Search Results - "BIDDICK, LAURA"

Small-Molecule Inhibition of GCNT3 Disrupts Mucin Biosynthesis and Malignant Cellular Behaviors in Pancreatic Cancer by Rao, Chinthalapally V, Janakiram, Naveena B, Madka, Venkateshwar, Kumar, Gaurav, Scott, Edgar J, Pathuri, Gopal, Bryant, Taylor, Kutche, Hannah, Zhang, Yuting, Biddick, Laura, Gali, Hariprasad, Zhao, Yan D, Lightfoot, Stan, Mohammed, Altaf

“…Pancreatic cancer is an aggressive neoplasm with almost uniform lethality and a 5-year survival rate of 7%. Several overexpressed mucins that impede drug…”
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Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma by Rao, Chinthalapally V, Janakiram, Naveena B, Madka, Venkateshwar, Devarkonda, Vishal, Brewer, Misty, Biddick, Laura, Lightfoot, Stan, Steele, Vernon E, Mohammed, Altaf

“…Cyclooxygenase-2 (COX-2), 5-Lipoxygenase (5-LOX), and epidermal growth factor receptor (EGRF) are over-expressed in human pancreatic ductal adenocarcinoma…”
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Eflornithine (DFMO) prevents progression of pancreatic cancer by modulating ornithine decarboxylase signaling by Mohammed, Altaf, Janakiram, Naveena B, Madka, Venkateshwar, Ritchie, Rebekah L, Brewer, Misty, Biddick, Laura, Patlolla, Jagan Mohan R, Sadeghi, Michael, Lightfoot, Stan, Steele, Vernon E, Rao, Chinthalapally V

“…Ornithine decarboxylase (ODC) is the key rate-limiting enzyme in the polyamine synthesis pathway and it is overexpressed in a variety of cancers. We found that…”
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Potentiating NK cell activity by combination of Rosuvastatin and Difluoromethylornithine for effective chemopreventive efficacy against Colon Cancer by Janakiram, Naveena B., Mohammed, Altaf, Bryant, Taylor, Zhang, Yuting, Brewer, Misty, Duff, Ashley, Biddick, Laura, Singh, Anil, Lightfoot, Stan, Steele, Vernon E, Rao, Chinthalapally V.

“…Colorectal cancer (CRC) is the second highest cause of cancer-related deaths. A successful strategy to improve chemopreventive efficacies is by down-regulating…”
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Systemic Chromosome Instability Resulted in Colonic Transcriptomic Changes in Metabolic, Proliferation, and Stem Cell Regulators in Sgo1-/+ Mice by Rao, Chinthalapally V, Sanghera, Saira, Zhang, Yuting, Biddick, Laura, Reddy, Arun, Lightfoot, Stan, Janakiram, Naveena B, Mohammed, Altaf, Dai, Wei, Yamada, Hiroshi Y

“…Colon cancer is the second most lethal cancer and is predicted to claim 49,700 lives in the United States this year. Chromosome instability (CIN) is observed…”
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Abstract 4983: Intermittent dosing regimens of naproxen and aspirin inhibit azoxymethane-induced rat colon adenoma progression to adenocarcinoma and carcinoma invasion by Mohammed, Altaf, Janakiram, Naveena B., Madka, Venkateshwar, Zhang, Yuting, Singh, Anil, Biddick, Laura, Li, Qian, Lightfoot, Stan, Steele, Vernon E., Lubet, Ronald, Miller, Mark S., Suen, Chen S., Sei, Shizuko, Rao, Chinthalapally V.

