Search Results - "BIRBE, Ruth"

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts by Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Ertel, Adam, Flomenberg, Neal, Witkiewicz, Agnieszka K., Birbe, Ruth, Howell, Anthony, Pavlides, Stephanos, Gandara, Ricardo, Pestell, Richard G., Sotgia, Federica, Philp, Nancy J., Lisanti, Michael P

“…Recently, we proposed a new mechanism for understanding the Warburg effect in cancer metabolism. In this new paradigm, cancer-associated fibroblasts undergo…”
Get full text

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue by Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E., Flomenberg, Neal, Birbe, Ruth, Witkiewicz, Agnieszka K., Howell, Anthony, Pavlides, Stephanos, Tsirigos, Aristotelis, Ertel, Adam, Pestell, Richard G., Broda, Paolo, Minetti, Carlo, Lisanti, Michael P., Sotgia, Federica

“…We have recently proposed a new mechanism for explaining energy transfer in cancer metabolism.  In this scenario, cancer cells behave as metabolic parasites,…”
Get full text

Mitochondrial metabolism in cancer metastasis: Visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue by Sotgia, Federica, Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E., Flomenberg, Neal, Birbe, Ruth, Witkiewicz, Agnieszka K., Howell, Anthony, Philp, Nancy J., Pestell, Richard G., Lisanti, Michael P.

“…We have recently proposed a new two-compartment model for understanding the Warburg effect in tumor metabolism. In this model, glycolytic stromal cells produce…”
Get full text

Genomic Prostate Cancer Classifier Predicts Biochemical Failure and Metastases in Patients After Postoperative Radiation Therapy by Den, Robert B., MD, Feng, Felix Y., MD, Showalter, Timothy N., MD, Mishra, Mark V., MD, Trabulsi, Edouard J., MD, Lallas, Costas D., MD, Gomella, Leonard G., MD, Kelly, W. Kevin, DO, Birbe, Ruth C., MD, McCue, Peter A., MD, Ghadessi, Mercedeh, MSc, Yousefi, Kasra, MSc, Davicioni, Elai, PhD, Knudsen, Karen E., PhD, Dicker, Adam P., MD, PhD

“…Purpose To test the hypothesis that a genomic classifier (GC) would predict biochemical failure (BF) and distant metastasis (DM) in men receiving radiation…”
Get full text

RB Loss Promotes Prostate Cancer Metastasis by Thangavel, Chellappagounder, Boopathi, Ettickan, Liu, Yi, Haber, Alex, Ertel, Adam, Bhardwaj, Anshul, Addya, Sankar, Williams, Noelle, Ciment, Stephen J, Cotzia, Paolo, Dean, Jeffry L, Snook, Adam, McNair, Chris, Price, Matt, Hernandez, James R, Zhao, Shuang G, Birbe, Ruth, McCarthy, James B, Turley, Eva A, Pienta, Kenneth J, Feng, Felix Y, Dicker, Adam P, Knudsen, Karen E, Den, Robert B

“…RB loss occurs commonly in neoplasia but its contributions to advanced cancer have not been assessed directly. Here we show that RB loss in multiple murine…”
Get full text

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth by Chiavarina, Barbara, Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E., Witkiewicz, Agnieszka K., Birbe, Ruth, Howell, Anthony, Pestell, Richard G., Smith, Johanna, Daniel, Rene, Sotgia, Federica, Lisanti, Michael P.

“…We have previously demonstrated that enhanced aerobic glycolysis and/or autophagy in the tumor stroma supports epithelial cancer cell growth and aggressive…”
Get full text

Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism: In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism by Ertel, Adam, Tsirigos, Aristotelis, Whitaker-Menezes, Diana, Birbe, Ruth, Pavlides, Stephanos, Martinez-Outschoorn, Ubaldo E., Pestell, Richard G., Howell, Anthony, Sotgia, Federica, Lisanti, Michael P.

