Search Results - "BIGENZAHN, W"

Gene essentiality and synthetic lethality in haploid human cells by Blomen, Vincent A., Májek, Peter, Jae, Lucas T., Bigenzahn, Johannes W., Nieuwenhuis, Joppe, Staring, Jacqueline, Sacco, Roberto, van Diemen, Ferdy R., Olk, Nadine, Stukalov, Alexey, Marceau, Caleb, Janssen, Hans, Carette, Jan E., Bennett, Keiryn L., Colinge, Jacques, Superti-Furga, Giulio, Brummelkamp, Thijn R.

“…Although the genes essential for life have been identified in less complex model organisms, their elucidation in human cells has been hindered by technical…”
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TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9 by Heinz, Leonhard X., Lee, JangEun, Kapoor, Utkarsh, Kartnig, Felix, Sedlyarov, Vitaly, Papakostas, Konstantinos, César-Razquin, Adrian, Essletzbichler, Patrick, Goldmann, Ulrich, Stefanovic, Adrijana, Bigenzahn, Johannes W., Scorzoni, Stefania, Pizzagalli, Mattia D., Bensimon, Ariel, Müller, André C., King, F. James, Li, Jun, Girardi, Enrico, Mbow, M. Lamine, Whitehurst, Charles E., Rebsamen, Manuele, Superti-Furga, Giulio

“…Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses 1 – 3 . Here we show that a previously…”
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Recent advances in combinatorial drug screening and synergy scoring by Pemovska, Tea, Bigenzahn, Johannes W, Superti-Furga, Giulio

“…•Currently a vast heterogeneity in synergistic drug action scoring and analysis exists.•Novel cellular models offer robust ways to identify relevant…”
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The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification by Sedlyarov, Vitaly, Eichner, Ruth, Girardi, Enrico, Essletzbichler, Patrick, Goldmann, Ulrich, Nunes-Hasler, Paula, Srndic, Ismet, Moskovskich, Anna, Heinz, Leonhard X., Kartnig, Felix, Bigenzahn, Johannes W., Rebsamen, Manuele, Kovarik, Pavel, Demaurex, Nicolas, Superti-Furga, Giulio

“…Macrophages represent the first line of immune defense against pathogens, and phagosome acidification is a necessary step in pathogen clearance. Here, we…”
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Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking by Fauster, Astrid, Rebsamen, Manuele, Willmann, Katharina L., César-Razquin, Adrian, Girardi, Enrico, Bigenzahn, Johannes W., Schischlik, Fiorella, Scorzoni, Stefania, Bruckner, Manuela, Konecka, Justyna, Hörmann, Katrin, Heinz, Leonhard X., Boztug, Kaan, Superti-Furga, Giulio

“…Regulation of cell and tissue homeostasis by programmed cell death is a fundamental process with wide physiological and pathological implications. The advent…”
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A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis by Fauster, A, Rebsamen, M, Huber, K V M, Bigenzahn, J W, Stukalov, A, Lardeau, C-H, Scorzoni, S, Bruckner, M, Gridling, M, Parapatics, K, Colinge, J, Bennett, K L, Kubicek, S, Krautwald, S, Linkermann, A, Superti-Furga, G

“…Necroptosis is a form of regulated necrotic cell death mediated by receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and RIPK3. Necroptotic cell…”
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Metabolic drug survey highlights cancer cell dependencies and vulnerabilities by Pemovska, Tea, Bigenzahn, Johannes W., Srndic, Ismet, Lercher, Alexander, Bergthaler, Andreas, César-Razquin, Adrián, Kartnig, Felix, Kornauth, Christoph, Valent, Peter, Staber, Philipp B., Superti-Furga, Giulio