“…Colorectal Cancer (CRC) is a major public health issue world-wide with an estimated 700,000 deaths annually. Adults 50 to 69 years of age considered high-risk…”
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Intermittent Dosing Regimens of Aspirin and Naproxen Inhibit Azoxymethane-Induced Colon Adenoma Progression to Adenocarcinoma and Invasive Carcinoma by Mohammed, Altaf, Janakiram, Naveena B, Madka, Venkateshwar, Zhang, Yuting, Singh, Anil, Biddick, Laura, Li, Qian, Lightfoot, Stanley, Steele, Vernon E, Lubet, Ronald A, Suen, Chen S, Miller, Mark Steven, Sei, Shizuko, Rao, Chinthalapally V

“…Chronic use of aspirin and related drugs to reduce cancer risk is limited by unwanted side effects. Thus, we assessed the efficacy associated with different…”
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Abstract 93: Antagonizing pathways leading to differential dynamics in colonic carcinogenesis in azoxymethane (AOM)-treated Sgo1 (Shugoshin1)-haploinsufficient chromosome instability (CIN) model mice by Rao, Chinthalapally V., Sanghera, Saira, Zhang, Yuting, Biddick, Laura, Lightfoot, Stan, Dai, Wei, Yamada, Hiroshi Y.

“…(a) Colon cancer is the second most lethal cancer and is predicted to claim 50,830 lives in 2013. Chromosome Instability (CIN) is observed in 80-90% of colon…”
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Abstract 2881: Systemic Chromosome Instability (CIN) resulted in transcriptomic changes in metabolic and proliferation regulators in colonic mucosal tissue of Sgo1-/+ mice by Rao, Chinthalapally V., Sanghera, Saira, Zhang, Yuting, Biddick, Laura, Reddy, Arun, Lightfoot, Stan, Mohammed, Altaf, Dai, Wei, Yamada, Hiroshi Y.

“…(a) Colon cancer is the second most lethal cancer and is predicted to claim 50,310 lives in 2014. Chromosome Instability (CIN) is observed in 80-90% of colon…”
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Intermittent dosing regimens of aspirin and naproxen inhibit azoxymethane-induced rat colon adenoma progression to adenocarcinoma and invasive carcinoma by Mohammed, Altaf, Janakiram, Naveena B., Madka, Venkateshwar, Zhang, Yuting, Singh, Anil, Biddick, Laura, Li, Qian, Lightfoot, Stanley, Steele, Vernon E., Lubet, Ronald A., Suen, Chen S., Miller, Mark Steven, Sei, Shizuko, Rao, Chinthalapally V.

“…Chronic use of aspirin and related drugs to reduce cancer risk is limited by unwanted side effects. Thus, we assessed the efficacy associated with different…”
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Abstract 5260: NGS Transcriptome analysis of colon adenocarcinomas treated with individual and combination of aspirin and omeprazole by Janakiram, Naveena B., Mohammed, Altaf, Patlolla, Jagan M.R., Zhang, Yuting, Biddick, Laura, Madka, Venkateshwar, Qian, Li, Lightfoot, Stan, Dunn, Barbara, Lubet, Ronald, Suen, Chen S., Steele, Vernon E., Rao, Chinthalapally V.

“…Colorectal cancer (CRC) is the third most common type of cancer in men and women in US. Anti-inflammatory agents have proven to be most effective in CRC…”
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Adoptive transfer of regulatory T cells promotes intestinal tumorigenesis and is associated with decreased NK cells and IL-22 binding protein by Janakiram, Naveena B., Mohammed, Altaf, Bryant, Taylor, Brewer, Misty, Biddick, Laura, Lightfoot, Stan, Lang, Mark L., Rao, Chinthalapally V.

“…High number of regulatory T cells (Tregs), both circulating and at the tumor site, often indicates a poor prognosis in CRC patient's possibly impairing natural…”
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Lack of chemopreventive effects of P2X7R inhibitors against pancreatic cancer by Mohammed, Altaf, Janakiram, Naveena B, Madka, Venkateshwar, Pathuri, Gopal, Li, Qian, Ritchie, Rebekah, Biddick, Laura, Kutche, Hannah, Zhang, Yuting, Singh, Anil, Gali, Hariprasad, Lightfoot, Stan, Steele, Vernon E, Suen, Chen S, Rao, Chinthalapally V

“…Pancreatic cancer (PC) is an almost uniformly lethal disease with inflammation playing an important role in its progression. Sustained stimulation of…”
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Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model by Rao, Chinthalapally V., Sanghera, Saira, Zhang, Yuting, Biddick, Laura, Reddy, Arun, Lightfoot, Stan, Dai, Wei, Yamada, Hiroshi Y.

