Search Results - "BHATIA, Kanchan"

Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy by Kannan, Annapoorna, Bhatia, Kanchan, Branzei, Dana, Gangwani, Laxman

“…Abstract Chronic low levels of survival motor neuron (SMN) protein cause spinal muscular atrophy (SMA). SMN is ubiquitously expressed, but the mechanisms…”
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Angiotensin (1-7) Receptor Antagonism Equalizes Angiotensin II-Induced Hypertension in Male and Female Spontaneously Hypertensive Rats by Sullivan, Jennifer C, Bhatia, Kanchan, Yamamoto, Tatsuo, Elmarakby, Ahmed A

“…Females are less sensitive to the hypertensive effects of angiotensin II compared with males, although the molecular mechanisms responsible are unknown. We…”
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Remote Ischemic Post-Conditioning Therapy is Protective in Mouse Model of Traumatic Optic Neuropathy by Nadeem, Muhammad, Kindelin, Adam, Mahady, Laura, Bhatia, Kanchan, Hoda, Md Nasrul, Ducruet, Andrew F., Ahmad, Saif

“…Traumatic optic neuropathy (TON) is characterized by visual dysfunction after indirect or direct injury to the optic nerve following blunt head trauma. TON is…”
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Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke by Ahmad, Saif, Elsherbiny, Nehal M., Haque, Rizwanul, Khan, M. Badruzzaman, Ishrat, Tauheed, Shah, Zahoor A., Khan, Mohammad M., Ali, Mehboob, Jamal, Arshad, Katare, Deepshikha Pande, Liou, Gregory I., Bhatia, Kanchan

“…•Anti-inflammatory and antioxidant role of sesamin evaluated in nurotoxicity induced by ischemic brain stroke.•Sesamin reduces activated inflammatory and…”
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Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy by Genabai, Naresh K., Kannan, Annapoorna, Ahmad, Saif, Jiang, Xiaoting, Bhatia, Kanchan, Gangwani, Laxman

“…Spinal muscular atrophy (SMA) is caused by the low levels of survival motor neuron (SMN) protein and is characterized by motor neuron degeneration and muscle…”
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Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy by Ahmad, Saif, Elsherbiny, Nehal M, Bhatia, Kanchan, Elsherbini, Ahmed M, Fulzele, Sadanand, Liou, Gregory I

“…Abstract Traumatic optic neuropathy (TON) is associated with apoptosis of retinal ganglion cells. Local productions of reactive oxygen species and inflammatory…”
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C3a Receptor Inhibition Protects Brain Endothelial Cells Against Oxygen-glucose Deprivation/Reperfusion by Ahmad, Saif, Kindelin, Adam, Khan, Shah Alam, Ahmed, Maaz, Hoda, Md Nasrul, Bhatia, Kanchan, Ducruet, Andrew F

“…The complement cascade is a central component of innate immunity which plays a critical role in brain inflammation. Complement C3a receptor (C3aR) is a key…”
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Exosomes in Vascular/Neurological Disorders and the Road Ahead by Alzahrani, Faisal A, Riza, Yasir M, Eid, Thamir M, Almotairi, Reema, Scherschinski, Lea, Contreras, Jessica, Nadeem, Muhammed, Perez, Sylvia E, Raikwar, Sudhanshu P, Jha, Ruchira M, Preul, Mark C, Ducruet, Andrew F, Lawton, Michael T, Bhatia, Kanchan, Akhter, Naseem, Ahmad, Saif

“…Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), stroke,…”
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The modulatory effect of deltamethrin on antioxidants in mice by Rehman, Hasibur, Ali, Mehboob, Atif, Fahim, Kaur, Manpreet, Bhatia, Kanchan, Raisuddin, Sheikh

“…Deltamethrin is a α-cyano pyrethroid insecticide used extensively in pest control. Although initially thought to be least toxic, a number of recent reports…”
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Remote Ischemic Perconditioning is Effective After Embolic Stroke in Ovariectomized Female Mice by Hoda, Md Nasrul, Bhatia, Kanchan, Hafez, Sherif S., Johnson, Maribeth H., Siddiqui, Shahneela, Ergul, Adviye, Zaidi, Syed Kashif, Fagan, Susan C., Hess, David C.

