Search Results - "BEWLEY, Carole A"

Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential by Lusvarghi, Sabrina, Bewley, Carole A

“…Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. It is currently being developed as a…”
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Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G by Stewart-Jones, Guillaume B.E., Soto, Cinque, Lemmin, Thomas, Chuang, Gwo-Yu, Druz, Aliaksandr, Kong, Rui, Thomas, Paul V., Wagh, Kshitij, Zhou, Tongqing, Behrens, Anna-Janina, Bylund, Tatsiana, Choi, Chang W., Davison, Jack R., Georgiev, Ivelin S., Joyce, M. Gordon, Kwon, Young Do, Pancera, Marie, Taft, Justin, Yang, Yongping, Zhang, Baoshan, Shivatare, Sachin S., Shivatare, Vidya S., Lee, Chang-Chun D., Wu, Chung-Yi, Bewley, Carole A., Burton, Dennis R., Koff, Wayne C., Connors, Mark, Crispin, Max, Baxa, Ulrich, Korber, Bette T., Wong, Chi-Huey, Mascola, John R., Kwong, Peter D.

“…The HIV-1-envelope (Env) trimer is covered by a glycan shield of ∼90 N-linked oligosaccharides, which comprises roughly half its mass and is a key component of…”
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The genome of antibiotic-producing colonies of the Pelagophyte alga Chrysophaeum taylorii reveals a diverse and non-canonical capacity for secondary metabolism by Davison, Jack R., Rajwani, Rahim, Zhao, Gengxiang, Bewley, Carole A.

“…Chrysophaeum taylorii is a member of an understudied clade of marine algae that can be responsible for harmful coastal blooms and is known to accumulate…”
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An Artificial Intelligence Approach for Tackling Conformational Energy Uncertainties in Chiroptical Spectroscopies by Marton, Gabriel, Koenis, Mark A J, Liu, Hong-Bing, Bewley, Carole A, Buma, Wybren Jan, Nicu, Valentin Paul

“…Determination of the absolute configuration of chiral molecules is a prerequisite for obtaining a fundamental understanding in any chirality-related field. The…”
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Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16 by Pancera, Marie, Shahzad-ul-Hussan, Syed, Doria-Rose, Nicole A, McLellan, Jason S, Bailer, Robert T, Dai, Kaifan, Loesgen, Sandra, Louder, Mark K, Staupe, Ryan P, Yang, Yongping, Zhang, Baoshan, Parks, Robert, Eudailey, Joshua, Lloyd, Krissey E, Blinn, Julie, Alam, S Munir, Haynes, Barton F, Amin, Mohammed N, Wang, Lai-Xi, Burton, Dennis R, Koff, Wayne C, Nabel, Gary J, Mascola, John R, Bewley, Carole A, Kwong, Peter D

“…Some broadly neutralizing antibodies against HIV-1 recognize glycopeptide epitopes in the gp120 V1–V2 region. Now X-ray crystallography and NMR approaches,…”
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Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops by Kwon, Young Do, Finzi, Andrés, Wu, Xueling, Dogo-Isonagie, Cajetan, Lee, Lawrence K, Moore, Lucas R, Schmidt, Stephen D, Stuckey, Jonathan, Yang, Yongping, Zhou, Tongqing, Zhu, Jiang, Vicic, David A, Debnath, Asim K, Shapiro, Lawrence, Bewley, Carole A, Mascola, John R, Sodroski, Joseph G, Kwong, Peter D

“…The HIV-1 envelope (Env) spike (gp1203/gp413) undergoes considerable structural rearrangements to mediate virus entry into cells and to evade the host immune…”
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Lentzeacins A-E, New Bacterial-Derived 2,5- and 2,6-Disubstituted Pyrazines from a BGC-Rich Soil Bacterium Lentzea sp. GA3-008 by Liu, Hong-Bing, Davison, Jack R, Rajwani, Rahim, Zhao, Gengxiang, Ohlemacher, Shannon I, O'Connor, Robert D, Bewley, Carole A

“…Pyrazines (1,4-diazirines) are an important group of natural products that have tremendous monetary value in the food and fragrance industries and can exhibit…”
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Regioisomerization of Antimalarial Drug WR99210 Explains the Inactivity of a Commercial Stock by Remcho, T Parks, Guggilapu, Sravanthi D, Cruz, Phillip, Nardone, Glenn A, Heffernan, Gavin, O'Connor, Robert D, Bewley, Carole A, Wellems, Thomas E, Lane, Kristin D

“…WR99210, a former antimalarial drug candidate now widely used for the selection of transfectants, selectively targets the parasite's dihydrofolate reductase…”
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Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity by Liu, Hongbing, Lohith, Katheryn, Rosario, Margaret, Pulliam, Thomas H, O’Connor, Robert D, Bell, Lori J, Bewley, Carole A

“…Antibacterial-guided fractionation of the Dictyoceratid sponges Lamellodysidea sp. and two samples of Dysidea granulosa yielded 14 polybrominated, diphenyl…”
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Structural Basis for Norovirus Inhibition and Fucose Mimicry by Citrate by HANSMAN, Grant S, SHAHZAD-UL-HUSSAN, Syed, MCLELLAN, Jason S, CHUANG, Gwo-Yu, GEORGIEV, Ivelin, SHIMOIKE, Takashi, KATAYAMA, Kazuhiko, BEWLEY, Carole A, KWONG, Peter D

