Gene Expression Profiles of Serous, Endometrioid, and Clear Cell Subtypes of Ovarian and Endometrial Cancer

Purpose: The presence of similar histologic subtypes of epithelial ovarian and endometrial cancers has long been noted, although the relevance of this finding to pathogenesis and clinical management is unclear. Despite similar clinical characteristics, histologic subtypes of cancers of the ovary and...

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Published in:	Clinical cancer research Vol. 11; no. 18; pp. 6422 - 6430
Main Authors:	ZORN, Kristin K, BONOME, Tomas, GANGI, Lisa, CHANDRAMOULI, Gadisetti V. R, AWTREY, Christopher S, GARDNER, Ginger J, BARRETT, J. Carl, BOYD, Jeff, BITTER, Michael J
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 15-09-2005
Subjects:	Adenocarcinoma, Clear Cell - genetics Adenocarcinoma, Clear Cell - metabolism Antineoplastic agents Biological and medical sciences Carcinoma, Endometrioid - genetics Carcinoma, Endometrioid - metabolism Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Clear Cell Cancers Cluster Analysis Cystadenocarcinoma, Serous - genetics Cystadenocarcinoma, Serous - metabolism Endometrial Neoplasms - genetics Endometrial Neoplasms - metabolism Female Female genital diseases Gene Expression Profiling Gene Expression Regulation, Neoplastic Gynecologic cancers: other Gynecologic cancers: ovarian Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Medical sciences Oligonucleotide Array Sequence Analysis - methods Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Pharmacology. Drug treatments Tumor Suppressor Protein p53 - analysis Tumors Ovarian diseases Clear cell Endometrium cancer Ovary cancer Uterine diseases Malignant tumor Subtype Female genital diseases Gene expression profile
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Summary:	Purpose: The presence of similar histologic subtypes of epithelial ovarian and endometrial cancers has long been noted, although the relevance of this finding to pathogenesis and clinical management is unclear. Despite similar clinical characteristics, histologic subtypes of cancers of the ovary and endometrium are treated according to organ of origin. This study compares the gene expression profiles of analogous histologic subtypes of cancers of the ovary and endometrium using the same genomic platform to determine the similarities and differences between these tumors. Experimental Design: Gene expression profiles of 75 cancers (endometrioid, serous, and clear cell) of the ovary and endometrium, five renal clear cell cancers, and seven normal epithelial brushings were determined using a 11,000-element cDNA array. All images were analyzed using BRB ArrayTools. Validation was done using real-time PCR on select genes and immunohistochemical staining. Results: Comparison across endometrial and ovarian cancers and serous and endometrioid tumors showed expression patterns reflecting their organ of origin. Clear cell tumors, however, showed remarkably similar expression patterns regardless of their origin, even when compared with renal clear cell samples. A set of 43 genes was common to comparisons of each of the three histologic subtypes of ovarian cancer with normal ovarian surface epithelium. Conclusions: The comparison of the gene expression profiles of endometrioid and serous subtypes of ovarian and endometrial cancer are largely unique to the combination of a particular subtype in a specific organ. In contrast, clear cell cancers show a remarkable similarity in gene expression profiles across organs (including kidney) and could not be statistically distinguished.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1078-0432 1557-3265
DOI:	10.1158/1078-0432.CCR-05-0508