“…Interrogation of cellular metabolism with high-throughput screening approaches can unravel contextual biology and identify cancer-specific metabolic…”
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The Comparability of Anti-Spike SARS-CoV-2 Antibody Tests is Time-Dependent: a Prospective Observational Study by Perkmann, Thomas, Mucher, Patrick, Perkmann-Nagele, Nicole, Radakovics, Astrid, Repl, Manuela, Koller, Thomas, Schmetterer, Klaus G, Bigenzahn, Johannes W, Leitner, Florentina, Jordakieva, Galateja, Wagner, Oswald F, Binder, Christoph J, Haslacher, Helmuth

“…Various commercial anti-Spike SARS-CoV-2 antibody tests are used for studies and in clinical settings after vaccination. An international standard for…”
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An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client by Bigenzahn, Johannes W., Fauster, Astrid, Rebsamen, Manuele, Kandasamy, Richard K., Scorzoni, Stefania, Vladimer, Gregory I., Müller, André C., Gstaiger, Matthias, Zuber, Johannes, Bennett, Keiryn L., Superti-Furga, Giulio

“…Tandem affinity purification–mass spectrometry (TAP-MS) is a popular strategy for the identification of protein–protein interactions, characterization of…”
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Identifying Kinase Substrates via a Heavy ATP Kinase Assay and Quantitative Mass Spectrometry by Müller, André C., Giambruno, Roberto, Weißer, Juliane, Májek, Peter, Hofer, Alexandre, Bigenzahn, Johannes W., Superti-Furga, Giulio, Jessen, Henning J., Bennett, Keiryn L.

“…Mass spectrometry-based in vitro kinase screens play an essential role in the discovery of kinase substrates, however, many suffer from biological and…”
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Global survey of the immunomodulatory potential of common drugs by Vladimer, Gregory I, Snijder, Berend, Krall, Nikolaus, Bigenzahn, Johannes W, Huber, Kilian V M, Lardeau, Charles-Hugues, Sanjiv, Kumar, Ringler, Anna, Berglund, Ulrika Warpman, Sabler, Monika, de la Fuente, Oscar Lopez, Knöbl, Paul, Kubicek, Stefan, Helleday, Thomas, Jäger, Ulrich, Superti-Furga, Giulio

“…A high-content screening platform that measures the immunological potential of small-molecule and biologic drugs by computationally determining changes in the…”
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High risk of unilateral recurrent laryngeal nerve paralysis after esophagectomy using cervical anastomosis by Pertl, L., Zacherl, J., Mancusi, G., Gächter, J. N., Asari, R., Schoppmann, S., Bigenzahn, W., Schneider-Stickler, B.

“…The goal of this study was to estimate the incidence of temporary and permanent unilateral recurrent laryngeal nerve paralysis (URLNP) after esophagectomies…”
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Superimposed high-frequency jet ventilation (SHFJV) for endoscopic laryngotracheal surgery in more than 1500 patients by Rezaie-Majd, A., Bigenzahn, W., Denk, D.-M., Burian, M., Kornfehl, J., Grasl, M.Ch, Ihra, G., Aloy, A.

“…Superimposed high-frequency jet ventilation (SHFJV), which does not require any tracheal tubes or catheters, was developed specifically for use in…”
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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1 by Rebsamen, Manuele, Pochini, Lorena, Stasyk, Taras, de Araújo, Mariana E. G., Galluccio, Michele, Kandasamy, Richard K., Snijder, Berend, Fauster, Astrid, Rudashevskaya, Elena L., Bruckner, Manuela, Scorzoni, Stefania, Filipek, Przemyslaw A., Huber, Kilian V. M., Bigenzahn, Johannes W., Heinz, Leonhard X., Kraft, Claudine, Bennett, Keiryn L., Indiveri, Cesare, Huber, Lukas A., Superti-Furga, Giulio