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability by Mason, Rosemarie D, Welles, Hugh C, Adams, Cameron, Chakrabarti, Bimal K, Gorman, Jason, Zhou, Tongqing, Nguyen, Richard, O'Dell, Sijy, Lusvarghi, Sabrina, Bewley, Carole A, Li, Hui, Shaw, George M, Sheng, Zizhang, Shapiro, Lawrence, Wyatt, Richard, Kwong, Peter D, Mascola, John R, Roederer, Mario

“…The simian immunodeficiency virus (SIV) challenge model of lentiviral infection is often used as a model to human immunodeficiency virus type 1 (HIV-1) for…”
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Phylogenomic analysis of the diversity of graspetides and proteins involved in their biosynthesis by Makarova, Kira S, Blackburne, Brittney, Wolf, Yuri I, Nikolskaya, Anastasia, Karamycheva, Svetlana, Espinoza, Marlene, Barry, 3rd, Clifton E, Bewley, Carole A, Koonin, Eugene V

“…Bacteria and archaea produce an enormous diversity of modified peptides that are involved in various forms of inter-microbial conflicts or communication. A…”
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Characterizing Carbohydrate-Protein Interactions by Nuclear Magnetic Resonance Spectroscopy by Bewley, Carole A., Shahzad-ul-Hussan, Syed

“…ABSTRACT Interactions between proteins and soluble carbohydrates and/or surface displayed glycans are central to countless recognition, attachment and…”
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Genome-Guided Discovery of Natural Products through Multiplexed Low-Coverage Whole-Genome Sequencing of Soil Actinomycetes on Oxford Nanopore Flongle by Rajwani, Rahim, Ohlemacher, Shannon I, Zhao, Gengxiang, Liu, Hong-Bing, Bewley, Carole A

“…Genome mining is an important tool for discovery of new natural products; however, the number of publicly available genomes for natural product-rich microbes…”
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Inhibition of Hepatitis C Virus by the Cyanobacterial Protein Microcystis viridis Lectin: Mechanistic Differences between the High-Mannose Specific Lectins MVL, CV-N, and GNA by Kachko, Alla, Loesgen, Sandra, Shahzad-ul-Hussan, Syed, Tan, Wendy, Zubkova, Iryna, Takeda, Kazuyo, Wells, Frances, Rubin, Steven, Bewley, Carole A, Major, Marian E

“…Plant or microbial lectins are known to exhibit potent antiviral activities against viruses with glycosylated surface proteins, yet the mechanism(s) by which…”
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Discovery and Synthesis of Namalide Reveals a New Anabaenopeptin Scaffold and Peptidase Inhibitor by Cheruku, Pradeep, Plaza, Alberto, Lauro, Gianluigi, Keffer, Jessica, Lloyd, John R, Bifulco, Giuseppe, Bewley, Carole A

“…The discovery, structure elucidation, and solid-phase synthesis of namalide, a marine natural product, are described. Namalide is a cyclic tetrapeptide; its…”
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A Model of Peptide Triazole Entry Inhibitor Binding to HIV‑1 gp120 and the Mechanism of Bridging Sheet Disruption by Emileh, Ali, Tuzer, Ferit, Yeh, Herman, Umashankara, Muddegowda, Moreira, Diogo R. M, LaLonde, Judith M, Bewley, Carole A, Abrams, Cameron F, Chaiken, Irwin M

“…Peptide triazole (PT) entry inhibitors prevent HIV-1 infection by blocking the binding of viral gp120 to both the HIV-1 receptor and the coreceptor on target…”
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Peptides from Second Extracellular Loop of C-C Chemokine Receptor Type 5 (CCR5) Inhibit Diverse Strains of HIV-1 by Dogo-Isonagie, Cajetan, Lam, Son, Gustchina, Elena, Acharya, Priyamvada, Yang, Yongping, Shahzad-ul-Hussan, Syed, Clore, G. Marius, Kwong, Peter D., Bewley, Carole A.

“…To initiate HIV entry, the HIV envelope protein gp120 must engage its primary receptor CD4 and a coreceptor CCR5 or CXCR4. In the absence of a high resolution…”
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Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformations by Louis, John M, Aniana, Annie, Lohith, Katheryn, Sayer, Jane M, Roche, Julien, Bewley, Carole A, Clore, G Marius

“…We previously reported a series of antibodies, in fragment antigen binding domain (Fab) formats, selected from a human non-immune phage library, directed…”
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Synthesis of Natural Product-Inspired Inhibitors of Mycobacterium tuberculosis Mycothiol-Associated Enzymes: The First Inhibitors of GlcNAc-Ins Deacetylase by Metaferia, Belhu B, Fetterolf, Brandon J, Shazad-ul-Hussan, Syed, Moravec, Matthew, Smith, Jeremy A, Ray, Satyajit, Gutierrez-Lugo, Maria-Teresa, Bewley, Carole A

“…Synthesis and evaluation of a chemical library of inhibitors of the mycothiol biosynthesis enzyme GlcNAc-Ins deacetylase (MshB) and the mycothiol-dependent…”
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