Search Results - "BINDON, C. I"

Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies by BRUGGEMANN, M, WILLIAMS, G. T, BINDON, C. I, CLARK, M. R, WALKER, M. R, JEFFERIS, R, WALDMANN, H, NEUBERGER, M. S

“…Cell lines have been established that secrete a matched set of human chimeric IgM, IgG1, IgG2, IgG3, IgG4, IgE, and IgA2 antibodies that are directed against…”
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Importance of antigen specificity for complement-mediated lysis by monoclonal antibodies by Bindon, C I, Hale, G, Waldmann, H

“…Lysis of human lymphocytes by autologous complement had been studied using a range of monoclonal antibodies against different antigens. Antigen specificity…”
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Complement activation by immunoglobulin does not depend solely on C1q binding by Bindon, C I, Hale, G, Waldmann, H

“…A matched set of rat chimeric antibodies has been studied for their ability to activate various key stages of the complement cascade. Rat IgM and IgG2b were…”
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Therapeutic potential of monoclonal antibodies to the leukocyte-common antigen. Synergy and interference in complement-mediated lysis by Bindon, C I, Hale, G, Clark, M, Waldmann, H

“…A series of rat monoclonal antibodies against the human leukocyte-common antigen were isolated and, by means of competitive binding assays with purified…”
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Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q by BINDON, C. I, HALE, G, BRÜGGEMANN, M, WALDMANN, H

“…Humanized antibodies are likely to have a major role in therapy and it is important to define their interaction with physiological effectors. By comparing a…”
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Synergistic complement lysis by monoclonal antibodies to the human leukocyte common antigen requires both the classical and alternative pathways by Bindon, C I, Hale, G, Hughes-Jones, N, Gorick, B, Waldmann, H

“…In a previous study we isolated a series of rat monoclonal antibodies to the human leukocyte common (LC) antigen and demonstrated that synergistic complement…”
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