Search Results - "BHOWMICK, DITI CHATTERJEE"

Adipsin Is an Adipokine that Improves β Cell Function in Diabetes by Lo, James C., Ljubicic, Sanda, Leibiger, Barbara, Kern, Matthias, Leibiger, Ingo B., Moede, Tilo, Kelly, Molly E., Chatterjee Bhowmick, Diti, Murano, Incoronata, Cohen, Paul, Banks, Alexander S., Khandekar, Melin J., Dietrich, Arne, Flier, Jeffrey S., Cinti, Saverio, Blüher, Matthias, Danial, Nika N., Berggren, Per-Olof, Spiegelman, Bruce M.

“…A hallmark of type 2 diabetes mellitus (T2DM) is the development of pancreatic β cell failure, which results in insulinopenia and hyperglycemia. We show that…”
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Development of insulin resistance in mice lacking PGC-1α in adipose tissues by Kleiner, Sandra, Mepani, Rina J, Laznik, Dina, Ye, Li, Jurczak, Michael J, Jornayvaz, Francois R, Estall, Jennifer L, Chatterjee Bhowmick, Diti, Shulman, Gerald I, Spiegelman, Bruce M

“…Reduced peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) expression and mitochondrial dysfunction in adipose tissue have been associated…”
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Conventional and Unconventional Mechanisms by which Exocytosis Proteins Oversee β-cell Function and Protection by Chatterjee Bhowmick, Diti, Ahn, Miwon, Oh, Eunjin, Veluthakal, Rajakrishnan, Thurmond, Debbie C

“…Type 2 diabetes (T2D) is one of the prominent causes of morbidity and mortality in the United States and beyond, reaching global pandemic proportions. One…”
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Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic β-cells by Chatterjee Bhowmick, Diti, Jeremic, Aleksandar

“…Human islet amyloid polypeptide (hIAPP) is the principal constituent of amyloid deposits and toxic oligomers in the pancreatic islets. Together with…”
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FoxA2 and RNA Pol II mediate human islet amyloid polypeptide turnover in ER-stressed pancreatic β-cells by Chatterjee Bhowmick, Diti, Burnett, Lydia, Kudaibergenova, Zhanar, Jeremic, Aleksandar M

“…Here, we investigated transcriptional and trafficking mechanisms of human islet amyloid polypeptide (hIAPP) in normal and stressed β-cells. In high…”
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DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism by Chatterjee Bhowmick, Diti, Aslamy, Arianne, Bhattacharya, Supriyo, Oh, Eunjin, Ahn, Miwon, Thurmond, Debbie C

“…Double C2 domain Β (DOC2b) protein is required for glucose-stimulated insulin secretion (GSIS) in β-cells, the underlying mechanism of which remains…”
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Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells by Gupta, Rana K., Mepani, Rina J., Kleiner, Sandra, Lo, James C., Khandekar, Melin J., Cohen, Paul, Frontini, Andrea, Bhowmick, Diti Chatterjee, Ye, Li, Cinti, Saverio, Spiegelman, Bruce M.

“…Progress has been made in elucidating the cell-surface phenotype of primary adipose progenitors; however, specific functional markers and distinct molecular…”
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Syntaxin 4 Mediates NF-κB Signaling and Chemokine Ligand Expression via Specific Interaction With IκBβ by Veluthakal, Rajakrishnan, Oh, Eunjin, Ahn, Miwon, Chatterjee Bhowmick, Diti, Thurmond, Debbie C

“…Enrichment of human islets with syntaxin 4 (STX4) improves functional β-cell mass through a nuclear factor-κB (NF-κB)-dependent mechanism. However, the…”
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Molecular Mechanisms of Amylin Turnover, Misfolding and Toxicity in the Pancreas by Bhowmick, Diti Chatterjee, Kudaibergenova, Zhanar, Burnett, Lydia, Jeremic, Aleksandar M

“…Amyloidosis is a common pathological event in which proteins self-assemble into misfolded soluble and insoluble molecular forms, oligomers and fibrils that are…”
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Effect of Therapeutic Ultrasound on the Release of Insulin, Glucagon, and Alpha‐Amylase from Ex Vivo Pancreatic Models by Suarez‐Castellanos, Ivan, Singh, Tania, Chatterjee Bhowmick, Diti, Cohen, Joshua, Jeremic, Aleksandar, Zderic, Vesna

