Search Results - "BILD, Andrea"

Alternative preprocessing of RNA-Sequencing data in The Cancer Genome Atlas leads to improved analysis results by Rahman, Mumtahena, Jackson, Laurie K, Johnson, W Evan, Li, Dean Y, Bild, Andrea H, Piccolo, Stephen R

“…The Cancer Genome Atlas (TCGA) RNA-Sequencing data are used widely for research. TCGA provides 'Level 3' data, which have been processed using a pipeline…”
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Paradoxical cancer cell proliferation after FGFR inhibition through decreased p21 signaling in FGFR1-amplified breast cancer cells by Chi, Feng, Griffiths, Jason I, Nath, Aritro, Bild, Andrea H

“…Fibroblast growth factors (FGFs) control various cellular functions through fibroblast growth factor receptor (FGFR) activation, including proliferation,…”
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ENDORSE: a prognostic model for endocrine therapy in estrogen‐receptor‐positive breast cancers by Nath, Aritro, Cohen, Adam L, Bild, Andrea H

“…Advanced and metastatic estrogen receptor‐positive (ER + ) breast cancers are often endocrine resistant. However, endocrine therapy remains the primary…”
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Leveraging Single-Cell Approaches in Cancer Precision Medicine by Nath, Aritro, Bild, Andrea H

“…Cancer precision medicine aims to improve patient outcomes by tailoring treatment to the unique genomic background of a tumor. However, efforts to develop…”
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Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer by Christie, Elizabeth L., Pattnaik, Swetansu, Beach, Jessica, Copeland, Anthony, Rashoo, Nineveh, Fereday, Sian, Hendley, Joy, Alsop, Kathryn, Brady, Samuel L., Lamb, Greg, Pandey, Ahwan, deFazio, Anna, Thorne, Heather, Bild, Andrea, Bowtell, David D. L.

“…ABCB1 encodes Multidrug Resistance protein (MDR1), an ATP-binding cassette member involved in the cellular efflux of chemotherapeutic drugs. Here we report…”
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Usefulness of Circulating Tumor DNA in Identifying Somatic Mutations and Tracking Tumor Evolution in Patients With Non-small Cell Lung Cancer by Roosan, Moom R., Mambetsariev, Isa, Pharaon, Rebecca, Fricke, Jeremy, Husain, Hatim, Reckamp, Karen L., Koczywas, Marianna, Massarelli, Erminia, Bild, Andrea H., Salgia, Ravi

“…The usefulness of circulating tumor DNA (ctDNA) in detecting mutations and monitoring treatment response has not been well studied beyond a few actionable…”
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Phylogenetic inference from single-cell RNA-seq data by Liu, Xuan, Griffiths, Jason I., Bishara, Isaac, Liu, Jiayi, Bild, Andrea H., Chang, Jeffrey T.

“…Tumors are comprised of subpopulations of cancer cells that harbor distinct genetic profiles and phenotypes that evolve over time and during treatment. By…”
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A single-sample microarray normalization method to facilitate personalized-medicine workflows by Piccolo, Stephen R., Sun, Ying, Campbell, Joshua D., Lenburg, Marc E., Bild, Andrea H., Johnson, W. Evan

“…Gene-expression microarrays allow researchers to characterize biological phenomena in a high-throughput fashion but are subject to technological biases and…”
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Circulating immune cell phenotype dynamics reflect the strength of tumor–immune cell interactions in patients during immunotherapy by Griffiths, Jason I., Wallet, Pierre, Pflieger, Lance T., Stenehjem, David, Liu, Xuan, Cosgrove, Patrick A., Leggett, Neena A., McQuerry, Jasmine A., Shrestha, Gajendra, Rossetti, Maura, Sunga, Gemalene, Moos, Philip J., Adler, Frederick R., Chang, Jeffrey T., Sharma, Sunil, Bild, Andrea H.

“…The extent to which immune cell phenotypes in the peripheral blood reflect within-tumor immune activity prior to and early in cancer therapy is unclear. To…”
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RAGE ablation attenuates glioma progression and enhances tumor immune responses by suppressing galectin-3 expression by Zhang, Ian Y, Liu, Shunan, Zhang, Leying, Liang, Rongrui, Fang, Qingxiao, Zhao, Jie, Ren, Lyuzhi, Medina, Eric F, Filippov, Aleksandr, Bonjoc, Kimberley-Jane, Chaudhry, Ammar, Dayyani, Mojtaba, Bild, Andrea H, Badie, Behnam

“…Abstract Background Malignant gliomas consist of heterogeneous cellular components that have adopted multiple overlapping escape mechanisms that overcome both…”
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Cell facilitation promotes growth and survival under drug pressure in breast cancer by Emond, Rena, Griffiths, Jason I., Grolmusz, Vince Kornél, Nath, Aritro, Chen, Jinfeng, Medina, Eric F., Sousa, Rachel S., Synold, Timothy, Adler, Frederick R., Bild, Andrea H.