“…Aging drives large systemic reductions in oxidative mitochondrial function, shifting the entire body metabolically towards aerobic glycolysis, a.k.a, the…”
Get full text

TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer by Ko, Ying-Hui, Domingo-Vidal, Marina, Roche, Megan, Lin, Zhao, Whitaker-Menezes, Diana, Seifert, Erin, Capparelli, Claudia, Tuluc, Madalina, Birbe, Ruth C., Tassone, Patrick, Curry, Joseph M., Navarro-Sabaté, Àurea, Manzano, Anna, Bartrons, Ramon, Caro, Jaime, Martinez-Outschoorn, Ubaldo

“…A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly…”
Get full text

TP53 Induced Glycolysis and Apoptosis Regulator and Monocarboxylate Transporter 4 drive metabolic reprogramming with c-MYC and NFkB activation in breast cancer by Roche, Megan E, Ko, Ying-Hui, Domingo-Vidal, Marina, Lin, Zhao, Whitaker-Menezes, Diana, Birbe, Ruth C, Tuluc, Madalina, Győrffy, Balázs, Caro, Jaime, Philp, Nancy J, Bartrons, Ramon, Martinez-Outschoorn, Ubaldo

“…Breast cancer is composed of metabolically coupled cellular compartments with upregulation of TP53 Induced Glycolysis and Apoptosis Regulator (TIGAR) in…”
Get full text

USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression by SCHRECENGOST, Randy S, DEAN, Jeffry L, VISAKORPI, Tapio, DEMARZO, Angelo M, MCMAHON, Steven B, KNUDSEN, Karen E, GOODWIN, Jonathan F, SCHIEWER, Matthew J, URBAN, Mark W, STANEK, Timothy J, SUSSMAN, Robyn T, HICKS, Jessica L, BIRBE, Ruth C, DRAGANOVA-TACHEVA, Rossitza A

“…Increasing evidence links deregulation of the ubiquitin-specific proteases 22 (USP22) deubitiquitylase to cancer development and progression in a select group…”
Get full text

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis by Goodwin, Jonathan F., Kothari, Vishal, Drake, Justin M., Zhao, Shuang, Dylgjeri, Emanuela, Dean, Jeffry L., Schiewer, Matthew J., McNair, Christopher, Jones, Jennifer K., Aytes, Alvaro, Magee, Michael S., Snook, Adam E., Zhu, Ziqi, Den, Robert B., Birbe, Ruth C., Gomella, Leonard G., Graham, Nicholas A., Vashisht, Ajay A., Wohlschlegel, James A., Graeber, Thomas G., Karnes, R. Jeffrey, Takhar, Mandeep, Davicioni, Elai, Tomlins, Scott A., Abate-Shen, Cory, Sharifi, Nima, Witte, Owen N., Feng, Felix Y., Knudsen, Karen E.

“…Emerging evidence demonstrates that the DNA repair kinase DNA-PKcs exerts divergent roles in transcriptional regulation of unsolved consequence. Here, in vitro…”
Get full text

Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer by Thangavel, Chellappagounder, Boopathi, Ettickan, Liu, Yi, McNair, Christopher, Haber, Alex, Perepelyuk, Maryna, Bhardwaj, Anshul, Addya, Sankar, Ertel, Adam, Shoyele, Sunday, Birbe, Ruth, Salvino, Joseph M, Dicker, Adam P, Knudsen, Karen E, Den, Robert B

“…The retinoblastoma tumor suppressor (RB), a key regulator of cell-cycle progression and proliferation, is functionally suppressed in up to 50% of non-small…”
Get full text

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production by Capparelli, Claudia, Guido, Carmela, Whitaker-Menezes, Diana, Bonuccelli, Gloria, Balliet, Renee, Pestell, Timothy G., Goldberg, Allison F., Pestell, Richard G., Howell, Anthony, Sneddon, Sharon, Birbe, Ruth, Tsirigos, Aristotelis, Martinez-Outschoorn, Ubaldo, Sotgia, Federica, Lisanti, Michael P.

