Search Results - "BILLER, A"

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis by Marjon, Katya, Cameron, Michael J., Quang, Phong, Clasquin, Michelle F., Mandley, Everton, Kunii, Kaiko, McVay, Michael, Choe, Sung, Kernytsky, Andrew, Gross, Stefan, Konteatis, Zenon, Murtie, Joshua, Blake, Michelle L., Travins, Jeremy, Dorsch, Marion, Biller, Scott A., Marks, Kevin M.

“…Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine…”
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Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation by Wang, Fang, Travins, Jeremy, DeLaBarre, Byron, Penard-Lacronique, Virginie, Schalm, Stefanie, Hansen, Erica, Straley, Kimberly, Kernytsky, Andrew, Liu, Wei, Gliser, Camelia, Yang, Hua, Gross, Stefan, Artin, Erin, Saada, Veronique, Mylonas, Elena, Quivoron, Cyril, Popovici-Muller, Janeta, Saunders, Jeffrey O., Salituro, Francesco G., Yan, Shunqi, Murray, Stuart, Wei, Wentao, Gao, Yi, Dang, Lenny, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., de Botton, Stephane, Yen, Katharine E.

“…A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter…”
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MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage by Kalev, Peter, Hyer, Marc L., Gross, Stefan, Konteatis, Zenon, Chen, Chi-Chao, Fletcher, Mark, Lein, Max, Aguado-Fraile, Elia, Frank, Victoria, Barnett, Amelia, Mandley, Everton, Goldford, Joshua, Chen, Yue, Sellers, Katie, Hayes, Sebastian, Lizotte, Kate, Quang, Phong, Tuncay, Yesim, Clasquin, Michelle, Peters, Rachel, Weier, Jaclyn, Simone, Eric, Murtie, Joshua, Liu, Wei, Nagaraja, Raj, Dang, Lenny, Sui, Zhihua, Biller, Scott A., Travins, Jeremy, Marks, Kevin M., Marjon, Katya

“…The methylthioadenosine phosphorylase (MTAP) gene is located adjacent to the cyclin-dependent kinase inhibitor 2A (CDKN2A) tumor-suppressor gene and is…”
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An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells by Rohle, Dan, Popovici-Muller, Janeta, Palaskas, Nicolaos, Turcan, Sevin, Grommes, Christian, Campos, Carl, Tsoi, Jennifer, Clark, Owen, Oldrini, Barbara, Komisopoulou, Evangelia, Kunii, Kaiko, Pedraza, Alicia, Schalm, Stefanie, Silverman, Lee, Miller, Alexandra, Wang, Fang, Yang, Hua, Chen, Yue, Kernytsky, Andrew, Rosenblum, Marc K., Liu, Wei, Biller, Scott A., Su, Shinsan M., Brennan, Cameron W., Chan, Timothy A., Graeber, Thomas G., Yen, Katharine E., Mellinghoff, Ingo K.

“…The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. One…”
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AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations by Yen, Katharine, Travins, Jeremy, Wang, Fang, David, Muriel D, Artin, Erin, Straley, Kimberly, Padyana, Anil, Gross, Stefan, DeLaBarre, Byron, Tobin, Erica, Chen, Yue, Nagaraja, Raj, Choe, Sung, Jin, Lei, Konteatis, Zenon, Cianchetta, Giovanni, Saunders, Jeffrey O, Salituro, Francesco G, Quivoron, Cyril, Opolon, Paule, Bawa, Olivia, Saada, Véronique, Paci, Angelo, Broutin, Sophie, Bernard, Olivier A, de Botton, Stéphane, Marteyn, Benoît S, Pilichowska, Monika, Xu, YingXia, Fang, Cheng, Jiang, Fan, Wei, Wentao, Jin, Shengfang, Silverman, Lee, Liu, Wei, Yang, Hua, Dang, Lenny, Dorsch, Marion, Penard-Lacronique, Virginie, Biller, Scott A, Su, Shin-San Michael

“…Somatic gain-of-function mutations in isocitrate dehydrogenases ( ) 1 and 2 are found in multiple hematologic and solid tumors, leading to accumulation of the…”
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Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations by Intlekofer, Andrew M., Shih, Alan H., Wang, Bo, Nazir, Abbas, Rustenburg, Ariën S., Albanese, Steven K., Patel, Minal, Famulare, Christopher, Correa, Fabian M., Takemoto, Naofumi, Durani, Vidushi, Liu, Hui, Taylor, Justin, Farnoud, Noushin, Papaemmanuil, Elli, Cross, Justin R., Tallman, Martin S., Arcila, Maria E., Roshal, Mikhail, Petsko, Gregory A., Wu, Bin, Choe, Sung, Konteatis, Zenon D., Biller, Scott A., Chodera, John D., Thompson, Craig B., Levine, Ross L., Stein, Eytan M.

