Search Results - "BIERY, Matt"

Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas by Przystal, Justyna M, Cianciolo Cosentino, Chiara, Yadavilli, Sridevi, Zhang, Jie, Laternser, Sandra, Bonner, Erin R, Prasad, Rachna, Dawood, Adam A, Lobeto, Nina, Chin Chong, Wai, Biery, Matt C, Myers, Carrie, Olson, James M, Panditharatna, Eshini, Kritzer, Bettina, Mourabit, Sulayman, Vitanza, Nicholas A, Filbin, Mariella G, de Iuliis, Geoffry N, Dun, Matthew D, Koschmann, Carl, Cain, Jason E, Grotzer, Michael A, Waszak, Sebastian M, Mueller, Sabine, Nazarian, Javad

“…Abstract Background Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The imipridone ONC201 has shown early clinical efficacy in a…”
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Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models by Vitanza, Nicholas A, Biery, Matt C, Myers, Carrie, Ferguson, Eric, Zheng, Ye, Girard, Emily J, Przystal, Justyna M, Park, Giulia, Noll, Alyssa, Pakiam, Fiona, Winter, Conrad A, Morris, Shelli M, Sarthy, Jay, Cole, Bonnie L, Leary, Sarah E S, Crane, Courtney, Lieberman, Nicole A P, Mueller, Sabine, Nazarian, Javad, Gottardo, Raphael, Brusniak, Mi-Youn, Mhyre, Andrew J, Olson, James M

“…Abstract Background Diffuse midline gliomas (DMGs), including diffuse intrinsic pontine gliomas (DIPGs), have a dismal prognosis, with less than 2% surviving 5…”
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Modulation of TCR-Induced Transcriptional Profiles by Ligation of CD28, ICOS, and CTLA-4 Receptors by Riley, James L., Mao Mao, Kobayashi, Sumire, Biery, Matt, Burchard, Julja, Cavet, Guy, Gregson, Brian P., June, Carl H., Linsley, Peter S.

“…Signals generated by T cell receptor (TCR) and CD28 engagement are required for optimal T cell activation, but how these signals integrate within the cell is…”
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Individual-specific variation of gene expression in peripheral blood leukocytes by RADICH, Jerald P, MAO MAO, LINSLEY, Peter S, STEPANIANTS, Sergey, BIERY, Matt, CASTLE, John, WARD, Terry, SCHIMMACK, Greg, KOBAYASHI, Sumire, CARLETON, Michael, LAMPE, Johanna

“…DNA microarray technology is used to determine gene expression profiles of various cell types, especially abnormal cells, such as cancer. By contrast,…”
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T lymphocyte activation gene identification by coregulated expression on DNA microarrays by MAO MAO, BIERY, Matt C, KOBAYASHI, Sumire V, WARD, Terry, SCHIMMACK, Greg, BURCHARD, Julja, SCHELTER, Janell M, HONGYUE DAI, HE, Yudong D, LINSLEY, Peter S

“…High-capacity methods for assessing gene function have become increasingly important because of the increasing number of newly identified genes emerging from…”
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DIPG-47. DISCOVERING A MOLECULAR BASIS FOR VULNERABILITY OF H3K27M-DMG TO HISTONE DEACETYLASE INHIBITORS by Paine, Danyelle, Hao, Yue, Tang, Nanyun, Biery, Matt, Vitanza, Nicholas, Berens, Michael

“…Using two H3K27M-DMG treatment-naive preclinical models (PBT22 and PBT29), we detected a 20-fold differential response to the histone deacetylase inhibitor,…”
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HGG-24. PRECLINICAL EFFICACY OF THE BRAIN PENETRANT CYCLIN-DEPENDENT KINASE INHIBITOR ZOTIRACICLIB IN PEDIATRIC DIFFUSE MIDLINE GLIOMAS by Mueller, Timothy, Yadavilli, Sridevi, Laternser, Sandra, Cianciolo, Chiara, Przystal, Justyna, Bonner, Erin, Biery, Matt C, Vitanza, Nicholas A, Grotzer, Michael, Mueller, Sabine, Nazarian, Javad

“…Children diagnosed with diffuse midline gliomas (DMG), including diffuse intrinsic pontine glioma (DIPG), have extremely poor outcomes with a median overall…”
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Abstract 4740: Molecular effects of histone deacetylase inhibitor Quisinostat on diffuse midline glioma of the pons by Paine, Danyelle, Tang, Nanyun, Hao, Yue, Biery, Matt, Meyers, Carrie, Noll, Alyssa, Vitanza, Nicholas, Berens, Michael

“…Diffuse Midline Glioma of the pons (DMG) is a lethal, aggressive heterogeneous brain stem tumor. Median overall survival is less than a year, with radiation as…”
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DIPG-10. OPTIMAL HDAC INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA by Vitanza, Nicholas, Biery, Matt, Myers, Carrie, Ferguson, Eric, Park, Giulia, Noll, Alyssa, Pakiam, Fiona, Girard, Emily, Morris, Shelli, Cole, Bonnie, Brusniak, Mi-Youn, Mhyre, Andrew, Olson, James

