Search Results - "BIANCHI, Marco E"

The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration by Bianchi, Marco E, Mezzapelle, Rosanna

“…The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention…”
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DAMPs, PAMPs and alarmins: all we need to know about danger by Bianchi, Marco E.

“…Multicellular animals detect pathogens via a set of receptors that recognize pathogen‐associated molecular patterns (PAMPs). However, pathogens are not the…”
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HMGB1 loves company by Bianchi, Marco E.

“…HMGB1 outside of a cell is both a trigger of inflammation and a stimulus for tissue reconstruction; the balance may depend on the complexes it forms with other…”
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The Janus face of HMGB1 in heart disease: a necessary update by Raucci, Angela, Di Maggio, Stefania, Scavello, Francesco, D’Ambrosio, Alessandro, Bianchi, Marco E., Capogrossi, Maurizio C.

“…High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein involved in transcription regulation, DNA replication and repair and nucleosome assembly…”
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High‐mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair by Bianchi, Marco E., Crippa, Massimo P., Manfredi, Angelo A., Mezzapelle, Rosanna, Rovere Querini, Patrizia, Venereau, Emilie

“…Summary A single protein, HMGB1, directs the triggering of inflammation, innate and adaptive immune responses, and tissue healing after damage. HMGB1 is the…”
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High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity by Bianchi, Marco E., Manfredi, Angelo A.

“…Tissue damage occurs often in the life of mammals and is usually repaired. Dying cells are swiftly phagocytosed, but before disappearing, they alert…”
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HMGB1 and leukocyte migration during trauma and sterile inflammation by Venereau, Emilie, Schiraldi, Milena, Uguccioni, Mariagrazia, Bianchi, Marco E.

“…► A specific complex between HMGB1 and CXCL12 directs leukocyte migration via CXCR4. ► HMGB1 attracts leukocytes to injury sites and activates them, but via…”
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Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity by Loffreda, Alessia, Jacchetti, Emanuela, Antunes, Sofia, Rainone, Paolo, Daniele, Tiziana, Morisaki, Tatsuya, Bianchi, Marco E., Tacchetti, Carlo, Mazza, Davide

“…Live-cell microscopy has highlighted that transcription factors bind transiently to chromatin but it is not clear if the duration of these binding interactions…”
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The receptor for advanced glycation end-products (RAGE) is only present in mammals, and belongs to a family of cell adhesion molecules (CAMs) by Sessa, Luca, Gatti, Elena, Zeni, Filippo, Antonelli, Antonella, Catucci, Alessandro, Koch, Michael, Pompilio, Giulio, Fritz, Günter, Raucci, Angela, Bianchi, Marco E

“…The human receptor for advanced glycation endproducts (RAGE) is a multiligand cell surface protein belonging to the immunoglobulin superfamily, and is involved…”
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Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice by Stark, Konstantin, Philippi, Vanessa, Stockhausen, Sven, Busse, Johanna, Antonelli, Antonella, Miller, Meike, Schubert, Irene, Hoseinpour, Parandis, Chandraratne, Sue, von Brühl, Marie-Luise, Gaertner, Florian, Lorenz, Michael, Agresti, Alessandra, Coletti, Raffaele, Antoine, Daniel J., Heermann, Ralf, Jung, Kirsten, Reese, Sven, Laitinen, Iina, Schwaiger, Markus, Walch, Axel, Sperandio, Markus, Nawroth, Peter P., Reinhardt, Christoph, Jäckel, Sven, Bianchi, Marco E., Massberg, Steffen

“…Deep venous thrombosis (DVT) is one of the most common cardiovascular diseases, but its pathophysiology remains incompletely understood. Although sterile…”
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Endogenous HMGB1 regulates autophagy by Tang, Daolin, Kang, Rui, Livesey, Kristen M, Cheh, Chun-Wei, Farkas, Adam, Loughran, Patricia, Hoppe, George, Bianchi, Marco E, Tracey, Kevin J, Zeh, Herbert J. III, Lotze, Michael T

“…Autophagy clears long-lived proteins and dysfunctional organelles and generates substrates for adenosine triphosphate production during periods of starvation…”
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Nucleosomes effectively shield DNA from radiation damage in living cells by Brambilla, Francesca, Garcia-Manteiga, Jose Manuel, Monteleone, Emanuele, Hoelzen, Lena, Zocchi, Angelica, Agresti, Alessandra, Bianchi, Marco E

“…Abstract Eukaryotic DNA is organized in nucleosomes, which package DNA and regulate its accessibility to transcription, replication, recombination and repair…”
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HMG proteins: dynamic players in gene regulation and differentiation by Bianchi, Marco E, Agresti, Alessandra

“…Core histones package the genome into nucleosomes and control its accessibility to transcription factors. High mobility group proteins (HMGs) are, after…”
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Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance by He, Mingzhu, Bianchi, Marco E, Coleman, Tom R, Tracey, Kevin J, Al-Abed, Yousef

“…High Mobility Group Box 1 (HMGB1) was first identified as a nonhistone chromatin-binding protein that functions as a pro-inflammatory cytokine and a…”
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NF-κB oscillations translate into functionally related patterns of gene expression by Zambrano, Samuel, De Toma, Ilario, Piffer, Arianna, Bianchi, Marco E, Agresti, Alessandra

“…Several transcription factors (TFs) oscillate, periodically relocating between the cytoplasm and the nucleus. NF-κB, which plays key roles in inflammation and…”
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Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release by Venereau, Emilie, Casalgrandi, Maura, Schiraldi, Milena, Antoine, Daniel J, Cattaneo, Angela, De Marchis, Francesco, Liu, Jaron, Antonelli, Antonella, Preti, Alessandro, Raeli, Lorenzo, Shams, Sara Samadi, Yang, Huan, Varani, Luca, Andersson, Ulf, Tracey, Kevin J, Bachi, Angela, Uguccioni, Mariagrazia, Bianchi, Marco E

“…Tissue damage causes inflammation, by recruiting leukocytes and activating them to release proinflammatory mediators. We show that high-mobility group box 1…”
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Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma by JUBE, Sandro, RIVERA, Zeyana S, BIANCHI, Marco E, POWERS, Amy, WANG, Ena, PAGANO, Ian, PASS, Harvey I, GAUDINO, Giovanni, CARBONE, Michele, HAINING YANG

“…Human malignant mesothelioma is an aggressive and highly lethal cancer that is believed to be caused by chronic exposure to asbestos and erionite. Prognosis…”
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HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses by Tamura, Tomohiko, Yanai, Hideyuki, Lu, Yan, Koshiba, Ryuji, Ronfani, Lorenza, Honda, Kenya, Choi, Myoung Kwon, Kawamura, Takeshi, Bianchi, Marco E, Akira, Shizuo, Nakasato, Makoto, Taniguchi, Tadatsugu, Savitsky, David, Kodama, Tatsuhiko, Negishi, Hideo, Hangai, Sho, Wang, ZhiChao, Ban, Tatsuma

“…The activation of innate immune responses by nucleic acids is crucial to protective and pathological immunities and is mediated by the transmembrane Toll-like…”
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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation by Bianchi, Marco E, Scaffidi, Paola, Misteli, Tom

“…High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor…”
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soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10) by Raucci, Angela, Cugusi, Simona, Antonelli, Antonella, Barabino, Silvia M, Monti, Lucilla, Bierhaus, Angelika, Reiss, Karina, Saftig, Paul, Bianchi, Marco E

“…The receptor for advanced glycation endproducts (RAGE) mediates responses to cell danger and stress. When bound by its many ligands (which include advanced…”
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