Search Results - "BIEBER, Marcia M"

Ovarian carcinoma glyco-antigen targeted by human IgM antibody by Chen, Yi, Bieber, Marcia M, Bhat, Neelima M, Teng, Nelson N H

“…Epithelial Ovarian Cancer (EOC) cells expression of a novel carbohydrate antigen was defined using a human VH4-34 encoded IgM monoclonal antibody (mAb216)…”
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Identification of Cell Surface Straight Chain Poly-N-Acetyl-Lactosamine Bearing Protein Ligands for VH4-34-Encoded Natural IgM Antibodies by Bhat, Neelima M, Adams, Christopher M, Chen, Yi, Bieber, Marcia M, Teng, Nelson N H

“…B cell binding and cytotoxicity by human VH4-34-encoded Abs of the IgM isotype has been well documented. A VH4-34-IgM has recently shown a favorable early…”
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Phase I trial of a novel human monoclonal antibody mAb216 in patients with relapsed or refractory B-cell acute lymphoblastic leukemia by LIEDTKE, Michaela, TWIST, Clare J, MEDEIROS, Bruno C, GOTLIB, Jason R, BERUBE, Caroline, BIEBER, Marcia M, BHAT, Neelima M, TENG, Nelson N, COUTRE, Steven E

“…This phase I trial was conducted to determine the safety and pharmacokinetics of monoclonal antibody 216, a human monoclonal Immunoglobulin M antibody…”
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Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer by Chen, Yi, Bieber, Marcia M., Teng, Nelson N.H.

“…A major challenge of successful chemotherapy in ovarian cancer is overcoming intrinsic or acquired multi‐drug resistance caused by active drug efflux mediated…”
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Effects of human monoclonal antibody 216 on B-progenitor acute lymphoblastic leukemia in vitro by Bieber, Marcia M, Twist, Clare J, Bhat, Neelima M, Teng, Nelson N H

“…Background Human monoclonal antibody (mAb) 216 is a naturally occurring IgM cytotoxic mAb that binds to a glycosylated epitope on the surface of B‐lymphocytes…”
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Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer by Chen, Yi, Bieber, Marcia M., Teng, Nelson N.H.

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VH4-34 encoded antibody in systemic lupus erythematosus: effect of isotype by BHAT, Neelima M, LEE, Lisa M, VAN VOLLENHOVEN, Ronald F, TENG, Nelson N. H, BIEBER, Marcia M

“…OBJECTIVE: To determine the clinical significance of elevated serum levels of VH4-34 encoded IgM and IgG antibodies with respect to the clinical…”
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Taxol-oligoarginine conjugates overcome drug resistance in-vitro in human ovarian carcinoma by Wender, Paul A, Galliher, Wesley C, Bhat, Neelima M, Pillow, Thomas H, Bieber, Marcia M, Teng, Nelson N.H

“…Abstract Objective Multidrug resistance is the major cause of failure of many chemotherapeutic agents. While resistance can arise from several factors, it is…”
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Detection of fetal trisomies 21 and 18 from maternal blood using triple gradient and magnetic cell sorting by Gänshirt-Ahlert, D, Börjesson-Stoll, R, Burschyk, M, Dohr, A, Garritsen, H S, Helmer, E, Miny, P, Velasco, M, Walde, C, Patterson, D

“…The need for an inexpensive and reproducible technique for noninvasive prenatal diagnosis by fetal cell isolation from maternal blood. For enrichment of fetal…”
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IgG Subclasses and Isotypes of VH4-34 Encoded Antibodies by Bhat, Neelima M., Kshirsagar, Mihir A., Bieber, Marcia M., Teng, Nelson N. H.