“…Colon cancer is the second most lethal cancer. It is predicted to claim 50,310 lives in 2014. Chromosome Instability (CIN) is observed in 80–90% of colon…”
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Abstract 2969: Combinational Targeting of EGFR and ODC pathways by Gefitinib and DFMO lead to complete blockade of PanIN progression to pancreatic ductal adenocarcinoma by Mohammed, Altaf, Janakiram, Naveena B., Ritchie, Rebekah L., Biddick, Laura, Brewer, Misty, Lightfoot, Stan, Steele, Vernon E., Rao, Chinthalapally V.

“…Pancreatic cancer (PC) is a devastating disease with almost uniform lethality despite aggressive treatment (5-year survival rate of <6%). Developing novel…”
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Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model: ANTAGONIZING PATHWAYS LEADING TO DIFFERENTIAL DYNAMICS by Rao, Chinthalapally V., Sanghera, Saira, Zhang, Yuting, Biddick, Laura, Reddy, Arun, Lightfoot, Stan, Dai, Wei, Yamada, Hiroshi Y.

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Abstract 1905: Galectin-3 and -4 as signature markers of lung, colon, pancreatic and bladder tumor progression and chemopreventive interventions by Kumar, Gaurav, Madka, Venkateshwar, Mohammed, Altaf, Patolla, Jagan M. r., Janakiram, Naveena B., Li, Qian, Zhang, Yuting, Biddick, Laura, Gillaspy, Allison, Lightfoot, Stanley, Rao, Chinthalapally V.

“…Galectins, a family of glycan-binding proteins, interact with cell-surface glycoconjugates and influence tumor progression by triggering a cascade of…”
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Abstract 2820: Omeprazole alone, or in combination with Aspirin inhibits azoxymethane-induced colon adenoma progression to adenocarcinoma and carcinoma invasion in F344 rat model by Mohammed, Altaf, Patlolla, Jagan M.R, Zhang, Yuting, Biddick, Laura, Madka, Venkateshwar, Li, Qian, Lightfoot, Stan, Lubet, Ronald, Suen, Chen S., Steele, Vernon E., Rao, Chinthalapally V.

“…Colorectal Cancer (CRC) is a major public health issue world-wide with an estimated over 600,000 deaths annually. Aspirin and Omeprazole are most commonly used…”
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Abstract 4653: Modulation of mTOR and p53 signaling using rapamycin plus CP-31398 inhibits growth and progression of urothelial carcinoma in-vivo by Madka, Venkateshwar, Mohammed, Altaf, Li, Qian, Zhang, Yuting, Biddick, Laura, Patlolla, Jagan M.R., Lightfoot, Stanley, Wu, Xue-Ru, Steele, Vernon, Kopelovich, Levy, Rao, Chinthalapally V.

“…Bladder cancer is the second most common genitourinary cancer worldwide. Despite multidisciplinary treatment advances, muscle-invasive bladder cancer continues…”
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Abstract 5255: Lack of chemopreventive effects of dietary P2×7R inhibitors against pancreatic cancer in p48Cre/+-LSL-KrasG12D/+ mice by Mohammed, Altaf, Janakiram, Naveena B., Madka, Venkateshwar, Pathuri, Gopal, Li, Qian, Ritchie, Rebekah, Biddick, Laura, Kutsche, Hannah, Zhang, Yuting, Singh, Anil, Gali, Hariprasad, Lightfoot, Stan, Steele, Vernon E., Suen, Chen S., Rao, Chinthalapally V.

“…Pancreatic cancer (PC) still remains a devastating disease that is almost uniformly lethal. Despite advances in the field of molecular genetics in human…”
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