, Courtney S, Roberts, Jill, Bix, Gregory J

“…Perlecan Domain V (DV) promotes brain angiogenesis by inducing VEGF release from brain endothelial cells (BECs) following stroke. In this study, we define the…”
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Recombinant Human Perlecan DV and Its LG3 Subdomain Are Neuroprotective and Acutely Functionally Restorative in Severe Experimental Ischemic Stroke by Biose, Ifechukwude Joachim, Rutkai, Ibolya, Clossen, Bryan, Gage, Gary, Schechtman, Kenneth, Adkisson, H. Davis, Bix, Gregory J.

“…Despite recent therapeutic advancements, ischemic stroke remains a major cause of death and disability. It has been previously demonstrated that  ~ 85-kDa…”
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Internal carotid artery stenosis: A novel surgical model for moyamoya syndrome by Roberts, Jill M, Maniskas, Michael E, Fraser, Justin F, Bix, Gregory J

“…Moyamoya is a cerebrovascular disorder characterized by progressive stenosis of the intracranial internal carotid arteries. There are two forms: Disease and…”
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Intra‐arterial combination therapy for experimental acute ischemic stroke by Maniskas, Michael E., Roberts, Jill M., Gorman, Amanda, Bix, Gregory J., Fraser, Justin F.

“…Acute ischemic stroke continues to devastate millions of individuals worldwide. Current treatments work to restore blood flow but not rescue affected tissue…”
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Perlecan Domain V Therapy for Stroke: A Beacon of Hope? by Bix, Gregory J

“…The sad reality is that in the year 2012, people are still dying or suffering from the extreme morbidity of ischemic stroke. This tragedy is only compounded by…”
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Evaluation of Patients with High National Institutes of Health Stroke Scale as Thrombectomy Candidates Using the Kentucky Appalachian Stroke Registry by Grewal, Parneet, Dobbs, Michael R, Pennypacker, Keith, Kryscio, Richard J, Kitzman, Patrick, Wolfe, Marc, Elkins, Kelley, Bix, Gregory J, Fraser, Justin F

“…Mechanical thrombectomy has become standard of care for emergent large vessel occlusive stroke. Estimates of incidence for thrombectomy eligibility vary…”
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