“…The interplay of positive and negative interactions between drug-sensitive and resistant cells influences the effectiveness of treatment in heterogeneous…”
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Oncogenic pathway signatures in human cancers as a guide to targeted therapies by Nevins, Joseph R, Bild, Andrea H, Yao, Guang, Chang, Jeffrey T, Wang, Quanli, Potti, Anil, Chasse, Dawn, Joshi, Mary-Beth, Harpole, David, Lancaster, Johnathan M, Berchuck, Andrew, Olson, John A, Marks, Jeffrey R, Dressman, Holly K, West, Mike

“…The development of an oncogenic state is a complex process involving the accumulation of multiple independent mutations that lead to deregulation of cell…”
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Multiplatform single-sample estimates of transcriptional activation by Piccolo, Stephen R., Withers, Michelle R., Francis, Owen E., Bild, Andrea H., Johnson, W. Evan

“…Over the past two decades, many biotechnology platforms have been developed for high-throughput gene expression profiling. However, because each platform is…”
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Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer by Nath, Aritro, Cosgrove, Patrick A., Mirsafian, Hoda, Christie, Elizabeth L., Pflieger, Lance, Copeland, Benjamin, Majumdar, Sumana, Cristea, Mihaela C., Han, Ernest S., Lee, Stephen J., Wang, Edward W., Fereday, Sian, Traficante, Nadia, Salgia, Ravi, Werner, Theresa, Cohen, Adam L., Moos, Philip, Chang, Jeffrey T., Bowtell, David D. L., Bild, Andrea H.

“…The evolution of resistance in high-grade serous ovarian cancer (HGSOC) cells following chemotherapy is only partially understood. To understand the selection…”
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A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells by Chefetz, Ilana, Grimley, Edward, Yang, Kun, Hong, Linda, Vinogradova, Ekaterina V., Suciu, Radu, Kovalenko, Ilya, Karnak, David, Morgan, Cynthia A., Chtcherbinine, Mikhail, Buchman, Cameron, Huddle, Brandt, Barraza, Scott, Morgan, Meredith, Bernstein, Kara A., Yoon, Euisik, Lombard, David B., Bild, Andrea, Mehta, Geeta, Romero, Iris, Chiang, Chun-Yi, Landen, Charles, Cravatt, Benjamin, Hurley, Thomas D., Larsen, Scott D., Buckanovich, Ronald J.

“…Ovarian cancer is typified by the development of chemotherapy resistance. Chemotherapy resistance is associated with high aldehyde dehydrogenase (ALDH)…”
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Combating subclonal evolution of resistant cancer phenotypes by Brady, Samuel W., McQuerry, Jasmine A., Qiao, Yi, Piccolo, Stephen R., Shrestha, Gajendra, Jenkins, David F., Layer, Ryan M., Pedersen, Brent S., Miller, Ryan H., Esch, Amanda, Selitsky, Sara R., Parker, Joel S., Anderson, Layla A., Dalley, Brian K., Factor, Rachel E., Reddy, Chakravarthy B., Boltax, Jonathan P., Li, Dean Y., Moos, Philip J., Gray, Joe W., Heiser, Laura M., Buys, Saundra S., Cohen, Adam L., Johnson, W. Evan, Quinlan, Aaron R., Marth, Gabor, Werner, Theresa L., Bild, Andrea H.

“…Metastatic breast cancer remains challenging to treat, and most patients ultimately progress on therapy. This acquired drug resistance is largely due to…”
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ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer by Farmaki, Elena, Nath, Aritro, Emond, Rena, Karimi, Kimya L, Grolmusz, Vince K, Cosgrove, Patrick A, Bild, Andrea H

“…The mTOR inhibitor, everolimus, is an important clinical management component of metastatic ER+ breast cancer (BC). However, most patients develop resistance…”
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Airway PI3K pathway activation is an early and reversible event in lung cancer development by Gustafson, Adam M, Soldi, Raffaella, Anderlind, Christina, Scholand, Mary Beth, Qian, Jun, Zhang, Xiaohui, Cooper, Kendal, Walker, Darren, McWilliams, Annette, Liu, Gang, Szabo, Eva, Brody, Jerome, Massion, Pierre P, Lenburg, Marc E, Lam, Stephen, Bild, Andrea H, Spira, Avrum

“…Although only a subset of smokers develop lung cancer, we cannot determine which smokers are at highest risk for cancer development, nor do we know the…”
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Mechanisms and clinical implications of tumor heterogeneity and convergence on recurrent phenotypes by McQuerry, Jasmine A., Chang, Jeffrey T., Bowtell, David D. L., Cohen, Adam, Bild, Andrea H.

“…Tumor heterogeneity has been identified at various -omic levels. The tumor genome, transcriptome, proteome, and phenome can vary widely across cells in patient…”
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Linking oncogenic pathways with therapeutic opportunities by Nevins, Joseph R, Bild, Andrea H, Potti, Anil

“…The accumulation of multiple mutations and alterations in the cancer genome underlies the complexity of cancer phenotypes. A consequence of these alterations…”
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