“…VH4-34 gene encoded autoantibodies are elevated in systemic lupus erythematosus (SLE) and in other diseases associated with B-cell…”
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B cell lymphoproliferative disorders and VH4-34 gene encoded antibodies by Bhat, Neelima M, Bieber, Marcia M, Yang, Yuh-Cheng, Leu, Yi-Shing, van Vollenhoven, Ronald F, Teng, Nelson N H

“…The VH4-34 represents an unusual Ig heavy chain variable region gene given that it is conserved and overexpressed despite its autoreactivity. Besides RBC 'I/i'…”
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The ontogeny and functional characteristics of human B-1 (CD5+ B) cells by Bhat, N M, Kantor, A B, Bieber, M M, Stall, A M, Herzenberg, L A, Teng, N N

“…We demonstrate that, on average, greater than 90% of B lymphocytes in fetal spleen express CD5 at gestational ages of 17-23 weeks. Similarly, CD5+ B cells (B-1…”
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Susceptibility of B-cell lymphoma to human antibodies encoded by the V4-34 gene by Bhat, Neelima M, Bieber, Marcia M, Young, Lawrence W, Teng, Nelson N.H

“…Our previous studies have shown that mAbs derived from the human V4-34 gene bind and kill human B-lymphocytes via membrane disruption. This study demonstrates…”
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Abstract 5373: In silico investigation of FOXM1 binding and novel inhibitors in epithelial ovarian cancer (EOC) by Chen, Yi, Ruben, Eliza A., Bieber, Marcia M., Rajadas, Jayakumar, Teng, Nelson N.h

“…Objective: Using TCGA database, we had demonstrated that aberrantly activated Forkhead box M1 (FOXM1) correlates to worse overall survival in a subgroup of…”
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Abstract 470: Artemisinin derivatives synergize with paclitaxel by targeting FOXM1 through Raf/MEK/MAPK signaling pathway in ovarian cancer by Chen, Yi, Chin, Brian W., Bieber, Marcia M., Tan, Xianjie, Teng, Nelson N.h

“…Objective: Artemisinin, the active principle of the Chinese medicinal herb Artemisia annua and its derivatives have the most efficacies against Plasmodium…”
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Anti-Endotoxin Human Monoclonal Antibody A6H4C5 (HA-IA) Utilizes the VH4.21 Gene by Bieber, Marcia M., Bhat, Neelima M., Teng, Nelson N. H.

“…Human IgM monoclonal antibody A6H4CS was manufactured by Centocor (Malvern, PA) and used in clinical trials as HA-IA (Centoxin). In vitro, A6H4CS binds to…”
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Synthesis and characterization of gentiobiose heptaacetate conjugate vaccines that produce endotoxin-neutralizing antibodies by Bhattacharjee, Apurba K, Sadoff, Jerald C, Collins, Hugh, Cross, Alan S, Khalil, Ali H, Bieber, Marcia M, Teng, Nelson N. H, Wright, Craig

“…We have prepared aminoethyl (AE), aminopropyl (AP), and aminopentyl (APT) derivatives of gentiobiose heptaacetate (GH). These spacer compounds (AEGH, APGH,…”
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VH4-34 encoded antibodies in systemic lupus erythematosus: a specific diagnostic marker that correlates with clinical disease characteristics by van Vollenhoven, R F, Bieber, M M, Powell, M J, Gupta, P K, Bhat, N M, Richards, K L, Albano, S A, Teng, N N

“…To determine the clinical significance of elevated serum levels of VH4-34 encoded antibodies (VH4-34 Ab) with respect to the diagnosis and clinical…”
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Human antilipid A monoclonal antibodies bind to human B cells and the i antigen on cord red blood cells by Bhat, NM, Bieber, MM, Chapman, CJ, Stevenson, FK, Teng, NN

“…We describe two independently derived human mAb, A6(H4C5) and 216, initially selected for their reactivity to the lipid A domain of bacterial LPS, which also…”
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One-step enrichment of nucleated red blood cells. A potential application in perinatal diagnosis by Bhat, N M, Bieber, M M, Teng, N N

“…We describe a discontinuous triple density gradient to obtain a 25-fold enrichment of nucleated red blood cells from mononuclear cells, granulocytes, and…”
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