“…Remote ischemic conditioning is neuroprotective in young male rodents after experimental stroke. However, it has never been tested in females whom remain at…”
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Molecular Mechanisms of Neurodegeneration in Spinal Muscular Atrophy by Ahmad, Saif, Bhatia, Kanchan, Kannan, Annapoorna, Gangwani, Laxman

“…Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease with a high incidence and is the most common genetic cause of infant mortality…”
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Abstract TP320: The Novel Potent Complement C3a Receptor (C3aR) Antagonist JR14a Confers Robust Neuroprotection in Stroke by Ahmad, Saif, Contreras, Jessica, Bhatia, Kanchan, Fairlie, David P, Waters, Michael F, Ducruet, Andrew F

“…Abstract only Background: The complement C3a receptor (C3aR) plays a prominent role in deleterious post-stroke neuroinflammation. We and others have shown that…”
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Complement C3a receptor–mediated vascular dysfunction: a complex interplay between aging and neurodegeneration by Bhatia, Kanchan, Ahmad, Saif, Kindelin, Adam, Ducruet, Andrew F

“…Vascular dysfunction resulting In compromised blood-brain barrier (BBB) Integrity is evident in aging and disease. Although the complement C3a/ C3a receptor…”
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Complement C3a receptor-mediated vascular dysfunction: a complex interplay between aging and neurodegeneration by Bhatia, Kanchan, Ahmad, Saif, Kindelin, Adam, Ducruet, Andrew F

“…Vascular dysfunction resulting in compromised blood-brain barrier (BBB) integrity is evident in aging and disease. Although the complement C3a/C3a receptor…”
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Abstract WP294: Endothelial Deletion of Complement C3a Receptor is Neuroprotective in Murine Stroke by Ahmad, Saif, Contreras, Jessica, Raikwar, Sudhanshu, Akhter, Naseem, Bhatia, Kanchan, Jha, Ruchira, Waters, Michael F, Ducruet, Andrew F

“…Abstract only Background: Stroke is among the leading causes of death and disability worldwide. We and others have shown that endothelial C3a receptor (C3aR)…”
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Remote Limb Preconditioning and Postconditioning: Will It Translate Into a Promising Treatment for Acute Stroke? by HESS, David C, NASRUL HODA, Md, BHATIA, Kanchan

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Acetyl-11-keto-β-boswellic acid (AKBA) Attenuates Oxidative Stress, Inflammation, Complement Activation and Cell Death in Brain Endothelial Cells Following OGD/Reperfusion by Ahmad, Saif, Khan, Shah Alam, Kindelin, Adam, Mohseni, Tasha, Bhatia, Kanchan, Hoda, Md Nasrul, Ducruet, Andrew F.

“…Brain endothelial cells play an important role in maintaining blood flow homeostasis in the brain. Cerebral ischemia is a major cause of endothelial…”
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The Role of Complement C3a Receptor in Stroke by Ahmad, Saif, Bhatia, Kanchan, Kindelin, Adam, Ducruet, Andrew F.

“…The complement system is a key regulator of the innate immune response against diseased tissue that functions across multiple organ systems. Dysregulation of…”
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Abstract 15: The Novel Complement C3ar Antagonist Jr14a Is Neuroprotective In Stroke by Ahmad, Saif, Kindelin, Adam, Wang, Kendra, Lambay, Ateeq, Karra, Sakshi, Miller, Karis, Bhatia, Kanchan, Fairlie, David P, Ahmad, Abdullah S, Waters, Michael F, Ducruet, Andrew F

“…BackgroundStroke is the third leading cause of disability and mortality in the world. The c omplement C3a receptor plays a prominent role in post stroke brain…”
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Abstract P772: Complement C3a Receptor Deletion is Neuroprotective in a Murine Model of Vascular Cognitive Impairment by Ahmad, Saif, Nadeem, Muhammed, Kindelin, Adam, Mahady, Laura, Bhatia, Kanchan, Fuentes, Alberto, Turner, Gregory H, Fulzele, Sadanand, Waters, Michael F, Hoda, Nasrul, Ducruet, Andrew F

“…BackgroundChronic cerebral hypoperfusion (CCH) leads to vascular contributions to cognitive impairment and dementia (VCID). We and others have reported that…”
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