Search Results - "BINDOLI, ALBERTO"

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs by Bindoli, Alberto, Rigobello, Maria Pia, Scutari, Guido, Gabbiani, Chiara, Casini, Angela, Messori, Luigi

“…The thioredoxin system plays a key role in regulating the overall intracellular redox balance. It basically comprises the small redox protein thioredoxin…”
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Milk-derived bioactive peptides exhibit antioxidant activity through the Keap1-Nrf2 signaling pathway by Tonolo, Federica, Folda, Alessandra, Cesaro, Luca, Scalcon, Valeria, Marin, Oriano, Ferro, Stefania, Bindoli, Alberto, Rigobello, Maria Pia

“…[Display omitted] •Milk-derived bioactive peptides inhibit lipid peroxidation in Caco-2 cells.•Antioxidant effect of bioactive peptides is exerted activating…”
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Nrf2-Activating Bioactive Peptides Exert Anti-Inflammatory Activity through Inhibition of the NF-κB Pathway by Tonolo, Federica, Folda, Alessandra, Scalcon, Valeria, Marin, Oriano, Bindoli, Alberto, Rigobello, Maria Pia

“…Redox status and inflammation are related to the pathogenesis of the majority of diseases. Therefore, understanding the role of specific food-derived molecules…”
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Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells by Marzano, Christine, Gandin, Valentina, Folda, Alessandra, Scutari, Guido, Bindoli, Alberto, Rigobello, Maria Pia

“…Cisplatin is an effective antitumor agent for the treatment of several carcinomas. However, the development of resistance to cisplatin represents a serious…”
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Thiol chemistry in peroxidase catalysis and redox signaling by Bindoli, Alberto, Fukuto, Jon M, Forman, Henry Jay

“…The oxidation chemistry of thiols and disulfides of biologic relevance is described. The review focuses on the interaction and kinetics of hydrogen peroxide…”
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From In Silico to a Cellular Model: Molecular Docking Approach to Evaluate Antioxidant Bioactive Peptides by Tonolo, Federica, Grinzato, Alessandro, Bindoli, Alberto, Rigobello, Maria Pia

“…The increasing need to counteract the redox imbalance in chronic diseases leads to focusing research on compounds with antioxidant activity. Among natural…”
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Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds by Casini, Angela, Gabbiani, Chiara, Sorrentino, Francesca, Rigobello, Maria Pia, Bindoli, Alberto, Geldbach, Tilmann J, Marrone, Alessandro, Re, Nazzareno, Hartinger, Christian G, Dyson, Paul J, Messori, Luigi

“…A series of ruthenium(II)−arene (RAPTA) compounds were evaluated for their ability to inhibit thioredoxin reductase (either cytosolic or mitochondrial) and…”
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Identification of New Peptides from Fermented Milk Showing Antioxidant Properties: Mechanism of Action by Tonolo, Federica, Fiorese, Federico, Moretto, Laura, Folda, Alessandra, Scalcon, Valeria, Grinzato, Alessandro, Ferro, Stefania, Arrigoni, Giorgio, Bindoli, Alberto, Feller, Emiliano, Bellamio, Marco, Marin, Oriano, Rigobello, Maria Pia

“…Due to their beneficial properties, fermented foods are considered important constituents of the human diet. They also contain bioactive peptides,…”
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Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State by Folda, Alessandra, Citta, Anna, Scalcon, Valeria, Calì, Tito, Zonta, Francesco, Scutari, Guido, Bindoli, Alberto, Rigobello, Maria Pia

“…The mitochondrial thioredoxin system (NADPH, thioredoxin reductase, thioredoxin) is a major redox regulator. Here we have investigated the redox correlation…”
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Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase by Gandin, Valentina, Fernandes, Aristi Potamitou, Rigobello, Maria Pia, Dani, Barbara, Sorrentino, Francesca, Tisato, Francesco, Björnstedt, Mikael, Bindoli, Alberto, Sturaro, Alberto, Rella, Rocco, Marzano, Cristina