“…Somatic mutations in the isocitrate dehydrogenase 2 gene ( IDH2 ) contribute to the pathogenesis of acute myeloid leukaemia (AML) through the production of the…”
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Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase by Padyana, Anil K., Gross, Stefan, Jin, Lei, Cianchetta, Giovanni, Narayanaswamy, Rohini, Wang, Feng, Wang, Rui, Fang, Cheng, Lv, Xiaobing, Biller, Scott A., Dang, Lenny, Mahoney, Christopher E., Nagaraja, Nelamangala, Pirman, David, Sui, Zhihua, Popovici-Muller, Janeta, Smolen, Gromoslaw A.

“…Squalene epoxidase (SQLE), also known as squalene monooxygenase, catalyzes the stereospecific conversion of squalene to 2,3( S )-oxidosqualene, a key step in…”
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IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition by Kernytsky, Andrew, Wang, Fang, Hansen, Erica, Schalm, Stefanie, Straley, Kimberly, Gliser, Camelia, Yang, Hua, Travins, Jeremy, Murray, Stuart, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., Liu, Wei, Yen, Katharine E.

“…Mutations of IDH1 and IDH2, which produce the oncometabolite 2-hydroxyglutarate (2HG), have been identified in several tumors, including acute myeloid…”
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Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats by SONGPING HAN, HAGAN, Deborah L, TAYLOR, Joseph R, LI XIN, WEI MENG, BILLER, Scott A, WETTERAU, John R, WASHBURN, William N, WHALEY, Jean M

“…Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats Songping Han 1 , Deborah L. Hagan 1 , Joseph R. Taylor 1 ,…”
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Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma by Konteatis, Zenon, Artin, Erin, Nicolay, Brandon, Straley, Kimberly, Padyana, Anil K, Jin, Lei, Chen, Yue, Narayaraswamy, Rohini, Tong, Shuilong, Wang, Feng, Zhou, Ding, Cui, Dawei, Cai, Zhenwei, Luo, Zhiyong, Fang, Cheng, Tang, Huachun, Lv, Xiaobing, Nagaraja, Raj, Yang, Hua, Su, Shin-San M, Sui, Zhihua, Dang, Lenny, Yen, Katharine, Popovici-Muller, Janeta, Codega, Paolo, Campos, Carl, Mellinghoff, Ingo K, Biller, Scott A

“…Inhibitors of mutant isocitrate dehydrogenase (mIDH) 1 and 2 cancer-associated enzymes prevent the accumulation of the oncometabolite d-2-hydroxyglutarate…”
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A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition by Mahoney, Christopher E., Pirman, David, Chubukov, Victor, Sleger, Taryn, Hayes, Sebastian, Fan, Zi Peng, Allen, Eric L., Chen, Ying, Huang, Lingling, Liu, Meina, Zhang, Yingjia, McDonald, Gabrielle, Narayanaswamy, Rohini, Choe, Sung, Chen, Yue, Gross, Stefan, Cianchetta, Giovanni, Padyana, Anil K., Murray, Stuart, Liu, Wei, Marks, Kevin M., Murtie, Joshua, Dorsch, Marion, Jin, Shengfang, Nagaraja, Nelamangala, Biller, Scott A., Roddy, Thomas, Popovici-Muller, Janeta, Smolen, Gromoslaw A.

“…Aberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging…”
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Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes by Meng, Wei, Ellsworth, Bruce A, Nirschl, Alexandra A, McCann, Peggy J, Patel, Manorama, Girotra, Ravindar N, Wu, Gang, Sher, Philip M, Morrison, Eamonn P, Biller, Scott A, Zahler, Robert, Deshpande, Prashant P, Pullockaran, Annie, Hagan, Deborah L, Morgan, Nathan, Taylor, Joseph R, Obermeier, Mary T, Humphreys, William G, Khanna, Ashish, Discenza, Lorell, Robertson, James G, Wang, Aiying, Han, Songping, Wetterau, John R, Janovitz, Evan B, Flint, Oliver P, Whaley, Jean M, Washburn, William N

