Search Results - "BIECHELE, Travis L"

Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4 by Davidson, Kathryn C, Adams, Allison M, Goodson, Jamie M, McDonald, Circe E, Potter, Jennifer C, Berndt, Jason D, Biechele, Travis L, Taylor, Russell J, Moon, Randall T

“…Signal transduction pathways play diverse, context-dependent roles in vertebrate development. In studies of human embryonic stem cells (hESCs), conflicting…”
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WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling by James, Richard G, Davidson, Kathryn C, Bosch, Katherine A, Biechele, Travis L, Robin, Nicholas C, Taylor, Russell J, Major, Michael B, Camp, Nathan D, Fowler, Kerry, Martins, Timothy J, Moon, Randall T

“…The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high…”
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Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/β-Catenin Signaling by Robin, Nicholas C., Agoston, Zsuzsa, Biechele, Travis L., James, Richard G., Berndt, Jason D., Moon, Randall T.

“…Statins improve recovery from traumatic brain injury and show promise in preventing Alzheimer disease. However, the mechanisms by which statins may be…”
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Wnt Signaling Exerts an Antiproliferative Effect on Adult Cardiac Progenitor Cells Through IGFBP3 by Oikonomopoulos, Angelos, Sereti, Konstantina-Ioanna, Conyers, Frank, Bauer, Michael, Liao, Annette, Guan, Jian, Crapps, Dylan, Han, Jung-Kyu, Dong, Hanhua, Bayomy, Ahmad F, Fine, Gabriel C, Westerman, Karen, Biechele, Travis L, Moon, Randall T, Force, Thomas, Liao, Ronglih

“…RATIONALE:Recent work in animal models and humans has demonstrated the presence of organ-specific progenitor cells required for the regenerative capacity of…”
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Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells by Woll, Petter S., Morris, Julie K., Painschab, Matt S., Marcus, Rebecca K., Kohn, Aimee D., Biechele, Travis L., Moon, Randall T., Kaufman, Dan S.

“…Human embryonic stem cells (hESCs) provide an important means to effectively study soluble and cell-bound mediators that regulate development of early blood…”
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AKT Kinase Activity Is Required for Lithium to Modulate Mood-Related Behaviors in Mice by PAN, Jen Q, LEWIS, Michael C, NEVE, Rachael L, BIECHELE, Travis L, MOON, Randall T, SCOLNICK, Edward M, PETRYSHEN, Tracey L, HAGGARTY, Stephen J, KETTERMAN, Josh K, CLORE, Elizabeth L, RILEY, Misha, RICHARDS, Keenan R, BERRY-SCOTT, Erin, XIULIN LIU, WAGNER, Florence F, HOLSON, Edward B

“…Bipolar disorder (BP) is a debilitating psychiatric disorder, affecting ∼2% of the worldwide population, for which the etiological basis, pathogenesis, and…”
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Targeted BRAF inhibition impacts survival in melanoma patients with high levels of Wnt/β-catenin signaling by Chien, Andy J, Haydu, Lauren E, Biechele, Travis L, Kulikauskas, Rima M, Rizos, Helen, Kefford, Richard F, Scolyer, Richard A, Moon, Randall T, Long, Georgina V

“…Unprecedented clinical responses have been reported in advanced stage metastatic melanoma patients treated with targeted inhibitors of constitutively activated…”
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Regulating the response to targeted MEK inhibition in melanoma: Enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation by Conrad, William H., Swift, Reyna D., Biechele, Travis L., Kulikauskas, Rima M., Moon, Randall T., Chien, Andy J.

“…The limitations of revolutionary new mutation-specific inhibitors of BRAF V600E include the universal recurrence seen in melanoma patients treated with this…”
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Wilms Tumor Suppressor WTX Negatively Regulates WNT/ beta -Catenin Signaling by Major, Michael B, Camp, Nathan D, Berndt, Jason D, Yi, XianHua, Goldenberg, Seth J, Hubbert, Charlotte, Biechele, Travis L, Gingras, Anne-Claude, Zheng, Ning, MacCoss, Michael J, Angers, Stephane, Moon, Randall T

“…Aberrant WNT signal transduction is involved in many diseases. In colorectal cancer and melanoma, mutational disruption of proteins involved in the degradation…”
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The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-β-catenin pathway by targeting Dishevelled for degradation by Moon, Randall T, Angers, Stephane, Thorpe, Chris J, Biechele, Travis L, Goldenberg, Seth J, Zheng, Ning, MacCoss, Michael J

