Search Results - "BIBLE, K."

Efatutazone, an Oral PPAR-γ Agonist, in Combination With Paclitaxel in Anaplastic Thyroid Cancer: Results of a Multicenter Phase 1 Trial by Smallridge, R. C, Copland, J. A, Brose, M. S, Wadsworth, J. T, Houvras, Y, Menefee, M. E, Bible, K. C, Shah, M. H, Gramza, A. W, Klopper, J. P, Marlow, L. A, Heckman, M. G, Von Roemeling, R

“…Purpose: A phase 1 study was initiated to determine the safety, potential effectiveness, and maximal tolerated dose and recommended phase 2 dose of efatutazone…”
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The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation by Isham, C R, Tibodeau, J D, Bossou, A R, Merchan, J R, Bible, K C

“…Background: We previously reported that chaetocin has potent and selective anti-myeloma activity attributable to reactive oxygen species (ROS) induction…”
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Old-growth CO2 flux measurements reveal high sensitivity to climate anomalies across seasonal, annual and decadal time scales by Wharton, S., Falk, M., Bible, K., Schroeder, M., Paw U, K.T.

“…► The old-growth forest is a small net sink of carbon over 10 years but exhibits high interannual variability. ► FNEE is closely linked to climate…”
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Preliminary results from a phase II trial of tipifarnib in squamous cell carcinomas (SCCs) with HRAS mutations by Ho, A.L., Chau, N., Bauman, J., Bible, K., Chintakuntlawar, A., Cabanillas, M.E., Wong, D.J., Braña Garcia, I., Brose, M.S., Boni, V., Even, C., Razaq, M., Mishra, V., Bracken, K., Wages, D., Scholz, C., Gualberto, A.

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Simvastatin improves physiological function and protects against muscle degeneration in mdx mice: A novel therapeutic approach for Duchenne muscular dystrophy by Whitehead, N, Kim, M, Bible, K, Adams, M, Froehner, S

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Quantification of terrestrial ecosystem carbon dynamics in the conterminous United States combining a process-based biogeochemical model and MODIS and AmeriFlux data by Chen, M., Zhuang, Q., Cook, D. R., Coulter, R., Pekour, M., Scott, R. L., Munger, J. W., Bible, K.

“…Satellite remote sensing provides continuous temporal and spatial information of terrestrial ecosystems. Using these remote sensing data and eddy flux…”
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Rebuttal to: Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy, Verhaart et al. 2020 by Whitehead, N P, Kim, M J, Bible, K L, Adams, M E, Froehner, S C

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Dynamics of water transport and storage in conifers studied with deuterium and heat tracing techniques by MEINZER, F. C., BROOKS, J. R., DOMEC, J.‐C., GARTNER, B. L., WARREN, J. M., WOODRUFF, D. R., BIBLE, K., SHAW, D. C.

“…ABSTRACT The volume and complexity of their vascular systems make the dynamics of long‐distance water transport in large trees difficult to study. We used heat…”
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Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents : The importance of sequence of administration by BIBLE, K. C, KAUFMANN, S. H

“…Flavopiridol, the first potent cyclin-dependent kinase inhibitor to undergo clinical trials as an antineoplastic agent in the United States, has attracted…”
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Stand-level gas-exchange responses to seasonal drought in very young versus old Douglas-fir forests of the Pacific Northwest, USA by Wharton, Sonia, Schroeder, Matt, Bible, Ken, Falk, Matthias, Paw U, Kyaw Tha

“…This study examines how stand age affects ecosystem mass and energy exchange response to seasonal drought in three adjacent Douglas-fir (Pseudotsuga menziesii…”
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Flavopiridol : A cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells by BIBLE, K. C, KAUFMANN, S. H

“…Flavopiridol (NSC 649890, L86-8275), a potent inhibitor of cyclin-dependent kinase 1/p34cdc2 phosphorylation and kinase activity, is currently undergoing Phase…”
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Antitumor Activity of VB-111, a Novel Antiangiogenic Virotherapeutic, in Thyroid Cancer Xenograft Mouse Models by Reddi, H V, Madde, P, Cohen, Y C, Bangio, L, Breitbart, E, Harats, D, Bible, K C, Eberhardt, N L

“…VB-111 is an engineered antiangiogenic adenovirus that expresses Fas-c in angiogenic blood vessels and has previously been shown to have significant antitumor…”
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Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer by SHRIDHAR, Viji, BIBLE, Keith C, STAUB, Julie, AVULA, Rajeswari, LEE, Yean Kit, KALLI, Kimberly, HUANG, Haojie, HARTMANN, Lynn C, KAUFMANN, Scott H, SMITH, David I

“…Differential display-PCR between ovarian tumor cell lines and short-term cultures of normal ovarian epithelial cell brushings was used to isolate a…”
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Flavopiridol binds to duplex DNA by BIBLE, K. C, BIBLE, R. H, KOTTKE, T. J, SVINGEN, P. A, KUN XU, PANG, Y.-P, HAJDU, E, KAUFMANN, S. H

“…Flavopiridol, the first potent cyclin-dependent kinase inhibitor to enter clinical trials, was recently found to be cytotoxic to noncycling cells. The present…”
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The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux by ERLICHMAN, Charles, BOERNER, Scott A, KAUFMANN, Scott H, HALLGREN, Christopher G, SPIEKER, Rebecca, WANG, Xiao-Yang, JAMES, C. David, SCHEFFER, George L, MALIEPAARD, Marc, ROSS, Douglas D, BIBLE, Keith C

“…Because the activities of HER family members are elevated and/or aberrant in a variety of human neoplasms, these cell surface receptors are receiving…”
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Effect of P-glycoprotein on flavopiridol sensitivity by BOERNER, S. A, TOURNE, M. E, KAUFMANN, S. H, BIBLE, K. C

“…Flavopiridol is the first potent inhibitor of cyclin-dependent kinases (CDKs) to enter clinical trials. Little is known about mechanisms of resistance to this…”
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canopy water relations of old-growth Douglas-fir trees by Bauerle, W.L, Hinckley, T.M, Cermak, J, Kucera, J, Bible, K

“…We investigated whole tree water relations in 56-65 m tall, old-growth Pseudotsuga menziesii trees within the Wind River Canopy Crane site, Carson, Washington,…”
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Cyclosporine A alleviates severe anaemia associated with refractory large granular lymphocytic leukaemia and chronic natural killer cell lymphocytosis by Bible, K C, Tefferi, A

“…Large granular lymphocytic (LGL) leukaemia and chronic natural killer cell lymphocytosis (CNKL) are chronic indolent disorders often associated with…”
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Characterization of an Ovarian Carcinoma Cell Line Resistant to Cisplatin and Flavopiridol by Keith C. Bible, Scott A. Boerner, Kathryn Kirkland, Kari L. Anderl, Duane Bartelt, Jr, Phyllis A. Svingen, Timothy J. Kottke, Yean K. Lee, Steven Eckdahl, Paul G. Stalboerger, Robert B. Jenkins, Scott H. Kaufmann

“…Flavopiridol, the first inhibitor of cyclin-dependent kinases to enter clinical trials, has shown promising antineoplastic activity and is currently undergoing…”
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Лечение токсических побочных эффектов у пациентов с распространенным медуллярным раком щитовидной железы by Brose, M. S., Bible, K. C., Chow, L. Q. M., Gilbert, J., Grande, C., Worden, F., Haddad, R.

“…Большой прогресс в лечении распространенного медуллярного рака щитовидной железы за последние 5 лет достигнут благодаря одобрению 2 препаратов – вандетаниба и…”
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