“…The C-aryl glucoside 6 (dapagliflozin) was identified as a potent and selective hSGLT2 inhibitor which reduced blood glucose levels in a dose-dependent manner…”
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Discovery and Preclinical Profile of Saxagliptin (BMS-477118):  A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes by Augeri, David J, Robl, Jeffrey A, Betebenner, David A, Magnin, David R, Khanna, Ashish, Robertson, James G, Wang, Aiying, Simpkins, Ligaya M, Taunk, Prakash, Huang, Qi, Han, Song-Ping, Abboa-Offei, Benoni, Cap, Michael, Xin, Li, Tao, Li, Tozzo, Effie, Welzel, Gustav E, Egan, Donald M, Marcinkeviciene, Jovita, Chang, Shu Y, Biller, Scott A, Kirby, Mark S, Parker, Rex A, Hamann, Lawrence G

“…Efforts to further elucidate structure−activity relationships (SAR) within our previously disclosed series of β-quaternary amino acid linked…”
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Improved Brain Tumor Classification by Sodium MR Imaging: Prediction of IDH Mutation Status and Tumor Progression by Biller, A, Badde, S, Nagel, A, Neumann, J-O, Wick, W, Hertenstein, A, Bendszus, M, Sahm, F, Benkhedah, N, Kleesiek, J

“…MR imaging in neuro-oncology is challenging due to inherent ambiguities in proton signal behavior. Sodium-MR imaging may substantially contribute to the…”
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The Gemini Planet-Finding Campaign: The Frequency of Giant Planets Around Debris Disk Stars by Wahhaj, Zahed, Liu, Michael C., Nielsen, Eric L., Biller, Beth A., Hayward, Thomas L., Close, Laird M., Males, Jared R., Skemer, Andrew, Ftaclas, Christ, Chun, Mark, Thatte, Niranjan, Tecza, Matthias, Shkolnik, Evgenya L., Kuchner, Marc, Reid, I. Neill, de Gouveia Dal Pino, Elisabete M., Alencar, Silvia H. P., Gregorio-Hetem, Jane, Boss, Alan, Lin, Douglas N. C., Toomey, Douglas W.

“…We have completed a high-contrast direct imaging survey for giant planets around 57 debris disk stars as part of the Gemini NICI Planet-Finding Campaign. We…”
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Constraints on Extrasolar Planet Populations from VLT NACO/SDI and MMT SDI and Direct Adaptive Optics Imaging Surveys: Giant Planets are Rare at Large Separations by Nielsen, Eric L, Close, Laird M, Biller, Beth A, Masciadri, Elena, Lenzen, Rainer

“…We examine the implications for the distribution of extrasolar planets based on the null results from two of the largest direct imaging surveys published to…”
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THE GEMINI NICI PLANET-FINDING CAMPAIGN: THE COMPANION DETECTION PIPELINE by WAHHAJ, ZAHED, Liu, Michael C, Biller, Beth A, Nielsen, Eric L, Close, Laird M, Hayward, Thomas L, Hartung, Markus, Chun, Mark, Ftaclas, Christ, Toomey, Douglas W

“…We present high-contrast image processing techniques used by the Gemini NICI Planet-Finding Campaign to detect faint companions to bright stars. The…”
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IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME AFTER WITHDRAWAL OF NATALIZUMAB? by LENHARD, T, BILLER, A, MUELLER, W, METZ, I, SCHÖNBERGER, J, WILDEMANN, B

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The Gemini NICI Planet-finding Campaign: Discovery of a Substellar L Dwarf Companion to the Nearby Young M Dwarf CD–35 2722 by Wahhaj, Zahed, Liu, Michael C, Biller, Beth A, Clarke, Fraser, Nielsen, Eric L, Close, Laird M, Hayward, Thomas L, Mamajek, Eric E, Cushing, Michael, Dupuy, Trent, Tecza, Matthias, Thatte, Niranjan, Chun, Mark, Ftaclas, Christ, Hartung, Markus, Reid, I. Neill, Shkolnik, Evgenya L, Alencar, Silvia H. P, Artymowicz, Pawel, Boss, Alan, de Gouveia Dal Pino, Elisabethe, Gregorio-Hetem, Jane, Ida, Shigeru, Kuchner, Marc, Lin, Douglas N. C, Toomey, Douglas W

“…We present the discovery of a wide (67 AU) substellar companion to the nearby (21 pc) young solar-metallicity M1 dwarf CD--35 2722, a member of the 100 Myr AB…”
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Evidence Against an Edge-on Disk Around the Extrasolar Planet, 2MASS 1207 b and a New Thick-cloud Explanation for Its Underluminosity by Skemer, Andrew J, Close, Laird M, Szűcs, László, Apai, Dániel, Pascucci, Ilaria, Biller, Beth A

“…Since the discovery of the first directly imaged, planetary-mass object, 2MASS 1207 b, several works have sought to explain a disparity between its observed…”
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