“…Dishevelled is a conserved protein that interprets signals received by Frizzled receptors. Using a tandem-affinity purification strategy and mass spectrometry…”
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Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness by Cheng, Jiongjia, Tsuda, Masanao, Okolotowicz, Karl, Dwyer, Mary, Bushway, Paul J, Colas, Alexandre R, Lancman, Joseph J, Schade, Dennis, Perea-Gil, Isaac, Bruyneel, Arne A N, Lee, Jaechol, Vadgama, Nirmal, Quach, Justine, McKeithan, Wesley L, Biechele, Travis L, Wu, Joseph C, Moon, Randall T, Si Dong, P Duc, Karakikes, Ioannis, Cashman, John R, Mercola, Mark

“…Wnt signaling plays a central role in tissue maintenance and cancer. Wnt activates downstream genes through β-catenin, which interacts with TCF/LEF…”
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Coexpression of IL-5 and Eotaxin-2 in Mice Creates an Eosinophil-Dependent Model of Respiratory Inflammation with Characteristics of Severe Asthma by Ochkur, Sergei I, Jacobsen, Elizabeth A, Protheroe, Cheryl A, Biechele, Travis L, Pero, Ralph S, McGarry, Michael P, Wang, Huiying, O'Neill, Katie R, Colbert, Dana C, Colby, Thomas V, Shen, Huahao, Blackburn, Michael R, Irvin, Charles C, Lee, James J, Lee, Nancy A

“…Mouse models of allergen provocation and/or transgenic gene expression have provided significant insights regarding the cellular, molecular, and immune…”
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Protein Kinase PKN1 Represses Wnt/β-Catenin Signaling in Human Melanoma Cells by James, Richard G., Bosch, Katherine A., Kulikauskas, Rima M., Yang, Peitzu T., Robin, Nick C., Toroni, Rachel A., Biechele, Travis L., Berndt, Jason D., von Haller, Priska D., Eng, Jimmy K., Wolf-Yadlin, Alejandro, Chien, Andy J., Moon, Randall T.

“…Advances in phosphoproteomics have made it possible to monitor changes in protein phosphorylation that occur at different steps in signal transduction and have…”
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Assaying beta-catenin/TCF transcription with beta-catenin/TCF transcription-based reporter constructs by Biechele, Travis L, Moon, Randall T

“…Transcription-based reporters have been instrumental in characterizing the Wnt/beta-catenin signaling pathway and will be essential in the search for…”
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Re: Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol by Biechele, Travis L, Chien, Andy J

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Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling by James, Richard G, Biechele, Travis L, Conrad, William H, Camp, Nathan D, Fass, Daniel M, Major, Michael B, Sommer, Karen, Yi, XianHua, Roberts, Brian S, Cleary, Michele A, Arthur, William T, MacCoss, Michael, Rawlings, David J, Haggarty, Stephen J, Moon, Randall T

“…Wnts are secreted ligands that activate several receptor-mediated signal transduction cascades. Homeostatic Wnt signaling through beta-catenin is required in…”
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Transcription-based reporters of Wnt/beta-catenin signaling by Biechele, Travis L, Adams, Allison M, Moon, Randall T

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Integrative analysis of genome-wide RNA interference screens by Berndt, Jason D, Biechele, Travis L, Moon, Randall T, Major, Michael B

“…High-throughput genetic screens have exponentially increased the functional annotation of the genome over the past 10 years. Likewise, genome-scale efforts to…”
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Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling by Major, Michael B., Camp, Nathan D., Berndt, Jason D., Yi, XianHua, Goldenberg, Seth J., Hubbert, Charlotte, Biechele, Travis L., Gingras, Anne-Claude, Zheng, Ning, MacCoss, Michael J., Angers, Stephane, Moon, Randall T.

“…Aberrant WNT signal transduction is involved in many diseases. In colorectal cancer and melanoma, mutational disruption of proteins involved in the degradation…”
Get full text

Wilms Tumor Suppressor WTX Negatively Regulates WNT/β-Catenin Signaling by Major, Michael B, Camp, Nathan D, Berndt, Jason D, Yi, XianHua, Goldenberg, Seth J, Hubbert, Charlotte, Biechele, Travis L, Gingras, Anne-Claude, Zheng, Ning, MacCoss, Michael J, Angers, Stephane, Moon, Randall T

“…Aberrant WNT signal transduction is involved in many diseases. In colorectal cancer and melanoma, mutational disruption of proteins involved in the degradation…”
Get full text