“…The mTORC1 protein kinase complex integrates nutrient and growth stimuli to modulate signalling pathways that regulate cellular metabolism and physiology, but…”
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LZTR1 is a regulator of RAS ubiquitination and signaling by Bigenzahn, Johannes W, Collu, Giovanna M, Kartnig, Felix, Pieraks, Melanie, Vladimer, Gregory I, Heinz, Leonhard X, Sedlyarov, Vitaly, Schischlik, Fiorella, Fauster, Astrid, Rebsamen, Manuele, Parapatics, Katja, Blomen, Vincent A, Müller, André C, Winter, Georg E, Kralovics, Robert, Brummelkamp, Thijn R, Mlodzik, Marek, Superti-Furga, Giulio

“…In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding…”
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Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3 LZTR1 E3 Ligase KRAS Complex by Piech, Sophie, Brüschweiler, Sven, Westphalen, Josepha, Siess, Katharina M, García Murias, Julio, Konrat, Robert, Bigenzahn, Johannes W, Superti-Furga, Giulio

“…The RAS family of GTPases is among the most frequently mutated proteins in human cancer, creating a high clinical demand for therapies that counteract their…”
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Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3LZTR1 E3 Ligase KRAS Complex by Piech, Sophie, Brüschweiler, Sven, Westphalen, Josepha, Siess, Katharina M., García Murias, Julio, Konrat, Robert, Bigenzahn, Johannes W., Superti-Furga, Giulio

“…The RAS family of GTPases is among the most frequently mutated proteins in human cancer, creating a high clinical demand for therapies that counteract their…”
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How we do it: Voice therapy to improve vocal constitution and endurance in female student teachers by Schneider, B., Bigenzahn, W.

“…Keypoints • Vocal hypofunction should be regarded as risk factor of occupational voice disorders. • Voice therapy is effective to improve vocal endurance and…”
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JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia by Boztug, Kaan, Järvinen, Päivi M, Salzer, Elisabeth, Racek, Tomas, Mönch, Sebastian, Garncarz, Wojciech, Gertz, E Michael, Schäffer, Alejandro A, Antonopoulos, Aristotelis, Haslam, Stuart M, Schieck, Lena, Puchałka, Jacek, Diestelhorst, Jana, Appaswamy, Giridharan, Lescoeur, Brigitte, Giambruno, Roberto, Bigenzahn, Johannes W, Elling, Ulrich, Pfeifer, Dietmar, Conde, Cecilia Domínguez, Albert, Michael H, Welte, Karl, Brandes, Gudrun, Sherkat, Roya, van der Werff ten Bosch, Jutte, Rezaei, Nima, Etzioni, Amos, Bellanné-Chantelot, Christine, Superti-Furga, Giulio, Penninger, Josef M, Bennett, Keiryn L, von Blume, Julia, Dell, Anne, Donadieu, Jean, Klein, Christoph

“…Christoph Klein and colleagues identify homozygous mutations in the JAGN1 gene in families and individuals with severe congenital neutropenia. They show that…”
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Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study by Snijder, Berend, Vladimer, Gregory I, Krall, Nikolaus, Miura, Katsuhiro, Schmolke, Ann-Sofie, Kornauth, Christoph, Lopez de la Fuente, Oscar, Choi, Hye-Soo, van der Kouwe, Emiel, Gültekin, Sinan, Kazianka, Lukas, Bigenzahn, Johannes W, Hoermann, Gregor, Prutsch, Nicole, Merkel, Olaf, Ringler, Anna, Sabler, Monika, Jeryczynski, Georg, Mayerhoefer, Marius E, Simonitsch-Klupp, Ingrid, Ocko, Katharina, Felberbauer, Franz, Müllauer, Leonhard, Prager, Gerald W, Korkmaz, Belgin, Kenner, Lukas, Sperr, Wolfgang R, Kralovics, Robert, Gisslinger, Heinz, Valent, Peter, Kubicek, Stefan, Jäger, Ulrich, Staber, Philipp B, Superti-Furga, Giulio

“…Patients with refractory or relapsed haematological malignancies have few treatment options and short survival times. Identification of effective therapies…”
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