“…The thioredoxin system, composed of thioredoxin reductase (TrxR), thioredoxin (Trx), and NADPH (nicotinamide adenine dinucleotide phosphate), plays a central…”
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Fermented Soy-Derived Bioactive Peptides Selected by a Molecular Docking Approach Show Antioxidant Properties Involving the Keap1/Nrf2 Pathway by Tonolo, Federica, Moretto, Laura, Grinzato, Alessandro, Fiorese, Federico, Folda, Alessandra, Scalcon, Valeria, Ferro, Stefania, Arrigoni, Giorgio, Bellamio, Marco, Feller, Emiliano, Bindoli, Alberto, Marin, Oriano, Rigobello, Maria Pia

“…Bioactive peptides are a group of molecules with health beneficial properties, deriving from food matrices. They are protein fragments consisting of 2-20 amino…”
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Mitochondrial depletion of glutaredoxin 2 induces metabolic dysfunction-associated fatty liver disease in mice by Scalcon, Valeria, Folda, Alessandra, Lupo, Maria Giovanna, Tonolo, Federica, Pei, Naixuan, Battisti, Ilaria, Ferri, Nicola, Arrigoni, Giorgio, Bindoli, Alberto, Holmgren, Arne, Coppo, Lucia, Rigobello, Maria Pia

“…Glutaredoxin 2 (Grx2) is a glutathione-dependent oxidoreductase that facilitates glutathionylation/de-glutathionylation of target proteins. The main variants…”
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Dimers of glutaredoxin 2 as mitochondrial redox sensors in selenite-induced oxidative stress by Scalcon, Valeria, Tonolo, Federica, Folda, Alessandra, Bindoli, Alberto, Rigobello, Maria Pia

“…Glutaredoxin 2 (Grx2) has been previously shown to link thioredoxin and glutathione systems receiving reducing equivalents by both thioredoxin reductase and…”
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Comparative analysis of the antioxidant capacity and lipid and protein oxidation of soy and oats beverages by Moretto, Laura, Tonolo, Federica, Folda, Alessandra, Scalcon, Valeria, Bindoli, Alberto, Bellamio, Marco, Feller, Emiliano, Rigobello, Maria Pia

“…Abstract Soy ( Glycine max) and oats ( Avena sativa ) are plant sources used in milk-alternative beverages. However, protein and lipid constituents of these…”
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Mitochondrial thioredoxin reductase inhibition by gold(I) compounds and concurrent stimulation of permeability transition and release of cytochrome c by Rigobello, Maria Pia, Scutari, Guido, Folda, Alessandra, Bindoli, Alberto

“…The effects of auranofin, chloro(triethylphosphine)gold(I) (TEPAu), and aurothiomalate on mitochondrial respiration, pyridine nucleotide redox state, membrane…”
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Induction of mitochondrial permeability transition by auranofin, a Gold(I)‐phosphine derivative by Rigobello, Maria Pia, Scutari, Guido, Boscolo, Rita, Bindoli, Alberto

“…Gold(I)‐thiolate drugs are compounds that specifically interact with thiol and/or selenol groups and are essentially utilized in the treatment of rheumatoid…”
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Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions by Pia Rigobello, Maria, Messori, Luigi, Marcon, Giordana, Agostina Cinellu, Maria, Bragadin, Marcantonio, Folda, Alessandra, Scutari, Guido, Bindoli, Alberto

“…The effects of gold(I) complexes (auranofin, triethylphosphine gold and aurothiomalate), gold(III) complexes ([Au(2,2 ′-diethylendiamine)Cl]Cl 2,…”
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Significance of the mitochondrial thioredoxin reductase in cancer cells: An update on role, targets and inhibitors by Scalcon, Valeria, Bindoli, Alberto, Rigobello, Maria Pia

“…Thioredoxin reductase 2 (TrxR2) is a key component of the mitochondrial thioredoxin system able to transfer electrons to peroxiredoxin 3 (Prx3) in a reaction…”
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Principles in redox signaling: from chemistry to functional significance by Bindoli, Alberto, Rigobello, Maria Pia

“…Reactive oxygen and nitrogen species are currently considered not only harmful byproducts of aerobic respiration but also critical mediators of redox…”
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Biochemical and toxicological properties of the oxidation products of catecholamines by Bindoli, A, Rigobello, M P, Deeble, D J

“…The normal catabolism of catecholamines proceeds through enzymatic pathways (monoaminooxidase, catechol-o-methyltranserase, and phenolsulphotransferase). In…”
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