Search Results - "BIRKE, F. W"

Inhibition of a store‐operated Ca2+ entry pathway in human endothelial cells by the isoquinoline derivative LOE 908 by Encabo, A., Romanin, C., Birke, F.W., Kukovetz, W.R., Groschner, Klaus

“…1 The novel cation channel blocker, LOE 908, was tested for its effects on Ca2+ entry and membrane currents activated by depletion of intracellular Ca2+ stores…”
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Inhibition of human HL-60 cell responses to chemotactic factors by antisense messenger RNA depletion of G proteins by Goetzl, E J, Shames, R S, Yang, J, Birke, F W, Liu, Y F, Albert, P R, An, S

“…Chemotactic factors bound to receptors of the seven-transmembrane domain family signal leukocytes through associated guanine nucleotide-binding (G) proteins…”
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Inhibition by the PAF antagonist WEB 2086 of PAF induced inositol‐1,4,5‐trisphosphate production in human platelets by Birke, F. W., Ensinger, H. A.

“…Platelet‐activating factor (PAF) activates human platelets by binding to a putative PAF receptor which evokes the rapid formation of…”
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Radioligand binding of antagonists of platelet-activating factor to intact human platelets by Ukena, Dieter, Dent, Gordon, Birke, Frank W., Robaut, Christine, Sybrecht, Gerhard W., Barnes, Peter J.

“…Two new antagonists of platelet-activating factor (PAF), the pyrrolothiazole derivative 52770 RP and the triazolodiazepine WEB 2086, have been studied as…”
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Pharmacodynamics, pharmacokinetics and safety profile of the new platelet-activating factor antagonist apafant in man by Brecht, H M, Adamus, W S, Heuer, H O, Birke, F W, Kempe, E R

“…Platelet-activating factor (PAF) is a unique phospholipid mediator with multifunctional properties. Evidence generated in experimental studies suggests that…”
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Preparation of tritium-labelled BIIL 260 of high specific radioactivity by Shevchenko, V.P., Nagaev, I.Yu, Myasoedov, N.F., Susan, A.B., Anderskewitz, R., Birke, F.W., Switek, K-H.

“…Various approaches to the synthesis of tritium‐labelled BIIL 260 with high specific radioactivity were investigated. Attempts to incorporate tritium directly…”
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Metabolism of naphthalene to naphthalene dihydrodiol glucuronide in isolated hepatocytes and in liver microsomes by Bock, K W, van Ackeren, G, Lorch, F, Birke, F W

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In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist by Birke, F W, Meade, C J, Anderskewitz, R, Speck, G A, Jennewein, H M

“…BIIL 284 is a new LTB(4) receptor antagonist. It is a prodrug and has negligible binding to the LTB(4) receptor. However, ubiquitous esterases metabolize BIIL…”
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Pyrrolidinohydroquinazolines––a novel class of CCR3 modulators by Anderskewitz, Ralf, Bauer, Rolf, Bodenbach, Gisela, Gester, Dirk, Gramlich, Bernd, Morschhäuser, Gerd, Birke, Franz W.

“…A novel class of CCR3 modulators is described. Optimization led to compound 8b ( K i: 28 nM), which surprisingly proved to be an agonist. A novel class of CCR3…”
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Specific inhibition of receptor-dependent human cellular responses by antisense mRNA depletion of individual G-proteins by Goetzl, E J, Kishiyama, J L, Shames, R S, Liu, Y F, Albert, P R, An, S, Birke, F W, Yang, J, Sreedharan, S P

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10 th Conference of the Central European Division e.V. of the International Isotope Society by Jones, J R, Lu, S‐Y, Shevchenko, V. P., Nagaev, I. Yu, Myasoedov, N. F., Susan, A. B., Anderskerskevitz, R., Birke, F. W., Switek, K‐H., Wiegerinck, Peter, Post, Olaf, Hofstede, Leontine, van den Heuvel, Marcel, Pleiss, U., Seidel, D., Switek, K.‐H., Braunger, H., Seidel, Dietrich, Schlecker, Rainer, Moenius, Thomas, Seiler, Max‐Peter, Nozulak, Joachim, Burtscher, Paul, Almi, Mario, Guelfi, Simone, Navacchia, Maria Luisa, Felicini, C., Giribone, D., Pignatti, A., Fontana, E., McGrath, J. W., Peric Simov, B., Preusser, W., Quinn, J. P., Schmidt, S., Woschek, A., Wuggenig, F., Hammerschmidt, F., Spies, H., Maas, Jochen, Krone, Volker, Diehl, Frank, Coy, Johannes, Hoheisel, Jörg, Doeberitz, Magnus von Knebel, Nees, Matthias, Klett, Alfred

“…Abstract Use of Microwaves in Organic Synthesis: Application in the Synthesis of Isotopically Labelled Compounds Preparation of Tritium‐Labelled BIIL 260 with…”
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10th Conference of the Central European Division e.V. of the International Isotope Society by Jones, J R, Lu, S-Y, Shevchenko, V. P., Nagaev, I. Yu, Myasoedov, N. F., Susan, A. B., Anderskerskevitz, R., Birke, F. W., Switek, K-H., Wiegerinck, Peter, Post, Olaf, Hofstede, Leontine, van den Heuvel, Marcel, Pleiss, U., Seidel, D., Switek, K.-H., Braunger, H., Seidel, Dietrich, Schlecker, Rainer, Moenius, Thomas, Seiler, Max-Peter, Nozulak, Joachim, Burtscher, Paul, Almi, Mario, Guelfi, Simone, Navacchia, Maria Luisa, Felicini, C., Giribone, D., Pignatti, A., Fontana, E., Pignatti, A., Fontana, E., McGrath, J. W., Peric Simov, B., Preusser, W., Quinn, J. P., Schmidt, S., Woschek, A., Wuggenig, F., Hammerschmidt, F., Spies, H., Maas, Jochen, Krone, Volker, Diehl, Frank, Coy, Johannes, Hoheisel, Jörg, Doeberitz, Magnus von Knebel, Nees, Matthias, Klett, Alfred

“…Use of Microwaves in Organic Synthesis: Application in the Synthesis of Isotopically Labelled Compounds Preparation of Tritium‐Labelled BIIL 260 with High…”
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WAL 2014 FU (Talsaclidine) : A preferentially neuron activating muscarinic agonist for the treatment of Alzheimer's disease: Challenges and opportunities for developing muscarinic receptor subtype-based therapeutic agents by ENSINGER, H. A, BECHTEL, W.-D, BIRKE, F. W, MENDLA, K. D, MIERAU, J, SPECK, G, TRÖGER, W

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Preparation of tritium-labelled BIIL 260 of high specific radioactivity by SHEVCHENKO, V. P, NAGAEV, I. Yu, MYASOEDOV, N. F, SUSAN, A. B, ANDERSKEWITZ, R, BIRKE, F. W, SWITEK, K-H

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WAL 2014 FU (talsaclidine): A preferentially neuron activating muscarinic agonist for the treatment of Alzheimer's disease by Ensinger, Helmut A., Bechtel, Wolf-Dieter, Birke, Franz W., Mendla, Klaus D., Mierau, Joachim, Speck, Georg, Tröger, Wolfgang

“…The functional selectivity of WAL 2014 FU with regard to stimulation of the neuronal muscarinic M1 receptor subtype in vitro and in vivo is shown in different…”
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