Search Results - "BICKLE, Quentin D"

Orally active antischistosomal early leads identified from the open access malaria box by Ingram-Sieber, Katrin, Cowan, Noemi, Panic, Gordana, Vargas, Mireille, Mansour, Nuha R, Bickle, Quentin D, Wells, Timothy N C, Spangenberg, Thomas, Keiser, Jennifer

“…Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of…”
Get full text

Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening by Mansour, Nuha R, Bickle, Quentin D

“…In view of the current widespread use of and reliance on a single schistosomicide, praziquantel, there is a pressing need to discover and develop alternative…”
Get full text

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases by Paveley, Ross A, Mansour, Nuha R, Hallyburton, Irene, Bleicher, Leo S, Benn, Alex E, Mikic, Ivana, Guidi, Alessandra, Gilbert, Ian H, Hopkins, Andrew L, Bickle, Quentin D

“…Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting…”
Get full text

Application of RNAi to Genomic Drug Target Validation in Schistosomes by Guidi, Alessandra, Mansour, Nuha R, Paveley, Ross A, Carruthers, Ian M, Besnard, Jérémy, Hopkins, Andrew L, Gilbert, Ian H, Bickle, Quentin D

“…Concerns over the possibility of resistance developing to praziquantel (PZQ), has stimulated efforts to develop new drugs for schistosomiasis. In addition to…”
Get full text

Chronic Intestinal Nematode Infection Exacerbates Experimental Schistosoma mansoni Infection by Bickle, Quentin D, Solum, Julie, Helmby, Helena

“…Mixed-parasite infections are common in many parts of the world, but little is known of the effects of concomitant parasite infections on the immune response…”
Get full text

The Schistosoma mansoni Hepatic Egg Granuloma Provides a Favorable Microenvironment for Sustained Growth of Leishmania donovani by Hassan, Mohammed F., Zhang, Yaobi, Engwerda, Christian R., Kaye, Paul M., Sharp, Hannah, Bickle, Quentin D.

“…Parasitic co-infections are prevalent in many parts of the world. However, relatively little is known about how an underlying infection may impact on the…”
Get full text

Reciprocal Immunomodulation in a Schistosome and Hepatotropic Virus Coinfection Model by Edwards, Matthew J, Buchatska, Olena, Ashton, Miranda, Montoya, Maria, Bickle, Quentin D, Borrow, Persephone

“…Human coinfection with the helminth parasite Schistosoma mansoni and hepatitis B and hepatitis C viruses is associated with increased hepatic viral burdens and…”
Get full text

Early exposure of infants to GI nematodes induces Th2 dominant immune responses which are unaffected by periodic anthelminthic treatment by Wright, Victoria J, Ame, Shaali Makame, Haji, Haji Said, Weir, Rosemary E, Goodman, David, Pritchard, David I, Mohamed, Mahdi Ramsan, Haji, Hamad Juma, Tielsch, James M, Stoltzfus, Rebecca J, Bickle, Quentin D

“…We have previously shown a reduction in anaemia and wasting malnutrition in infants <3 years old in Pemba Island, Zanzibar, following repeated anthelminthic…”
Get full text

Analysis of Human Antibodies to Erythrocyte Binding Antigen 175 of Plasmodium falciparum by OKENU, Daniel M. N, RILEY, Eleanor M, BICKLE, Quentin D, AGOMO, Philip U, BARBOSA, Arnoldo, DAUGHERTY, Jon R, LANAR, David E, CONWAY, David J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria by Engwerda, Christian R, Mynott, Tracey L, Sawhney, Sanjeet, De Souza, J Brian, Bickle, Quentin D, Kaye, Paul M

“…Cerebral malaria (CM) causes death in children and nonimmune adults. TNF-alpha has been thought to play a key role in the development of CM. In contrast, the…”
Get full text

Adjusting for the acute phase response is essential to interpret iron status indicators among young Zanzibari children prone to chronic malaria and helminth infections by Kung'u, Jacqueline K, Wright, Victoria J, Haji, Hamad J, Ramsan, Mahdi, Goodman, David, Tielsch, James M, Bickle, Quentin D, Raynes, John G, Stoltzfus, Rebecca J

