Search Results - "BIGAUD, Marc"

Second generation S1P pathway modulators: Research strategies and clinical developments by Bigaud, Marc, Guerini, Danilo, Billich, Andreas, Bassilana, Frederic, Brinkmann, Volker

“…Multiple Sclerosis (MS) is a chronic autoimmune disorder affecting the central nervous system (CNS) through demyelination and neurodegeneration. Until…”
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Impact of Siponimod on Enteric and Central Nervous System Pathology in Late-Stage Experimental Autoimmune Encephalomyelitis by Weier, Alicia, Enders, Michael, Kirchner, Philipp, Ekici, Arif, Bigaud, Marc, Kapitza, Christopher, Wörl, Jürgen, Kuerten, Stefanie

“…Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Although immune modulation and suppression are effective during…”
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Distribution and efficacy of ofatumumab and ocrelizumab in humanized CD20 mice following subcutaneous or intravenous administration by Torres, Julia Baguña, Roodselaar, Jay, Sealey, Megan, Ziehn, Marina, Bigaud, Marc, Kneuer, Rainer, Leppert, David, Weckbecker, Gisbert, Cornelissen, Bart, Anthony, Daniel C

“…Approval of B-cell-depleting therapies signifies an important advance in the treatment of multiple sclerosis (MS). However, it is unclear whether the…”
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Siponimod (BAF312) penetrates, distributes, and acts in the central nervous system: Preclinical insights by Bigaud, Marc, Rudolph, Bettina, Briard, Emmanuelle, Beerli, Christian, Hofmann, Andreas, Hermes, Erwin, Muellershausen, Florian, Schubart, Anna, Gardin, Anne

“…Background Siponimod (BAF312), a selective S1P1/S1P5 agonist, reduces disability progression in secondary progressive MS. Recent observations suggest it could…”
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Siponimod is a Functional Agonist for the S1P5 Receptor (P3.404) by Bigaud, Marc, Nuesslein-Hildesheim, Barbara, Tran, Thi-Thanh-Thao, Guerini, Danilo

“…Abstract only…”
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Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology by Martin, Kea, Junker, Ursula, Tritto, Elaine, Sutter, Esther, Rubic-Schneider, Tina, Morgan, Hannah, Niwa, Satoru, Li, Jianping, Schlapbach, Achim, Walker, Dana, Bigaud, Marc, Beerli, Christian, Littlewood-Evans, Amanda, Rudolph, Bettina, Laisney, Marc, Ledieu, David, Beltz, Karen, Quancard, Jean, Bornancin, Frédéric, Zamurovic Ribrioux, Natasa, Calzascia, Thomas

“…Genetic disruption or short-term pharmacological inhibition of MALT1 protease is effective in several preclinical models of autoimmunity and B cell…”
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Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism by Bigaud, Marc, Dincer, Zuhal, Bollbuck, Birgit, Dawson, Janet, Beckmann, Nicolau, Beerli, Christian, Fishli-Cavelti, Gina, Nahler, Michaela, Angst, Daniela, Janser, Philipp, Otto, Heike, Rosner, Elisabeth, Hersperger, Rene, Bruns, Christian, Quancard, Jean

“…Homeostasis of vascular barriers depends upon sphingosine 1-phosphate (S1P) signaling via the S1P1 receptor. Accordingly, S1P1 competitive antagonism is known…”
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Central Versus Peripheral Drug Exposure Ratio, a Key Differentiator for Siponimod Over Fingolimod? by Bigaud, Marc, Ramseier, Pamela, Tisserand, Sarah, Lang, Meike, Urban, Beatrice, Beerli, Christian, Karlsson, Göril

“…Introduction Siponimod, a potent and selective sphingosine-1-phosphate (S1P 1,5 ) agonist, is the only therapeutic agent that has shown efficacy against…”
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Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis by Billich, Andreas, Baumruker, Thomas, Beerli, Christian, Bigaud, Marc, Bruns, Christian, Calzascia, Thomas, Isken, Andrea, Kinzel, Bernd, Loetscher, Erika, Metzler, Barbara, Mueller, Matthias, Nuesslein-Hildesheim, Barbara, Kleylein-Sohn, Bernadette

“…Sphingosine-1-phosphate (S1P) regulates the egress of T cells from lymphoid organs; levels of S1P in the tissues are controlled by S1P lyase (Sgpl1). Hence,…”
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Reduced cardiac side-effect potential by introduction of polar groups: Discovery of NIBR-1282, an orally bioavailable CCR5 antagonist which is active in vivo by Thoma, Gebhard, Beerli, Christian, Bigaud, Marc, Bruns, Christian, Cooke, Nigel G., Streiff, Markus B., Zerwes, Hans-Guenter