“…As the majority of diffuse intrinsic pontine glioma (DIPG) have H3K27M mutations, epigenetic-targeting agents have been studied, though evaluations have been…”
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DIPG-29. A CONNECT CONSORTIUM PRECLINICAL STUDY IDENTIFIES MEK INHIBITION AND RADIATION AS POTENTIAL COMBINATION PARTNERS FOR THE ALK2 INHIBITOR TP-0184 IN ACVR1-MUTANT DMG by Rogers, Rebecca, Tsoli, Maria, Kumar, Shiva Senthil, Potente, Elisabet Fernandez, Biery, Matt, Grabovska, Yura, Mackay, Alan, Carvalho, Diana, Pereria, Rita, Burford, Anna, Sejdiu, Drenusha, Ruddle, Ruth, Gabel, Florian, Raynaud, Florence, Yadavilli, Sridevi, Mizoguchi, Sean, Subramaniam, Bavani, Kilburn, Lindsey, Hwang, Eugene, Nazarian, Javad, Vitanza, Nicholas, Ziegler, David, Drissi, Rachid, Jones, Chris

“…Somatic mutations in ACVR1, which encodes the serine/threonine kinase ALK2, are found in 20-25% of DMG-H3K27 patients. Treatment of ACVR1-mutant orthotopic…”
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EXTH-58. THERAPEUTIC HDAC INHIBITION IN HYPERMUTANT DIFFUSE INTRINSIC PONTINE GLIOMA by Noll, Alyssa, Biery, Matt, Myers, Carrie, Paine, Danyelle, Zheng, Ye, Girard, Emily, Winter, Conrad, Morris, Shelli, Brusniak, Mi-Youn, Gottardo, Raphael, Mhyre, Andrew, Foster, Jessica, Dun, Matthew, Murtaza, Muhammed, Berens, Michael, Olson, James, Vitanza, Nicholas

“…Diffuse intrinsic pontine glioma (DIPG) continues to carry a dismal prognosis despite a growing understanding of its epigenetic regulation. While generally…”
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Abstract 2835: Voruciclib, a clinical stage oral CDK inhibitor, sensitizes triple negative breast cancer xenografts to proteasome inhibition by Dey, Joyoti, Casalini, Joseph, Ditzler, Sally, Biery, Matt, Merrell, Angela, Thirstrup, Derek, Grenley, Marc, Klinghoffer, Richard

“…Triple negative breast cancer (TNBC) is a highly heterogeneous disease, notoriously challenging to treat with standard chemotherapy options, and therefore is…”
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HGG-32. ONC201 AND ONC206 TARGET TUMOR CELL METABOLISM IN PEDIATRIC DIFFUSE MIDLINE GLIOMA PRECLINICAL MODELS by Przystal, Justyna M, Cosentino, Chiara Cianciolo, Yadavilli, Sridevi, Zhang, Jie, Laternser, Sandra, Bonner, Erin R, Biery, Matt, Vitanza, Nicholas A, Koschmann, Carl, Cain, Jason, Waszak, Sebastian M, Mueller, Sabine, Nazarian, Javad

“…Diffuse midline gliomas (DMGs) remain incurable cancers and new treatments are urgently needed. One promising new therapeutic avenue for these cancers is…”
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IMMU-09. Interim analysis from BrainChild-03: Seattle Children’s Locoregional B7-H3 CAR T Cell Trial for Children with Recurrent Central Nervous System Tumors and DIPG by Vitanza, Nicholas, Gust, Juliane, Wilson, Ashley, Huang, Wenjun, Chen, Dickson, Meechan, Michael, Biery, Matt, Myers, Carrie, Tahiri, Sophie, Crotty, Erin, Leary, Sarah, Cole, Bonnie, Browd, Samuel, Hauptman, Jason, Lee, Amy, Albert, Catherine, Pinto, Navin, Orentas, Rimas, Gardner, Rebecca, Jensen, Michael, Park, Julie

“…BrainChild-03 is a phase 1 clinical trial delivering repeated locoregional 2nd generation B7-H3 CAR T cells with 4-1BB co-stimulation to children with central…”
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DDRE-03. INTERNATIONAL PRECLINICAL DRUG DISCOVERY AND BIOMARKER PROGRAM INFORMING AN ADOPTIVE COMBINATORIAL TRIAL FOR DIFFUSE MIDLINE GLIOMAS by Przystal, Justyna, Yadavilli, Sridevi, Abadi, Christina Coleman, Yadav, Viveka Nand, Laternser, Sandra, Cosentino, Chiara Cianciolo, Waszak, Sebastian, Cartaxo, Rodrigo, Biery, Matt, Myers, Carrie, Jayasekara, Samantha, Olson, James, Filbin, Mariella, Vitanza, Nicholas, Cain, Jason, Koschmann, Carl, Mueller, Sabine, Nazarian, Javad

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DIPG-64. INTERNATIONAL PRECLINICAL DRUG DISCOVERY AND BIOMARKER PROGRAM INFORMING AN ADOPTIVE COMBINATORIAL TRIAL FOR DIFFUSE MIDLINE GLIOMAS by Przystal, Justyna M, Yadavilli, Sridevi, Abadi, Christina Colman, Yadav, Viveka Nand, Laternser, Sandra, Cosentino, Chiara Cianciolo, Waszak, Sebastian M, Cartaxo, Rodrigo, Biery, Matt, Myers, Carrie, Jayasekara, Samantha, Olson, James M, Filbin, Mariella G, Vitanza, Nicholas A, Cain, Jason, Koschmann#, Carl, Müller#, Sabine, Nazarian#, Javad

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Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans by Johnson, Alexander D, Uhl, M.Andrew, Biery, Matt, Craig, Nancy

“…Candida albicans is the most prevalent human fungal pathogen. Here, we take advantage of haploinsufficiency and transposon mutagenesis to perform large‐scale…”
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