Search Results - "BEYER, Richard P"

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo by Vincow, Evelyn S., Merrihew, Gennifer, Thomas, Ruth E., Shulman, Nicholas J., Beyer, Richard P., MacCoss, Michael J., Pallanck, Leo J.

“…The accumulation of damaged mitochondria has been proposed as a key factor in aging and the pathogenesis of many common agerelated diseases, including…”
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Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice by Bitto, Alessandro, Ito, Takashi K, Pineda, Victor V, LeTexier, Nicolas J, Huang, Heather Z, Sutlief, Elissa, Tung, Herman, Vizzini, Nicholas, Chen, Belle, Smith, Kaleb, Meza, Daniel, Yajima, Masanao, Beyer, Richard P, Kerr, Kathleen F, Davis, Daniel J, Gillespie, Catherine H, Snyder, Jessica M, Treuting, Piper M, Kaeberlein, Matt

“…The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions…”
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Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart by Dai, Dao‐Fu, Karunadharma, Pabalu P., Chiao, Ying A., Basisty, Nathan, Crispin, David, Hsieh, Edward J., Chen, Tony, Gu, Haiwei, Djukovic, Danijel, Raftery, Daniel, Beyer, Richard P., MacCoss, Michael J., Rabinovitch, Peter S.

“…Summary Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin (mTOR) signaling, thereby regulating metabolism and…”
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The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription by Tang, Weiliang, Robles, Ana I, Beyer, Richard P, Gray, Lucas T, Nguyen, Giang H, Oshima, Junko, Maizels, Nancy, Harris, Curtis C, Monnat, Jr, Raymond J

“…The Werner syndrome (WS) is a prototypic adult Mendelian progeroid syndrome in which signs of premature aging are associated with genomic instability and an…”
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Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts by Chiao, Ying Ann, Kolwicz, Stephen C, Basisty, Nathan, Gagnidze, Arni, Zhang, Julia, Gu, Haiwei, Djukovic, Danijel, Beyer, Richard P, Raftery, Daniel, MacCoss, Michael, Tian, Rong, Rabinovitch, Peter S

“…Rapamycin, an inhibitor of mTOR signaling, has been shown to reverse diastolic dysfunction in old mice in 10 weeks, highlighting its therapeutic potential for…”
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Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex by Bedogni, Francesco, Hodge, Rebecca D., Elsen, Gina E., Nelson, Branden R., Daza, Ray A. M., Beyer, Richard P., Bammler, Theo K., Rubenstein, John L. R., Hevner, Robert F., Rakic, Pasko

“…Areas and layers of the cerebral cortex are specified by genetic programs that are initiated in progenitor cells and then, implemented in postmitotic neurons…”
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Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs by Nguyen, Giang Huong, Tang, Weiliang, Robles, Ana I., Beyer, Richard P., Gray, Lucas T., Welsh, Judith A., Schetter, Aaron J., Kumamoto, Kensuke, Wang, Xin Wei, Hickson, Ian D., Maizels, Nancy, Monnat, Raymond J., Harris, Curtis C.

“…Bloom syndrome is a rare autosomal recessive disorder characterized by genetic instability and cancer predisposition, and caused by mutations in the gene…”
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Age modifies respiratory complex I and protein homeostasis in a muscle type‐specific manner by Kruse, Shane E., Karunadharma, Pabalu P., Basisty, Nathan, Johnson, Richard, Beyer, Richard P., MacCoss, Michael J., Rabinovitch, Peter S., Marcinek, David J.

“…Summary Changes in mitochondrial function with age vary between different muscle types, and mechanisms underlying this variation remain poorly defined. We…”
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Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus by Doronin, Konstantin, Flatt, Justin W., Di Paolo, Nelson C., Khare, Reeti, Kalyuzhniy, Oleksandr, Acchione, Mauro, Sumida, John P., Ohto, Umeharu, Shimizu, Toshiyuki, Akashi-Takamura, Sachiko, Miyake, Kensuke, MacDonald, James W., Bammler, Theo M., Beyer, Richard P., Farin, Frederico M., Stewart, Phoebe L., Shayakhmetov, Dmitry M.