“…Introduction of polar groups in a series of potent CCR5 antagonists which are very likely to adversely affect the conduction system in the heart led to the…”
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Gene expression profiling of immunomagnetically separated cells directly from stabilized whole blood for multicenter clinical trials by Letzkus, Martin, Luesink, Evert, Starck-Schwertz, Sandrine, Bigaud, Marc, Mirza, Fareed, Hartmann, Nicole, Gerstmayer, Bernhard, Janssen, Uwe, Scherer, Andreas, Schumacher, Martin M, Verles, Aurelie, Vitaliti, Alessandra, Nirmala, Nanguneri, Johnson, Keith J, Staedtler, Frank

“…Background Clinically useful biomarkers for patient stratification and monitoring of disease progression and drug response are in big demand in drug…”
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Meta-analysis for Neurofilament Light Chain as a Biomarker in Mouse Experimental Autoimmune Encephalomyelitis Studies (S17.008) by Kieseier, Bernd, Tisserand, Sarah, Ramseier, Pamela, Uffelmann, Tatjana, Locatelli, Giuseppe, Cenni, Bruno, Nuesslein-Hildesheim, Barbara, Bigaud, Marc

“…Abstract only…”
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Comparative Pharmacology of Ofatumumab vs Ocrelizumab in Humanized CD20 Transgenic Mice (S9.007) by Bigaud, Marc, Anthony, Daniel, Zipfel, Geraldine, Uffelmann, Tatjana, Vostiarova, Helena, Engelhardt, Volker, Nuesslein-Hildesheim, Barbara, Kieseier, Bernd

“…Abstract only…”
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Siponimod Penetrates, Distributes and Acts on the Central Nervous System: Translational Insights (3973) by Bigaud, Marc, Rudolph, Bettina, Briard, Emmanuelle, Beerli, Christian, Schubart, Anna, Gardin, Anne

“…Abstract only…”
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Siponimod: From Understanding Mode of Action to Differentiation Versus Fingolimod (1536) by Bigaud, Marc, Tisserand, Sarah, Albrecht, Philipp, Zalc, Bernard, Hach, Thomas, Dahlke, Frank, Meier, Daniela Piani

“…Abstract only…”
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Blockade of CD40-CD154 pathway interactions suppresses ectopic lymphoid structures and inhibits pathology in the NOD/ShiLtJ mouse model of Sjögren's syndrome by Wieczorek, Grazyna, Bigaud, Marc, Pfister, Sabina, Ceci, Melanie, McMichael, Katriona, Afatsawo, Catherine, Hamburger, Meike, Texier, Celine, Henry, Maurane, Cojean, Celine, Erard, Marinette, Mamber, Nadja, Rush, James S

“…To examine the role of CD40-CD154 costimulation and effects of therapeutic pathway blockade in the non-obese diabetic (NOD/ShiLtJ) model of Sjögren's syndrome…”
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Rationale for Use of Sphingosine-1-Phosphate Receptor Modulators in COVID-19 Patients: Overview of Scientific Evidence by Hach, Thomas, Shakeri-Nejad, Kasra, Bigaud, Marc, Dahlke, Frank, de Micco, Massimiliano, Petricoul, Olivier, Graham, Gordon, Piani-Meier, Daniela, Turrini, Renato, Brinkmann, Volker, Nicoletti, Ferdinando

“…Maladjusted immune responses to the coronavirus disease 2019 (COVID-19), for example, cytokine release syndrome, may result in immunopathology and acute…”
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Pharmacokinetic/Pharmacodynamic Characterization of Siponimod (BAF312) in Blood versus Brain in Experimental Autoimmune Encephalomyelitis Mice (P2.2-066) by Bigaud, Marc, Perdoux, Julien, Ramseier, Pamela, Tisserand, Sarah, Urban, Beatrice, Beerli, Christian

“…Abstract only…”
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A simple method to optimize peripheral blood mononuclear cell preparation from cynomolgus monkeys and improve mixed lymphocyte reactions by Bigaud, Marc, Maurer, Claudine, Vedrine, Corrine, Puissant, Bénédicte, Blancher, Antoine

“…Introduction: The standard Ficoll–Hypaque method used to isolate peripheral blood mononuclear cells (PBMC) gives very variable results when used with…”
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Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation by Bornancin, Frédéric, Renner, Florian, Touil, Ratiba, Sic, Heiko, Kolb, Yeter, Touil-Allaoui, Ismahane, Rush, James S, Smith, Paul A, Bigaud, Marc, Junker-Walker, Ursula, Burkhart, Christoph, Dawson, Janet, Niwa, Satoru, Katopodis, Andreas, Nuesslein-Hildesheim, Barbara, Weckbecker, Gisbert, Zenke, Gerhard, Kinzel, Bernd, Traggiai, Elisabetta, Brenner, Dirk, Brüstle, Anne, St Paul, Michael, Zamurovic, Natasa, McCoy, Kathy D, Rolink, Antonius, Régnier, Catherine H, Mak, Tak W, Ohashi, Pamela S, Patel, Dhavalkumar D, Calzascia, Thomas

“…The paracaspase MALT1 plays an important role in immune receptor-driven signaling pathways leading to NF-κB activation. MALT1 promotes signaling by acting as a…”
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