Search Results - "BIRNBAUM, A. K"

Formulation and Characterization of Conjugate Vaccines to Reduce Opioid Use Disorders Suitable for Pharmaceutical Manufacturing and Clinical Evaluation by Baruffaldi, F, Raleigh, M. D, King, S. J, Roslawski, M. J, Birnbaum, A. K, Hassler, C, Carroll, F. I, Runyon, S. P, Winston, S, Pentel, P. R, Pravetoni, M

“…This study focused on formulating conjugate vaccines targeting oxycodone and heroin for technology transfer, good manufacturing practice (GMP), and clinical…”
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Selective effects of a morphine conjugate vaccine on heroin and metabolite distribution and heroin-induced behaviors in rats by Raleigh, M D, Pravetoni, M, Harris, A C, Birnbaum, A K, Pentel, P R

“…Morphine conjugate vaccines have effectively reduced behavioral effects of heroin in rodents and primates. To better understand how these effects are mediated,…”
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Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats by Pravetoni, M, Raleigh, M.D, Le Naour, M, Tucker, A.M, Harmon, T.M, Jones, J.M, Birnbaum, A.K, Portoghese, P.S, Pentel, P.R

“…Highlights ► Morphine and oxycodone vaccines were combined in a bivalent vaccine.► The immunogenicity of the monovalent vaccines was fully retained when they…”
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Steady‐State Carbamazepine Pharmacokinetics Following Oral and Stable‐Labeled Intravenous Administration in Epilepsy Patients: Effects of Race and Sex by Marino, S E, Birnbaum, A K, Leppik, I E, Conway, J M, Musib, L C, Brundage, R C, Ramsay, R E, Pennell, P B, White, J R, Gross, C R, Rarick, J O, Mishra, U, Cloyd, J C

“…Carbamazepine is a widely prescribed antiepileptic drug. Owing to the lack of an intravenous formulation, its absolute bioavailability, absolute clearance, and…”
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Zonisamide discontinuation due to psychiatric and cognitive adverse events: A case-control study by WHITE, J. R, WALCZAK, T. S, MARINO, S. E, BENIAK, T. E, LEPPIK, I. E, BIRNBAUM, A. K

“…Zonisamide (ZNS) is an antiepileptic drug (AED) that has been associated with psychiatric adverse events (PAE) and cognitive adverse events (CAE); controlled…”
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Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy by AHN, J. E, CLOYD, J. C, LEPPIK, I. E, BRUNDAGE, R. C, MARINO, S. E, CONWAY, J. M, RAMSAY, R. E, WHITE, J. R, MUSIB, L. C, RARICK, J. O, BIRNBAUM, A. K

“…Phenytoin (PHT) is widely used to treat epilepsy in elderly patients, but information on its pharmacokinetics in this population is limited. The purpose of…”
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Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors by Nelson, M.H., Birnbaum, A.K., Remmel, R.P.

“…Several case reports have indicated that the selective serotonin re-uptake inhibitor (SSRI) fluoxetine increases phenytoin blood levels when given…”
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The effect of topiramate plasma concentration on linguistic behavior, verbal recall and working memory by Marino, S.E, Pakhomov, S.V.S, Han, S, Anderson, K.L, Ding, M, Eberly, L.E, Loring, D.W, Hawkins-Taylor, C, Rarick, J.O, Leppik, I.E, Cibula, J.E, Birnbaum, A.K

“…Abstract This is the first study of the effect of topiramate on linguistic behavior and verbal recall using a computational linguistics system for automated…”
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Using PharmGKB to train text mining approaches for identifying potential gene targets for pharmacogenomic studies by Pakhomov, S., McInnes, B.T., Lamba, J., Liu, Y., Melton, G.B., Ghodke, Y., Bhise, N., Lamba, V., Birnbaum, A.K.

“…[Display omitted] ► Automatic classification of drug–gene relations is 85% sensitive and 69% specific. ► Our approach prospectively found more gene targets…”
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Rectal Absorption of Lamotrigine Compressed Tablets by Birnbaum, Angela K., Kriel, Robert L., Burkhardt, R. Todd, Remmel, Rory P.