“…Objectives Our previously published studies showed the potential of therapeutic ultrasound (US) as a novel non‐pharmacological alternative for the treatment of…”
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Role of Cholesterol and Phospholipids in Amylin Misfolding, Aggregation and Etiology of Islet Amyloidosis by Singh, Sanghamitra, Trikha, Saurabh, Bhowmick, Diti Chatterjee, Sarkar, Anjali A, Jeremic, Aleksandar M

“…Amyloidosis is a biological event in which proteins undergo structural transitions from soluble monomers and oligomers to insoluble fibrillar aggregates that…”
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1712-P: DOC2b Enrichment Mitigates Cytokine-Induced CXCL10 Expression via Attenuating IKK-NFkB and STAT-1 Signaling in Beta Cells by Bhowmick, Diti Chatterjee, Ahn, Miwon, Bhattacharya, Supriyo, Thurmond, Debbie C

“…Introduction & Objective: The reduction of beta-cell dysfunction, and demise hold promise for therapeutic intervention for type 1 diabetes. Previously, we have…”
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DOC2b Protects Functional Beta‐cell Mass via A Novel Tyrosine Phosphorylation Dependent Mechanism by Bhowmick, Diti Chatterjee, Aslamy, Arianne, Oh, Eunjin, Ahn, Miwon, Thurmond, Debbie C.

“…Abstract only…”
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128-OR: DOC2b Boosts Insulin Secretion via a Yes Kinase-Dependent Mechanism by BHOWMICK, DITI CHATTERJEE, ASLAMY, ARIANNE, BHATTACHARYA, SUPRIYO, OH, EUNJIN, AHN, MIWON, THURMOND, DEBBIE C.

“…Exocytosis regulatory protein DOC2b is a crucial regulator of SNARE assembly in β-cells and enrichment of DOC2b enhances glucose-stimulated insulin secretion…”
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Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells by Singh, Sanghamitra, Bhowmick, Diti Chatterjee, Pany, Satyabrata, Joe, Myungkuk, Zaghlula, Noor, Jeremic, Aleksandar M.

“…Misfolded toxic human islet amyloid polypeptide or amylin (hA) and plasma membrane-associated redox complex, NADPH oxidase (NOX), have been implicated in the…”
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Therapeutic Ultrasound-Induced Insulin Release in Vivo by Singh, Tania, Suarez Castellanos, Ivan, Bhowmick, Diti Chatterjee, Cohen, Joshua, Jeremic, Aleksandar, Zderic, Vesna

“…The tolerability and efficacy of low-frequency, low-intensity therapeutic ultrasound-induced insulin release was investigated in a pre-clinical in vivo murine…”
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An inducible model of human amylin overexpression reveals diverse transcriptional changes by Aldras, Yoseph, Singh, Sanghamitra, Bode, Katrin, Bhowmick, Diti Chatterjee, Jeremic, Aleksandar, O’Halloran, Damien M.

“…•A novel inducible in vivo system of human amylin overexpression.•Amylin overexpression results in sensory and neural development defects.•Expression of human…”
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Therapeutic ultrasound-induced insulin release in vivo by Singh, Tania, Suarez Castellanos, Ivan, Chatterjee Bhowmick, Diti, Cohen, Joshua, Jeremic, Aleksandar, Zderic, Vesna

“…We have previously shown that therapeutic ultrasound is capable of stimulating insulin release from pancreatic beta cells, non-invasively, safely and…”
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Calcium-dependent ultrasound stimulation of secretory events from pancreatic beta cells by Suarez Castellanos, Ivan, Singh, Tania, Balteanu, Bogdan, Bhowmick, Diti Chatterjee, Jeremic, Aleksandar, Zderic, Vesna

“…Our previous studies have indicated that ultrasound can stimulate the release of insulin from pancreatic beta cells, providing a potential novel treatment for…”
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The Molecular Mechanisms of Stress-Induced Amylin Turnover in Pancreatic Beta Cell by Chatterjee Bhowmick, Diti

“…Islet amyloid polypeptide (IAPP) or amylin is a pancreatic hormone produced and co-secreted with insulin from pancreatic islet ?-cells that exerts local and…”
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