“…The extent to which the acute phase response (APR) influences iron status indicators in chronic infections is not well documented. We investigated this…”
Get more information

Early Helminth Infections Are Inversely Related to Anemia, Malnutrition, and Malaria and Are Not Associated with Inflammation in 6- to 23-Month-Old Zanzibari Children by Kung'u, Jacqueline K, Goodman, David, Haji, Hamad J, Ramsan, Mahdi, Wright, Victoria J, Bickle, Quentin D, Tielsch, James M, Raynes, John G, Stoltzfus, Rebecca J

“…Helminths aggravate anemia and malnutrition among school children. We studied this association in a cross-sectional study of 6- to 23-month-old Zanzibari…”
Get full text

A comparison of methods for detecting the eggs of Ascaris, Trichuris, and hookworm in infant stool, and the epidemiology of infection in Zanzibari infants by Goodman, David, Haji, Hamad J, Bickle, Quentin D, Stoltzfus, Rebecca J, Tielsch, James M, Ramsan, Mahdi, Savioli, Lorenzo, Albonico, Marco

“…This study compared five methods for detecting the eggs of the human parasitic geohelminths Ascaris, Trichuris, and hookworm in infant stool, and describes the…”
Get more information

Vaccination of mice with a cocktail DNA vaccine induces a Th1-type immune response and partial protection against Schistosoma japonicum infection by Zhang, Yaobi, Taylor, Martin G, Johansen, Maria V, Bickle, Quentin D

“…Several defined vaccine candidate antigens of Schistosoma japonicum have shown promise in large animal vaccination experiments. However, vaccination of mice in…”
Get full text

Field testing of Schistosoma japonicum DNA vaccines in cattle in China by Shi, Fuhui, Zhang, Yaobi, Lin, Jiaojiao, Zuo, Xin, Shen, Wei, Cai, Yiumin, Ye, Ping, Bickle, Quentin D, Taylor, Martin G

“…Vaccines are needed to reduce the zoonotic reservoir of Schistosoma japonicum infection in bovines in China. We have developed two experimental DNA vaccines…”
Get full text

Laboratory and field evaluation of Schistosoma japonicum DNA vaccines in sheep and water buffalo in China by Shi, Fuhui, Zhang, Yaobi, Ye, Ping, Lin, Jiaojiao, Cai, Yiumin, Shen, Wei, Bickle, Quentin D., Taylor, Martin G.

“…Vaccines are needed to control zoonotic Schistosoma japonicum infection and several vaccine candidates have now been identified. Two of these (Sj28GST and…”
Get full text

Comparison of the vaccine efficacy of γ-irradiated Schistosoma japonicum cercariae with the defined antigen Sj62(IrV-5) in pigs by Bickle, Quentin D, Bøgh, Henrik O, Johansen, Maria V, Zhang, Yaobi

“…Development of a vaccine against Schistosoma japonicum which can protect both man and the domestic animal zoonotic reservoirs of infection would be an…”
Get full text

Molecular cloning and characterization of a novel Schistosoma japonicum "irradiated vaccine-specific" antigen, Sj14-3-3 by Zhang, Y, Taylor, M G, McCrossan, M V, Bickle, Q D

“…A Schistosoma japonicum cDNA coding for a full length S. japonicum 14-3-3 protein was obtained by antibody screening of an adult worm cDNA library using sera…”
Get full text

Cloning of Schistosoma japonicum 14-3-3 epsilon (Sj14-3-3ε), a new member of the 14-3-3 family of proteins from schistosomes by Zhang, Yaobi, Bickle, Quentin D., Taylor, Martin G.

“…A new member of the 14-3-3 protein family from Schistosoma japonicum has been identified. Phylogenetic analysis showed that this member belongs to the epsilon…”
Get full text

Application of RNAi to Genomic Drug Target Validation in Schistosomes: e0003801 by Guidi, Alessandra, Mansour, Nuha R, Paveley, Ross A, Carruthers, Ian M, Besnard, Jérémy, Hopkins, Andrew L, Gilbert, Ian H, Bickle, Quentin D

“…Concerns over the possibility of resistance developing to praziquantel (PZQ), has stimulated efforts to develop new drugs for schistosomiasis. In addition to…”
Get full text