“…Purpose: Interruption of oral drug administration poses a significant clinical problem for antiepileptic drugs that have no parenteral formulation. If a drug…”
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Failure of Absorption of Gabapentin After Rectal Administration by Kriel, Robert L., Birnbaum, Angela K., Cloyd, James C., Ricker, Beverly J., Saete, Carolyn Jones, Caruso, Kimberly J.

“…Purpose: We wished to determine the extent of absorption of gabapentin (GBP) after rectal administration to children on maintenance therapy. Methods: Two…”
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A capillary GC-MS method for analysis of phenytoin and [13C3]-phenytoin from plasma obtained from pulse dose pharmacokinetic studies by NELSON, M. H, BIRNBAUM, A. K, NYHUS, P. J, REMMEL, R. P

“…Stable isotope analogues of phenytoin are useful for pulse dose pharmacokinetic studies in epilepsy patients. A simultaneous assay was developed to quantitate…”
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PharmGKB summary: lamotrigine pathway, pharmacokinetics and pharmacodynamics by Mitra-Ghosh, Taraswi, Callisto, Samuel P., Lamba, Jatinder K., Remmel, Rory P., Birnbaum, Angela K., Barbarino, Julia M., Klein, Teri E., Altman, Russ B.

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Relative Bioavailability of Lamotrigine Chewable Dispersible Tablets Administered Rectally by Birnbaum, Angela K., Kriel, Robert L., Im, Yoonsun, Remmel, Rory P.

“…Study Objective. To determine the relative bioavailability of lamotrigine (LTG) chewable dispersible tablets after rectal administration. Design. Two‐period,…”
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Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception by Laughlin, Tinna M, Tram, Kevin V, Wilcox, George L, Birnbaum, Angela K

“…Some antiepileptic drugs have been shown to be clinically effective in the treatment of neuropathic pain. This study determined whether the new antiepileptic…”
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μ-Opioid receptor regulates CFTR coexpressed in Xenopus oocytes in a cAMP independent manner by Wotta, Diane R, Birnbaum, Angela K, Wilcox, George L, Elde, Robert, Law, Ping-Yee

“…The objective of this study was to characterize the signaling mechanisms of the μ-opioid receptor in its coupling to the cystic fibrosis transmembrane…”
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PII-65 by Marino, S. E., Cloyd, J. C., Brundage, R. C., Birnbaum, A. K., Conway, J. M., Musib, L. C., Ramsay, R. E., Pennell, P. B., White, J. R., Leppik, I. E., Rarick, J. O., Mishra, U. R., Beattie, J.

“…BACKGROUND Carbamazepine (CBZ) is among the most widely prescribed antiepileptic drugs. There are no reports describing the absolute bioavailability,…”
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LBOVI-B-1 by Clark, A. M., Cloyd, J. C., Leppik, I. E., Marino, S. E., Birnbaum, A. K., Gross, C. R., Conway, J. M., Ramsay, R. E., Pennell, P. B., Exconde, R. E., White, J. R., Rarick, J. O., Brundage, R. C., Beattie, J.

“…BACKGROUND Carbamazepine (CBZ) disposition has been extensively investigated, but CBZ protein binding (PB) is not well characterized. As part of a CBZ…”
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Inherent correlation between dose and clearance in therapeutic drug monitoring settings: possible misinterpretation in population pharmacokinetic analyses by Ahn, Jae Eun, Birnbaum, Angela K, Brundage, Richard C

“…During the course of therapeutic drug monitoring (TDM), doses are adjusted to attain a target concentration range and a correlation between clearance (CL) and…”
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Steady-state Carbamazepine Pharmacokinetics following Oral and Stable-Labeled Intravenous Administration in Epilepsy Patients: Effect of Race and Sex by Marino, SE, Birnbaum, AK, Leppik, IE, Conway, JM, Musib, LC, Brundage, RC, Ramsay, RE, Pennell, PB, White, JR, Gross, CR, Rarick, JO, Mishra, U, Cloyd, JC

“…Carbamazepine is a widely prescribed antiepileptic drug. Due to a lack of an intravenous formulation, its absolute bioavailability, absolute clearance, and…”
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