“…Although coagulation factors play a role in host defense for "living fossils" such as horseshoe crabs, the role of the coagulation system in immunity in higher…”
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Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides by Dai, Dao-Fu, Hsieh, Edward J, Chen, Tony, Menendez, Lorena G, Basisty, Nathan B, Tsai, Lauren, Beyer, Richard P, Crispin, David A, Shulman, Nicholas J, Szeto, Hazel H, Tian, Rong, MacCoss, Michael J, Rabinovitch, Peter S

“…We investigated the protective effects of mitochondrial-targeted antioxidant and protective peptides, Szeto-Schiller (SS) 31 and SS20, on cardiac function,…”
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Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3 by Riehle, Kimberly J, Campbell, Jean S, McMahan, Ryan S, Johnson, Melissa M, Beyer, Richard P, Bammler, Theo K, Fausto, Nelson

“…Suppressor of cytokine signaling 3 (SOCS3) down-regulates several signaling pathways in multiple cell types, and previous data suggest that SOCS3 may shut off…”
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Decreased Fibronectin Production Significantly Contributes to Dysregulated Repair of Asthmatic Epithelium by KICIC, Anthony, HALLSTRAND, Teal S, SUTANTO, Erika N, STEVENS, Paul T, KOBOR, Michael S, TAPLIN, Christopher, PARE, Peter D, BEYER, Richard P, STICK, Stephen M, KNIGHT, Darryl A

“…Damage to airway epithelium is followed by deposition of extracellular matrix (ECM) and migration of adjacent epithelial cells. We have shown that epithelial…”
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Group B streptococcal infection of the choriodecidua induces dysfunction of the cytokeratin network in amniotic epithelium: a pathway to membrane weakening by Vanderhoeven, Jeroen P, Bierle, Craig J, Kapur, Raj P, McAdams, Ryan M, Beyer, Richard P, Bammler, Theo K, Farin, Federico M, Bansal, Aasthaa, Spencer, Min, Deng, Mei, Gravett, Michael G, Rubens, Craig E, Rajagopal, Lakshmi, Adams Waldorf, Kristina M

“…Early events leading to intrauterine infection remain poorly defined, but may hold the key to preventing preterm delivery. To determine molecular pathways…”
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Dose-dependent effects of morphine exposure on mRNA and microRNA (miR) expression in hippocampus of stressed neonatal mice by McAdams, Ryan M, McPherson, Ronald J, Beyer, Richard P, Bammler, Theo K, Farin, Frederico M, Juul, Sandra E

“…Morphine is used to sedate critically ill infants to treat painful or stressful conditions associated with intensive care. Whether neonatal morphine exposure…”
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A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans by Krishnan, Ranjini M, Sullivan, Jeffrey H, Carlsten, Chris, Wilkerson, Hui-Wen, Beyer, Richard P, Bammler, Theo, Farin, Fred, Peretz, Alon, Kaufman, Joel D

“…Exposure to traffic-related air pollution (TRAP) is considered a trigger for acute cardiovascular events. Diesel Exhaust (DE) is a major contributor to TRAP in…”
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Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS by Hiolski, Emma M., Kendrick, Preston S., Frame, Elizabeth R., Myers, Mark S., Bammler, Theo K., Beyer, Richard P., Farin, Federico M., Wilkerson, Hui-wen, Smith, Donald R., Marcinek, David J., Lefebvre, Kathi A.

“…•Low-level seafood toxin exposure alters gene transcription in the CNS.•Transcriptional responses to low-level exposure are highly dynamic over…”
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Microarray Analysis of High-Dose Recombinant Erythropoietin Treatment of Unilateral Brain Injury in Neonatal Mouse Hippocampus by Juul, Sandra E, Beyer, Richard P, Bammler, Theo K, McPherson, Ronald J, Wilkerson, Jasmine, Farin, Federico M

“…Recombinant human erythropoietin (rEpo) is neuroprotective in neonatal models of brain injury. Proposed mechanisms of neuroprotection include activation of…”
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Seasonal changes in patterns of gene expression in avian song control brain regions by Thompson, Christopher K, Meitzen, John, Replogle, Kirstin, Drnevich, Jenny, Lent, Karin L, Wissman, Anne Marie, Farin, Federico M, Bammler, Theo K, Beyer, Richard P, Clayton, David F, Perkel, David J, Brenowitz, Eliot A

“…Photoperiod and hormonal cues drive dramatic seasonal changes in structure and function of the avian song control system. Little is known, however, about the…”
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The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked manner by Kisby, Glen E, Fry, Rebecca C, Lasarev, Michael R, Bammler, Theodor K, Beyer, Richard P, Churchwell, Mona, Doerge, Daniel R, Meira, Lisiane B, Palmer, Valerie S, Ramos-Crawford, Ana-Luiza, Ren, Xuefeng, Sullivan, Robert C, Kavanagh, Terrance J, Samson, Leona D, Zarbl, Helmut, Spencer, Peter S

“…Methylazoxymethanol (MAM), the genotoxic metabolite of the cycad azoxyglucoside cycasin, induces genetic alterations in bacteria, yeast, plants, insects and…”
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Evaluation of methods for oligonucleotide array data via quantitative real-time PCR by Qin, Li-Xuan, Beyer, Richard P, Hudson, Francesca N, Linford, Nancy J, Morris, Daryl E, Kerr, Kathleen F

“…There are currently many different methods for processing and summarizing probe-level data from Affymetrix oligonucleotide arrays. It is of great interest to…”
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