“…Senescent fibroblasts are known to promote tumor growth. However, the exact mechanism remains largely unknown. An important clue comes from recent studies…”
Get full text

Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis by Castello-Cros, Remedios, Bonnuccelli, Gloria, Molchansky, Alex, Capozza, Franco, Witkiewicz, Agnieszka K., Birbe, Ruth, Howell, Anthony, Pestell, Richard G., Whitaker-Menezes, Diana, Sotgia, Federica, Lisanti, Michael P

“…We have previously demonstrated that loss of stromal caveolin-1 (Cav-1) in cancer-associated fibroblasts is a strong and independent predictor of poor clinical…”
Get full text

Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial by Curry, Joseph, Johnson, Jennifer, Tassone, Patrick, Vidal, Marina Domingo, Menezes, Diana Whitaker, Sprandio, John, Mollaee, Mehri, Cotzia, Paolo, Birbe, Ruth, Lin, Zhao, Gill, Kurren, Duddy, Elizabeth, Zhan, Tingting, Leiby, Benjamin, Reyzer, Michelle, Cognetti, David, Luginbuhl, Adam, Tuluc, Madalina, Martinez‐Outschoorn, Ubaldo

“…Objective The tumor microenvironment frequently displays abnormal cellular metabolism, which contributes to aggressive behavior. Metformin inhibits…”
Get full text

BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: Implications for breast cancer prevention with antioxidant therapies by Martinez-Outschoorn, Ubaldo E., Balliet, Renee, Lin, Zhao, Whitaker-Menezes, Diana, Birbe, Ruth C., Bombonati, Alessandro, Pavlides, Stephanos, Lamb, Rebecca, Sneddon, Sharon, Howell, Anthony, Sotgia, Federica, Lisanti, Michael P.

“…Mutations in the BRCA1 tumor suppressor gene are commonly found in hereditary breast cancer. Similarly, downregulation of BRCA1 protein expression is observed…”
Get full text

Epidermoid cyst: An unusual presentation of a testicular mass by Stemberger, Andrew, Zeffren, Marc, Birbe, Ruth, Tan, Wei Phin

Get full text

Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4 by Martinez-Outschoorn, Ubaldo E, Curry, Joseph M, Ko, Ying-Hui, Lin, Zhao, Tuluc, Madalina, Cognetti, David, Birbe, Ruth C, Pribitkin, Edmund, Bombonati, Alessandro, Pestell, Richard G, Howell, Anthony, Sotgia, Federica, Lisanti, Michael P

“…Here, we developed a model system to evaluate the metabolic effects of oncogene(s) on the host microenvironment. A matched set of "normal" and oncogenically…”
Get full text

MCT1 in Invasive Ductal Carcinoma: Monocarboxylate Metabolism and Aggressive Breast Cancer by Johnson, Jennifer M, Cotzia, Paolo, Fratamico, Roberto, Mikkilineni, Lekha, Chen, Jason, Colombo, Daniele, Mollaee, Mehri, Whitaker-Menezes, Diana, Domingo-Vidal, Marina, Lin, Zhao, Zhan, Tingting, Tuluc, Madalina, Palazzo, Juan, Birbe, Ruth C, Martinez-Outschoorn, Ubaldo E

“…Monocarboxylate transporter 1 (MCT1) is an importer of monocarboxylates such as lactate and pyruvate and a marker of mitochondrial metabolism. MCT1 is highly…”
Get full text

Parathyroid Hormone-Related Peptide–Linked Hypercalcemia in a Melanoma Patient Treated With Ipilimumab: Hormone Source and Clinical and Metabolic Correlates by Mills, Teresa Anne, Orloff, Marlana, Domingo-Vidal, Marina, Cotzia, Paolo, Birbe, Ruth C, Draganova-Tacheva, Rossitza, Martinez Cantarin, Maria P, Tuluc, Madalina, Martinez-Outschoorn, Ubaldo

“…A patient diagnosed with metastatic melanoma developed the paraneoplastic syndrome of humoral hypercalcemia of malignancy and cachexia after receiving…”
Get full text